Mounjaro vs Saxenda UK: Which Works Best? | Cured

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Cheapest Mounjaro vs Saxenda - UK Price £124.99

Compare Mounjaro and Saxenda with the cheapest UK price from £124.99 plus £20 off with code Weightlossnew.

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Pricing Disclaimer: Prices on some pages may not be up to date — the live pricing table below and pricing shown during consultation are official current prices and take precedence over any other figures on the site.

Mounjaro (Tirzepatide)
Weeks 1–4

2.5mg

1 pen • 4 Weeks

£145 £124.99

£31.25 / Per Week

Your starting dose – designed to help your body adjust gently to treatment

⭐ Future Orders at £145
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Mounjaro (Tirzepatide)
Weeks 5–8

5mg

1 pen • 4 Weeks

£179 £159.00

£39.75 / Per Week

First step up – builds on your progress as your body adapts to treatment

⭐ Future Orders at £179
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Mounjaro (Tirzepatide)
Weeks 9–12

7.5mg

1 pen • 4 Weeks

£220 £200.00

£50.00 / Per Week

Mid-range dose – for continued progression and enhanced results

⭐ Future Orders at £220
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Mounjaro (Tirzepatide)
Weeks 13–16

10mg

1 pen • 4 Weeks

£245 £225.00

£56.25 / Per Week

Higher strength dose – supports significant weight loss progress

⭐ Future Orders at £245
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Mounjaro (Tirzepatide)
Weeks 17–20

12.5mg

1 pen • 4 Weeks

£270 £250.00

£62.50 / Per Week

Advanced dose – for patients requiring stronger therapeutic effect

⭐ Future Orders at £270
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Mounjaro (Tirzepatide)
Weeks 21+

15mg

1 pen • 4 Weeks

£287 £267.00

£66.75 / Per Week

Maximum dose – the highest available strength for optimal results

⭐ Future Orders at £287
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Wegovy (Semaglutide)
Weeks 1–4

0.25mg

1 pen • 4 Weeks

£89 £69.00

£17.25 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £89
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Wegovy (Semaglutide)
Weeks 5–8

0.5mg

1 pen • 4 Weeks

£99 £79.00

£19.75 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £99
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Wegovy (Semaglutide)
Weeks 9–12

1mg

1 pen • 4 Weeks

£119 £99.00

£24.75 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £119
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Wegovy (Semaglutide)
Weeks 13–16

1.7mg

1 pen • 4 Weeks

£169 £149.00

£37.25 / Per Week

Higher strength – supports accelerated weight loss progress

⭐ Future Orders at £169
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Wegovy (Semaglutide)
Weeks 17+

2.4mg

1 pen • 4 Weeks

£199 £179.00

£44.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199
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Wegovy Oral Pill
Weeks 1–4

1.5mg

1 pen • 4 Weeks

£83.00 £63.00

£20.75 / Per Week

Your starting dose – eases your body into treatment with minimal side effects

⭐ Future Orders at £83.00
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Wegovy Oral Pill
Weeks 5–8

4mg

1 pen • 4 Weeks

£110.00 £90.00

£27.50 / Per Week

First step up – continues building tolerance for long-term success

⭐ Future Orders at £110.00
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Wegovy Oral Pill
Weeks 9–12

9mg

1 pen • 4 Weeks

£140.00 £120.00

£35.00 / Per Week

Mid-range dose – where most patients start seeing meaningful results

⭐ Future Orders at £140.00
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Wegovy Oral Pill
Weeks 13+

25mg

1 pen • 4 Weeks

£199.00 £179.00

£49.75 / Per Week

Maximum dose – the highest available strength for optimal weight management

⭐ Future Orders at £199.00
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Mounjaro vs Saxenda: Clinical Comparison for UK Patients

Published on: June 03, 2026

When considering mounjaro vs saxenda uk comparison options, understanding the clinical differences between tirzepatide and liraglutide is essential for making an informed treatment choice. Both are MHRA-licensed injectable medications for weight management, but they work through different mechanisms and produce distinct clinical outcomes. At Cured Pharmacy, our UK-registered clinical team provides evidence-based guidance to help you choose the most suitable treatment, with transparent pricing from £135.00 for Saxenda and from £135.00 for Mounjaro.

How Mounjaro and Saxenda Work Differently

Mounjaro contains tirzepatide, the first dual GIP/GLP-1 receptor agonist licensed in the UK for weight management [1]. This dual-action mechanism activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, producing enhanced effects on appetite regulation, insulin secretion, and energy expenditure compared to single-pathway treatments.

Saxenda contains liraglutide, a GLP-1 receptor agonist that has been available in the UK since 2015 [2]. It works by mimicking a single natural hormone that regulates appetite and food intake, slowing gastric emptying and increasing feelings of fullness after meals. While effective, its single-pathway mechanism produces more modest weight loss outcomes compared to dual-receptor agonists.

The fundamental difference in mechanism translates directly to clinical efficacy. In head-to-head comparisons, dual-action treatments consistently demonstrate superior weight reduction, though both medications require daily or weekly injections and ongoing clinical monitoring by UK prescribers.

Mounjaro vs Saxenda: Clinical Effectiveness Compared

In the SURPASS-3 trial, patients receiving the highest maintenance dose of Mounjaro (15mg weekly) achieved an average 22.5% total body weight reduction over 72 weeks [1]. This represents significantly greater efficacy than traditional single-pathway GLP-1 treatments, with over half of participants achieving at least 20% weight loss.

By comparison, the SCALE Obesity and Prediabetes trial showed that Saxenda users achieved an average 8.0% body weight reduction over 56 weeks, with 33.1% of participants losing at least 10% of their initial weight [2]. While clinically meaningful, these outcomes are notably lower than those observed with dual-receptor agonist therapy.

Both medications require adherence to a reduced-calorie diet and increased physical activity to achieve optimal results. Your UK prescriber will assess your medical history, current BMI, and any contraindications before determining which treatment is most appropriate for your individual circumstances.

Weight Loss Timeline Expectations

Mounjaro follows a gradual dose escalation schedule, starting at 2.5mg weekly and increasing every four weeks until reaching your maintenance dose. Most patients begin noticing appetite reduction within the first two weeks, with measurable weight loss typically evident by week 4-8 [3].

Saxenda is administered as a daily injection, starting at 0.6mg and increasing by 0.6mg increments weekly until reaching the 3.0mg maintenance dose. Weight loss typically becomes noticeable within 4-6 weeks of reaching the full dose, with maximum effects seen after several months of consistent use [2].

Dosing and Administration: Mounjaro vs Saxenda UK

Mounjaro is administered once weekly using a pre-filled KwikPen device. The standard dose escalation begins at 2.5mg weekly for four weeks, then increases to 5mg, 7.5mg, 10mg, 12.5mg, and finally 15mg at four-week intervals, depending on individual response and tolerability [1]. This weekly schedule offers greater convenience for patients who prefer less frequent injections.

Saxenda requires daily subcutaneous injections, with the pen delivering doses from 0.6mg up to the maintenance dose of 3.0mg. The daily administration schedule provides steady medication levels but requires greater commitment to a daily injection routine [2]. Each Saxenda pen contains enough medication for several days, depending on your prescribed dose.

Both medications are injected subcutaneously into the abdomen, thigh, or upper arm. Injection sites should be rotated to prevent lipodystrophy. Your UK clinical team will provide detailed administration instructions during your consultation, and all prescription orders include patient information leaflets with step-by-step guidance.

Feature Mounjaro (Tirzepatide) Saxenda (Liraglutide)
Active Ingredient Tirzepatide (dual GIP/GLP-1 agonist) Liraglutide (GLP-1 agonist)
Injection Frequency Once weekly Once daily
Starting Dose 2.5mg weekly 0.6mg daily
Maintenance Dose 5mg to 15mg weekly 3.0mg daily
Average Weight Loss Up to 22.5% (72 weeks) Average 8.0% (56 weeks)
Price at Cured Pharmacy From £124.99 From £124.99
Most Common Side Effects Nausea, diarrhoea, vomiting Nausea, diarrhoea, constipation
MHRA Licensed Yes Yes

Side Effects: What UK Patients Should Expect

The most common side effects for both Mounjaro and Saxenda are gastrointestinal, including nausea, diarrhoea, vomiting, constipation, and abdominal discomfort [1][2]. These effects are typically most pronounced during dose escalation and often diminish as your body adjusts to the medication. Starting with lower doses and increasing gradually helps minimise these symptoms.

In clinical trials, approximately 44% of Mounjaro users experienced nausea, compared to 39% of Saxenda users [1][2]. However, severe gastrointestinal side effects leading to treatment discontinuation were relatively uncommon in both groups when proper dose titration protocols were followed.

Rare but serious side effects include pancreatitis, gallbladder problems, and thyroid C-cell tumours (observed in animal studies). Both medications carry a boxed warning regarding thyroid tumours and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 [1][2]. Your UK prescriber will screen for these contraindications during your clinical assessment.

Managing Common Side Effects

To minimise nausea and gastrointestinal discomfort, eat smaller, more frequent meals and avoid high-fat foods, particularly during the first few weeks of treatment. Staying well-hydrated and avoiding lying down immediately after eating can also reduce symptoms. If side effects become severe or persistent, contact your prescriber to discuss dose adjustments or alternative treatment options.

Cost Comparison: Mounjaro vs Saxenda at UK Pharmacies

At Cured Pharmacy, Saxenda is available from £135.00 and Mounjaro from £124.99, with final pricing determined by your prescribed dose and treatment duration. Both medications require ongoing monthly prescriptions, and your UK prescriber will determine the most cost-effective treatment plan based on your clinical response and individual circumstances.

When comparing overall value, consider both the upfront cost and the clinical effectiveness demonstrated in trials. While Mounjaro carries a higher initial price point, its superior average weight loss outcomes and once-weekly dosing schedule may represent better long-term value for some patients. Conversely, Saxenda's lower starting price and established safety profile make it an accessible option for those beginning weight management treatment.

All prescription weight loss medications at Cured Pharmacy include a free online consultation with a UK-registered prescriber, discreet packaging, and transparent upfront pricing with no hidden fees. Our superintendent pharmacist, Tarun Kumar (GPhC 2233073), ensures all dispensed medications meet MHRA standards for quality and safety.

Choosing Between Mounjaro and Saxenda: Clinical Considerations

Your UK prescriber will assess multiple factors when recommending treatment, including your current BMI, weight loss goals, medical history, existing medications, and any contraindications. Patients with higher baseline BMI or those who have not achieved adequate results with single-pathway GLP-1 treatments may be better candidates for Mounjaro's dual-receptor mechanism [3].

Saxenda may be more appropriate for patients new to weight loss medications, those with budget constraints, or individuals who have previously responded well to GLP-1 therapy. Its longer track record in the UK market and daily dosing schedule provide flexibility for patients who prefer more frequent, lower-dose administration [2].

Both treatments require commitment to lifestyle modifications, including a reduced-calorie diet and increased physical activity, to achieve optimal results. Neither medication is suitable for patients with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, or severe gastrointestinal disease. Your clinical assessment will identify any contraindications before treatment begins.

Alternative Weight Loss Treatments Available

If neither Mounjaro nor Saxenda is suitable for your circumstances, Cured Pharmacy offers alternative MHRA-licensed weight management treatments including Wegovy (semaglutide) from £135.00, Orlistat from £135.00, and Xenical from £135.00. Each treatment works through different mechanisms and may be more appropriate depending on your individual clinical profile and treatment goals. Your UK prescriber will discuss all suitable options during your free online consultation.

Scientific References

  1. Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038 [accessed 13 August 2026]
  2. Pi-Sunyer, X., Astrup, A., Fujioka, K., et al. (2015). A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. New England Journal of Medicine, 373(1), 11–22. https://doi.org/10.1056/NEJMoa1411892 [accessed 13 August 2026]
  3. Frias, J. P., Davies, M. J., Rosenstock, J., et al. (2021). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. New England Journal of Medicine, 385(6), 503–515. https://doi.org/10.1056/NEJMoa2107519 [accessed 13 August 2026]
  4. NHS. (2026). Tirzepatide: a medicine to manage type 2 diabetes and treat obesity. https://www.nhs.uk/medicines/tirzepatide/ Accessed 13 August 2026.
  5. NHS. (2026). Overweight and obesity in adults. https://www.nhs.uk/conditions/overweight-and-obesity/ Accessed 13 August 2026.
  6. NHS England. (2026). Weight management injections. https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/ Accessed 13 August 2026.

Information on this page is for educational purposes only and is not medical advice. All prescription treatments require clinical assessment by a UK-registered prescriber. Always consult a qualified healthcare professional before starting any new medication. Individual results may vary, and weight loss outcomes depend on adherence to a reduced-calorie diet and increased physical activity alongside medication use.

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Jane L.

"Brilliant. Lost 4 stone on mounjaro no side effects at all. Cured pharmacy are excellent. Always helpful pens sent out quickly always comes with needles and sterile wipes. If you want to go on GLP-1 go to cured pharmacy. So professional. Thank you cured pharmacy you changed my health and well being."

Ann-Marie

"I absolutely love this product, I have been using 2.5mg as maintenance dose and have managed to control my weight without any side effects and can still eat well balanced meals. The pharmacy is very efficient friendly and helpful I would not purchase from anywhere else."

Sacha W.

"So far I'm really impressed by my results it's crazy cause I'm not snacking like how I used to do and I see my face slimming down already and it's only been 2 and a half weeks. Can't wait to give my feedback in 5 months time thank you cured pharmacy."

Kimberly G.

"Mounjaro has corrected my hormonal weight gain during menopause. I am using it now to maintain that balance. The results for me have been exceptional!"

Jennifer

"Great really helps cure those nasty habits can't wait for my next mounjaro pen."

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Faq

Is Mounjaro more effective than Saxenda for weight loss?
In clinical trials, Mounjaro demonstrated superior weight loss outcomes, with patients achieving an average 22.5% body weight reduction compared to 8.0% with Saxenda. However, individual results vary, and your UK prescriber will recommend the most appropriate treatment based on your medical history and clinical profile.
Can I switch from Saxenda to Mounjaro?
Switching between weight loss medications is possible subject to clinical assessment by a UK prescriber. Your prescriber will evaluate your response to Saxenda, current health status, and any contraindications before approving a switch to Mounjaro.
How long does it take to see results with Mounjaro vs Saxenda?
Most Mounjaro patients notice appetite reduction within 2 weeks and measurable weight loss by weeks 4-8, while Saxenda users typically see results within 4-6 weeks of reaching the 3.0mg maintenance dose. Individual response times vary based on adherence to diet and lifestyle modifications.
Do I need a prescription for Mounjaro or Saxenda in the UK?
Yes, both Mounjaro and Saxenda are prescription-only medications in the UK and require clinical assessment by a UK-registered prescriber before they can be dispensed. Cured Pharmacy provides a free online consultation as part of every prescription order.
What are the main side effects of Mounjaro vs Saxenda?
Both medications commonly cause gastrointestinal side effects including nausea, diarrhoea, and vomiting, particularly during dose escalation. These effects typically diminish over time and can be managed through dietary adjustments and gradual dose titration under prescriber supervision.
Which is cheaper: Mounjaro or Saxenda?
Saxenda starts from £135.00 at Cured Pharmacy, while Mounjaro starts from £124.99. However, when comparing overall value, consider the clinical effectiveness, dosing frequency, and individual treatment response alongside upfront cost.
Can I use Mounjaro or Saxenda if I have diabetes?
Mounjaro is licensed for both weight management and type 2 diabetes treatment, while Saxenda is licensed specifically for weight management in the UK. Your prescriber will assess your diabetic status and current medications to determine the most appropriate treatment and monitor for potential drug interactions.
How do I start treatment with Mounjaro or Saxenda at Cured Pharmacy?
Complete the free online consultation on the Cured Pharmacy website, which takes under 3 minutes. A UK-registered prescriber will review your medical history and, if appropriate, approve your prescription for discreet delivery to your address with transparent upfront pricing and no hidden fees.
Is Mounjaro or Saxenda cheaper in the UK?
Mounjaro is generally more cost-effective long-term, starting from £124.99 at Cured Pharmacy compared to Saxenda which requires daily injections. Mounjaro's weekly dosing and superior weight loss results often provide better value despite similar starting prices.
Can I switch from Saxenda to Mounjaro with Cured Pharmacy?
Yes, you can switch from Saxenda to Mounjaro through Cured Pharmacy after a UK-registered prescriber reviews your treatment history. Many patients switch to Mounjaro for its once-weekly convenience and clinically proven greater weight loss compared to daily Saxenda injections.
Which works faster for weight loss, Mounjaro or Saxenda?
Clinical trials show Mounjaro typically produces faster and greater weight loss than Saxenda, with patients losing an average of 15-20% body weight versus 5-10% with Saxenda. Cured Pharmacy provides both options with full prescriber consultation to determine the best treatment for your goals.
Does Mounjaro have more side effects than Saxenda?
Both Mounjaro and Saxenda share similar side effects like nausea and digestive issues, though Mounjaro's weekly dosing may cause less frequent symptoms than Saxenda's daily injections. Cured Pharmacy's prescribers will discuss your tolerance and medical history when comparing these treatments during your consultation.
Is Mounjaro available on the NHS or only privately like Saxenda?
Mounjaro is currently available privately in the UK through services like Cured Pharmacy from £124.99, while NHS availability remains extremely limited with long waiting lists. Saxenda faces similar NHS restrictions, making private prescriptions the most accessible option for both medications.
Is Mounjaro cheaper than Saxenda in the UK?
Mounjaro starts from £124.99 at Cured Pharmacy, while Saxenda typically costs more per month of treatment. Mounjaro is administered once weekly, whereas Saxenda requires daily injections, making Mounjaro more cost-effective and convenient for most patients.
Which is more effective for weight loss - Mounjaro or Saxenda?
Clinical trials show Mounjaro (tirzepatide) typically delivers greater weight loss than Saxenda (liraglutide), with patients losing an average of 15-22% body weight on Mounjaro compared to 5-10% with Saxenda. Cured Pharmacy can help you determine which treatment suits your weight loss goals during your online consultation.
Can I switch from Saxenda to Mounjaro through Cured Pharmacy?
Yes, many patients switch from Saxenda to Mounjaro for better results and weekly dosing convenience. Cured Pharmacy's UK-registered prescribers will review your medical history and current treatment during consultation to ensure a safe transition between medications.
Does Mounjaro have fewer side effects than Saxenda?
Both Mounjaro and Saxenda share similar gastrointestinal side effects like nausea and diarrhoea, though some patients find Mounjaro's weekly injection schedule easier to tolerate than Saxenda's daily dosing. Cured Pharmacy provides full guidance on managing side effects with either medication.
How long does Mounjaro take to work compared to Saxenda?
Both medications begin working within days, but noticeable weight loss typically appears after 4-8 weeks with either treatment. Mounjaro's dual-action mechanism often produces faster and greater results than Saxenda over 3-6 months, and Cured Pharmacy offers ongoing support throughout your weight loss journey.
Tarun Kumar, Prescribing Pharmacist

Medically reviewed by

Tarun Kumar, Prescribing Pharmacist (GPhC 2233073)

Reviewed on: June 03, 2026

Last reviewed: 13 August 2026

Last updated on 13 August 2026.

Review History

Our experts continually monitor new findings in health and medicine, and we update our articles when new information becomes available.

Why this page was updated on 13 August 2026

Content checked and updated as part of our periodic review, to ensure accuracy and currentness.

Current version (13 August 2026)

Edited by: The Editorial Team

Medically reviewed by:

Tarun Kumar, GPhC No. 2233073, Prescribing Pharmacist


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