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Numark Diarrhoea Relief 2mg Capsules Loperamide Hydrochloride 2mg - 12's

Numark Diarrhoea Relief 2mg Capsules Loperamide Hydrochloride 2mg - 12's

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  • ✔️ Relieves acute diarrhoea by slowing intestinal contractions effectively
  • ✔️ Each capsule contains 2mg loperamide hydrochloride for targeted gut action
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Convenient 12-capsule pack ideal for home use or travel
  • ✔️ Works within one to two hours of the initial dose

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What Are Loperamide 2mg Capsules Used For?

 

Diarrhoea can strike at the worst possible moment — whether you're at work, travelling, or simply trying to get through a normal day. Numark Diarrhoea Relief 2mg Capsules contain loperamide hydrochloride, a well-established antidiarrhoeal medicine used to reduce the frequency of loose stools and help you regain control quickly. Each capsule contains 2mg of loperamide hydrochloride, and the pack contains 12 capsules, making it a practical option to keep in your medicine cabinet or travel bag. You can browse our full range of diarrhoea treatments if you need additional support alongside this product.

Acute diarrhoea is one of the most common digestive complaints in the UK, affecting most people at some point. The NHS notes that it usually clears up on its own within a few days, but medicines like loperamide can help manage symptoms in the meantime, particularly when you need to function normally.

 

How Do Numark Diarrhoea Relief Capsules Work?

 

Loperamide acts on opioid receptors in the wall of the large intestine. Unlike opioid painkillers, it does not cross the blood-brain barrier in standard doses, so it has no effect on the central nervous system. Here's how it works step by step:

  • Binds to mu-opioid receptors in the gut wall, slowing intestinal muscle contractions
  • Reduces the speed at which contents move through the bowel (transit time)
  • Decreases the secretion of fluid and electrolytes into the intestinal lumen
  • Increases anal sphincter tone, helping to reduce urgency

The result is firmer stools and fewer trips to the toilet. It's worth noting that loperamide treats the symptom of diarrhoea — it doesn't treat the underlying cause, such as a bacterial infection. If you suspect an infection or have blood in your stools, you should seek medical advice rather than self-treating.

 

Who Is Numark Diarrhoea Relief Suitable For?

 

This product is suitable for most adults and young people experiencing acute, uncomplicated diarrhoea. It's particularly useful when symptoms are disruptive and you need fast relief. That said, it's not appropriate for everyone.

  • Adults aged 18 and over with acute diarrhoea
  • Young people aged 12–17 (under adult supervision)
  • Travellers experiencing traveller's diarrhoea
  • People who need short-term symptom control while awaiting medical review

It is not suitable for children under 12, people with bloody or mucus-containing stools, those with acute ulcerative colitis, or anyone with a known hypersensitivity to loperamide. If you have a long-term bowel condition, speak to your GP before using this product.

 

How Does Numark Diarrhoea Relief Compare to Other Antidiarrhoeals?

 

Feature Numark Diarrhoea Relief 2mg Kaolin and Morphine Mixture
Active ingredient Loperamide hydrochloride 2mg Kaolin, morphine tincture
Form Capsule (oral) Liquid (oral)
Mechanism Opioid receptor agonist (gut-selective) Adsorbent + mild opioid
Suitable for children under 12 No No (morphine content)

 

How Should You Store Numark Diarrhoea Relief Capsules?

 

Store this product below 25°C in a dry place, away from direct sunlight. Keep it out of the reach and sight of children at all times. Do not use after the expiry date printed on the packaging. If you're travelling, loperamide 2mg capsules are compact and easy to pack — just ensure they're kept in their original blister packaging to protect them from moisture. If you're also managing related digestive discomfort, you might find our IBS and cramps range helpful alongside this product.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Numark Diarrhoea Relief 2mg Capsules Loperamide Hydrochloride 2mg - 12's specifications
Treatment category Antidiarrhoeal
Active ingredient Loperamide Hydrochloride 2mg
Mechanism of action Mu-opioid receptor agonist (gut-selective); slows intestinal motility
Suitable for Adults and young people aged 12 and over
Pack size 12 capsules
Strength 2mg per capsule
UK classification General Sale List (GSL)
Drug class Antidiarrhoeal / Opioid receptor agonist
Preparation Hard capsule
Route of administration Oral
Effective for Acute diarrhoea, traveller's diarrhoea

Specifications of Numark Diarrhoea Relief 2mg Capsules Loperamide Hydrochloride 2mg - 12's

 

What Is Numark Diarrhoea Relief and What Is It Used For?

 

Numark Diarrhoea Relief 2mg Capsules are an over-the-counter medicine used to treat acute diarrhoea in adults and young people aged 12 and over. Each capsule contains 2mg of loperamide hydrochloride, which works by slowing down bowel movements and reducing fluid loss. The product is licensed for short-term use and is available without a prescription from UK pharmacies. It is not a cure for the underlying cause of diarrhoea — rather, it helps manage symptoms while your body recovers.

 

What Do You Need to Know Before Using Numark Diarrhoea Relief?

 

Before taking this medicine, read the following carefully. There are situations where loperamide should not be used, and others where caution is needed.

Do not take this medicine if you:

  • Are under 12 years of age
  • Have bloody or black, tarry stools
  • Have a high fever alongside diarrhoea
  • Have been diagnosed with acute ulcerative colitis or pseudomembranous colitis
  • Are allergic to loperamide hydrochloride or any other ingredient in the capsule
  • Have a condition where slowing gut motility would be harmful (e.g. ileus)

Speak to your pharmacist or GP before use if you:

  • Are pregnant or breastfeeding
  • Have liver disease
  • Have HIV/AIDS with diarrhoea (risk of toxic megacolon)
  • Are taking medicines that may interact with loperamide

Known drug interactions:

  • Quinidine — may increase loperamide blood levels
  • Ritonavir — may significantly increase loperamide plasma concentration
  • Itraconazole — may raise loperamide levels via CYP3A4 inhibition
  • Other medicines that slow gut motility — additive effect possible

 

How Should You Take Numark Diarrhoea Relief Capsules?

 

Always take this medicine exactly as described in the patient information leaflet. Swallow the capsules whole with a glass of water. Do not chew or crush them.

  1. Take 2 capsules (4mg) as your initial dose at the start of treatment
  2. After each subsequent loose stool, take 1 capsule (2mg)
  3. Do not take more than 8 capsules (16mg) in any 24-hour period
  4. If diarrhoea has not improved within 48 hours, stop taking the capsules and seek medical advice
  5. Drink plenty of fluids to replace lost water and electrolytes — the NHS recommends oral rehydration solutions for this purpose
Age Group Initial Dose Subsequent Dose Maximum Daily Dose
Adults (18+) 2 capsules (4mg) 1 capsule (2mg) after each loose stool 8 capsules (16mg)
Young people (12–17) 2 capsules (4mg) 1 capsule (2mg) after each loose stool 8 capsules (16mg)
Children under 12 Not suitable — do not use

Staying hydrated is just as important as taking the medicine itself. If you're also experiencing nausea alongside diarrhoea, you may find our sickness and nausea range useful.

 

What Are the Possible Side Effects of Numark Diarrhoea Relief?

 

Like all medicines, loperamide can cause side effects, although not everyone experiences them. Most side effects are mild and resolve once you stop taking the medicine.

Common side effects:

  • Constipation
  • Flatulence (wind)
  • Abdominal cramps or discomfort
  • Nausea
  • Headache

Less common side effects:

  • Dizziness or drowsiness
  • Dry mouth
  • Skin rash or itching
  • Urinary retention
  • Vomiting

Serious cardiac side effects (including QT prolongation and cardiac arrest) have been reported when loperamide is taken at doses higher than recommended. Never exceed the stated dose. If you experience chest pain, palpitations, or fainting, stop taking the medicine immediately and seek urgent medical attention.

 

How Should You Store Numark Diarrhoea Relief Capsules?

 

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the blister pack or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you're travelling abroad and want to be prepared for a range of health concerns, our travel health collection includes a variety of useful OTC products to take with you.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Numark Diarrhoea Relief loperamide 2mg capsules online in the UK?

You can buy Numark Diarrhoea Relief loperamide 2mg capsules directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. No prescription is required as this is an over-the-counter (GSL) medicine. Simply add it to your basket and it will be dispatched promptly to your door.

How do loperamide 2mg capsules work in the body?

Loperamide binds to mu-opioid receptors in the gut wall, slowing down the muscular contractions that move contents through the intestine. This increases the time food and fluid spend in the bowel, allowing more water to be reabsorbed and resulting in firmer, less frequent stools. It does not enter the brain in standard doses, so it has no sedative or addictive effect at therapeutic levels.

How do I take Numark Diarrhoea Relief capsules step by step?

Start with 2 capsules (4mg) as your initial dose, then take 1 capsule (2mg) after each subsequent loose stool. Do not exceed 8 capsules in any 24-hour period. Swallow the capsules whole with water and make sure you drink plenty of fluids throughout the day to stay hydrated.

What is the maximum daily dose of loperamide 2mg capsules?

The maximum dose for adults and young people aged 12 and over is 8 capsules (16mg) in any 24-hour period. Exceeding this dose is dangerous and has been associated with serious heart rhythm problems, including QT prolongation. Always follow the dosage instructions on the pack or as directed by your pharmacist.

What are the side effects of Numark Diarrhoea Relief capsules?

Common side effects include constipation, abdominal cramps, flatulence, nausea, and headache. Less commonly, you might experience dizziness, dry mouth, or a skin rash. If you develop chest pain, palpitations, or feel faint, stop taking the medicine immediately and seek urgent medical attention, as these could indicate a serious cardiac reaction.

Who should not take loperamide 2mg capsules?

Loperamide is not suitable for children under 12, people with bloody or black stools, those with a high fever alongside diarrhoea, or anyone with acute ulcerative colitis. People with liver disease or those taking medicines such as quinidine or ritonavir should speak to a pharmacist or GP before use. Always check the full list of contraindications in the patient information leaflet.

How long can I take loperamide 2mg capsules for acute diarrhoea?

For acute diarrhoea, you should not take loperamide for more than 48 hours without seeking medical advice. If your symptoms haven't improved within this time, stop taking the capsules and consult your GP or pharmacist. Prolonged diarrhoea may indicate an underlying condition that needs investigation.

Can I take loperamide 2mg capsules during pregnancy or breastfeeding?

Loperamide is not recommended during pregnancy, particularly in the first trimester, unless a doctor has specifically advised it. Small amounts may pass into breast milk, so it is generally not recommended while breastfeeding either. Always speak to your GP or midwife before taking any medicine during pregnancy or whilst nursing.

What happens if I miss a dose of loperamide 2mg capsules?

Because loperamide is taken as needed after each loose stool rather than on a fixed schedule, a missed dose simply means you wait until your next loose stool before taking one. Do not double up doses to compensate. If you're unsure, your pharmacist can advise you on the correct approach for your situation.

Can I drink alcohol while taking loperamide 2mg capsules?

There is no well-documented direct interaction between loperamide and alcohol, but alcohol can itself irritate the gut and worsen diarrhoea symptoms. It's sensible to avoid alcohol while you're unwell with diarrhoea, as it can also contribute to dehydration. Focus on drinking water and oral rehydration solutions instead.

What are the alternatives to loperamide for diarrhoea relief?

Alternatives include oral rehydration salts (such as Dioralyte) to replace lost fluids and electrolytes, or kaolin-based preparations for mild symptoms. For longer-term or recurrent diarrhoea linked to IBS, your GP may suggest other treatments — you can also explore our IBS and cramps range for supportive options. Always speak to a healthcare professional if symptoms are persistent.

Is Numark Diarrhoea Relief the same as Imodium?

Yes, both products contain the same active ingredient — loperamide hydrochloride 2mg — and work in exactly the same way. The main difference is the brand name and price point; Numark is a pharmacy own-brand offering the same therapeutic effect at a more accessible cost. Always check the active ingredient and dosage instructions regardless of brand.

Can loperamide 2mg capsules be used for traveller's diarrhoea?

Yes, loperamide is commonly used to manage traveller's diarrhoea in adults and young people aged 12 and over. It can help reduce the frequency of loose stools when you need to travel or function normally. However, if you have a fever or blood in your stools, do not use loperamide — seek medical advice instead, as these may indicate a bacterial infection requiring antibiotics. Our travel health collection has other useful products for trips abroad.

Does loperamide interact with any other medicines?

Yes, loperamide can interact with certain medicines. Quinidine and ritonavir can significantly increase loperamide plasma levels, raising the risk of side effects including cardiac effects. Itraconazole may also raise loperamide concentrations via CYP3A4 inhibition. Always tell your pharmacist about all medicines you are taking before starting loperamide.

What are the latest clinical findings on loperamide safety?

In recent years, the MHRA and international regulators have issued warnings about the risk of serious cardiac events — including QT interval prolongation and cardiac arrest — when loperamide is taken at doses above the recommended maximum. These risks are associated with misuse or overdose, not with correct therapeutic use. At the recommended OTC dose, loperamide remains a safe and effective short-term treatment for acute diarrhoea when used as directed.

How Should You Use Numark Diarrhoea Relief 2mg Capsules?

Always read the patient information leaflet before taking this medicine. Swallow the capsules whole with a full glass of water — do not chew, crush, or open them. It's equally important to keep drinking fluids throughout the day to replace what you've lost.

What Is the Correct Dose of Numark Diarrhoea Relief 2mg Capsules?

The dose varies depending on age. Children under 12 must not take this product under any circumstances. Always follow the dosage table below and never exceed the stated maximum.

When Is the Best Time to Use Numark Diarrhoea Relief 2mg Capsules?

Take the first dose as soon as acute diarrhoea begins — there is no specific time of day requirement. Subsequent doses are taken reactively, after each loose stool, rather than at fixed intervals. This means the timing is driven by your symptoms rather than a clock, which makes it straightforward to use even when you're on the go or travelling.

If you're using this medicine for traveller's diarrhoea, it can be particularly helpful to take the initial dose before a long journey where access to facilities may be limited — but only if diarrhoea has already started. Do not take it as a preventative measure.

How Long Can You Use Numark Diarrhoea Relief 2mg Capsules For?

This product is intended for short-term use only. For acute diarrhoea, do not use it for more than 48 hours without seeking medical advice. Most episodes of acute diarrhoea resolve within one to two days with appropriate fluid intake and rest.

If your symptoms persist beyond 48 hours, worsen, or are accompanied by fever, blood in the stool, or severe abdominal pain, stop taking the capsules and contact your GP promptly. Prolonged or recurrent diarrhoea may indicate an underlying condition that requires investigation and should not be managed with OTC medicines alone.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Numark Diarrhoea Relief 2mg Capsules?

Most people tolerate loperamide well at the recommended dose, but some side effects can occur. Common side effects are generally mild and tend to resolve once you stop taking the medicine or your diarrhoea settles.

  • Constipation — the most frequently reported effect, as loperamide slows bowel transit
  • Flatulence (wind) and bloating
  • Abdominal cramps or discomfort
  • Nausea
  • Headache

What Are the Less Common Side Effects of Numark Diarrhoea Relief 2mg Capsules?

Less commonly, some people experience side effects that are more noticeable but still generally mild. If any of the following persist or bother you, speak to your pharmacist.

  • Dizziness or drowsiness
  • Dry mouth
  • Vomiting
  • Skin rash, itching, or hives
  • Urinary retention (difficulty passing urine)
  • Fatigue or general tiredness

What Are the Serious Side Effects of Numark Diarrhoea Relief 2mg Capsules?

Serious side effects are rare when loperamide is taken at the recommended dose. However, taking more than the stated maximum — or taking it alongside certain medicines — can cause dangerous cardiac effects. The MHRA has issued guidance warning that doses above 16mg per day in adults can cause QT interval prolongation, ventricular arrhythmias, and in rare cases, cardiac arrest.

Seek emergency medical help immediately if you experience any of the following:

  • Chest pain or tightness
  • Palpitations or irregular heartbeat
  • Fainting or loss of consciousness
  • Severe allergic reaction (swelling of the face, lips, or throat; difficulty breathing)

What Should You Do If You Experience Side Effects of Numark Diarrhoea Relief?

For mild side effects such as constipation or nausea, stopping the medicine once your diarrhoea has resolved is usually sufficient. Make sure you're drinking enough fluids, as dehydration can worsen some symptoms. If a side effect is troubling you or doesn't improve, your pharmacist is a good first point of contact — they can advise whether you need to see a GP.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines in real-world use.

Can Numark Diarrhoea Relief 2mg Capsules Interact With Other Medicines?

Yes. Loperamide is metabolised by liver enzymes, and certain medicines can interfere with this process, raising loperamide levels in the blood and increasing the risk of side effects — particularly cardiac effects. Known interactions include quinidine, ritonavir, and itraconazole, all of which can significantly increase loperamide plasma concentrations. Other medicines that slow gut motility may have an additive effect when taken alongside loperamide.

Always tell your pharmacist about every medicine you are currently taking — including prescription medicines, over-the-counter products, and herbal supplements — before starting loperamide.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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