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Excilor Ultra Anti-Fungal Nail Fungus Treatment

Excilor Ultra Anti-Fungal Nail Fungus Treatment

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  • ✔️ Targets fungal nail infections using pH-acidifying ethyl lactate
  • ✔️ Inhibits dermatophyte growth directly within the nail plate
  • ✔️ Daily application supports healthy nail regrowth over time
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Convenient integrated brush applicator for precise nail coverage

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What Is Excilor Ultra Fungal Nail Treatment?

 

Fungal nail infections are more common than many people realise. The NHS estimates that around 3 in 100 people in the UK will develop a fungal nail infection at some point in their lives — and toenails are affected far more often than fingernails. If your nails have become thickened, discoloured, or brittle, you may well be dealing with one. Fungal nail treatment is the first step towards getting your nails back to health, and Excilor Ultra Anti-Fungal Nail Fungus Treatment is a clinically developed, over-the-counter option designed specifically for this purpose. You can also browse our wider range of athletes foot and fungal infection treatments if you need additional support alongside nail care.

Excilor Ultra is a topical solution applied directly to the affected nail. It does not require a prescription and is available to order online from Cured Pharmacy for £22.99. It is suitable for adults and children aged 12 and over, making it a practical choice for most households dealing with this stubborn condition.

 

How Does Excilor Ultra Work on Nail Fungus?

 

Rather than relying on a traditional antifungal drug, Excilor Ultra uses a physical-chemical approach. Its active ingredient, ethyl lactate, works by penetrating the nail plate and reducing the local pH — in other words, it makes the nail environment more acidic. Fungi responsible for nail infections, primarily dermatophytes such as Trichophyton rubrum, thrive in a neutral-to-alkaline environment. By shifting the pH, Excilor Ultra creates conditions in which the fungus cannot survive or replicate effectively.

  • Ethyl lactate penetrates the nail plate on application
  • The nail's pH is lowered, creating an acidic microenvironment
  • Fungal growth is inhibited as the environment becomes hostile
  • Healthy nail tissue gradually replaces the infected nail as it grows out

This mechanism is distinct from antifungal lacquers that contain amorolfine or ciclopirox, which work by directly targeting fungal cell membranes. Excilor's approach is considered a medical device action rather than a pharmacological one, which is why it is classified differently to prescription antifungals.

 

Who Should Use Excilor Ultra Nail Treatment?

 

Excilor Ultra is designed for adults and young people aged 12 and over who have a confirmed or suspected fungal nail infection. It is particularly suited to those who prefer a non-prescription option or who have not yet tried a topical treatment. That said, it is always worth confirming your diagnosis with a pharmacist or GP before starting any treatment, as nail changes can occasionally have other causes.

  • Adults with mild to moderate fungal nail infection affecting one or more nails
  • People who prefer an OTC solution before seeking prescription treatment
  • Those who have previously used antifungal lacquers and want to try an alternative approach
  • Individuals aged 12 and over (not recommended for younger children)

 

How Does Excilor Ultra Compare to Other Fungal Nail Treatments?

 

Feature Excilor Ultra Amorolfine Nail Lacquer (e.g. Loceryl)
Mechanism pH acidification (physical-chemical) Disrupts fungal cell membrane (pharmacological)
Application frequency Once daily Once or twice weekly
Prescription required? No No (OTC strength)
Suitable age 12 years and over 18 years and over (varies by brand)

 

Is Excilor Ultra Suitable for People With Diabetes or Circulation Problems?

 

If you have diabetes, peripheral vascular disease, or any condition affecting circulation or sensation in your feet, you should speak to your GP or pharmacist before using any fungal nail treatment. The NHS advises that people with diabetes take particular care with foot health, as even minor issues can escalate if not managed correctly. Excilor Ultra is applied topically and does not enter the bloodstream, but professional guidance is still recommended for this group.

Store Excilor Ultra below 25°C, away from direct sunlight, and keep it out of reach of children. If you are managing other foot conditions alongside a fungal nail infection, our foot care collection includes a range of supportive products that may help.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Excilor Ultra Anti-Fungal Nail Fungus Treatment specifications
Treatment category Antifungal nail treatment
Mechanism of action pH acidification via ethyl lactate to inhibit fungal growth
Effective against Dermatophyte fungal nail infections (onychomycosis)
Suitable for Adults and children aged 12 and over
Active ingredient Ethyl lactate
UK classification Medical device / General Sale
Preparation Topical solution
Route of administration Topical (applied directly to nail)

Specifications of Excilor Ultra Anti-Fungal Nail Fungus Treatment

 

What Is Excilor Ultra and What Is It Used For?

 

Excilor Ultra Anti-Fungal Nail Fungus Treatment is a topical solution used to treat onychomycosis — the medical term for a fungal nail infection. It is applied directly to the surface of the affected nail and works by creating an acidic environment that inhibits the growth of the fungi responsible for the infection. The NHS notes that fungal nail infections most commonly affect toenails and are caused by dermatophyte fungi, though yeasts and moulds can also be responsible in some cases.

The product is available over the counter without a prescription and is intended for use in adults and young people aged 12 and over. It is not a cure in the traditional sense — rather, it supports the nail's natural regrowth by stopping the fungus from spreading, allowing healthy nail to gradually replace the infected tissue. Treatment duration can be several months, reflecting the slow growth rate of toenails.

 

What Do You Need to Know Before Using Excilor Ultra?

 

Before you start using Excilor Ultra, it is important to check whether it is appropriate for you. There are certain situations in which you should not use this product or should seek advice first.

Do not use Excilor Ultra if you:

  • Are allergic to ethyl lactate or any other ingredient in the formulation
  • Are under 12 years of age
  • Have open wounds, cuts, or broken skin around the nail area
  • Have a known sensitivity to lactic acid-based products

Speak to your GP or pharmacist before use if you:

  • Have diabetes or poor circulation affecting your feet
  • Are pregnant or breastfeeding
  • Have a nail condition that has not been formally diagnosed
  • Are currently using other topical nail treatments

Drug interactions:

  • No significant drug interactions are currently known for topically applied ethyl lactate
  • If you are using prescription antifungal nail lacquers concurrently, consult your pharmacist before combining treatments

 

How Should You Use Excilor Ultra Correctly?

 

Consistent daily application is key to getting the most from this treatment. The built-in applicator brush makes it straightforward to use at home. Follow these steps carefully each time you apply.

  1. Clean the affected nail thoroughly and ensure it is completely dry before application
  2. If possible, file down any thickened areas of the nail using a nail file (use a separate file for infected nails)
  3. Open the Excilor Ultra bottle and use the integrated brush to apply the solution directly to the entire surface of the affected nail
  4. Allow the solution to dry fully — this usually takes a minute or two
  5. Apply once daily, ideally at the same time each day to build a consistent routine
  6. Wash your hands after application
Indication Age Group Dose Frequency
Fungal nail infection (onychomycosis) 12 years and over Apply to cover the full nail surface Once daily
Fungal nail infection (onychomycosis) Under 12 years Not recommended

If you are also managing athlete's foot alongside a nail infection, you may find it helpful to explore our athletes foot and fungal infections range for complementary treatments to address both conditions simultaneously.

 

What Are the Possible Side Effects of Excilor Ultra?

 

Excilor Ultra is generally well tolerated when used as directed. Because it is applied topically and does not enter the bloodstream, systemic side effects are not expected. However, as with any topical product, localised reactions can occasionally occur.

Common side effects:

  • Mild skin irritation around the nail fold
  • Temporary redness at or near the application site
  • Slight stinging sensation immediately after application

Less common side effects:

  • Dryness or flaking of the skin surrounding the nail
  • Contact dermatitis in individuals with sensitive skin

If you experience persistent irritation, swelling, or any sign of an allergic reaction — such as a rash spreading beyond the application area — stop using the product and speak to your pharmacist or GP. Serious allergic reactions to topical ethyl lactate are rare but should be treated promptly if they occur.

 

How Should You Store Excilor Ultra Safely?

 

Correct storage helps maintain the product's effectiveness throughout the course of treatment. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and sources of heat
  • Keep the cap tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not store in the bathroom, where humidity can affect the solution

If you are looking for additional skin and nail health support, our skin care collection includes a variety of products to help maintain healthy skin around the feet and nails during treatment.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Excilor Ultra Anti-Fungal Nail Treatment online in the UK?

You can buy Excilor Ultra Anti-Fungal Nail Fungus Treatment directly from Cured Pharmacy online for £22.99, with no prescription required. It is an over-the-counter product available to adults and young people aged 12 and over. Simply add it to your basket and choose your preferred delivery option at checkout.

How does Excilor Ultra work to treat nail fungus?

Excilor Ultra uses ethyl lactate to lower the pH of the nail plate, creating an acidic environment that is hostile to the fungi causing the infection. Dermatophyte fungi — the most common culprits in fungal nail infections — cannot thrive in acidic conditions, so their growth is inhibited. Over time, as the nail grows out, healthy nail tissue replaces the infected area.

How do I use Excilor Ultra step by step?

Start by cleaning and thoroughly drying the affected nail, then file down any thickened areas if possible. Use the integrated applicator brush to apply the solution across the entire nail surface once daily, and allow it to dry completely before putting on socks or shoes. Wash your hands after each application and try to apply at the same time each day to maintain consistency.

How long does Excilor Ultra take to show results?

Toenails grow very slowly — typically around 1.5 mm per month — so visible improvement can take several months of consistent daily use. The NHS notes that fungal nail infections can take up to 12 months to fully resolve even with treatment, depending on how many nails are affected and the severity of the infection. Patience and daily application are essential for the best outcome.

What are the side effects of Excilor Ultra?

Most people tolerate Excilor Ultra well, but some may notice mild skin irritation, temporary redness, or a slight stinging sensation around the nail immediately after application. Less commonly, dryness or contact dermatitis may occur in people with sensitive skin. If any reaction persists or worsens, stop using the product and consult your pharmacist.

How do I manage side effects from Excilor Ultra?

If you experience mild irritation, try applying the solution more sparingly and ensure the surrounding skin is not wet at the time of application. Avoid getting the solution on the skin around the nail where possible. If irritation continues beyond a few days, speak to your pharmacist — they may suggest an alternative fungal nail treatment from our athletes foot and fungal infections range.

Who is eligible to use Excilor Ultra?

Excilor Ultra is suitable for adults and young people aged 12 and over who have a fungal nail infection affecting one or more nails. It is not recommended for children under 12, and people with diabetes, circulatory problems, or immune conditions should consult their GP or pharmacist before use. Pregnant or breastfeeding individuals should also seek professional advice first.

Is Excilor Ultra safe to use if I have diabetes?

People with diabetes need to take extra care with foot health, and the NHS recommends regular foot checks and professional guidance for any nail or skin changes in this group. Excilor Ultra is applied topically and does not enter the bloodstream, but you should still speak to your GP or pharmacist before starting treatment. They can confirm whether it is appropriate for your individual circumstances.

Can I use Excilor Ultra if I am pregnant or breastfeeding?

There is insufficient clinical data to confirm the safety of Excilor Ultra during pregnancy or breastfeeding, so it is important to consult your GP or midwife before using it. Your healthcare professional can advise on whether the benefits outweigh any potential risks in your specific situation. Do not self-treat without seeking advice first if you are pregnant or nursing.

What happens if I miss a day of applying Excilor Ultra?

If you miss a day, simply apply the solution as normal the following day — do not double up to compensate for a missed application. Consistency is important with fungal nail treatment, so try to build it into a daily routine, such as applying it after your evening shower. Missing the occasional day is unlikely to significantly affect the overall outcome, but frequent gaps may slow progress.

What are the alternatives to Excilor Ultra for fungal nail infections?

Common OTC alternatives include amorolfine nail lacquer (such as Loceryl), which works by targeting fungal cell membranes and is applied once or twice weekly. For more severe or widespread infections, a GP may prescribe oral terbinafine tablets, which the NHS considers the most effective treatment for onychomycosis. You can explore a range of topical options in our foot care collection.

How long can I use Excilor Ultra for?

Excilor Ultra can be used for as long as necessary to allow the infected nail to grow out fully, which may take up to 12 months for toenails. If you see no improvement after three months of consistent daily use, it is worth speaking to your GP or pharmacist to reassess your treatment plan. They may recommend a different approach or investigate whether the nail change has another underlying cause.

Can I use nail varnish while using Excilor Ultra?

It is generally advisable to avoid applying nail varnish or artificial nails over the treated nail during the course of treatment, as these can prevent the solution from penetrating the nail plate effectively. If you are concerned about the appearance of your nails during treatment, speak to your pharmacist about suitable options. Keeping nails clean, short, and free from cosmetic products will support the treatment process.

Is Excilor Ultra the same as a prescription antifungal?

No — Excilor Ultra works via a physical-chemical mechanism (pH acidification) rather than a pharmacological antifungal drug action, which is how prescription treatments such as oral terbinafine or topical amorolfine work. It is classified as a medical device in some markets rather than a licensed medicine, which is why it is available without a prescription. For severe or resistant infections, a GP may recommend prescription-strength treatment instead.

What are the latest findings on topical fungal nail treatments?

Current clinical guidance from NICE and the NHS acknowledges that topical treatments for fungal nail infections are most effective for mild to moderate cases where less than 50% of the nail is affected and the nail matrix is not involved. Oral antifungals remain the most clinically effective option for widespread infection, but topical solutions like Excilor Ultra offer a convenient, accessible starting point for many patients. Research continues into novel delivery systems to improve nail penetration and treatment outcomes.

How Should You Use Excilor Ultra?

Using Excilor Ultra correctly every day gives you the best chance of clearing a fungal nail infection. The built-in applicator brush makes application straightforward, but technique matters — applying the solution to a clean, dry nail ensures it can penetrate the nail plate effectively. Follow these steps each time you use it:

Avoid applying the solution to broken or inflamed skin around the nail. If you accidentally get the solution in your eyes, rinse immediately with plenty of water and seek medical advice if irritation persists.

What Is the Correct Dose of Excilor Ultra?

Excilor Ultra is applied topically, so the "dose" refers to the amount applied to the nail surface rather than a measured quantity. The goal is to cover the entire nail with a thin, even layer of solution at each application. There is no benefit to applying more than needed — a single coat covering the full nail is sufficient.

When Is the Best Time to Use Excilor Ultra?

There is no single "correct" time of day to apply Excilor Ultra, but consistency is what matters most. Many people find it easiest to apply the solution in the evening after bathing or showering, when the nail is clean and there is no immediate need to put on footwear. Applying at the same time each day helps build a reliable habit, which is important given that treatment may continue for several months.

Avoid applying immediately before swimming or bathing, as water exposure may wash away the solution before it has had time to work. If you exercise regularly, apply after your workout rather than before.

How Long Can You Use Excilor Ultra For?

Fungal nail infections are notoriously slow to resolve because nails grow very gradually. Toenails typically grow around 1.5 mm per month, meaning a full nail can take nine to twelve months to grow out completely. You should continue using Excilor Ultra daily until the infected nail has fully grown out and been replaced by healthy nail tissue. If you see no improvement after three months of consistent use, speak to your pharmacist or GP — they may recommend an alternative approach or investigate whether another condition is responsible for the nail changes.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Excilor Ultra?

Because Excilor Ultra is applied directly to the nail and surrounding skin, any side effects that do occur tend to be localised to the application area. The product is generally well tolerated, and most people complete their course of treatment without significant problems. That said, it is worth knowing what to look out for.

  • Mild skin irritation around the nail fold
  • Temporary redness at or near the application site
  • Slight stinging or tingling sensation immediately after applying the solution

These reactions are usually mild and short-lived. They often settle on their own as your skin adjusts to the product. If they persist beyond a few days, reduce the amount applied or speak to your pharmacist.

What Are the Less Common Side Effects of Excilor Ultra?

Less frequently, some individuals — particularly those with sensitive skin — may experience more noticeable localised reactions. These are not dangerous in most cases, but they do warrant attention.

  • Dryness or flaking of the skin surrounding the nail
  • Contact dermatitis — a localised inflammatory skin reaction characterised by redness, itching, and sometimes blistering
  • Discomfort or tenderness around the nail bed

If you notice any of these reactions, try applying the solution more carefully to avoid contact with the surrounding skin. A thin layer applied precisely to the nail surface is all that is needed.

What Are the Serious Side Effects of Excilor Ultra?

Serious side effects from topically applied ethyl lactate are rare. However, signs of a significant allergic reaction should never be ignored. Seek urgent medical attention if you experience any of the following after using Excilor Ultra:

  • Widespread rash or hives spreading beyond the application area
  • Swelling of the face, lips, or throat
  • Difficulty breathing
  • Severe blistering or skin breakdown around the nail

These symptoms may indicate anaphylaxis or a severe hypersensitivity reaction, both of which require immediate medical attention. Call 999 or go to your nearest A&E department if you suspect a serious allergic reaction.

What Should You Do If You Experience Side Effects From Excilor Ultra?

For mild side effects such as temporary irritation or redness, you can usually continue treatment while monitoring the reaction. Applying the solution more sparingly and ensuring the surrounding skin is dry before application may help reduce discomfort. If the reaction does not improve within a few days, stop using the product and consult your pharmacist or GP before restarting.

Never ignore a worsening reaction. Your pharmacist is well placed to advise on whether to continue, switch to an alternative treatment, or refer you to your GP for further assessment.

Can Excilor Ultra Interact With Other Medicines?

No significant drug interactions are currently known for topically applied ethyl lactate. Because the solution acts locally on the nail and does not enter the bloodstream in meaningful amounts, systemic interactions with oral medications are not expected. However, if you are already using another topical antifungal nail treatment — such as an amorolfine lacquer — speak to your pharmacist before combining products, as using multiple nail treatments simultaneously has not been formally studied and may affect how each product performs.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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