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Maxalt

Maxalt

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  • ✔️ Targets migraine pain at its neurological source
  • ✔️ Relieves headache, nausea, and light sensitivity
  • ✔️ Works within 30 minutes for most adults
  • ✔️ Available as tablet or dissolving Melt wafer
  • ✔️ Suitable for migraines with or without aura

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What Are Rizatriptan Tablets and How Does Maxalt Help Migraines?

 

Maxalt is a prescription migraine treatment containing the active ingredient rizatriptan benzoate. It belongs to a class of medicines called triptans, which are specifically designed to treat acute migraine attacks — not to prevent them. If you've ever been floored by a migraine and found that standard pain relief simply doesn't cut it, Maxalt may be a more targeted option worth discussing with your doctor. It's available in two forms: standard film-coated tablets and Maxalt Melt wafers, which dissolve on the tongue without water.

Migraines affect roughly one in seven people in the UK, according to the NHS, and they can be genuinely debilitating — not just a bad headache. Rizatriptan tablets like Maxalt are among the most widely prescribed acute migraine treatments in the UK, and they work differently from everyday painkillers by targeting the underlying mechanisms of a migraine attack rather than simply masking pain.

 

How Does Maxalt Work to Relieve a Migraine?

 

Maxalt works by binding to serotonin receptors — specifically the 5-HT1B and 5-HT1D subtypes — in the brain. This triggers a chain of events that helps to resolve the migraine attack:

  • Constricts dilated cranial blood vessels that contribute to migraine pain
  • Inhibits the release of pro-inflammatory neuropeptides such as CGRP (calcitonin gene-related peptide)
  • Blocks pain signal transmission along the trigeminal nerve pathway
  • Reduces associated symptoms such as nausea, vomiting, and sensitivity to light and sound

The result is that Maxalt addresses the migraine at its source rather than simply dulling the sensation of pain. Most people notice an improvement within 30 to 60 minutes of taking a dose.

 

Who Is Maxalt Suitable For?

 

Maxalt is licensed for the acute treatment of migraine attacks in adults aged 18 and over. It can be used whether or not your migraine is accompanied by aura. It is not suitable for everyone, so a prescriber will always assess your medical history before issuing a prescription. Maxalt may be appropriate if you:

  • Experience moderate to severe migraine attacks that don't respond adequately to standard analgesics
  • Have been formally diagnosed with migraine by a healthcare professional
  • Do not have cardiovascular disease, uncontrolled hypertension, or a history of stroke
  • Are not currently taking monoamine oxidase inhibitors (MAOIs) or ergotamine-containing medicines

 

How Does Maxalt Compare to Other Triptan Migraine Treatments?

 

Feature Maxalt (Rizatriptan) Imigran (Sumatriptan)
Active ingredient Rizatriptan benzoate Sumatriptan succinate
Onset of action ~30 minutes ~30–60 minutes
Available forms Tablet, orodispersible wafer Tablet, nasal spray, injection
Max daily dose 20mg 300mg

 

How Should You Store Maxalt and Is It Right for You?

 

Store Maxalt tablets below 25°C in their original packaging, away from moisture and direct sunlight. Keep them out of the reach and sight of children. Do not use after the expiry date printed on the pack. If you are unsure whether rizatriptan tablets are appropriate for your situation — for example, if you have liver or kidney problems, or if you are pregnant or breastfeeding — speak to your GP or pharmacist before taking this medicine. You can also browse our sickness and nausea range for supportive products that may help manage migraine-associated symptoms.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Maxalt specifications
Treatment category Migraine — acute treatment
Mechanism of action Serotonin 5-HT1B/1D receptor agonist (triptan)
Effective for Acute migraine attacks with or without aura
Suitable for Adults aged 18 and over
Active ingredient Rizatriptan benzoate
Pack sizes 3 tablets, 6 tablets
Strengths 5mg, 10mg
UK classification Prescription Only Medicine (POM)
Drug class Triptan (serotonin receptor agonist)
Preparation Film-coated tablet; orodispersible wafer (Maxalt Melt)
Route of administration Oral

Specifications of Maxalt

 

What Is Maxalt and What Is It Used For?

 

Maxalt (rizatriptan benzoate) is a prescription-only medicine used to treat acute migraine headaches in adults. It is not a preventative treatment — you take it when a migraine attack begins, not daily. It works to relieve the headache pain itself as well as associated symptoms like nausea and sensitivity to light. Maxalt is available as a standard tablet and as Maxalt Melt, an orodispersible wafer that dissolves on the tongue — useful if swallowing tablets during a migraine is difficult.

 

What Do You Need to Know Before Using Maxalt?

 

Before taking Maxalt, your prescriber will check your medical history carefully. There are several important contraindications and warnings to be aware of:

  • Do not take Maxalt if you have ischaemic heart disease, angina, or have had a heart attack or stroke
  • Do not use if you have uncontrolled high blood pressure (hypertension)
  • Do not take within 24 hours of using another triptan or an ergotamine-containing medicine
  • Do not use if you have severe liver or kidney impairment
  • Not licensed for use in patients under 18 years of age
  • Use with caution if you have risk factors for cardiovascular disease
  • Tell your prescriber if you are pregnant, planning to become pregnant, or breastfeeding

Maxalt can interact with several other medicines. Known interactions include:

  • MAOIs (monoamine oxidase inhibitors) — do not take Maxalt if you are taking or have taken an MAOI in the last two weeks
  • Propranolol — increases rizatriptan blood levels; use the 5mg dose only and take no more than two doses in 24 hours
  • SSRIs and SNRIs — concurrent use may increase the risk of serotonin syndrome; monitor carefully
  • Ergotamine or ergot derivatives — do not use within 24 hours of Maxalt
  • St John's Wort — may increase the risk of serotonin-related side effects

 

How Should You Use Maxalt?

 

  1. Take Maxalt as soon as your migraine headache begins — do not wait for it to worsen
  2. Swallow the tablet whole with water, or place the Maxalt Melt wafer on your tongue and allow it to dissolve
  3. If your migraine returns after initial relief, you may take a second dose at least 2 hours after the first
  4. Do not take more than two doses in any 24-hour period
  5. If the first dose provides no relief at all, do not take a second dose for the same attack — seek medical advice instead
Indication Age Group Dose Frequency
Acute migraine Adults 18+ 10mg (5mg if taking propranolol) Max 2 doses per 24 hours, at least 2 hours apart
Acute migraine (propranolol users) Adults 18+ 5mg Max 2 doses per 24 hours, at least 2 hours apart

 

What Are the Possible Side Effects of Maxalt?

 

Like all medicines, Maxalt can cause side effects, although not everyone experiences them. If you're concerned about any reaction, contact your pharmacist or GP. You might also find it helpful to explore our pain relief range for complementary options to discuss with your healthcare team.

Common side effects (may affect up to 1 in 10 people):

  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Nausea
  • Sensation of tingling, warmth, or heaviness
  • Dry mouth
  • Headache (distinct from the migraine being treated)

Less common side effects (may affect up to 1 in 100 people):

  • Chest tightness, pressure, or pain — seek urgent medical attention if this occurs
  • Palpitations or increased heart rate
  • Flushing
  • Tremor
  • Blurred vision
  • Allergic reactions including rash or swelling — stop taking and seek help immediately

Overuse of migraine treatments — including triptans — can lead to medication overuse headache (MOH). If you find yourself using Maxalt on 10 or more days per month, speak to your GP.

 

How Should You Store Maxalt?

 

Proper storage helps maintain the effectiveness and safety of your medicine. Follow these guidelines:

  • Store below 25°C
  • Keep in the original packaging to protect from moisture
  • Do not store in the bathroom or near a heat source
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're managing multiple health conditions alongside migraines, our vitamins and supplements range includes products such as magnesium, which some evidence suggests may support migraine management as part of a broader plan agreed with your GP.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Maxalt online in the UK?

You can order Maxalt through a GPhC-registered online pharmacy such as Cured Pharmacy, provided you have a valid UK prescription. An online prescriber will review your medical history before the medicine is dispensed. This ensures the treatment is safe and appropriate for you specifically.

How does Maxalt work in the body?

Maxalt contains rizatriptan, which acts on serotonin 5-HT1B and 5-HT1D receptors in the brain. This causes constriction of dilated cranial blood vessels and blocks the release of inflammatory neuropeptides that drive migraine pain. The result is targeted relief from both the headache and associated symptoms like nausea and light sensitivity.

How do I use Maxalt step by step?

Take one Maxalt tablet or Melt wafer as soon as your migraine headache starts — don't wait for it to peak. If the migraine returns after initial relief, you can take a second dose at least 2 hours later. Never exceed two doses in any 24-hour period, and if the first dose gives no relief at all, do not take a second dose for that same attack.

How long does Maxalt take to start working?

Most people begin to notice relief from their migraine within 30 minutes of taking Maxalt. Significant pain relief is typically achieved within 2 hours for the majority of patients. Taking it early in the attack — as soon as the headache phase begins — tends to give the best results.

What is the correct dose of Maxalt for adults?

The standard adult dose is one 10mg tablet or wafer taken at the onset of a migraine. If you are also taking propranolol, your dose should be reduced to 5mg. No more than two doses should be taken in any 24-hour period, with at least 2 hours between doses.

Can I take Maxalt if I am on propranolol?

Yes, but with an important dose adjustment. Propranolol significantly increases the blood levels of rizatriptan, so you should only use the 5mg strength of Maxalt if you are taking propranolol. Always inform your prescriber about all medicines you are currently taking before starting Maxalt.

What are the side effects of Maxalt and how do I manage them?

Common side effects include dizziness, drowsiness, nausea, and a tingling or warm sensation — these are usually mild and short-lived. Resting in a quiet, dark room after taking Maxalt can help manage these effects. If you experience chest tightness, palpitations, or signs of an allergic reaction, stop taking the medicine and seek urgent medical attention.

Who should not take Maxalt?

Maxalt is not suitable for people with ischaemic heart disease, uncontrolled hypertension, a history of stroke or TIA, or severe liver or kidney problems. It should not be taken by anyone currently using MAOIs or ergotamine-containing medicines. It is also not licensed for use in patients under 18 years of age.

What happens if I miss a dose of Maxalt?

Maxalt is taken on an as-needed basis during a migraine attack, so the concept of a "missed dose" doesn't apply in the traditional sense. If your migraine has already passed, there is no need to take a dose. Simply take it at the start of your next migraine attack as directed.

Can I take Maxalt during pregnancy or while breastfeeding?

The safety of rizatriptan during pregnancy has not been fully established, and it should only be used if your doctor considers it clearly necessary. Rizatriptan passes into breast milk, so breastfeeding is not recommended for 24 hours after taking a dose. Always discuss this with your GP or midwife before using Maxalt.

What are the alternatives to Maxalt for migraine?

Other triptans available in the UK include sumatriptan (Imigran), zolmitriptan (Zomig), eletriptan (Relpax), and naratriptan (Naramig). Non-triptan options include aspirin, ibuprofen, or paracetamol combined with an antiemetic. You can explore our pain relief range for over-the-counter options, though triptans require a prescription.

How often can I take Maxalt each month?

You should not use Maxalt — or any triptan — on more than 10 days per month on a regular basis. Using acute migraine treatments too frequently can lead to medication overuse headache (MOH), a condition where the treatment itself begins to cause daily or near-daily headaches. If you find you need Maxalt this often, speak to your GP about preventative migraine treatment.

Is Maxalt the same as rizatriptan?

Yes. Maxalt is the branded version of rizatriptan benzoate, manufactured by Organon. Generic rizatriptan tablets containing the same active ingredient are also available on prescription in the UK. Both the branded and generic versions work in the same way and have the same clinical profile.

Can Maxalt be used for cluster headaches?

Maxalt is not licensed for the treatment of cluster headaches — it is specifically indicated for acute migraine attacks. Cluster headaches are a distinct condition and are typically managed with different treatments such as high-flow oxygen or subcutaneous sumatriptan. Speak to your GP or a neurologist if you think you may have cluster headaches.

What are the latest studies on rizatriptan for migraine?

Rizatriptan has been extensively studied since its introduction and remains one of the most clinically validated triptans for acute migraine. Research published in clinical literature consistently shows it has a faster onset than some other triptans, with good tolerability. For the most current guidance, the NHS and NICE continue to recommend triptans — including rizatriptan — as first-line acute migraine treatment for patients who do not respond to standard analgesics. You can also browse our cold and flu range if you're unsure whether your symptoms are migraine-related or linked to another condition.

How Should You Use Maxalt?

Maxalt should be taken as soon as your migraine headache begins. Do not wait for the pain to become severe — early treatment generally gives the best results. The Maxalt Melt wafer can be placed directly on the tongue where it dissolves without water, making it a practical option if nausea makes swallowing difficult.

What Is the Correct Dose of Maxalt?

The dose of Maxalt depends on your individual circumstances, including any other medicines you are taking. Your prescriber will confirm the right dose for you. The table below summarises the standard dosing guidance based on the licensed product information.

When Is the Best Time to Use Maxalt?

Take Maxalt at the very onset of the headache phase of your migraine — not during the aura phase if one occurs, and not before the headache has actually started. Clinical evidence suggests that taking a triptan during the aura phase is less effective and is not recommended. The sooner you take it once the headache begins, the more likely it is to work well.

Avoid taking Maxalt on an empty stomach if you find this worsens nausea, though food does not significantly affect how the medicine is absorbed. If you regularly experience migraines at a predictable time — for example, upon waking — keep your medication accessible so you can act quickly.

How Long Can You Use Maxalt For?

Maxalt is intended for acute, as-needed use only — it is not taken daily. There is no fixed maximum duration of treatment, but you should not use it on more than 10 days per month on a regular basis. Frequent use beyond this threshold can lead to medication overuse headache, a condition where the treatment itself begins to cause chronic daily headaches. If you find your migraines are becoming more frequent or harder to control, speak to your GP about preventative migraine therapies. Regular review with your prescriber is important to ensure Maxalt continues to be the right treatment for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Maxalt?

Most people who take Maxalt tolerate it well, but like all medicines, it can cause side effects. Common side effects tend to be mild and short-lived, often resolving on their own as the medicine works. If any of these bother you or persist, speak to your pharmacist or GP.

  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Nausea
  • Sensation of tingling, warmth, or heaviness in the body
  • Dry mouth
  • Headache (separate from the migraine being treated)

What Are the Less Common Side Effects of Maxalt?

Less common side effects occur in fewer people but are still worth knowing about. Some of these require prompt medical attention, particularly those affecting the heart or circulation. Do not ignore symptoms that feel unusual or severe.

  • Flushing or a feeling of heat
  • Tremor or shakiness
  • Blurred vision
  • Increased heart rate (tachycardia)
  • Palpitations
  • Indigestion or abdominal discomfort
  • Feeling of weakness in the limbs

What Are the Serious Side Effects of Maxalt?

Serious side effects are rare but can occur. Chest tightness, pressure, or pain after taking Maxalt may indicate a cardiovascular reaction and requires urgent medical attention — do not dismiss this as a typical migraine symptom. Signs of a serious allergic reaction (anaphylaxis) include swelling of the face, lips, or throat, difficulty breathing, and a widespread rash. Stop taking Maxalt immediately and call 999 or go to your nearest A&E if you experience any of these.

Serotonin syndrome is a rare but potentially serious condition that can occur if Maxalt is taken alongside other serotonergic medicines such as SSRIs or SNRIs. Symptoms include agitation, confusion, rapid heart rate, high temperature, and muscle twitching. Seek emergency help if you suspect serotonin syndrome.

What Should You Do If You Experience Side Effects?

For mild side effects such as dizziness or nausea, resting in a quiet, darkened room after taking Maxalt can help. Staying hydrated is also important during a migraine attack. If side effects are troublesome or you are unsure whether what you are experiencing is a side effect of the medicine or part of the migraine itself, contact your pharmacist for advice. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Maxalt Interact With Other Medicines?

Yes. Maxalt has several clinically significant drug interactions that you must be aware of. Taking it alongside MAOIs is contraindicated and can cause dangerous increases in rizatriptan levels. Propranolol slows the breakdown of rizatriptan, requiring a dose reduction to 5mg. Concurrent use with SSRIs, SNRIs, or other serotonergic agents increases the risk of serotonin syndrome. Ergotamine and other triptans must not be taken within 24 hours of Maxalt. Always give your prescriber and pharmacist a full list of your current medicines, including herbal remedies such as St John's Wort.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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