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Orajel Dental Gel Pain Relief - 5.3g

Orajel Dental Gel Pain Relief - 5.3g

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  • ✔️ Temporarily numbs toothache pain within minutes of application
  • ✔️ Contains 10% benzocaine for targeted local anaesthetic action
  • ✔️ Suitable for adults and children aged 12 and over
  • ✔️ Compact 5.3g tube ideal for use at home or on the go
  • ✔️ Relieves gum irritation and minor mouth ulcer discomfort

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Is Orajel Dental Gel Right for Your Toothache?

 

Toothache can strike at the worst possible moment — a weekend, a bank holiday, or the evening before a dental appointment. When you need something fast, orajel dental gel is one of the most recognised over-the-counter options available in the UK. This 5.3g tube contains 10% benzocaine, a topical local anaesthetic that temporarily numbs the affected area to ease dental pain. It's compact, easy to use, and available without a prescription. You can browse our full range of dental products if you're looking for additional oral care support alongside this gel.

Toothache is one of the most common reasons people visit a pharmacist for advice. According to the NHS, dental pain can range from mild sensitivity to severe, throbbing discomfort — and while this gel won't treat the underlying cause, it can provide meaningful short-term relief while you wait for a dental appointment.

 

How Does Orajel Dental Gel Work to Relieve Pain?

 

The active ingredient in this gel is benzocaine at a concentration of 10%. Benzocaine is a local anaesthetic that works by blocking sodium channels in nerve cell membranes, which prevents pain signals from being transmitted to the brain. The result is a temporary numbing effect at the site of application.

  • Benzocaine is applied directly to the gum or tooth surface
  • It penetrates the mucous membrane and inhibits nerve conduction locally
  • Pain relief typically begins within a few minutes of application
  • The effect is temporary and will wear off as the gel disperses

It's worth noting that this gel addresses the symptom — pain — rather than the cause. If you have an abscess, cracked tooth, or decay, you'll still need to see a dentist. Think of it as a bridge, not a solution.

 

Who Is Orajel Dental Gel Suitable For?

 

This gel is designed for adults and children aged 12 and over who are experiencing temporary dental pain. It's particularly useful in situations where immediate dental care isn't available. That said, it's not appropriate for everyone.

  • Adults with toothache awaiting a dental appointment
  • People with minor gum irritation or mouth ulcer discomfort
  • Individuals aged 12 and over who can apply the gel carefully
  • Those who need short-term relief (up to 7 days)

It is not suitable for children under 12, and anyone with a known allergy to benzocaine or other local anaesthetics should avoid it. If you're unsure whether this product is right for you, speak to a pharmacist before purchasing.

 

How Does Orajel Dental Gel Compare to Other Toothache Remedies?

 

Feature Orajel Dental Gel 5.3g Oral Analgesic (e.g. Ibuprofen)
Active ingredient Benzocaine 10% Ibuprofen 200–400mg
Route of action Topical (local) Systemic (whole body)
Speed of onset Within minutes 30–60 minutes
Suitable for under 12s No Age-dependent (check product)

 

How Should You Store Orajel Dental Gel?

 

Store this product below 25°C, away from direct sunlight and heat sources. Keep the tube tightly closed when not in use, and always store it out of the reach and sight of children. Do not use the gel after the expiry date printed on the tube or packaging.

If you're managing multiple health concerns alongside dental pain, our pain relief collection includes a range of options that may complement your care. As with all medicines, check the label carefully before use and consult a pharmacist if you have any doubts about suitability.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Orajel Dental Gel Pain Relief 5.3g specifications
Treatment category Dental pain relief
Active ingredient Benzocaine 10%
Mechanism of action Topical local anaesthetic — blocks sodium channels in nerve membranes
Effective for Toothache, gum pain, minor mouth ulcer discomfort
Suitable for Adults and children aged 12 and over
Pack size 5.3g
UK classification General Sale List (GSL)
Drug class Local anaesthetic
Preparation Topical gel
Route of administration Topical application to oral mucosa

Specifications of Orajel Dental Gel Pain Relief 5.3g

 

What Is Orajel Dental Gel and What Is It Used For?

 

Orajel Dental Gel is a topical local anaesthetic gel used for the temporary relief of toothache and dental pain. It contains 10% benzocaine as its active ingredient, which works by numbing the affected area of the gum or tooth. It is an over-the-counter (OTC) medicine available without a prescription in the UK.

This gel is intended for short-term use only. It does not treat the underlying dental condition causing the pain — whether that's decay, an abscess, or a cracked tooth. If your pain persists beyond 7 days, or worsens, you should seek dental or medical advice promptly. You can also explore our oral health collection for complementary products to support your dental care routine.

 

What Do You Need to Know Before Using Orajel Dental Gel?

 

Before using this gel, read the following carefully. There are certain situations where this product should not be used, and others where caution is needed.

Do not use Orajel Dental Gel if you:

  • Are allergic to benzocaine, other local anaesthetics of the ester type, or any other ingredient in the gel
  • Are under 12 years of age
  • Have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Have a history of methaemoglobinaemia

Use with caution and speak to a pharmacist or GP if you:

  • Are pregnant or breastfeeding
  • Have broken or damaged skin or mucosa in the mouth
  • Are taking medicines that may interact (see below)
  • Have any known allergies to dental anaesthetics

Known drug interactions:

  • Benzocaine may interact with sulphonamide antibiotics — inform your pharmacist if you are taking these
  • Use with other local anaesthetics may increase the risk of side effects
  • No significant systemic interactions are expected at topical doses in healthy adults

 

How Should You Use Orajel Dental Gel?

 

Always use this gel exactly as directed on the label. Do not apply more than the recommended amount, and do not use it more frequently than advised.

  1. Wash your hands thoroughly before use
  2. Using a clean fingertip or cotton bud, apply a small amount of gel (approximately 0.5cm) directly to the affected tooth or gum
  3. Allow the gel to remain on the area — do not rinse immediately
  4. Avoid eating or drinking for at least 30 minutes after application if possible
  5. Repeat up to four times daily as needed
  6. Do not use for more than 7 days without seeking dental advice
Indication Age Group Dose Frequency
Toothache / dental pain Adults and children 12+ Small amount (~0.5cm strip) Up to 4 times daily
Gum irritation Adults and children 12+ Small amount (~0.5cm strip) Up to 4 times daily
Under 12 years Not applicable Not recommended Not recommended

 

What Are the Possible Side Effects of Orajel Dental Gel?

 

Like all medicines, Orajel Dental Gel can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects:

  • Temporary numbness beyond the intended application site
  • Mild burning or stinging sensation on application
  • Localised redness or irritation of the gum

Less common side effects:

  • Allergic reaction — including rash, swelling, or difficulty breathing (seek immediate medical help)
  • Methaemoglobinaemia — a rare but serious condition where the blood's ability to carry oxygen is reduced; symptoms include pale, grey, or blue-coloured skin, shortness of breath, and fatigue
  • Contact dermatitis around the mouth in sensitive individuals

If you notice any signs of a serious allergic reaction or methaemoglobinaemia, stop using the gel immediately and seek urgent medical attention. For general pain management support, our first aid collection includes products that may help in the interim.

 

How Should You Store Orajel Dental Gel?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the cap tightly closed after each use
  • Store out of the reach and sight of children
  • Do not use after the expiry date printed on the tube
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Orajel Dental Gel online in the UK?

You can buy Orajel Dental Gel 5.3g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.85. It's available without a prescription and can be ordered for fast home delivery. Browse our full dental products range for more oral care options.

How does Orajel Dental Gel work in the body?

Orajel Dental Gel contains 10% benzocaine, a local anaesthetic that blocks sodium channels in the nerve cell membranes at the site of application. This prevents pain signals from travelling to the brain, producing a temporary numbing effect. It acts locally on the gum or tooth surface and does not enter the bloodstream in significant amounts when used as directed.

How do I apply Orajel Dental Gel step by step?

Wash your hands first, then apply a small amount — roughly a 0.5cm strip — directly to the affected tooth or gum using a clean fingertip or cotton bud. Allow the gel to sit on the area without rinsing, and try to avoid eating or drinking for at least 30 minutes afterwards. You can repeat this up to four times a day as needed.

How quickly does Orajel Dental Gel start working?

Most people notice a numbing effect within a few minutes of applying the gel to the affected area. The duration of relief varies between individuals but typically lasts for a short period before the gel disperses. Reapplication up to four times daily is permitted if needed.

How often can I use Orajel Dental Gel each day?

You can apply Orajel Dental Gel up to four times daily. Do not exceed this frequency, and do not use the gel for more than 7 consecutive days without seeking advice from a dentist or pharmacist. Persistent dental pain always warrants a professional assessment.

Is Orajel Dental Gel safe for children?

Orajel Dental Gel is not recommended for children under 12 years of age. This is because benzocaine carries a small risk of methaemoglobinaemia in younger children, which is why regulatory guidance advises against its use in this age group. If your child has dental pain, speak to a pharmacist or GP for suitable alternatives.

Can I use Orajel Dental Gel if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your pharmacist or GP before using Orajel Dental Gel. While topical benzocaine is applied locally and systemic absorption is minimal, professional guidance is always recommended during pregnancy and lactation to ensure safety for you and your baby.

What are the side effects of Orajel Dental Gel?

Common side effects include a mild burning or stinging sensation on application, temporary numbness beyond the intended area, and localised gum irritation. Rarely, an allergic reaction or a serious condition called methaemoglobinaemia may occur — if you experience pale or bluish skin, shortness of breath, or swelling, stop use immediately and seek urgent medical help.

Who should not use Orajel Dental Gel?

You should not use this gel if you are allergic to benzocaine or other ester-type local anaesthetics, if you are under 12 years old, or if you have a condition called G6PD deficiency or a history of methaemoglobinaemia. Always check the full list of ingredients before use and consult a pharmacist if you are unsure.

Does Orajel Dental Gel treat the cause of toothache?

No — orajel dental gel provides temporary symptomatic relief only and does not treat the underlying cause of dental pain. Whether your toothache is caused by decay, an abscess, a cracked tooth, or gum disease, you will still need to see a dentist for proper diagnosis and treatment. Use the gel as a short-term measure while you arrange an appointment.

Can I use Orajel Dental Gel for mouth ulcers?

Orajel Dental Gel can help relieve the discomfort associated with minor mouth ulcers, as benzocaine numbs the affected area temporarily. However, if your mouth ulcer persists for more than 3 weeks, is unusually large, or keeps returning, you should seek medical advice as this may require further investigation. Visit our oral health section for additional mouth ulcer products.

What happens if I accidentally swallow Orajel Dental Gel?

Swallowing a small amount of the gel as used in normal application is unlikely to cause serious harm in adults, but you should avoid deliberately swallowing it. If a child swallows a significant amount, or if you experience any unusual symptoms after accidental ingestion, contact NHS 111 or your nearest A&E immediately. Always keep the tube out of reach of children.

How long can I use Orajel Dental Gel for?

You should not use Orajel Dental Gel for more than 7 consecutive days without seeking dental or medical advice. Prolonged use without addressing the underlying cause of pain is not recommended. If your symptoms persist or worsen, book an appointment with your dentist as soon as possible.

What are the alternatives to Orajel Dental Gel for toothache?

Alternatives include oral analgesics such as paracetamol or ibuprofen, which work systemically to reduce pain and inflammation, or clove oil-based products, which have a traditional use in dental pain relief. Your pharmacist can advise on the most appropriate option based on your individual circumstances and any other medicines you may be taking.

Are there any medicines that interact with Orajel Dental Gel?

Benzocaine may interact with sulphonamide antibiotics, potentially reducing their effectiveness. Using multiple local anaesthetic products simultaneously may also increase the risk of side effects. Always inform your pharmacist of all medicines you are currently taking — including over-the-counter products — before using this gel.

How Should You Use Orajel Dental Gel?

Using Orajel Dental Gel correctly makes a real difference to how well it works. Always wash your hands before and after application, and make sure the area you're treating is as dry as possible — this helps the gel adhere to the gum or tooth surface rather than dispersing immediately.

Follow these steps each time you apply the gel:

What Is the Correct Dose of Orajel Dental Gel?

The correct dose is a small amount — roughly a 0.5cm strip of gel — applied directly to the affected area. Using more than this will not increase the pain-relieving effect and may increase the risk of side effects. Always stick to the recommended amount.

When Is the Best Time to Use Orajel Dental Gel?

There is no fixed time of day for using this gel — apply it whenever dental pain becomes uncomfortable and you need relief. Many people find it particularly helpful before meals, when chewing can aggravate toothache, or at night when pain can feel more intense and disruptive to sleep.

Try to space applications evenly throughout the day rather than using multiple doses close together. If you find yourself needing the gel very frequently, this is a sign that you should seek dental advice sooner rather than later.

How Long Can You Use Orajel Dental Gel For?

Orajel Dental Gel is intended for short-term use only. Do not use it for more than 7 consecutive days without consulting a dentist or pharmacist. Dental pain that persists beyond this period almost always indicates an underlying problem — such as decay, infection, or a cracked tooth — that requires professional treatment.

Using the gel beyond 7 days without addressing the root cause simply delays necessary care and may allow the underlying condition to worsen. If your pain is severe, spreading, or accompanied by swelling or fever, seek urgent dental or medical attention regardless of how long you have been using the gel.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Orajel Dental Gel?

Most people use Orajel Dental Gel without experiencing any significant side effects. When side effects do occur, they are usually mild and limited to the area where the gel has been applied. They tend to resolve quickly once the gel disperses.

  • Mild burning or stinging sensation immediately after application
  • Temporary numbness extending slightly beyond the intended area
  • Localised redness or irritation of the gum tissue
  • A bitter taste in the mouth

What Are the Less Common Side Effects of Orajel Dental Gel?

Less commonly, some individuals may experience reactions that go beyond mild local irritation. These are not typical but are worth being aware of before you use the product.

  • Contact dermatitis — redness, itching, or a rash around the mouth or lips
  • Swelling of the gum or surrounding tissue
  • Prolonged or excessive numbness that does not resolve within a reasonable time
  • Headache or dizziness if a larger-than-recommended amount is accidentally ingested

What Are the Serious Side Effects of Orajel Dental Gel?

Serious side effects are rare but require immediate medical attention if they occur. The most significant risk associated with benzocaine — particularly in children under 12, which is why this product is not recommended for that age group — is methaemoglobinaemia. This is a condition where the blood's ability to carry oxygen is reduced.

Symptoms of methaemoglobinaemia include pale, grey, or blue-coloured skin (particularly around the lips and fingernails), shortness of breath, rapid heart rate, fatigue, and confusion. If you or someone else experiences these symptoms after using this gel, stop use immediately and call 999 or go to your nearest A&E.

  • Signs of a serious allergic reaction: hives, facial swelling, difficulty breathing, or anaphylaxis
  • Methaemoglobinaemia: bluish skin, breathlessness, rapid heartbeat

What Should You Do If You Experience Side Effects of Orajel Dental Gel?

For mild side effects such as localised stinging or temporary numbness, no specific action is usually needed — simply wait for the effect to pass and avoid reapplying until the sensation has resolved. If irritation persists or worsens, discontinue use and speak to a pharmacist.

For any signs of a serious allergic reaction or methaemoglobinaemia, stop using the gel immediately and seek urgent medical help. You can also report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Orajel Dental Gel Interact With Other Medicines?

Benzocaine at topical doses is unlikely to cause significant systemic drug interactions in most people. However, there are a couple of interactions worth noting. Benzocaine may reduce the antibacterial activity of sulphonamide antibiotics, so inform your pharmacist if you are taking these. Using multiple local anaesthetic products at the same time may also increase the risk of adverse effects. Always tell your pharmacist about all medicines you are taking — including other topical products — before using this gel.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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