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Lemsip Max Day & Night Cold & Flu Relief - 16 Capsules

Lemsip Max Day & Night Cold & Flu Relief - 16 Capsules

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  • ✔️ Relieves cold and flu fever, headache, and sore throat
  • ✔️ Day capsules keep you alert and functional
  • ✔️ Night capsules aid sleep with diphenhydramine sedation
  • ✔️ Dual-action formula works across a full 24 hours
  • ✔️ Suitable for adults and children aged 12 and over

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What Are Lemsip Max Day Night Cold Flu Capsules?

 

Coming down with a cold is never convenient. The blocked nose, the aching head, the sore throat that makes swallowing feel like a chore — it all adds up fast. Lemsip Max Day Night cold flu capsules are designed to tackle those symptoms around the clock, giving you targeted relief during the day and helping you get the rest you need at night. Each pack of 16 contains two distinct capsule types: day capsules to keep you functioning, and night capsules to help you sleep. You can browse the full range of cold and flu treatments at Cured Pharmacy's cold and flu collection if you'd like to compare your options.

This is an over-the-counter (OTC) medicine, meaning you don't need a prescription to buy it. It's suitable for adults and children aged 12 and over, and at £5.99 for 16 capsules, it offers a practical solution for managing cold and flu symptoms without a GP visit.

 

How Do Lemsip Max Day & Night Capsules Work?

 

The day and night capsules each have a slightly different formulation, which is what makes this product useful across a full 24-hour period. Here's how each works:

  • Day capsules: Contain paracetamol 500mg. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It works by inhibiting the production of prostaglandins in the brain — the chemicals responsible for pain signalling and raising body temperature.
  • Night capsules: Contain paracetamol 500mg plus diphenhydramine hydrochloride 25mg. Diphenhydramine is a first-generation antihistamine with sedative properties. It crosses the blood-brain barrier and blocks histamine H1 receptors, producing drowsiness that helps you fall asleep more easily.
  • Combined effect: Together, the two formulations address fever, headache, sore throat, and aching muscles — while the night capsule's sedative component supports rest and recovery.

It's worth noting that these capsules do not contain a decongestant such as pseudoephedrine. If nasal congestion is your primary concern, you may want to consider additional products from our ear, nose and throat range.

 

Who Is Lemsip Max Day & Night Suitable For?

 

These capsules are intended for adults and young people who need symptom relief from a cold or flu. They're particularly useful if you need to stay alert during the day but struggle to sleep at night due to discomfort. That said, they're not right for everyone.

This product is suitable for:

  • Adults aged 18 and over
  • Young people aged 12–17 (under adult supervision)
  • Those experiencing fever, headache, sore throat, or aching limbs associated with cold or flu
  • People who want a combined day/night solution in a single pack

 

How Does Lemsip Max Day & Night Compare to Lemsip Max All-in-One?

 

Feature Lemsip Max Day & Night (16 Capsules) Lemsip Max All-in-One Liquid
Active ingredients Paracetamol; Paracetamol + Diphenhydramine (night) Paracetamol, Phenylephrine, Guaifenesin
Decongestant included No Yes (Phenylephrine)
Sleep aid included Yes (night capsules) No
Formulation Capsules (day & night) Oral liquid
Suitable from age 12 years 12 years

 

How Should You Store Lemsip Max Day & Night Capsules?

 

Store below 25°C in a dry place, away from direct sunlight. Keep the pack out of sight and reach of children at all times. Do not use after the expiry date printed on the packaging. If you're unsure whether a medicine is still safe to use, your local pharmacist can advise you — and you can also find general guidance on the NHS website.

Lemsip Max Day Night cold flu capsules should be kept in their original blister packaging until use. Do not transfer capsules to another container, as this can make it harder to track expiry dates and dosage.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lemsip Max Day & Night Cold & Flu Relief - 16 Capsules specifications
Treatment category Cold and flu relief
Mechanism of action Analgesic/antipyretic (paracetamol); sedative antihistamine (diphenhydramine, night only)
Effective for Fever, headache, sore throat, aching limbs, sleeplessness due to cold/flu
Suitable for Adults and children aged 12 and over
Active ingredient (Day) Paracetamol 500mg
Active ingredient (Night) Paracetamol 500mg, Diphenhydramine hydrochloride 25mg
Pack size 16 capsules (12 day + 4 night)
UK classification General Sale List (GSL)
Drug class Analgesic / Antipyretic / Sedative antihistamine
Preparation Hard capsule
Route of administration Oral

Specifications of Lemsip Max Day & Night Cold & Flu Relief - 16 Capsules

 

What Is Lemsip Max Day & Night and What Is It Used For?

 

Lemsip Max Day & Night Cold & Flu Relief capsules are an OTC medicine used to relieve the symptoms of colds and flu in adults and children aged 12 and over. The pack contains two types of capsule: day capsules to manage symptoms while you're awake, and night capsules to ease discomfort and promote sleep. Symptoms treated include fever, headache, sore throat, and general aching. According to the NHS, most colds clear up within 7 to 10 days without the need for antibiotics, but symptom relief medicines like these can make that time considerably more comfortable.

 

What Do You Need to Know Before Using Lemsip Max Day & Night?

 

Before taking these capsules, read the following carefully. Some people should not use this product at all, and others may need to take extra care.

Do not take if you:

  • Are allergic to paracetamol, diphenhydramine, or any other ingredient in the capsules
  • Are under 12 years of age
  • Have severe liver or kidney disease
  • Are taking monoamine oxidase inhibitors (MAOIs) or have taken them in the last 14 days
  • Are taking any other product containing paracetamol — this includes many other cold remedies, pain relief tablets, and some prescription medicines
  • Have a condition called phenylketonuria (PKU)

Speak to your pharmacist or GP before use if you:

  • Have liver or kidney problems
  • Regularly drink alcohol
  • Are pregnant or breastfeeding
  • Have glaucoma, an enlarged prostate, or urinary retention
  • Are taking sedatives, sleeping tablets, or antidepressants

Known drug interactions — avoid taking alongside:

  • Other paracetamol-containing medicines (risk of overdose)
  • MAOIs and tricyclic antidepressants
  • Sedatives, hypnotics, or anxiolytics (increased drowsiness risk with night capsules)
  • Warfarin and other anticoagulants (paracetamol may enhance anticoagulant effect with prolonged use)
  • Metoclopramide or domperidone (may affect paracetamol absorption rate)

If you're managing other health conditions alongside a cold, it may also be worth exploring our pain relief collection for additional options your pharmacist can help you choose safely.

 

How Should You Use Lemsip Max Day & Night Capsules?

 

Always follow the dosage instructions on the pack. Swallow capsules whole with a glass of water. Do not chew or open the capsules.

  1. Take 2 day capsules during the day when symptoms are present.
  2. Leave at least 4 hours between each dose of day capsules.
  3. Do not take more than 3 doses of day capsules in any 24-hour period.
  4. At bedtime, take 2 night capsules — once only per night.
  5. Do not take night capsules during the day, as they cause drowsiness.
  6. Do not drive or operate machinery after taking the night capsules.
  7. Avoid alcohol, especially when taking the night capsules.
Capsule Type Age Group Dose Frequency
Day capsules Adults & children 16+ 2 capsules Every 4–6 hours, max 3 times daily
Day capsules Children 12–15 2 capsules Every 4–6 hours, max 3 times daily (under adult supervision)
Night capsules Adults & children 16+ 2 capsules Once at bedtime only
Night capsules Children 12–15 Not recommended

 

What Are the Possible Side Effects of Lemsip Max Day & Night?

 

Like all medicines, these capsules can cause side effects, although not everyone experiences them. The night capsules carry a higher risk of side effects due to the diphenhydramine component.

Common side effects:

  • Drowsiness (particularly with night capsules — this is expected)
  • Dry mouth
  • Dizziness
  • Headache (if paracetamol is taken too frequently)

Less common side effects:

  • Nausea or stomach upset
  • Blurred vision
  • Difficulty urinating
  • Skin rash or itching
  • Palpitations

Stop taking the capsules and seek immediate medical attention if you notice any signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction. Paracetamol overdose is a medical emergency — if you suspect you or someone else has taken too much, go to A&E immediately, even if you feel well, as liver damage may not be apparent for several days.

 

How Should You Store Lemsip Max Day & Night Capsules?

 

  • Store below 25°C in a dry place away from direct sunlight and heat
  • Keep in the original blister packaging until use
  • Keep out of sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you're looking to support your recovery more broadly, maintaining good nutrition during illness can help. You might find our vitamins and supplements collection useful for immune support products recommended by your pharmacist.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lemsip Max Day & Night Cold & Flu capsules online in the UK?

You can buy Lemsip Max Day & Night Cold & Flu Relief 16 Capsules directly from Cured Pharmacy's cold and flu collection for £5.99 with fast UK delivery. It's a GPhC-registered online pharmacy, so you can order with confidence. The product is also available from most UK supermarkets and high street pharmacies without a prescription.

How do Lemsip Max Day & Night capsules work in the body?

The day capsules contain paracetamol 500mg, which reduces fever by acting on the hypothalamus and relieves pain by inhibiting prostaglandin synthesis. The night capsules add diphenhydramine hydrochloride 25mg, a sedating antihistamine that crosses the blood-brain barrier to promote drowsiness. Together, they provide symptom relief during the day and support restful sleep at night.

How do I take Lemsip Max Day & Night capsules step by step?

Swallow 2 day capsules with water every 4 to 6 hours during the day, taking no more than 3 doses in 24 hours. At bedtime, take 2 night capsules once only — do not take them during the day as they cause drowsiness. Never take more than the stated dose, and avoid taking alongside any other paracetamol-containing product.

What is the maximum daily dose of Lemsip Max Day & Night capsules?

The maximum in any 24-hour period is 3 doses of 2 day capsules plus 1 dose of 2 night capsules — that's 8 capsules in total. Each day capsule contains 500mg paracetamol, so the total paracetamol intake across day and night capsules must not exceed 4g (4,000mg) in 24 hours. If you are smaller than average, elderly, or have liver concerns, speak to a pharmacist before use.

What are the side effects of Lemsip Max Day & Night capsules?

Common side effects include drowsiness (expected with night capsules), dry mouth, and dizziness. Less commonly, you may experience nausea, blurred vision, difficulty urinating, or a skin rash. If you develop signs of a serious allergic reaction — such as facial swelling or difficulty breathing — stop taking the capsules and seek emergency medical help immediately.

Who should not take Lemsip Max Day & Night capsules?

These capsules are not suitable for children under 12, people with severe liver or kidney disease, or anyone taking MAOIs or other paracetamol-containing medicines. Those with glaucoma, an enlarged prostate, or urinary retention should also avoid the night capsules due to the diphenhydramine content. Always read the full label and speak to a pharmacist if you're unsure.

Can I take Lemsip Max Day & Night capsules with other cold medicines?

No — do not take these capsules alongside any other product containing paracetamol, as this significantly increases the risk of accidental overdose. Many cold and flu remedies, headache tablets, and even some prescription medicines contain paracetamol, so always check the ingredients of everything you're taking. If you're unsure, ask your pharmacist before combining any medicines.

Is it safe to drive after taking Lemsip Max Day & Night capsules?

The day capsules do not contain a sedative, so they are unlikely to affect your ability to drive. However, the night capsules contain diphenhydramine, which causes drowsiness — you must not drive or operate heavy machinery after taking them. Even the following morning, some residual drowsiness may be present, so exercise caution.

Can I drink alcohol while taking Lemsip Max Day & Night capsules?

You should avoid alcohol while taking these capsules, particularly the night capsules. Alcohol combined with diphenhydramine increases sedation and can impair your judgement and coordination significantly. Alcohol can also place additional strain on the liver when taken alongside paracetamol, especially in people who drink regularly.

Are Lemsip Max Day & Night capsules safe during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, speak to your GP or midwife before taking these capsules. Paracetamol is generally considered the pain reliever of choice during pregnancy when used at the lowest effective dose for the shortest time, but the diphenhydramine in the night capsules has not been established as safe in pregnancy. Your healthcare provider can advise on the most appropriate option for you.

What happens if I accidentally take too many Lemsip Max Day & Night capsules?

If you take more than the recommended dose, go to your nearest A&E immediately — even if you feel well. Paracetamol overdose can cause serious liver damage that may not become apparent for several days. Take the packaging with you so medical staff can see exactly what you've taken and how much.

How long can I take Lemsip Max Day & Night capsules for?

These capsules are intended for short-term use only — no more than 3 days without medical advice. If your symptoms persist beyond 3 days, worsen, or are accompanied by a high fever, difficulty breathing, or a rash, stop taking the capsules and consult your GP. Prolonged use of diphenhydramine can also lead to tolerance and rebound insomnia.

What are the alternatives to Lemsip Max Day & Night capsules?

Alternatives include Lemsip Max All-in-One liquid (which contains a decongestant but no sleep aid), Beechams All-in-One, or Night Nurse liquid for night-time relief. If nasal congestion is your main concern, you might also explore our ear, nose and throat range for targeted decongestant options. Your pharmacist can help you choose the most appropriate product based on your specific symptoms.

Do Lemsip Max Day & Night capsules contain a decongestant?

No — unlike some other Lemsip products, the Day & Night capsules do not contain a decongestant such as phenylephrine or pseudoephedrine. They are formulated to relieve fever, pain, and sore throat, and to aid sleep at night. If you need relief from a severely blocked nose, you may want to use a separate nasal decongestant spray alongside these capsules — ask your pharmacist for advice.

What is the latest guidance on using paracetamol for cold and flu symptoms?

The NHS continues to recommend paracetamol as a first-line option for managing fever and pain associated with colds and flu in adults and children over 12. Current guidance emphasises using the lowest effective dose for the shortest necessary duration and avoiding concurrent use with other paracetamol-containing products. There is no evidence that taking paracetamol prolongs the duration of a cold or flu illness.

How Should You Use Lemsip Max Day & Night Cold & Flu Relief Capsules?

Always read the label before taking these capsules. Swallow them whole with a full glass of water — do not chew, crush, or open them. Take the day capsules during waking hours only, and reserve the night capsules strictly for bedtime use.

Follow these steps each time you take a dose:

What Is the Correct Dose of Lemsip Max Day & Night Capsules?

The correct dose depends on your age. Children under 12 must not take these capsules. Night capsules are not recommended for children aged 12 to 15 due to the diphenhydramine content.

When Is the Best Time to Use Lemsip Max Day & Night Capsules?

Take the day capsules as soon as cold or flu symptoms begin to interfere with your daily activities — there's no benefit in waiting until symptoms become severe. The night capsules should be taken immediately before you get into bed, as the drowsiness they cause can set in quickly.

Try to space your day capsule doses evenly throughout the day to maintain consistent symptom relief. Avoid taking a day capsule too close to bedtime, as this could result in you taking too much paracetamol when you then take the night capsules.

How Long Can You Use Lemsip Max Day & Night Capsules For?

These capsules are intended for short-term use only. Do not take them for more than 3 consecutive days without speaking to a doctor or pharmacist. Most colds and flu episodes resolve within 7 to 10 days, but if your symptoms are not improving after 3 days of treatment, or if they are getting worse, you should seek medical advice.

Prolonged use of diphenhydramine (the sleep aid in the night capsules) can lead to tolerance, meaning it becomes less effective over time. It can also cause rebound insomnia when stopped. For this reason, the night capsules should only be used for as long as your cold or flu symptoms genuinely disrupt your sleep.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Lemsip Max Day & Night Cold & Flu Relief Capsules?

Always read the label before taking these capsules. Swallow them whole with a full glass of water — do not chew, crush, or open them. Take the day capsules during waking hours only, and reserve the night capsules strictly for bedtime use.

Follow these steps each time you take a dose:

What Is the Correct Dose of Lemsip Max Day & Night Capsules?

The correct dose depends on your age. Children under 12 must not take these capsules. Night capsules are not recommended for children aged 12 to 15 due to the diphenhydramine content.

When Is the Best Time to Use Lemsip Max Day & Night Capsules?

Take the day capsules as soon as cold or flu symptoms begin to interfere with your daily activities — there's no benefit in waiting until symptoms become severe. The night capsules should be taken immediately before you get into bed, as the drowsiness they cause can set in quickly.

Try to space your day capsule doses evenly throughout the day to maintain consistent symptom relief. Avoid taking a day capsule too close to bedtime, as this could result in you taking too much paracetamol when you then take the night capsules.

How Long Can You Use Lemsip Max Day & Night Capsules For?

These capsules are intended for short-term use only. Do not take them for more than 3 consecutive days without speaking to a doctor or pharmacist. Most colds and flu episodes resolve within 7 to 10 days, but if your symptoms are not improving after 3 days of treatment, or if they are getting worse, you should seek medical advice.

Prolonged use of diphenhydramine (the sleep aid in the night capsules) can lead to tolerance, meaning it becomes less effective over time. It can also cause rebound insomnia when stopped. For this reason, the night capsules should only be used for as long as your cold or flu symptoms genuinely disrupt your sleep.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Lemsip Max Day & Night Capsules?

Most people tolerate these capsules well, particularly the day capsules. The most frequently reported side effects are associated with the night capsules, which contain diphenhydramine — a sedating antihistamine.

  • Drowsiness and sedation (expected with night capsules)
  • Dry mouth
  • Dizziness or light-headedness
  • Headache
  • Feeling of grogginess the morning after taking night capsules

What Are the Less Common Side Effects of Lemsip Max Day & Night Capsules?

Less commonly, some people may experience the following. If any of these persist or become bothersome, stop taking the capsules and speak to your pharmacist or GP.

  • Nausea or stomach discomfort
  • Blurred vision
  • Difficulty passing urine (urinary retention)
  • Constipation
  • Palpitations or a faster than normal heartbeat
  • Skin rash or itching
  • Restlessness or excitability (more common in older adults and children)

What Are the Serious Side Effects of Lemsip Max Day & Night Capsules?

Serious side effects are rare but require immediate medical attention. Paracetamol overdose — whether accidental or intentional — is a medical emergency. Liver damage from paracetamol overdose may not produce obvious symptoms for 24 to 72 hours, by which time significant harm may already have occurred. If you suspect an overdose, go to A&E immediately and take the packaging with you.

Signs of a serious allergic reaction (anaphylaxis) include swelling of the face, lips, tongue, or throat, difficulty breathing, a sudden drop in blood pressure, or a widespread skin rash. These symptoms require emergency treatment — call 999 without delay.

What Should You Do If You Experience Side Effects?

For mild side effects such as dry mouth or morning grogginess, these often resolve on their own and do not usually require you to stop treatment. Staying well hydrated can help with dry mouth. If drowsiness from the night capsules is affecting your ability to function the following morning, consider whether you genuinely need the night capsules or whether the day capsules alone would be sufficient.

For any side effect that concerns you, or that does not resolve, contact your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Lemsip Max Day & Night Capsules Interact With Other Medicines?

Yes — interactions are possible and some are clinically significant. The most important is the risk of paracetamol overdose if these capsules are taken alongside any other paracetamol-containing product. Diphenhydramine in the night capsules can interact with sedatives, sleeping tablets, antidepressants (particularly MAOIs and tricyclics), and antihistamines, increasing the risk of excessive sedation. Paracetamol may also enhance the effect of anticoagulants such as warfarin with prolonged use. Always tell your pharmacist about every medicine you are taking — including herbal remedies and supplements — before starting these capsules.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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