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Avomine 25mg Tablets - 10 Tablets

Avomine 25mg Tablets - 10 Tablets

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  • ✔️ Prevents and relieves motion sickness nausea effectively
  • ✔️ Contains 25mg promethazine theoclate per tablet
  • ✔️ Provides up to 24 hours of travel sickness protection
  • ✔️ Suitable for adults and children aged 5 and over
  • ✔️ Convenient 10-tablet pack ideal for short trips

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What Are Avomine Travel Sickness Tablets?

 

If the thought of a long car journey, choppy ferry crossing, or winding mountain road fills you with dread, you're not alone. Motion sickness affects a significant number of people in the UK, and it can genuinely ruin a trip before it's even begun. Avomine travel sickness tablets are a well-established, over-the-counter option that can help you travel with far more confidence. Each tablet contains 25mg of promethazine theoclate — a sedating antihistamine with a long history of use for preventing and treating nausea and vomiting associated with motion. You can browse our full range of travel medicines if you're putting together a complete holiday health kit.

Avomine is available without a prescription and is classified as a Pharmacy (P) medicine in the UK. This 10-tablet pack is ideal for shorter trips or for those trying the medicine for the first time. It's compact, easy to carry, and straightforward to use — which matters when you're already juggling luggage and travel plans.

 

How Do Avomine Tablets Work to Prevent Nausea?

 

Motion sickness happens when your brain receives conflicting signals — your eyes might say you're sitting still, but your inner ear senses movement. This mismatch triggers the nausea, dizziness, and vomiting that many travellers know all too well. Avomine works by interrupting that process at a neurological level.

  • Promethazine theoclate blocks histamine H1 receptors in the brain's vomiting centre (the chemoreceptor trigger zone).
  • It also acts on the vestibular system in the inner ear, reducing the sensitivity to motion-related signals.
  • Its anticholinergic properties further suppress the nerve pathways that drive nausea and vomiting.
  • Because it's a sedating antihistamine, it also has a mild calming effect — which can be helpful during long or stressful journeys.

The result is a reduction in both the frequency and severity of motion sickness symptoms. It won't eliminate all sensation of movement, but for most people it makes travel significantly more manageable.

 

Who Is Avomine Suitable For?

 

Avomine is suitable for adults and children aged 5 years and over who experience nausea, vomiting, or dizziness related to travel. It's particularly useful for people who know from experience that they're prone to motion sickness on specific types of transport — ferries and winding roads tend to be the worst offenders.

  • Adults and teenagers who experience motion sickness on any form of transport
  • Children aged 5 and over (under medical or pharmacist guidance)
  • People planning long-haul journeys where nausea is a known concern
  • Those who prefer a once-nightly dose taken the evening before travel

It is not suitable for everyone. People with certain liver conditions, glaucoma, urinary retention, or epilepsy should seek medical advice before use. Always read the full patient information leaflet before taking any medicine.

 

How Does Avomine Compare to Other Travel Sickness Medicines?

 

Feature Avomine 25mg (Promethazine theoclate) Kwells (Hyoscine hydrobromide)
Active ingredient Promethazine theoclate 25mg Hyoscine hydrobromide 300mcg
Duration of action Up to 24 hours Up to 6 hours
Suitable age 5 years and over 10 years and over (adult strength)
Drowsiness Common — sedating Less sedating

 

How Should You Store Avomine Tablets?

 

Store Avomine 25mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original blister packaging until you're ready to use them. As with all medicines, keep them out of the reach and sight of children.

If you're travelling to a hot climate, be mindful of where you store your medicines — a car glove compartment in direct sun can easily exceed safe storage temperatures. A cool bag or your hand luggage is a better option. If you're also managing other health needs on holiday, our sickness and nausea range has additional options worth considering alongside avomine travel sickness tablets.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Avomine 25mg Tablets - 10 Tablets specifications
Treatment category Motion sickness / Nausea and vomiting
Active ingredient Promethazine theoclate 25mg
Mechanism of action H1 antihistamine; anticholinergic; vestibular suppressant
Effective for Prevention and treatment of motion sickness
Suitable for Adults and children aged 5 years and over
Pack size 10 tablets
Strength 25mg
UK classification Pharmacy (P) medicine
Drug class Sedating antihistamine
Preparation Tablet
Route of administration Oral

Specifications of Avomine 25mg Tablets - 10 Tablets

 

What Is Avomine and What Is It Used For?

 

Avomine 25mg tablets contain promethazine theoclate, a sedating antihistamine used to prevent and treat the nausea, vomiting, and dizziness that come with motion sickness. Whether you're on a ferry, in the back of a car, or on a small aircraft in turbulence, Avomine can help reduce those unpleasant symptoms so you can actually enjoy your journey. It's an OTC medicine, meaning you don't need a prescription to buy it in the UK.

Beyond travel sickness, promethazine is also used in some clinical settings for nausea and vomiting from other causes — but for this product, the licensed indication is motion sickness specifically. Always use it as directed on the packaging or as advised by your pharmacist.

 

What Do You Need to Know Before Using Avomine?

 

Before taking Avomine, it's important to check whether it's appropriate for you. There are several conditions and medicines that may make it unsuitable or require extra caution.

Do not take Avomine if you:

  • Are allergic to promethazine theoclate or any other ingredient in the tablet
  • Are under 5 years of age
  • Have been told you have a rare hereditary problem of galactose intolerance
  • Are taking monoamine oxidase inhibitors (MAOIs) or have taken them in the last 14 days
  • Have severe liver disease

Speak to your doctor or pharmacist before use if you have:

  • Epilepsy or a history of seizures
  • Glaucoma (raised pressure in the eye)
  • Difficulty passing urine or an enlarged prostate
  • Heart disease or irregular heartbeat
  • Severe respiratory conditions such as asthma
  • Renal or hepatic impairment

Known drug interactions — tell your pharmacist if you are taking:

  • Other sedatives, sleeping tablets, or anxiolytics (increased drowsiness risk)
  • Alcohol (significantly worsens sedation)
  • Anticholinergic medicines such as some antidepressants or bladder medicines
  • Antipsychotics or other CNS depressants
  • Metoclopramide (effects may be reduced)

If you are pregnant or breastfeeding, seek medical advice before taking Avomine. The NHS advises caution with sedating antihistamines during pregnancy.

 

How Should You Use Avomine Tablets?

 

Always take Avomine exactly as described in the patient information leaflet or as directed by your pharmacist. The tablets are taken orally with a glass of water.

  1. Check you are not contraindicated before taking your first dose.
  2. For prevention of travel sickness, take the tablet the night before travel or at least 1–2 hours before your journey.
  3. Swallow the tablet whole with a full glass of water.
  4. If your journey is long, a further tablet may be taken after 6–8 hours if needed.
  5. Do not exceed the maximum recommended daily dose for your age group.
Indication Age Group Dose Frequency
Motion sickness prevention Adults and children 10+ 25mg (1 tablet) Night before or 1–2 hrs before travel; repeat after 6–8 hrs if needed
Motion sickness prevention Children 5–9 years 12.5mg (half a tablet) Night before or 1–2 hrs before travel
Motion sickness treatment Adults 25mg (1 tablet) Up to twice in 24 hours

If you're also dealing with an upset stomach during travel, our diarrhoea treatments range may be a useful addition to your travel health kit.

 

What Are the Possible Side Effects of Avomine?

 

Like all medicines, Avomine can cause side effects, although not everyone experiences them. Knowing what to look out for helps you manage them sensibly.

Common side effects:

  • Drowsiness or sedation (very common — affects most users)
  • Dry mouth
  • Blurred vision
  • Dizziness
  • Headache

Less common side effects:

  • Difficulty passing urine
  • Constipation
  • Restlessness or agitation (more likely in children)
  • Skin sensitivity to sunlight (photosensitivity)
  • Low blood pressure (hypotension)
  • Palpitations or irregular heartbeat

Serious allergic reactions are rare but possible. Seek immediate medical attention if you develop a rash, swelling of the face or throat, difficulty breathing, or severe dizziness after taking Avomine. Stop taking the tablets and contact your GP or call 111 if you experience any unexpected or concerning symptoms.

 

How Should You Store Avomine Tablets?

 

  • Store below 25°C in a dry place away from direct sunlight and heat
  • Keep in the original blister packaging until ready to use
  • Do not store in a bathroom or near a sink — moisture can degrade the tablets
  • Keep out of the reach and sight of children at all times
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're building a broader travel health kit, you might also want to explore our pain relief range for headaches and muscle aches that can accompany long journeys.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Avomine travel sickness tablets online in the UK?

You can buy Avomine 25mg tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. No prescription is needed as it's an over-the-counter Pharmacy (P) medicine. Simply add the pack to your basket, complete a brief health check at checkout, and your order will be dispatched promptly. You can also browse our full travel medicine range for other holiday health essentials.

How does Avomine work in the body?

Avomine contains promethazine theoclate, which blocks histamine H1 receptors in the brain's vomiting centre and reduces signals from the vestibular system in the inner ear. This dual action helps prevent the nausea and dizziness triggered by conflicting motion signals. Its anticholinergic properties add a further layer of symptom control, making it effective for a range of travel scenarios.

How do I take Avomine tablets step by step?

Take one 25mg tablet the night before travel, or at least one to two hours before your journey begins. Swallow it whole with a full glass of water — do not crush or chew. If your journey is particularly long, a second tablet may be taken after six to eight hours, but do not exceed two tablets in 24 hours without medical advice.

What is the correct dose of Avomine for adults and children?

Adults and children aged 10 and over should take one 25mg tablet for motion sickness prevention. Children aged 5 to 9 years may take half a tablet (12.5mg), ideally the night before or at least two hours before travel. Avomine is not suitable for children under 5 years of age — always check with a pharmacist if you're unsure about the right dose for your child.

When is the best time to take Avomine before a journey?

The most effective approach is to take Avomine the night before your journey, as this gives the medicine time to reach therapeutic levels in your system before travel begins. If that's not possible, taking it at least one to two hours before departure is the next best option. Taking it too close to departure may reduce its effectiveness, particularly for longer or more turbulent journeys.

Can Avomine make you drowsy?

Yes — drowsiness is one of the most commonly reported effects of Avomine because promethazine theoclate is a sedating antihistamine. This is actually why many people prefer to take it the night before travel, as the sedation can aid sleep. However, you should not drive, cycle, or operate heavy machinery after taking it, and alcohol will significantly worsen the sedative effect.

Who should not take Avomine tablets?

Avomine is not suitable for children under 5 years, people with severe liver disease, those taking MAOIs, or anyone with a known allergy to promethazine. People with glaucoma, epilepsy, urinary retention, or significant heart conditions should speak to their GP before use. Pregnant or breastfeeding women should also seek medical advice before taking this medicine.

What happens if I miss a dose of Avomine?

If you forget to take Avomine before your journey, take it as soon as you remember — ideally at least two hours before travel begins. Do not take a double dose to make up for a missed one. If you're already mid-journey and feeling unwell, speak to a pharmacist about whether it's still appropriate to take a dose at that point.

How do I manage the side effects of Avomine?

The most common side effect — drowsiness — can be managed by taking Avomine the night before travel rather than on the day. Dry mouth can be eased by sipping water regularly. If you experience restlessness, agitation, or any unusual symptoms, stop taking the tablets and contact your pharmacist or GP. Avoid alcohol entirely while taking Avomine to reduce the risk of excessive sedation.

Can I take Avomine with other medicines?

Avomine can interact with several medicines, including other sedatives, antidepressants, antipsychotics, and anticholinergic drugs. Taking it alongside alcohol or other CNS depressants significantly increases the risk of excessive drowsiness. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are currently taking before starting Avomine.

Is Avomine safe to take during pregnancy?

The safety of promethazine during pregnancy has not been fully established, and the NHS advises caution with sedating antihistamines in pregnancy. If you are pregnant and struggling with nausea related to travel or morning sickness, speak to your GP or midwife before taking Avomine. They can advise on the safest option for your specific situation and stage of pregnancy.

What are the alternatives to Avomine for travel sickness?

The main alternatives available over the counter in the UK include hyoscine hydrobromide (Kwells) and cinnarizine (Stugeron). Hyoscine acts faster but has a shorter duration, while cinnarizine is often preferred for longer journeys. You can explore our sickness and nausea range to compare options and find the most suitable one for your needs.

How long does Avomine last once taken?

A single 25mg dose of Avomine can provide protection against motion sickness for up to 24 hours, which makes it particularly useful for full-day journeys such as long ferry crossings or extended road trips. This longer duration is one of the key differences between Avomine and shorter-acting alternatives like hyoscine. If your journey extends beyond 24 hours, consult your pharmacist about whether a repeat dose is appropriate.

How long can you keep taking Avomine?

Avomine is intended for short-term use in relation to travel. It is not designed for long-term daily use, and prolonged use of sedating antihistamines without medical supervision is not recommended. If you find you need motion sickness relief on a very frequent basis, speak to your GP about whether an alternative approach or investigation into the underlying cause is warranted.

What does the latest research say about promethazine for motion sickness?

Promethazine has been used clinically for motion sickness for decades and remains one of the most studied antihistamines for this indication. Published evidence supports its effectiveness in reducing nausea and vomiting associated with motion, particularly for longer journeys. The NHS and BNF continue to recognise promethazine theoclate as an appropriate OTC option for motion sickness in adults and children aged 5 and over.

How Should You Use Avomine Tablets?

Avomine 25mg tablets are taken orally with a glass of water. They should not be crushed or chewed. Always read the patient information leaflet before use and follow the instructions provided by your pharmacist.

What Is the Correct Dose of Avomine?

The dose of Avomine varies depending on age and the purpose of use. Always follow the dosage instructions on the packaging or as directed by your pharmacist. Do not give Avomine to children under 5 years of age.

When Is the Best Time to Use Avomine?

The most effective time to take Avomine is the night before your journey. This allows the medicine to reach adequate levels in your system before travel begins, giving you the best chance of a symptom-free trip. If you can't take it the night before, aim for at least one to two hours before departure — taking it any closer to your journey may reduce how well it works.

Because Avomine causes drowsiness, taking it at night also means the sedative effect is less likely to interfere with your daytime activities. Plan ahead, especially if you're driving to your departure point.

How Long Can You Use Avomine For?

Avomine is intended for short-term use in connection with travel. It is not designed for continuous daily use over extended periods. If you find yourself needing motion sickness relief very frequently, it's worth speaking to your GP to explore whether there's an underlying cause or a more suitable long-term management strategy.

For occasional travel use, Avomine can be taken as needed for each journey, provided you observe the recommended dosage and do not exceed the stated daily limits. Always reassess your need for the medicine if your symptoms change or worsen.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Avomine?

The most frequently reported side effect of Avomine is drowsiness. Because promethazine theoclate is a sedating antihistamine, most people who take it will feel noticeably sleepy — this is expected and is actually why many people choose to take it the night before travel. Other common effects include dry mouth and blurred vision, which are related to the medicine's anticholinergic action.

  • Drowsiness or sedation
  • Dry mouth
  • Blurred vision
  • Dizziness
  • Headache

What Are the Less Common Side Effects of Avomine?

Some people experience side effects that are less frequent but still worth being aware of. These tend to be more likely in older adults or in people taking other medicines that have similar anticholinergic effects. If any of the following persist or feel severe, contact your pharmacist.

  • Difficulty passing urine (urinary retention)
  • Constipation
  • Restlessness or agitation (more common in children)
  • Skin sensitivity to sunlight (photosensitivity)
  • Low blood pressure (hypotension), particularly on standing
  • Palpitations or irregular heartbeat
  • Confusion, particularly in elderly patients

What Are the Serious Side Effects of Avomine?

Serious side effects from Avomine are rare, but they do require prompt medical attention if they occur. A severe allergic reaction (anaphylaxis) is possible with any medicine. Signs include swelling of the face, lips, tongue, or throat, difficulty breathing, a widespread rash, or a sudden drop in blood pressure. Stop taking Avomine immediately and call 999 or go to your nearest A&E if you experience these symptoms.

In very rare cases, promethazine has been associated with blood disorders and severe skin reactions. If you notice unusual bruising, persistent sore throat, or a blistering skin rash, seek urgent medical advice.

What Should You Do If You Experience Side Effects?

For mild side effects such as drowsiness or dry mouth, these usually resolve on their own once the medicine wears off. Staying well hydrated and avoiding alcohol can help minimise discomfort. Do not drive or operate machinery if you feel drowsy — this is a legal requirement as well as a safety one.

If you experience any side effect that concerns you, or one that is not listed in the patient information leaflet, stop taking Avomine and speak to your pharmacist or GP. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Avomine Interact With Other Medicines?

Yes. Avomine can interact with a number of medicines, and some combinations can be dangerous. The most significant interactions involve other medicines that cause sedation — combining these with Avomine can lead to excessive drowsiness, impaired coordination, and in severe cases, respiratory depression. Always tell your pharmacist about everything you are taking, including herbal remedies and supplements.

  • Alcohol — significantly increases sedation
  • Sleeping tablets, anxiolytics, or opioid painkillers — additive CNS depression
  • MAOIs — contraindicated; do not take within 14 days of stopping an MAOI
  • Anticholinergic medicines (e.g. bladder medicines, some antidepressants) — increased anticholinergic side effects
  • Antipsychotics — increased risk of sedation and cardiac effects
  • Metoclopramide — opposing effects on gut motility

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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