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Dermalex Psoriasis Treatment Cream - 60g

Dermalex Psoriasis Treatment Cream - 60g

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  • ✔️ Reduces redness, scaling, and itching from plaque psoriasis
  • ✔️ Steroid-free formula safe for long-term daily use
  • ✔️ Restores the skin barrier to prevent moisture loss
  • ✔️ Clinically developed for mild to moderate plaque psoriasis
  • ✔️ Twice-daily application supports visible improvement within weeks

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What Is Dermalex Psoriasis Cream and How Can It Help?

 

Living with psoriasis can be genuinely exhausting. The persistent itch, the visible plaques, the constant search for something that actually works — it takes a toll. Psoriasis cream from Dermalex is a clinically developed, over-the-counter topical treatment designed to help manage the symptoms of mild to moderate plaque psoriasis, including redness, scaling, and itching. At just £20.99 for a 60g tube, it offers an accessible option for people who want to take control of their skin without needing a prescription. According to the NHS, psoriasis affects around 2% of people in the UK, and while there is no cure, symptoms can often be managed effectively with the right topical treatments.

Dermalex Psoriasis Treatment Cream is steroid-free, which makes it a particularly appealing choice for those who are cautious about long-term corticosteroid use or who have been advised to explore non-steroidal alternatives. You can browse a wider range of topical options in our creams and ointments collection if you're comparing products.

 

How Does Dermalex Psoriasis Treatment Cream Work?

 

Psoriasis is caused by an overactive immune response that speeds up the skin cell cycle, causing cells to build up rapidly on the surface. Dermalex works by targeting this process at a cellular level. Here's how it functions:

  • Activates the skin's natural repair mechanisms to help normalise the accelerated skin cell turnover seen in psoriasis
  • Helps restore and strengthen the skin's protective barrier, reducing moisture loss and sensitivity
  • Contains zinc pyrithione, which has recognised antimicrobial and anti-inflammatory properties that help calm irritated skin
  • Allantoin supports skin healing and softening, reducing the appearance of scales
  • Glycerine acts as a humectant, drawing moisture into the skin to relieve dryness and tightness

The result is a gradual reduction in the classic symptoms of plaque psoriasis — the redness, the flaking, and that relentless itch. It doesn't suppress the immune system systemically, which is one reason it's considered suitable for longer-term use under appropriate guidance.

 

Who Should Use Dermalex Psoriasis Treatment Cream?

 

This cream is intended for adults with mild to moderate plaque psoriasis affecting the body. It's particularly suited to people who:

  • Have been diagnosed with mild to moderate plaque psoriasis by a healthcare professional
  • Are looking for a steroid-free topical option to manage day-to-day symptoms
  • Want to maintain skin health between flare-ups as part of a regular skincare routine
  • Have previously used corticosteroid creams and are seeking an alternative for ongoing maintenance

It is not intended for use on the face, scalp, or genitals without specific medical advice. Children and pregnant or breastfeeding women should consult a GP before use. If you're unsure whether this product is right for you, speaking to a pharmacist is always a sensible first step.

 

How Does Dermalex Psoriasis Cream Compare to Other OTC Options?

 

Feature Dermalex Psoriasis Cream Coal Tar-Based Cream
Steroid-free Yes Yes
Odour Neutral / pleasant Strong, distinctive smell
Suitable for daily use Yes Variable — some formulations not recommended daily
Skin barrier repair Yes — key mechanism Limited

 

Is Dermalex Psoriasis Cream Safe to Use Long-Term?

 

Because Dermalex Psoriasis Treatment Cream is steroid-free, it does not carry the risks associated with prolonged topical corticosteroid use, such as skin thinning. This makes it a reasonable option for ongoing maintenance between flare-ups. That said, if your symptoms are not improving after four weeks of consistent use, or if they worsen at any point, you should seek advice from your GP. Psoriasis can sometimes be a sign of broader inflammatory conditions, and a healthcare professional can help rule out anything that needs further investigation. For those managing multiple skin concerns, our skin care collection includes a range of complementary products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Dermalex Psoriasis Treatment Cream 60g specifications
Treatment category Psoriasis / Skin conditions
Mechanism of action Activates skin repair, restores skin barrier, reduces inflammation and scaling
Effective for Mild to moderate plaque psoriasis
Suitable for Adults with plaque psoriasis on the body
Active ingredients Zinc pyrithione, allantoin, glycerine
Pack size 60g
UK classification General Sale / OTC
Preparation Cream
Route of administration Topical (skin)

Specifications of Dermalex Psoriasis Treatment Cream 60g

 

What Is Dermalex Psoriasis Treatment Cream and What Is It Used For?

 

Dermalex Psoriasis Treatment Cream is a topical, steroid-free cream used to relieve the symptoms of mild to moderate plaque psoriasis in adults. Psoriasis is a long-term skin condition where the immune system mistakenly attacks healthy skin cells, causing them to reproduce too quickly. This leads to the build-up of red, flaky, crusty patches covered with silvery scales — most commonly on the elbows, knees, scalp, and lower back, though it can appear anywhere on the body. The NHS notes that psoriasis affects people of all ages and can have a significant impact on quality of life.

This psoriasis cream is designed for topical application to affected areas of the body. It is not a cure for psoriasis, but used consistently, it can help reduce the severity of symptoms and support the skin's natural recovery process during and between flare-ups.

 

What Do You Need to Know Before Using Dermalex Psoriasis Treatment Cream?

 

Before using this cream, read the following carefully. Not everyone is suitable for this product, and there are some important precautions to be aware of.

Do not use Dermalex Psoriasis Treatment Cream if you:

  • Are allergic to any of the ingredients, including zinc pyrithione or allantoin
  • Have infected, broken, or weeping skin at the site of application
  • Are applying it to the face, scalp, or genital area without specific medical advice
  • Are under 18 years of age — consult a GP before use in children

Speak to your GP or pharmacist before use if you:

  • Are pregnant or breastfeeding
  • Have a history of severe or widespread psoriasis
  • Are currently using other topical treatments on the same area
  • Have any other skin conditions affecting the area you intend to treat

Known drug interactions:

  • No significant drug interactions have been identified for topical use of this product
  • Avoid using alongside other topical products on the same area at the same time unless advised by a healthcare professional

 

How Should You Use Dermalex Psoriasis Treatment Cream?

 

Using this cream correctly is important for getting the most benefit. Follow these steps each time you apply it:

  1. Wash and gently dry the affected area before application
  2. Squeeze a small amount of cream onto your fingertip
  3. Apply a thin, even layer directly to the psoriasis-affected skin
  4. Gently massage in using circular motions until fully absorbed
  5. Wash your hands after application unless your hands are the area being treated
  6. Allow the cream to absorb fully before dressing or covering the area
Indication Age Group Dose Frequency
Mild to moderate plaque psoriasis Adults (18+) Thin layer to affected area Twice daily
Maintenance between flare-ups Adults (18+) Thin layer to affected area Once daily or as needed

 

What Are the Possible Side Effects of Dermalex Psoriasis Treatment Cream?

 

Like all skincare treatments, Dermalex Psoriasis Treatment Cream may cause side effects in some people, although not everyone will experience them. If you notice any unexpected reaction, stop using the cream and speak to your pharmacist or GP. You can also find further guidance on managing skin conditions through our skin care collection.

Common side effects:

  • Mild skin irritation at the application site
  • Temporary redness or warmth of the skin
  • Slight tingling sensation after application

Less common side effects:

  • Skin dryness or tightness
  • Contact dermatitis (allergic skin reaction) — seek medical advice if this occurs
  • Worsening of psoriasis symptoms — discontinue use and consult your GP

 

How Should You Store Dermalex Psoriasis Treatment Cream?

 

Correct storage helps maintain the effectiveness of the cream throughout its shelf life. If you're also managing other health conditions and storing multiple products, our vitamins and supplements collection includes products that support overall skin and immune health.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the packaging
  • Do not freeze

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Dermalex Psoriasis Treatment Cream online in the UK?

You can buy Dermalex Psoriasis Treatment Cream 60g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £20.99. It is available without a prescription as an over-the-counter product. No GP referral is needed — simply add it to your basket and it will be dispatched to your door.

How does Dermalex Psoriasis Treatment Cream work in the body?

Dermalex Psoriasis Treatment Cream works topically by activating the skin's natural repair process to help normalise the overactive skin cell turnover that causes psoriasis plaques. Its key ingredients — zinc pyrithione, allantoin, and glycerine — work together to calm inflammation, soften scales, and restore the skin's protective barrier. It does not affect the immune system systemically, which is why it is considered suitable for longer-term use.

How do I use Dermalex Psoriasis Treatment Cream step by step?

Clean and gently dry the affected area, then apply a thin layer of the cream directly to the psoriasis-affected skin. Massage it in gently using circular motions until fully absorbed, then wash your hands. Repeat this process twice daily for best results, and avoid applying to broken, infected, or weeping skin.

How long does it take for Dermalex Psoriasis Cream to show results?

Many users begin to notice a reduction in redness, scaling, and itching within two to four weeks of consistent twice-daily use. Individual results will vary depending on the severity of your psoriasis and how regularly you apply the cream. If you see no improvement after four weeks, consult your GP for further assessment.

What are the side effects of Dermalex Psoriasis Treatment Cream?

Side effects are uncommon but can include mild skin irritation, temporary redness, or a slight tingling sensation at the application site. Less commonly, some people may experience contact dermatitis or a worsening of their psoriasis symptoms. If any reaction persists or concerns you, stop using the cream and speak to your pharmacist or GP promptly.

Is Dermalex Psoriasis Cream suitable for children?

Dermalex Psoriasis Treatment Cream is formulated for adults aged 18 and over. If your child has been diagnosed with psoriasis, you should speak to your GP before using any topical treatment, as children may require a different approach. The NHS recommends that children with psoriasis are assessed by a healthcare professional to determine the most appropriate management plan.

Can I use Dermalex Psoriasis Cream on my face?

Dermalex Psoriasis Treatment Cream is not specifically indicated for use on the face, and you should consult your GP or pharmacist before applying it to facial skin or other sensitive areas such as the scalp or genitals. Facial skin is thinner and more reactive, so a healthcare professional can advise on the safest option for you. There are specific formulations available for facial and scalp psoriasis that may be more appropriate.

What is the correct dose of Dermalex Psoriasis Treatment Cream?

The recommended dose is a thin layer applied to the affected area twice daily — once in the morning and once in the evening. You do not need to use a large amount; a thin, even layer is sufficient and more effective than applying thickly. During maintenance periods between flare-ups, once-daily application may be adequate.

How long can you use Dermalex Psoriasis Treatment Cream for?

Because Dermalex Psoriasis Treatment Cream is steroid-free, it can be used as part of an ongoing skincare routine without the skin-thinning risks associated with prolonged corticosteroid use. Many people use it continuously to manage their psoriasis symptoms over the long term. However, if your condition does not improve or worsens, always seek advice from your GP rather than continuing to self-treat.

Is Dermalex Psoriasis Cream steroid-free?

Yes, Dermalex Psoriasis Treatment Cream is completely steroid-free, which is one of its key distinguishing features. This makes it a suitable option for people who are concerned about the side effects of topical corticosteroids, such as skin thinning with prolonged use. It is also a good choice for those who have been advised by their GP to reduce their reliance on steroid-based treatments.

Can I use Dermalex Psoriasis Cream if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should consult your GP or midwife before using Dermalex Psoriasis Treatment Cream. While the cream is applied topically and systemic absorption is minimal, it is always best to seek professional advice before using any new product during pregnancy or whilst nursing. Your healthcare provider can help you weigh up the benefits and any potential risks.

What are the alternatives to Dermalex Psoriasis Treatment Cream?

Alternatives to Dermalex include coal tar-based creams, salicylic acid preparations, and prescription-strength topical corticosteroids or vitamin D analogues such as calcipotriol. You can explore a range of topical options in our creams and ointments collection. The right choice depends on the severity and location of your psoriasis, so speaking to your GP or pharmacist is always advisable before switching treatments.

Can I use Dermalex Psoriasis Cream alongside other psoriasis treatments?

You should avoid applying multiple topical products to the same area at the same time unless specifically advised by a healthcare professional, as this can cause irritation or reduce the effectiveness of each product. If you are using prescription treatments such as corticosteroids or vitamin D analogues, speak to your GP before adding Dermalex to your routine. They can advise on the safest and most effective combination approach for your individual needs.

What triggers psoriasis flare-ups and can Dermalex help?

Common psoriasis triggers include stress, skin injury, certain medications, infections, and alcohol consumption, according to the NHS. Dermalex Psoriasis Treatment Cream can help manage symptoms during a flare-up and may help maintain skin health between episodes when used regularly. Identifying and avoiding your personal triggers, alongside consistent use of a suitable psoriasis cream, is generally the most effective approach to long-term management.

What are the latest findings on OTC psoriasis creams like Dermalex?

Research into non-steroidal topical treatments for psoriasis continues to grow, with increasing interest in products that support the skin barrier and reduce inflammation without the side effects of corticosteroids. Zinc pyrithione, one of the active ingredients in Dermalex, has been studied for its anti-inflammatory and antimicrobial properties in skin conditions. For the most up-to-date clinical guidance on psoriasis management, the NHS and NICE both publish regularly updated treatment summaries that your GP can refer to.

How Should You Use Dermalex Psoriasis Treatment Cream?

Using Dermalex Psoriasis Treatment Cream correctly gives you the best chance of seeing a meaningful improvement in your symptoms. Always read the product leaflet before starting, and follow these steps each time you apply the cream.

Avoid applying the cream to healthy, unaffected skin. Do not use on broken, infected, or weeping skin without first consulting your GP or pharmacist.

What Is the Correct Dose of Dermalex Psoriasis Treatment Cream?

The correct dose is a thin layer applied to the affected area. You do not need to use a large amount — a thin, even application is more effective than applying the cream thickly, and it helps the tube last longer too.

Do not apply more than twice daily unless specifically advised by a healthcare professional. Using more cream than recommended will not speed up results and may increase the risk of skin irritation.

When Is the Best Time to Use Dermalex Psoriasis Treatment Cream?

For active flare-ups, apply the cream once in the morning and once in the evening, ideally after washing the affected area. Applying it at consistent times each day helps build a routine, which in turn supports more consistent symptom control. Evening application is particularly useful as the skin undergoes much of its natural repair process overnight, so the cream can work in tandem with this.

If you are using the cream once daily for maintenance, the evening is generally the preferred time. Try to apply it at roughly the same time each day to maintain steady skin hydration and barrier support.

How Long Can You Use Dermalex Psoriasis Treatment Cream For?

Dermalex Psoriasis Treatment Cream is steroid-free, which means it does not carry the risk of skin thinning associated with long-term corticosteroid use. This makes it suitable for ongoing use as part of a regular skincare routine for managing psoriasis. Many people use it continuously to keep symptoms under control between flare-ups as well as during them.

If your symptoms have not improved after four weeks of consistent use, or if they worsen at any point, stop using the cream and consult your GP. Psoriasis can sometimes require a different treatment approach, and a healthcare professional is best placed to advise you on next steps.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Dermalex Psoriasis Treatment Cream?

Most people who use Dermalex Psoriasis Treatment Cream tolerate it well, and serious side effects are uncommon. However, as with any topical product, some people may experience mild reactions, particularly when first starting treatment. These usually settle down within a few days as your skin adjusts.

  • Mild skin irritation at the application site
  • Temporary redness or warmth of the skin
  • Slight tingling or stinging sensation immediately after application
  • Feeling of tightness in the skin

What Are the Less Common Side Effects of Dermalex Psoriasis Treatment Cream?

Less commonly, some people may experience more noticeable reactions. These are not typical but are worth being aware of before you start using the cream. If any of the following occur, stop using the product and seek advice from your pharmacist or GP.

  • Contact dermatitis — an allergic skin reaction causing itching, swelling, or a rash beyond the treated area
  • Increased dryness or flaking of the skin
  • Worsening of psoriasis symptoms rather than improvement
  • Skin discolouration at the application site

What Are the Serious Side Effects of Dermalex Psoriasis Treatment Cream?

Serious side effects from Dermalex Psoriasis Treatment Cream are rare given its topical, steroid-free formulation. However, if you develop signs of a severe allergic reaction — such as widespread rash, swelling of the face or throat, difficulty breathing, or dizziness — seek emergency medical attention immediately by calling 999 or going to your nearest A&E. Do not continue using the cream if you suspect a serious allergic reaction.

Because the cream is applied to the skin and not taken orally, systemic side effects are not expected under normal use. Avoid applying to large areas of broken skin, as this could theoretically increase absorption of the active ingredients.

What Should You Do If You Experience Side Effects of Dermalex Psoriasis Treatment Cream?

If you experience mild irritation or redness, try reducing application to once daily and see if symptoms settle. Make sure you are applying only a thin layer and not over-applying the cream. If the reaction persists beyond a few days, stop use entirely and consult your pharmacist — they can advise whether to continue, switch products, or refer you to your GP.

You can also report suspected side effects from any medicine or skincare product to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve safety monitoring for all patients in the UK.

Can Dermalex Psoriasis Treatment Cream Interact With Other Medicines?

No significant drug interactions have been identified for Dermalex Psoriasis Treatment Cream when used as directed. However, you should avoid applying it to the same area of skin as other topical treatments at the same time, as this can cause irritation or reduce the effectiveness of both products. If you are using prescription topical treatments such as corticosteroids, calcipotriol, or tacrolimus, speak to your GP or pharmacist before adding Dermalex to your routine. They can advise on the safest way to use multiple topical products together.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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