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Chlorphenamine Maleate 4mg Tablets 30s

Chlorphenamine Maleate 4mg Tablets 30s

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  • ✔️ Relieves hay fever, hives, and allergic rhinitis symptoms
  • ✔️ Blocks histamine to reduce sneezing, itching, and watery eyes
  • ✔️ Fast-acting formula — works within 30 minutes of taking
  • ✔️ Suitable for adults and children aged 6 years and over
  • ✔️ 30-tablet pack provides reliable short-term allergy relief

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What Are Chlorphenamine 4mg Tablets Used For?

 

If you've ever dealt with the misery of a blocked nose, streaming eyes, or relentless sneezing during hay fever season, you'll know how much it can disrupt your day. Chlorphenamine 4mg tablets are a well-established, first-generation antihistamine used to relieve a wide range of allergic symptoms — from hay fever and allergic rhinitis to hives and insect bites. Available over the counter without a prescription, they offer a straightforward, affordable option for managing allergy symptoms quickly. You can browse our full range of allergy and hay fever treatments to find the right product for your needs.

Each tablet contains 4mg of chlorphenamine maleate as the active ingredient. The pack contains 30 tablets, giving you a reliable supply whether you're managing a short-term reaction or seasonal symptoms. At just £3.29, it's one of the most cost-effective antihistamine options available in the UK.

 

How Do Chlorphenamine Tablets Work in the Body?

 

Chlorphenamine works by blocking histamine H1 receptors. When your immune system encounters an allergen — pollen, pet dander, dust mites — it releases histamine, a chemical that triggers the familiar symptoms of an allergic reaction. By blocking those receptors, chlorphenamine reduces or prevents those symptoms from taking hold.

  • Allergen exposure triggers histamine release from mast cells
  • Histamine binds to H1 receptors, causing sneezing, itching, and inflammation
  • Chlorphenamine competitively blocks H1 receptors, reducing the allergic response
  • Because it crosses the blood-brain barrier, it can also cause sedation — which is why drowsiness is a known side effect

 

Who Is Chlorphenamine Maleate Suitable For?

 

Chlorphenamine is suitable for adults and children aged 6 years and over. It's particularly useful if you need fast-acting relief and aren't concerned about the sedating effect — in fact, some people find the mild drowsiness helpful when allergy symptoms are disrupting sleep.

  • Adults and teenagers managing hay fever or allergic rhinitis
  • People with urticaria (hives) or skin reactions to insect bites or stings
  • Children aged 6–12 years (at a lower dose — see dosage section)
  • Those who need short-term relief from food allergy symptoms (under medical guidance)

It is not suitable for children under 6, and caution is needed in older adults due to the increased risk of side effects such as confusion and urinary retention.

 

How Does Chlorphenamine Compare to Other Antihistamines?

 

Feature Chlorphenamine 4mg Cetirizine 10mg
Generation First-generation Second-generation
Drowsiness Common side effect Less likely to cause drowsiness
Dosing frequency Every 4–6 hours Once daily
Suitable for driving No — avoid driving Generally yes, with caution

 

How Should You Store Chlorphenamine Tablets?

 

Store chlorphenamine 4mg tablets below 25°C in a dry place, away from direct sunlight. Keep them in their original packaging and out of reach of children. Do not use after the expiry date printed on the pack. If you're unsure whether a medicine is still safe to use, your pharmacist can advise you — and you can also explore our cold and flu range for other symptom-relief options during allergy season.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Chlorphenamine Maleate 4mg Tablets 30s specifications
Treatment category Allergy & Hay Fever
Active ingredient Chlorphenamine Maleate 4mg
Mechanism of action H1 histamine receptor antagonist
Drug class First-generation antihistamine
Preparation Tablet
Route of administration Oral
Strengths 4mg
Pack sizes 30 tablets
UK classification General Sale List (GSL)
Suitable for Adults and children aged 6 years and over
Effective for Hay fever, allergic rhinitis, urticaria, insect bites, food allergy symptoms

Specifications of Chlorphenamine Maleate 4mg Tablets 30s

 

What Is Chlorphenamine Maleate and What Is It Used For?

 

Chlorphenamine maleate 4mg tablets are an antihistamine medicine used to relieve the symptoms of allergic conditions. These include hay fever (seasonal allergic rhinitis), perennial allergic rhinitis, urticaria (hives), angioedema, food allergy reactions, and reactions to insect bites or stings. They work by reducing the effect of histamine — the chemical your body releases during an allergic response. Chlorphenamine 4mg tablets are available over the counter and do not require a prescription for adults or children aged 6 and over.

 

What Do You Need to Know Before Using Chlorphenamine Tablets?

 

Before taking chlorphenamine, it's important to check whether it's appropriate for you. Do not take these tablets if any of the following apply:

  • You are allergic to chlorphenamine maleate or any other ingredient in the tablet
  • You are taking or have taken monoamine oxidase inhibitors (MAOIs) in the last 14 days
  • You are under 6 years of age
  • You have acute asthma or a lower respiratory tract condition
  • You are pregnant or breastfeeding (seek medical advice first)
  • You have glaucoma, urinary retention, or an enlarged prostate
  • You have epilepsy or liver disease

The following medicines may interact with chlorphenamine. Tell your pharmacist or doctor if you are taking:

  • Sedatives, sleeping tablets, or anxiolytics — increased drowsiness risk
  • Tricyclic antidepressants — enhanced anticholinergic effects
  • Alcohol — significantly increases sedation
  • Other antihistamines — additive effects
  • Phenytoin — chlorphenamine may inhibit its metabolism

 

How Should You Take Chlorphenamine 4mg Tablets?

 

Always take chlorphenamine exactly as directed on the patient information leaflet or as advised by your pharmacist. Swallow the tablet whole with a glass of water. Taking it with food may help reduce the chance of stomach upset.

  1. Read the patient information leaflet before taking your first dose
  2. Swallow one tablet whole with water — do not crush or chew
  3. Take with or after food if you experience any stomach discomfort
  4. Wait at least 4–6 hours before taking your next dose
  5. Do not exceed the maximum daily dose for your age group
  6. If symptoms persist beyond a few days, speak to your pharmacist or GP
Age Group Dose Frequency Maximum Daily Dose
Adults and children 12+ 1 tablet (4mg) Every 4–6 hours 6 tablets (24mg)
Children 6–12 years ½ tablet (2mg) Every 4–6 hours 3 tablets (12mg)
Children under 6 Not recommended

 

What Are the Possible Side Effects of Chlorphenamine Tablets?

 

Like all medicines, chlorphenamine can cause side effects, although not everyone experiences them. If you're concerned about any reaction, stop taking the tablets and speak to your pharmacist or GP. You can also find additional support through our ear, nose and throat range if you're managing related symptoms alongside your allergy treatment.

Common side effects:

  • Drowsiness or sedation
  • Dry mouth, nose, or throat
  • Dizziness or impaired coordination
  • Headache
  • Blurred vision

Less common side effects:

  • Urinary retention or difficulty passing urine
  • Nausea or stomach upset
  • Palpitations or tachycardia
  • Confusion (particularly in older adults)
  • Skin rashes or hypersensitivity reactions

 

How Should You Store Chlorphenamine Maleate Tablets?

 

Correct storage helps maintain the effectiveness and safety of your tablets. If you're managing multiple medicines at home, it's worth keeping everything organised and checking expiry dates regularly. For other health essentials, take a look at our first aid collection.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Store in the original packaging to protect from light
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy chlorphenamine 4mg tablets online in the UK?

You can buy chlorphenamine 4mg tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. No prescription is needed — they are available over the counter for adults and children aged 6 and over. Browse our full allergy and hay fever range for more options.

How does chlorphenamine work in the body?

Chlorphenamine is a first-generation antihistamine that works by blocking H1 histamine receptors in the body. When you're exposed to an allergen, your immune system releases histamine, which causes symptoms like sneezing, itching, and a runny nose. By blocking those receptors, chlorphenamine reduces or prevents these symptoms from developing.

How do I take chlorphenamine 4mg tablets step by step?

Swallow one tablet whole with a full glass of water — do not crush or chew it. You can take it with food if it upsets your stomach. Wait at least 4–6 hours before taking your next dose, and never exceed the maximum daily dose for your age group.

What is the correct dose of chlorphenamine 4mg for adults?

Adults and children aged 12 and over should take one 4mg tablet every 4–6 hours as needed. The maximum dose is six tablets (24mg) in any 24-hour period. Children aged 6–12 should take half a tablet (2mg) every 4–6 hours, up to a maximum of 12mg per day.

What is the best time to take chlorphenamine tablets?

Because chlorphenamine can cause drowsiness, many people find it helpful to take a dose in the evening when symptoms are at their worst or when sleep is being disrupted. If you need daytime relief, be aware of the sedating effect and avoid driving or operating machinery. Taking it with food can also help reduce any stomach discomfort.

Does chlorphenamine cause drowsiness?

Yes — drowsiness is one of the most common side effects of chlorphenamine because it crosses the blood-brain barrier. This is different from second-generation antihistamines like cetirizine or loratadine, which are less likely to cause sedation. You should not drive, operate heavy machinery, or drink alcohol while taking chlorphenamine.

How do I manage the side effects of chlorphenamine?

The most common side effects — drowsiness and dry mouth — can often be managed by taking the tablet in the evening and staying well hydrated throughout the day. Avoid alcohol entirely while taking chlorphenamine, as it significantly worsens sedation. If side effects are troublesome or persistent, speak to your pharmacist about switching to a non-drowsy antihistamine.

Who should not take chlorphenamine maleate tablets?

Chlorphenamine is not suitable for children under 6 years old, people taking MAOIs, or those with acute asthma, glaucoma, urinary retention, or an enlarged prostate. Pregnant or breastfeeding women should seek medical advice before taking it. Older adults should use it with caution due to an increased risk of confusion and urinary side effects.

Is chlorphenamine safe during pregnancy or breastfeeding?

Chlorphenamine is not recommended during pregnancy or breastfeeding unless specifically advised by a doctor. The NHS advises speaking to your GP or midwife before taking any antihistamine if you are pregnant. There are limited data on its safety in these situations, so medical guidance is essential.

What happens if I miss a dose of chlorphenamine?

If you miss a dose, take it as soon as you remember — unless it's nearly time for your next scheduled dose. In that case, skip the missed dose and carry on as normal. Never take two doses at the same time to make up for a missed one, as this increases the risk of side effects.

What are the alternatives to chlorphenamine tablets?

If you'd prefer a non-drowsy option, second-generation antihistamines such as cetirizine 10mg or loratadine 10mg are widely available and taken just once a day. These are generally better suited to daytime use. You can explore our allergy and hay fever collection to compare available options.

Can I take chlorphenamine with other medicines?

Chlorphenamine can interact with several medicines, including MAOIs, tricyclic antidepressants, sedatives, sleeping tablets, and other antihistamines. It can also interact with phenytoin, an anti-epileptic drug. Always tell your pharmacist or GP about all medicines you are currently taking before starting chlorphenamine.

How long can you take chlorphenamine for?

Chlorphenamine is intended for short-term use to manage acute allergic symptoms. If you find yourself needing it regularly for more than a few weeks, it's worth speaking to your GP to explore longer-term allergy management strategies. Prolonged use without medical review is not recommended.

Can chlorphenamine be used for insect bites and stings?

Yes — chlorphenamine is commonly used to relieve itching, swelling, and redness caused by insect bites and stings. It helps by blocking the histamine response triggered by the bite or sting. For severe reactions involving swelling of the face, lips, or throat, seek emergency medical attention immediately rather than relying on an antihistamine tablet alone.

What are the latest findings on chlorphenamine use?

Chlorphenamine has been in clinical use for decades and remains a well-understood, effective antihistamine for short-term allergy relief. Current NHS and NICE guidance continues to support its use for allergic conditions, though second-generation antihistamines are now generally preferred for daytime use due to their improved tolerability profile. Your pharmacist can advise on the most up-to-date treatment options for your specific situation.

How Should You Use Chlorphenamine Maleate 4mg Tablets?

Chlorphenamine tablets are taken by mouth with a full glass of water. You can take them with or without food, though taking them with a meal or snack may help if you notice any stomach discomfort. Always read the patient information leaflet before starting treatment and follow the instructions carefully.

Follow these steps each time you take a dose:

What Is the Correct Dose of Chlorphenamine Maleate 4mg Tablets?

The dose varies depending on age. It is important to stick to the recommended dose and not exceed the daily maximum, as taking too much increases the risk of side effects including severe drowsiness and anticholinergic effects. If you are unsure about the right dose for you or your child, ask your pharmacist before starting.

When Is the Best Time to Use Chlorphenamine Maleate 4mg Tablets?

Because chlorphenamine commonly causes drowsiness, many people find it most useful in the evening — particularly if allergy symptoms are disrupting sleep. Taking a dose before bed can help you rest more comfortably while the medicine works overnight. If you need daytime relief, plan ahead and avoid driving, cycling, or operating machinery after taking a dose.

For hay fever, you may find it helpful to take a dose before anticipated allergen exposure — for example, before going outdoors during high pollen periods. Check the daily pollen forecast and plan your doses accordingly.

How Long Can You Use Chlorphenamine Maleate 4mg Tablets For?

Chlorphenamine is suitable for short-term use to manage acute allergic symptoms. Most people use it for a few days to a couple of weeks during peak allergy season or following an allergic reaction. If your symptoms persist beyond a week without improvement, or if you find yourself relying on it daily for more than a few weeks, speak to your GP.

Long-term, unsupervised use is not recommended. Your GP can help identify the underlying cause of your symptoms and discuss whether a longer-term treatment plan — such as immunotherapy or a daily non-sedating antihistamine — might be more appropriate for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Chlorphenamine Maleate 4mg Tablets?

Drowsiness is by far the most frequently reported side effect of chlorphenamine. Because it is a first-generation antihistamine, it crosses the blood-brain barrier and has a sedating effect that can significantly impair your ability to drive or concentrate. This is something to be aware of before you take your first dose.

  • Drowsiness or excessive sleepiness
  • Dry mouth, nose, or throat
  • Dizziness or light-headedness
  • Headache
  • Blurred vision
  • Impaired coordination or reaction time

What Are the Less Common Side Effects of Chlorphenamine Tablets?

Some people experience side effects that are less frequent but still worth knowing about. These tend to be more likely in older adults or those taking higher doses. If any of the following occur and are troublesome, stop taking the tablets and speak to your pharmacist or GP.

  • Nausea or stomach upset
  • Urinary retention or difficulty passing urine
  • Constipation
  • Palpitations or a faster-than-normal heartbeat
  • Confusion or disorientation (particularly in elderly patients)
  • Restlessness or excitability (more common in children)
  • Skin rash or hypersensitivity reactions

What Are the Serious Side Effects of Chlorphenamine Maleate?

Serious side effects are rare but can occur. Seek immediate medical attention if you experience any of the following after taking chlorphenamine. These may indicate a severe allergic reaction or a dangerous drug interaction.

  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or wheezing
  • Severe skin reactions such as blistering or peeling
  • Seizures or convulsions
  • Severe confusion or hallucinations

What Should You Do If You Experience Side Effects of Chlorphenamine?

For mild side effects such as drowsiness or dry mouth, these often improve as your body adjusts to the medicine. Staying well hydrated and avoiding alcohol can help reduce their severity. If drowsiness is a significant problem, consider switching to a non-sedating antihistamine — your pharmacist can advise on suitable alternatives.

If you experience a serious or unexpected reaction, stop taking the tablets immediately and seek medical advice. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Chlorphenamine Interact With Other Medicines?

Yes — chlorphenamine has several clinically significant interactions. Taking it alongside sedatives, sleeping tablets, or alcohol will significantly increase drowsiness and impair your judgement. Combining it with MAOIs can cause dangerous interactions and is strictly contraindicated. Tricyclic antidepressants taken alongside chlorphenamine can enhance anticholinergic effects such as dry mouth, urinary retention, and constipation. Always inform your pharmacist or GP of all medicines, supplements, and herbal remedies you are currently taking before starting chlorphenamine.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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