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Amorolfine 5% Nail Lacquer 3ml

Amorolfine 5% Nail Lacquer 3ml

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  • ✔️ Treats fungal nail infections in fingernails and toenails
  • ✔️ Targets fungus directly within the nail plate
  • ✔️ Once or twice weekly application for easy compliance
  • ✔️ Suitable for adults with mild to moderate onychomycosis
  • ✔️ Available without a prescription as a Pharmacy medicine

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What Is Amorolfine Nail Lacquer and Does It Treat Fungal Nails?

 

Fungal nail infections — known medically as onychomycosis — are surprisingly common. They affect roughly 3% of the UK population at any one time, causing nails to become thickened, discoloured, and brittle. If you've been dealing with this for a while, you'll know how stubborn these infections can be. Amorolfine nail lacquer is a clinically proven, over-the-counter antifungal treatment that targets the fungus directly at the nail, helping to clear the infection over time with consistent use.

Available from Cured Pharmacy for just £15.99, this 3ml lacquer contains 5% amorolfine hydrochloride as its active ingredient. It's applied directly to the affected nail like a varnish, making it a straightforward option for adults who want to treat mild to moderate fungal nail infections without a prescription. If you're also dealing with athlete's foot alongside a nail infection, you might want to explore our range of athletes foot and fungal infection treatments to tackle both at once.

 

How Does Amorolfine Nail Lacquer Work Against Fungal Infections?

 

Amorolfine belongs to a class of antifungal medicines called morpholine derivatives. It works by interfering with the fungal cell membrane — specifically by blocking two key enzymes involved in ergosterol biosynthesis. Ergosterol is essential for maintaining the integrity of fungal cell membranes, so without it, the fungus cannot survive or replicate.

  • Amorolfine inhibits the enzymes delta-14 reductase and delta-7,8-isomerase in the fungal sterol pathway
  • This leads to depletion of ergosterol and accumulation of toxic sterol intermediates
  • The fungal cell membrane becomes structurally compromised
  • The fungus is unable to grow, spread, or survive within the nail

Because the lacquer is applied topically and penetrates the nail plate, it delivers the active ingredient directly to the site of infection. This targeted approach means systemic absorption is minimal, which is one reason it's available without a prescription for adults.

 

Who Should Use Amorolfine Nail Lacquer?

 

This treatment is suitable for adults aged 18 and over who have a mild to moderate fungal nail infection affecting the fingernails or toenails. It's particularly useful when the infection has not yet reached the base of the nail (the lunula). If the infection is more severe or involves the nail matrix, you should speak to your GP, as oral antifungal treatment may be more appropriate.

  • Adults with discoloured, thickened, or crumbling nails due to fungal infection
  • People who prefer a topical treatment over oral antifungal tablets
  • Those with mild to moderate onychomycosis not involving the nail root
  • Individuals looking for a convenient once or twice weekly application routine

 

How Does Amorolfine Nail Lacquer Compare to Other Fungal Nail Treatments?

 

Feature Amorolfine 5% Nail Lacquer Terbinafine Oral Tablets
Route of administration Topical (applied to nail) Oral (swallowed)
Prescription required? No — available OTC Yes — prescription only
Systemic side effects Minimal — localised use Possible — liver monitoring may be needed
Typical treatment duration 6–12 months 6 weeks (fingernails) to 3 months (toenails)

 

Is Amorolfine Nail Lacquer Safe to Store and Use Long-Term?

 

Amorolfine nail lacquer is generally well tolerated when used as directed. Because it's applied topically rather than taken orally, the risk of systemic side effects is very low. That said, it's important to keep the product stored correctly — below 30°C, with the cap tightly closed, and away from heat sources or open flames, as the formulation is flammable. Keep it out of reach of children at all times.

For long-term use, consistency is key. Missing applications can allow the fungus to recover, prolonging treatment. If you're managing other skin conditions alongside a nail infection, our foot care collection includes a range of products that may complement your treatment plan. Always complete the full course even if the nail looks better before treatment ends.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Amorolfine 5% Nail Lacquer 3ml specifications
Treatment category Antifungal — nail infection
Mechanism of action Inhibits ergosterol biosynthesis in fungal cell membranes
Effective against Dermatophytes, some yeasts and moulds causing onychomycosis
Suitable for Adults aged 18 and over
Active ingredient Amorolfine hydrochloride 5% w/v
Pack size 3ml
Strength 5%
UK classification Pharmacy (P) medicine
Drug class Morpholine antifungal
Preparation Nail lacquer (solution)
Route of administration Topical — applied directly to affected nails

Specifications of Amorolfine 5% Nail Lacquer 3ml

 

What Is Amorolfine 5% Nail Lacquer and What Is It Used For?

 

Amorolfine 5% Nail Lacquer is a topical antifungal medicine used to treat fungal infections of the fingernails and toenails in adults. The active ingredient, amorolfine hydrochloride, penetrates the nail plate to attack the fungus causing the infection. It is used for mild to moderate onychomycosis where the nail root (lunula) is not yet involved. Treatment must be continued for several months to allow the healthy nail to fully grow through and replace the infected nail tissue.

 

What Do You Need to Know Before Using Amorolfine 5% Nail Lacquer?

 

Before starting treatment, read the following carefully. This product is not suitable for everyone.

Do not use this product if you:

  • Are allergic to amorolfine hydrochloride or any other ingredient in the lacquer
  • Are under 18 years of age
  • Are pregnant or breastfeeding — speak to your GP before use
  • Have a nail infection involving the nail matrix (base of the nail)

Warnings and precautions:

  • Avoid contact with eyes, ears, nose, and mouth
  • Do not apply to broken or inflamed skin surrounding the nail
  • The lacquer is flammable — keep away from naked flames and heat sources
  • Do not use cosmetic nail varnish over the treated nail during treatment
  • If you have diabetes or a condition affecting circulation, consult your GP before use, as nail infections may require medical supervision

Drug interactions:

  • No clinically significant interactions are known when amorolfine is used topically
  • If you are taking any oral antifungal medicines, inform your pharmacist before using this product

 

How Should You Use Amorolfine 5% Nail Lacquer?

 

Always use this product exactly as described. Do not apply more frequently than directed, as this will not speed up recovery and may increase the risk of local irritation.

  1. File down the surface of the affected nail using the nail file provided, removing as much of the infected nail as possible
  2. Clean the nail surface with one of the cleansing swabs included in the pack
  3. Allow the nail to dry completely before applying the lacquer
  4. Dip the spatula into the lacquer and apply a thin, even coat to the entire surface of the affected nail
  5. Allow the lacquer to dry for approximately 3 minutes before replacing the cap
  6. Clean the spatula with a fresh swab after each use to avoid contamination
  7. Repeat once or twice weekly throughout the full treatment course
Indication Age Group Dose Frequency
Fungal fingernail infection Adults 18+ One coat to affected nail(s) Once weekly
Fungal toenail infection Adults 18+ One coat to affected nail(s) Once or twice weekly
Children under 18 Not applicable Not recommended Not recommended

 

What Are the Possible Side Effects of Amorolfine 5% Nail Lacquer?

 

Like all medicines, amorolfine nail lacquer can cause side effects, although not everyone experiences them. Because it is applied topically, side effects are generally mild and localised to the treated area. If you experience any severe or unexpected reactions, stop use and speak to a pharmacist or GP promptly. You can also browse our skin care range if you need products to soothe the surrounding skin during treatment.

Common side effects (may affect up to 1 in 10 people):

  • Mild burning or stinging sensation at the application site
  • Itching around the treated nail
  • Redness of the surrounding skin

Less common side effects (may affect up to 1 in 100 people):

  • Nail discolouration
  • Nail brittleness or changes in nail texture
  • Contact dermatitis (skin irritation or rash near the nail)

 

How Should You Store Amorolfine 5% Nail Lacquer?

 

Correct storage helps maintain the product's effectiveness throughout the treatment course. Follow these instructions carefully.

  • Store below 30°C in a cool, dry place
  • Keep the cap tightly closed when not in use to prevent evaporation
  • Keep away from naked flames, sparks, and heat sources — the lacquer is flammable
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of via wastewater or household waste — return unused medicine to your pharmacist

If you're managing multiple foot-related conditions, our creams and ointments collection includes a variety of topical treatments that may support your overall foot health alongside this nail lacquer.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy amorolfine nail lacquer online in the UK?

You can buy Amorolfine 5% Nail Lacquer 3ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £15.99. It is available without a prescription as a Pharmacy (P) medicine for adults aged 18 and over. Simply add it to your basket and complete a short health questionnaire at checkout to confirm suitability.

How does amorolfine nail lacquer work in the body?

Amorolfine works by blocking two key enzymes — delta-14 reductase and delta-7,8-isomerase — that fungi need to produce ergosterol, a vital component of their cell membranes. Without ergosterol, the fungal cell membrane breaks down and the organism can no longer survive or replicate. Because it is applied topically, it penetrates the nail plate directly and acts locally with minimal systemic absorption.

How do I use amorolfine nail lacquer step by step?

Start by filing down the infected nail surface with the nail file provided, then clean the nail with the alcohol swab included in the pack. Apply a thin, even coat of lacquer to the entire nail surface using the spatula, allow it to dry for around three minutes, then replace the cap. Repeat this process once or twice weekly throughout the full treatment course.

How long does amorolfine nail lacquer take to work?

Treatment duration varies depending on which nails are affected. Fingernail infections typically require around six months of treatment, while toenail infections can take up to twelve months. You should continue applying the lacquer until the nail has fully grown out and the infection has completely cleared, even if the nail looks healthier before then.

What is the correct dose of amorolfine nail lacquer?

The standard dose is one coat of lacquer applied to each affected nail once or twice weekly. For toenail infections, twice-weekly application is often recommended due to the slower nail growth rate. Do not apply more frequently than directed, as this does not improve outcomes and may cause local irritation.

What are the side effects of amorolfine nail lacquer?

Most people tolerate amorolfine nail lacquer well. Common side effects include mild burning, itching, or redness around the treated nail. Less commonly, you may notice nail discolouration, brittleness, or a mild skin rash near the application site. If you experience a more significant skin reaction, stop use and consult your pharmacist or GP.

Can I use amorolfine nail lacquer if I am pregnant or breastfeeding?

Amorolfine nail lacquer is not recommended during pregnancy or breastfeeding due to insufficient safety data. If you are pregnant, planning to become pregnant, or currently breastfeeding, you should speak to your GP or pharmacist before starting treatment. They can advise on the most appropriate and safe option for your situation.

What is the difference between amorolfine nail lacquer and Loceryl?

Loceryl is a well-known branded version of amorolfine 5% nail lacquer and contains exactly the same active ingredient at the same concentration. Amorolfine 5% Nail Lacquer is the generic equivalent — it works in precisely the same way but is typically available at a lower price. Both are used to treat fungal nail infections in adults.

Can I paint over amorolfine nail lacquer with nail varnish?

No — you should not apply cosmetic nail varnish over amorolfine nail lacquer during treatment. Nail varnish creates a barrier that can prevent the active ingredient from penetrating the nail plate properly, reducing its effectiveness. Wait until your treatment course is fully complete before using cosmetic nail products on the treated nails.

Who is eligible to use amorolfine nail lacquer?

Amorolfine nail lacquer is suitable for adults aged 18 and over with a mild to moderate fungal nail infection that has not reached the nail matrix. It is not suitable for children, pregnant or breastfeeding women, or people with known hypersensitivity to amorolfine. If you have diabetes or poor circulation, consult your GP before use, as nail infections in these groups may need closer medical supervision.

What happens if I miss a dose of amorolfine nail lacquer?

If you miss a weekly application, simply apply the lacquer as soon as you remember and then continue with your usual schedule. Do not apply a double dose to make up for a missed one. Consistency is important — missing applications regularly can allow the fungus to recover and may prolong the overall treatment duration.

What are the alternatives to amorolfine nail lacquer?

Alternatives to amorolfine nail lacquer include other topical antifungal nail treatments such as ciclopirox nail lacquer, as well as oral antifungal medicines like terbinafine or itraconazole, which require a prescription. You can explore a wider range of options in our athletes foot and fungal infections collection. Your GP or pharmacist can advise on the most suitable treatment based on the severity and extent of your infection.

How long can you use amorolfine nail lacquer for?

Treatment should continue until the infected nail has fully grown out and been replaced by healthy nail tissue — this typically means six months for fingernails and up to twelve months for toenails. Do not stop treatment early just because the nail looks better, as the fungus may still be present. If there is no improvement after three months, speak to your GP.

Can amorolfine nail lacquer be used on both fingernails and toenails?

Yes — amorolfine nail lacquer can be used on both fingernails and toenails affected by fungal infection. The application method is the same for both, though toenails generally require a longer treatment course due to their slower growth rate. Make sure to treat all affected nails to prevent reinfection from an untreated nail.

What are the latest findings on amorolfine for fungal nail treatment?

Amorolfine 5% nail lacquer has been used clinically for several decades and remains a well-established first-line topical option for mild to moderate onychomycosis. Published clinical evidence supports its efficacy against dermatophytes, the most common cause of fungal nail infections in the UK. For broader foot health support during and after treatment, our foot care collection offers complementary products to help maintain nail and skin health.

How Should You Use Amorolfine 5% Nail Lacquer?

Always use this product exactly as directed on the packaging or as advised by your pharmacist. Before each application, it is important to prepare the nail properly to allow the lacquer to penetrate effectively.

Do not apply cosmetic nail varnish over the treated nail during the course of treatment, as this may reduce the effectiveness of the lacquer.

What Is the Correct Dose of Amorolfine 5% Nail Lacquer?

The dose is one coat of lacquer applied to each affected nail. Do not apply more than directed — applying extra coats or increasing frequency will not speed up recovery and may cause unnecessary irritation to the surrounding skin.

When Is the Best Time to Use Amorolfine 5% Nail Lacquer?

There is no specific time of day required for application, but many people find it easiest to apply the lacquer in the evening, after bathing or showering, when the nail is clean and dry. Choosing a consistent day each week — for example, every Sunday evening — helps you build a routine and reduces the chance of missing an application.

Avoid applying the lacquer immediately before handling food, wearing gloves, or submerging your hands in water, as this may affect how well the lacquer adheres to the nail surface.

How Long Can You Use Amorolfine 5% Nail Lacquer For?

Treatment duration depends on which nails are affected and how quickly they grow. Fingernail infections typically require around six months of continuous treatment, while toenail infections may need up to twelve months. It is essential to continue treatment until the infected nail has fully grown out and been replaced by healthy nail tissue — stopping early, even if the nail looks better, risks the infection returning.

If you see no improvement after three months of consistent use, stop treatment and consult your GP, as a more severe infection may require oral antifungal therapy.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Amorolfine 5% Nail Lacquer?

Because amorolfine nail lacquer is applied topically rather than taken orally, side effects are generally mild and confined to the area of application. Most people complete the full treatment course without significant problems. However, it is still important to be aware of what to look out for.

  • Mild burning or stinging sensation at the application site
  • Itching around the treated nail
  • Redness or mild irritation of the skin surrounding the nail

These effects are usually short-lived and settle on their own. If they persist or become bothersome, speak to your pharmacist.

What Are the Less Common Side Effects of Amorolfine 5% Nail Lacquer?

Less commonly, some people may notice changes to the nail itself during treatment. These are generally not harmful and may simply reflect the nail responding to the antifungal action of the lacquer.

  • Nail discolouration — the nail may appear slightly yellowed or altered in colour
  • Nail brittleness or changes in nail texture
  • Contact dermatitis — a localised skin rash or irritation near the nail fold
  • Nail pain or tenderness at the application site

If you notice significant changes to the nail or surrounding skin that concern you, stop use and seek advice from a pharmacist or GP.

What Are the Serious Side Effects of Amorolfine 5% Nail Lacquer?

Serious side effects from topical amorolfine are rare. However, if you develop signs of a severe allergic reaction — such as widespread rash, swelling of the face or throat, difficulty breathing, or dizziness — stop using the product immediately and seek urgent medical attention. This type of reaction, known as anaphylaxis, is uncommon but requires prompt treatment.

Do not ignore any unusual or severe symptoms. When in doubt, always err on the side of caution and contact a healthcare professional.

What Should You Do If You Experience Side Effects?

For mild side effects such as localised itching or redness, you may be able to continue treatment while monitoring the reaction. Avoid applying the lacquer to broken or inflamed skin, and ensure you are not accidentally getting the product on the surrounding skin during application. If side effects are persistent, worsening, or causing significant discomfort, stop use and consult your pharmacist or GP for guidance.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Amorolfine Nail Lacquer Interact With Other Medicines?

No clinically significant drug interactions have been identified with topical amorolfine when used as directed. Because systemic absorption is minimal, the risk of interactions with other medicines is very low. That said, if you are currently taking oral antifungal medicines such as terbinafine or itraconazole, inform your pharmacist before using this product to ensure there is no duplication of treatment or unintended interaction.

Always tell your pharmacist about all medicines, supplements, and topical products you are currently using before starting a new treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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