Mysimba vs Mounjaro UK | Compare Weight Loss Treatments

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Cheapest Mysimba vs Mounjaro - UK Price £124.99

Compare Mysimba and Mounjaro with the cheapest UK price from £124.99 plus £20 off your first order with code Weightlossnew.

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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy Oral Pill
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy Oral Pill
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy Oral Pill
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy Oral Pill
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Mysimba vs Mounjaro Weight Loss UK: Clinical Comparison

Published on: June 03, 2026

Choosing between mysimba vs mounjaro weight loss UK treatments requires understanding how each medication works and which suits your clinical profile. At Cured Pharmacy, our UK-registered prescribers assess your medical history to recommend the most appropriate option, whether that's the dual-action tablet Mysimba or the once-weekly injectable Mounjaro.

How Mysimba and Mounjaro Work Differently

Mysimba contains naltrexone 8mg and bupropion 90mg, two active ingredients that work on the central nervous system to reduce appetite and food cravings [1]. This oral tablet targets the brain's reward pathways and hunger centres, making it easier to adhere to reduced-calorie diets without the need for injections.

Mounjaro (tirzepatide) is the UK's first dual GIP/GLP-1 receptor agonist, administered as a once-weekly subcutaneous injection [2]. It mimics two naturally occurring hormones that regulate blood sugar, slow gastric emptying, and enhance satiety signals. In the SURPASS-1 trial, participants achieved up to 22.5% body weight reduction over 72 weeks at the highest dose [2].

The fundamental difference lies in their mechanisms: Mysimba modifies neurological appetite signals through oral administration, whilst Mounjaro activates hormonal pathways via injection. Both require prescription and clinical assessment by a UK prescriber before dispensing.

Mysimba vs Mounjaro Weight Loss Results

Clinical trial data shows distinct efficacy profiles for each treatment. In the COR-I trial, Mysimba users lost an average of 8.1% body weight over 56 weeks when combined with diet and exercise [1]. Responders—those who lost at least 5% body weight by week 16—achieved significantly greater reductions, with many reaching 10-12% total weight loss.

Mounjaro demonstrates higher average weight loss in clinical trials. The SURMOUNT-1 study reported mean reductions of 15% to 20.9% depending on dose, with the 15mg weekly injection producing the greatest effect [3]. These results surpass those seen with single-pathway GLP-1 medications like semaglutide.

Individual response varies considerably. Some patients respond better to neurological appetite suppression with Mysimba, whilst others achieve superior results with hormonal regulation via Mounjaro. Your UK prescriber will consider your BMI, medical history, previous weight loss attempts, and tolerance for injections when recommending treatment.

Factors Influencing Treatment Choice

Patients with needle phobia or preference for oral medication may favour Mysimba tablets taken twice daily. Those seeking maximum weight loss potential or who have struggled with previous oral treatments might benefit more from Mounjaro injections. Medical contraindications also play a role—Mysimba is unsuitable for patients with uncontrolled hypertension or seizure disorders, whilst Mounjaro requires caution in those with diabetic retinopathy or pancreatitis history [1][2].

Side Effects: Mysimba vs Mounjaro Comparison

Mysimba's most common side effects include nausea (affecting up to 30% of users initially), constipation, headache, dizziness, and insomnia [1]. These typically diminish after the first month as the body adjusts to the medication. The dose is gradually increased over four weeks to minimise gastrointestinal discomfort. Serious but rare risks include seizures and elevated blood pressure, which is why regular monitoring is required.

Mounjaro users frequently experience gastrointestinal effects, particularly nausea (12-22% depending on dose), vomiting, diarrhoea, and constipation [2]. These side effects are usually mild to moderate and decrease over time. More serious but uncommon risks include pancreatitis, gallbladder disease, and thyroid tumours (observed in animal studies). Injection site reactions such as redness or itching affect approximately 2% of patients.

Both medications require clinical supervision throughout treatment. At Cured Pharmacy, our UK prescribers review your progress and side effect profile during follow-up consultations, adjusting treatment plans as needed to optimise outcomes whilst minimising adverse effects.

Managing Common Side Effects

For Mysimba users experiencing nausea, taking tablets with food and staying well-hydrated can help. The gradual dose escalation protocol exists specifically to improve tolerability. Mounjaro patients should inject on the same day each week and may find nausea lessens by avoiding large, fatty meals. If side effects persist beyond the first month or become severe, contact your prescriber—dose adjustment or treatment change may be appropriate.

Feature Mysimba Mounjaro
Active Ingredient Naltrexone 8mg + Bupropion 90mg Tirzepatide
Administration Oral tablet, twice daily Subcutaneous injection, once weekly
Mechanism Central nervous system appetite suppression Dual GIP/GLP-1 receptor agonist
Average Weight Loss 8.1% over 56 weeks 15-20.9% over 72 weeks
Starting Price From £124.99 From £124.99
Common Side Effects Nausea, constipation, headache Nausea, vomiting, diarrhoea
Dose Escalation 4-week titration to maintenance dose Gradual increases every 4 weeks
Storage Room temperature Refrigeration required before first use

Dosing and Administration: Practical Considerations

Mysimba requires twice-daily oral administration, starting with one tablet each morning for week one, then increasing gradually to the maintenance dose of two tablets twice daily by week four [1]. This titration schedule helps minimise side effects. Tablets should be swallowed whole with water and can be taken with or without food. Missing doses can reduce efficacy, so establishing a consistent routine is important.

Mounjaro is administered as a single subcutaneous injection once weekly, on the same day each week. Treatment begins at 2.5mg for four weeks, then increases to 5mg. Your prescriber may further increase the dose every four weeks based on response and tolerability, up to a maximum of 15mg weekly [2]. The pre-filled KwikPen is designed for self-administration into the abdomen, thigh, or upper arm.

The practical difference is significant: Mysimba demands daily commitment and consistency, whilst Mounjaro requires only weekly injections but involves needle use and proper storage (refrigeration until first use). At Cured Pharmacy, we provide detailed administration guidance and support for whichever treatment your UK prescriber recommends.

Cost Comparison and Treatment Duration

Mysimba is available at Cured Pharmacy from £135.00 for a one-month supply. Treatment duration varies—NICE guidance suggests discontinuing if patients haven't lost at least 5% body weight after 16 weeks, or 10% after one year [4]. Many patients continue for 6-12 months to achieve and consolidate their weight loss goals.

Mounjaro starts from £124.99 at Cured Pharmacy, with pricing dependent on your prescribed dose. Clinical trials evaluated treatment over 72 weeks, though some patients may require longer or shorter courses based on individual response. Both medications are intended for long-term weight management alongside lifestyle modifications, not short-term fixes.

When comparing costs, consider the total treatment journey including consultation fees, monitoring requirements, and potential dose adjustments. Cured Pharmacy offers transparent upfront pricing with no hidden charges—you'll see the exact cost before completing your free online consultation with a UK prescriber.

Value Beyond Price

The most cost-effective treatment isn't always the cheapest—it's the one that works best for your body and circumstances. Some patients achieve excellent results with the more affordable option, whilst others require the higher-efficacy treatment to reach their health goals. Your UK prescriber will help balance clinical suitability, efficacy expectations, and budget considerations when recommending between Mysimba and Mounjaro.

Who Should Choose Mysimba vs Mounjaro?

Mysimba may be more suitable for patients who prefer oral medication, have needle phobia, or have struggled with previous weight loss attempts using diet and exercise alone. It's licensed for adults with BMI ≥30 kg/m², or ≥27 kg/m² with weight-related comorbidities such as hypertension or type 2 diabetes [1]. Patients must be willing to commit to twice-daily dosing and gradual dose escalation.

Mounjaro is often recommended for patients seeking maximum weight loss efficacy, those comfortable with weekly injections, or individuals who haven't responded adequately to other weight management treatments. It's particularly effective for patients with type 2 diabetes due to its glucose-lowering properties, though it's also licensed for weight management in non-diabetic patients [2]. The once-weekly schedule suits those who struggle with daily medication adherence.

Contraindications differ between treatments. Mysimba cannot be used by patients taking opioid medications, MAOIs, or those with seizure disorders, eating disorders, or uncontrolled hypertension [1]. Mounjaro requires caution in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 [2]. Your UK prescriber at Cured Pharmacy will review your complete medical history to determine which treatment—if any—is clinically appropriate for you.

Scientific References

  1. Greenway, F. L., et al. (2010). Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet, 376(9741), 595-605. https://doi.org/10.1016/S0140-6736(10)60888-4 [accessed 13 August 2026]
  2. Rosenstock, J., et al. (2021). Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial. The Lancet, 398(10295), 143-155. https://doi.org/10.1016/S0140-6736(21)01324-6 [accessed 13 August 2026]
  3. Jastreboff, A. M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216. https://doi.org/10.1056/NEJMoa2206038 [accessed 13 August 2026]
  4. National Institute for Health and Care Excellence. (2014). Obesity: identification, assessment and management (CG189). NICE. https://www.nice.org.uk/guidance/cg189 [accessed 13 August 2026]
  5. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 13 August 2026.
  6. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 13 August 2026.
  7. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 13 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary. Weight loss medications are most effective when combined with a reduced-calorie diet and increased physical activity.

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Real people, real results

Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

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Faq

Can I switch from Mysimba to Mounjaro or vice versa?
Yes, switching between treatments is possible under prescriber supervision. Your UK clinician will assess your response to the current medication and determine appropriate timing and transition protocols to minimise side effects.
Which is better for weight loss: Mysimba or Mounjaro?
Clinical trials show Mounjaro produces greater average weight loss, but individual response varies. The 'better' option depends on your medical history, preferences regarding injections versus tablets, and how your body responds to each medication's mechanism.
Do I need a prescription for Mysimba or Mounjaro in the UK?
Yes, both are prescription-only medications requiring clinical assessment by a UK-registered prescriber. At Cured Pharmacy, you'll complete a free online consultation which our clinical team reviews before approving and dispensing treatment.
How quickly will I see results with Mysimba vs Mounjaro?
Most Mysimba users notice appetite changes within 4-8 weeks, with measurable weight loss by 16 weeks. Mounjaro patients often experience earlier effects, with noticeable weight reduction within 4-12 weeks as the dose increases.
Can I take Mysimba and Mounjaro together?
No, these medications should not be combined. Each works through different mechanisms and combining them increases side effect risks without proven additional benefit. Your prescriber will recommend one treatment based on your clinical profile.
What happens if I stop taking Mysimba or Mounjaro?
Weight regain is possible after discontinuing either medication, particularly without maintained lifestyle changes. Gradual tapering may be recommended for some patients. Your UK prescriber will discuss long-term weight maintenance strategies when you're ready to stop treatment.
Are Mysimba and Mounjaro available on the NHS?
Availability through the NHS is limited and subject to local commissioning decisions and strict eligibility criteria. Private prescription through registered UK pharmacies like Cured Pharmacy offers faster access for eligible patients following clinical assessment.
Which treatment has fewer side effects: Mysimba or Mounjaro?
Both cause gastrointestinal side effects in many users, though the specific profile differs. Mysimba more commonly causes headache and insomnia, whilst Mounjaro has higher rates of nausea and vomiting. Most side effects diminish after the first month with either treatment.
Which is more effective for weight loss - Mysimba or Mounjaro?
Clinical trials show Mounjaro typically delivers greater weight loss results than Mysimba, with patients losing an average of 15-20% body weight on Mounjaro versus 5-10% on Mysimba. Cured Pharmacy can help you compare both options during your online consultation to determine which treatment suits your weight loss goals and medical history.
Is Mounjaro more expensive than Mysimba in the UK?
Mounjaro starts from £124.99 at Cured Pharmacy, while Mysimba typically costs between £40-60 per month, making Mysimba the lower-cost option initially. However, Mounjaro's stronger weight loss efficacy may offer better value for patients seeking more significant results, and Cured Pharmacy offers £20 off your first Mounjaro order with code Weightlossnew.
Can I switch from Mysimba to Mounjaro for weight loss?
Yes, you can switch from Mysimba to Mounjaro after consulting with a prescriber to ensure it's safe based on your medical history. Cured Pharmacy's UK-registered clinicians can review your progress on Mysimba and determine whether transitioning to Mounjaro is appropriate for your weight loss journey.
How do Mysimba and Mounjaro work differently for weight loss?
Mysimba combines naltrexone and bupropion to reduce appetite and cravings through brain chemistry, while Mounjaro mimics GIP and GLP-1 hormones to regulate blood sugar and significantly reduce hunger. Mounjaro is an injectable medication used weekly, whereas Mysimba is a daily tablet, and Cured Pharmacy can guide you through the pros and cons of each treatment method.
Do I need different blood tests for Mysimba vs Mounjaro?
Mounjaro requires monitoring for thyroid function and pancreatic health due to its mechanism, while Mysimba needs screening for liver function, blood pressure, and mental health history. Cured Pharmacy's prescribers will assess your suitability for either Mysimba or Mounjaro during your online consultation and advise on any necessary blood tests before starting treatment.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 13 August 2026

Last updated on 13 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 13 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (13 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


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