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Imigrain Nasal Sparay

Imigrain Nasal Sparay

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  • ✔️ Targets migraine pain at its neurological source directly
  • ✔️ Nasal route works without swallowing — ideal if nauseous
  • ✔️ Relief may begin within 15 to 30 minutes of use
  • ✔️ Suitable for adults 18–65 with confirmed migraine diagnosis
  • ✔️ Contains sumatriptan 10mg — clinically established triptan therapy

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What Is Sumatriptan Nasal Spray and How Can It Help Your Migraine?

 

Migraines are far more than a bad headache. They can leave you unable to work, care for your family, or even get out of bed. If you've ever experienced the throbbing pain, nausea, and sensitivity to light that comes with a migraine attack, you'll know how desperately you want relief — and fast. Sumatriptan nasal spray, available here as Imigrain Nasal Spray, is a clinically established treatment designed to tackle migraine symptoms at the source. It belongs to a class of medicines called triptans, which are specifically developed for acute migraine relief rather than general pain management. You can explore other pain relief options on our site if you're managing other types of discomfort alongside your migraines.

Imigrain Nasal Spray contains 10mg of sumatriptan per actuation and is suitable for adults aged 18 to 65 who have already received a confirmed diagnosis of migraine from a doctor. It is available to purchase without a prescription in the UK, though it is important to use it correctly and only when appropriate. Each pack contains two single-dose nasal spray units, priced at £24.99.

 

How Does Imigrain Nasal Spray Work to Relieve a Migraine?

 

Understanding how this medicine works can help you feel more confident using it. Sumatriptan is a selective serotonin (5-HT1B/1D) receptor agonist. During a migraine, blood vessels around the brain dilate and certain pain pathways become activated. Sumatriptan targets this process directly.

  • It binds to serotonin receptors on the blood vessels surrounding the brain.
  • This causes those vessels to constrict (narrow), reducing the throbbing sensation.
  • It also inhibits the release of inflammatory neuropeptides that contribute to migraine pain.
  • The nasal route allows the medicine to be absorbed quickly into the bloodstream, bypassing the digestive system — particularly useful if nausea is making it hard to swallow tablets.

Many people find that symptoms begin to ease within 15 to 30 minutes of using the spray, though individual responses do vary.

 

Who Is Imigrain Nasal Spray Suitable For?

 

This product is intended for a specific group of patients. It is not a general painkiller and should only be used by those who meet the criteria below.

  • Adults aged 18 to 65 with a confirmed diagnosis of migraine (with or without aura).
  • People who experience nausea or vomiting during migraines and find tablets difficult to take.
  • Those who have not responded adequately to standard over-the-counter pain relief such as paracetamol or ibuprofen.
  • Patients who have previously used sumatriptan without adverse effects.

It is not suitable for use in children, adolescents under 18, or adults over 65. It should also not be used to prevent migraines — only to treat an attack once it has started.

 

How Does Imigrain Nasal Spray Compare to Sumatriptan Tablets?

 

Feature Imigrain Nasal Spray (10mg) Sumatriptan Tablets (50mg/100mg)
Route of administration Intranasal Oral
Onset of action 15–30 minutes (approximate) 30–60 minutes (approximate)
Suitable if nauseous Yes — no swallowing required May be difficult if vomiting
Available OTC in UK Yes (10mg) Yes (50mg)

 

How Should You Store Imigrain Nasal Spray?

 

Store Imigrain Nasal Spray below 30°C, away from direct light and moisture. Keep it in its original packaging until you are ready to use it. Do not store it in the bathroom or near a heat source. Keep all medicines out of the reach and sight of children. Do not use the spray after the expiry date printed on the pack.

If you are managing multiple health concerns alongside your migraines — such as sleep disruption, which is a known migraine trigger — you may find it helpful to browse our sleep aid range for additional support.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Imigrain Nasal Spray specifications
Treatment category Migraine relief
Mechanism of action Selective serotonin (5-HT1B/1D) receptor agonist
Effective for Acute migraine attacks (with or without aura)
Suitable for Adults aged 18–65 with confirmed migraine diagnosis
Active ingredient Sumatriptan 10mg per actuation
Pack sizes 2 single-dose nasal spray units
Strengths 10mg
UK classification Pharmacy (P) medicine
Drug class Triptan (serotonin receptor agonist)
Preparation Nasal spray solution
Route of administration Intranasal

Specifications of Imigrain Nasal Spray

 

What Is Imigrain Nasal Spray and What Is It Used For?

 

Imigrain Nasal Spray contains sumatriptan, a triptan medicine used to treat acute migraine attacks in adults. It is not a painkiller in the traditional sense — it works specifically on the mechanisms that cause migraine, rather than simply masking pain. It is used to relieve the headache phase of a migraine, along with associated symptoms such as nausea and sensitivity to light and sound. It is not intended for the prevention of migraines or for treating other types of headache, including tension headaches or cluster headaches (unless specifically directed by a doctor).

 

What Do You Need to Know Before Using Imigrain Nasal Spray?

 

Before using this medicine, it is essential to check whether it is appropriate for you. Do not use Imigrain Nasal Spray if any of the following apply:

  • You have a history of heart disease, angina, or heart attack.
  • You have had a stroke or transient ischaemic attack (TIA).
  • You have uncontrolled or severe high blood pressure.
  • You have severe liver impairment.
  • You have peripheral vascular disease.
  • You are under 18 or over 65 years of age.
  • You are allergic to sumatriptan or any other ingredient in the spray.
  • You have taken an ergotamine-containing medicine or another triptan in the last 24 hours.
  • You are taking or have taken a monoamine oxidase inhibitor (MAOI) in the last two weeks.

The following medicines may interact with sumatriptan. Always tell your pharmacist or doctor about everything you are taking:

  • SSRIs (e.g. fluoxetine, sertraline) and SNRIs — risk of serotonin syndrome.
  • Lithium — increased risk of serotonin-related effects.
  • St John's Wort — may increase the risk of side effects.
  • Other triptans or ergotamine — do not use within 24 hours of each other.

 

How Should You Use Imigrain Nasal Spray?

 

Always use this medicine exactly as directed. Using it correctly ensures you get the most benefit and reduces the risk of side effects. Follow these steps:

  1. Blow your nose gently to clear your nostrils.
  2. Hold the device with your thumb at the bottom and your first two fingers on either side of the nozzle.
  3. Close one nostril by pressing gently with a finger.
  4. Insert the nozzle into the open nostril.
  5. Press the plunger firmly with your thumb to release the spray.
  6. Breathe in gently through your nose at the same time — do not sniff hard.
  7. Remove the device and breathe out through your mouth.
Indication Age Group Dose Frequency
Acute migraine Adults 18–65 10mg (one spray into one nostril) Once; may repeat after 2 hours if symptoms return. Max 20mg in 24 hours.
Acute migraine Under 18 / Over 65 Not recommended Not applicable

If your migraine does not improve after the first dose, do not take a second dose for the same attack. Seek medical advice if this happens regularly. If you find yourself using sumatriptan nasal spray on more than 10 days per month, speak to your GP — overuse can lead to medication-overuse headache.

 

What Are the Possible Side Effects of Imigrain Nasal Spray?

 

Like all medicines, Imigrain Nasal Spray can cause side effects, though not everyone experiences them. Most are mild and resolve on their own. If you experience anything severe or unusual, stop using the spray and seek medical advice promptly. You can also find general guidance on managing symptoms through our ear, nose and throat section if nasal irritation is a concern.

Common side effects (may affect up to 1 in 10 people):

  • Tingling, warmth, or flushing sensation
  • Nasal discomfort, irritation, or burning in the nostril
  • Bitter or unpleasant taste in the mouth
  • Dizziness or drowsiness
  • Feeling of heaviness, pressure, or tightness (usually in the chest, throat, or limbs)
  • Nausea or vomiting

Less common side effects (may affect up to 1 in 100 people):

  • Transient increases in blood pressure
  • Shortness of breath
  • Visual disturbances
  • Fatigue or weakness
  • Palpitations or irregular heartbeat

Seek emergency medical help immediately if you experience chest pain, severe tightening in the chest, or signs of an allergic reaction such as swelling of the face, lips, or throat.

 

How Should You Store Imigrain Nasal Spray?

 

  • Store below 30°C in a cool, dry place.
  • Keep away from direct sunlight and moisture.
  • Do not store in the bathroom or near a heat source.
  • Keep in the original packaging until use.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the pack.
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy.

If you are also managing other health conditions that may be linked to your migraines — such as nausea or digestive discomfort — our sickness and nausea range may offer additional support alongside your migraine treatment.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Imigrain Nasal Spray online in the UK?

You can buy Imigrain Nasal Spray directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available as a Pharmacy (P) medicine for adults aged 18 to 65 who have a confirmed migraine diagnosis. No prescription is required, but you will need to complete a short health questionnaire to ensure it is suitable for you.

How does sumatriptan nasal spray work in the body?

Sumatriptan works by binding to serotonin (5-HT1B/1D) receptors on blood vessels around the brain, causing them to narrow and reducing the throbbing pain of a migraine. It also blocks the release of inflammatory substances that trigger migraine symptoms. This targeted action means it works specifically on migraines rather than acting as a general painkiller.

How do I use Imigrain Nasal Spray step by step?

Blow your nose gently first, then close one nostril and insert the nozzle into the other. Press the plunger firmly to release the spray while breathing in gently through your nose — do not sniff hard or tilt your head back. Remove the device and breathe out through your mouth; the medicine will be absorbed through the nasal lining.

What is the correct dose of Imigrain Nasal Spray for adults?

The standard dose is one 10mg spray into one nostril at the onset of a migraine attack. If your symptoms return after initial relief, you may take a second 10mg dose after at least two hours, but do not exceed 20mg in any 24-hour period. If the first dose does not work at all, do not take a second dose for the same attack.

How quickly does Imigrain Nasal Spray start to work?

Many people begin to notice relief within 15 to 30 minutes of using the spray, as the nasal route allows sumatriptan to be absorbed into the bloodstream without passing through the digestive system. This can be particularly helpful if nausea is making it difficult to keep tablets down. Individual response times can vary depending on the severity of the attack and how quickly you use the spray after symptoms begin.

Who should not use Imigrain Nasal Spray?

Imigrain Nasal Spray is not suitable for people with a history of heart disease, stroke, TIA, uncontrolled high blood pressure, or severe liver problems. It should not be used by anyone under 18 or over 65, or by those who are allergic to sumatriptan. If you are unsure whether it is right for you, speak to your pharmacist or GP before purchasing.

Can I use Imigrain Nasal Spray during pregnancy or breastfeeding?

The use of sumatriptan during pregnancy is not recommended unless your doctor has specifically advised it, as data on safety in pregnancy is limited. If you are breastfeeding, you should avoid breastfeeding for 12 hours after using the spray and discard any milk expressed during that time. Always consult your GP or midwife before using any migraine treatment during pregnancy or while breastfeeding.

What are the most common side effects of Imigrain Nasal Spray?

The most commonly reported side effects include a tingling or warm sensation, nasal discomfort or irritation, a bitter taste in the mouth, and mild dizziness. Some people also experience a feeling of pressure or tightness in the chest or throat, which is usually temporary and not dangerous. If chest pain is severe or persistent, stop using the spray and seek medical attention immediately.

Can I take Imigrain Nasal Spray with other medicines?

You should not use Imigrain Nasal Spray alongside MAOIs, ergotamine-containing medicines, or other triptans within a 24-hour period. Caution is also advised if you are taking SSRIs, SNRIs, or lithium, due to the risk of serotonin syndrome. Always inform your pharmacist of all medicines, supplements, and herbal remedies you are currently taking — including St John's Wort — before using this product. You can browse our vitamins and supplements range for products that are generally considered safe alongside migraine treatments.

What happens if I miss a dose or forget to use Imigrain Nasal Spray?

Because Imigrain Nasal Spray is used on an as-needed basis rather than on a regular schedule, there is no concept of a "missed dose" in the traditional sense. Simply use it as soon as your migraine symptoms begin — the earlier in the attack you use it, the more effective it tends to be. Do not use it to make up for a missed opportunity during a previous attack.

How often can I use Imigrain Nasal Spray each month?

You should not use sumatriptan nasal spray on more than 10 days per month, as frequent use can lead to medication-overuse headache — a condition where the treatment itself begins to cause daily or near-daily headaches. If you find you are needing migraine treatment this frequently, speak to your GP about preventative migraine therapies. Managing migraine frequency often involves identifying and addressing triggers such as poor sleep or stress.

What are the alternatives to Imigrain Nasal Spray?

Alternatives include sumatriptan tablets (50mg), which are also available over the counter in the UK, as well as other triptans such as rizatriptan or zolmitriptan on prescription. For milder attacks, standard over-the-counter options from our pain relief range — such as ibuprofen or aspirin — may be sufficient. Your GP can advise on the most appropriate option based on your migraine pattern and medical history.

Is Imigrain Nasal Spray the same as Imigran Nasal Spray?

Imigrain Nasal Spray and Imigran Nasal Spray both contain sumatriptan as the active ingredient and are used for the same indication — acute migraine relief. The names are very similar and can cause confusion, but they are distinct products; always check the packaging and active ingredient carefully. If you have any questions about which product is right for you, our pharmacist team is available to help.

How long can I keep using Imigrain Nasal Spray?

Imigrain Nasal Spray is intended for short-term, as-needed use during individual migraine attacks rather than as a long-term daily treatment. If you are relying on it frequently, this is a signal to speak to your GP about whether a preventative migraine treatment might be more appropriate for you. Long-term overuse of triptans can worsen headache patterns over time.

What does the latest research say about sumatriptan nasal spray for migraine?

Sumatriptan has been used clinically for migraine treatment since the early 1990s and remains one of the most well-studied acute migraine treatments available. Current NHS and NICE guidance supports its use as a first-line triptan for adults with moderate to severe migraine. Ongoing research continues to explore optimised delivery methods and combination therapies, but the nasal spray formulation is well-established as an effective option for those who cannot tolerate oral tablets during an attack.

How Should You Use Imigrain Nasal Spray?

Use Imigrain Nasal Spray as soon as your migraine symptoms begin. The earlier you use it during an attack, the more likely it is to be effective. Follow these steps carefully to ensure correct administration:

Each device is single-use only. Do not attempt to reuse or refill it. If you are unsure about the technique, ask your pharmacist to demonstrate before you need to use it during an attack.

What Is the Correct Dose of Imigrain Nasal Spray?

The dose of Imigrain Nasal Spray depends on your age and the nature of your migraine. Always follow the dosage guidance below and never exceed the maximum recommended amount in a 24-hour period. If your migraine does not respond to the first dose, do not take a second dose for the same attack — seek medical advice instead.

When Is the Best Time to Use Imigrain Nasal Spray?

Use Imigrain Nasal Spray at the first sign of a migraine headache — not during the aura phase if one occurs, but as soon as the headache itself begins. Using it early in the headache phase gives sumatriptan the best opportunity to work effectively. It is not intended for use as a preventative treatment, so do not take it before a migraine starts in anticipation of an attack.

If you experience nausea or vomiting early in your migraine, the nasal spray is particularly well-suited as it does not require swallowing and is absorbed directly through the nasal lining.

How Long Can You Use Imigrain Nasal Spray For?

Imigrain Nasal Spray is intended for short-term, as-needed use only. It should not be used on more than 10 days per month, as overuse can lead to medication-overuse headache — a condition where frequent use of acute migraine treatments paradoxically worsens headache frequency. If you find yourself needing it more than 10 days a month, speak to your GP about preventative migraine management options. There is no set maximum duration of use, provided you stay within the monthly usage limits and continue to have a confirmed migraine diagnosis.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Imigrain Nasal Spray?

Most people who use Imigrain Nasal Spray tolerate it well, but like all medicines, it can cause side effects in some individuals. Common side effects are generally mild and short-lived, often resolving within an hour or two of use.

  • Tingling, warmth, or flushing sensation in the face, neck, or limbs
  • Nasal discomfort, burning, or irritation in the nostril
  • Bitter or unpleasant taste in the mouth after use
  • Dizziness or light-headedness
  • Feeling of heaviness, pressure, or tightness (commonly in the chest, throat, or jaw)
  • Nausea or vomiting
  • Drowsiness or fatigue

What Are the Less Common Side Effects of Imigrain Nasal Spray?

Less common side effects occur in fewer people but are still worth being aware of. If you notice any of the following, monitor them carefully and contact your pharmacist or GP if they persist or worsen.

  • Transient rise in blood pressure
  • Palpitations or a rapid heartbeat
  • Shortness of breath or difficulty breathing
  • Visual disturbances, such as flickering or blurred vision
  • Muscle weakness or aching
  • Increased sensitivity to touch or temperature

What Are the Serious Side Effects of Imigrain Nasal Spray?

Serious side effects are rare but require immediate medical attention. Stop using the spray and call 999 or go to your nearest A&E if you experience any of the following:

  • Severe or crushing chest pain — this could indicate a cardiac event and must be assessed urgently.
  • Signs of a stroke, such as sudden weakness on one side of the body, slurred speech, or facial drooping.
  • Symptoms of serotonin syndrome — including agitation, confusion, rapid heart rate, high temperature, and muscle twitching — particularly if you are also taking SSRIs or SNRIs.
  • Severe allergic reaction (anaphylaxis) — swelling of the face, lips, tongue, or throat, difficulty breathing, or a sudden drop in blood pressure.

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as nasal irritation or a bitter taste, these usually resolve on their own and do not require treatment. Sitting quietly in a darkened room and staying hydrated can help while the medicine takes effect. If side effects are troubling you or do not resolve within a couple of hours, contact your pharmacist for advice.

You should report any suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines in real-world use.

Can Imigrain Nasal Spray Interact With Other Medicines?

Yes — sumatriptan can interact with several medicines, and some combinations can be dangerous. Do not use Imigrain Nasal Spray if you are taking MAOIs (or have taken them in the last two weeks), ergotamine-containing medicines, or other triptans. Using sumatriptan alongside SSRIs, SNRIs, or lithium increases the risk of serotonin syndrome, a potentially serious condition. St John's Wort, a herbal supplement, may also increase the risk of side effects. Always tell your pharmacist or doctor about every medicine and supplement you are taking before using this product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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