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Trimovate Cream 30g

Trimovate Cream 30g

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  • ✔️ Treats infected eczema with steroid, antibiotic and antifungal
  • ✔️ Reduces skin inflammation caused by bacterial or fungal infection
  • ✔️ Contains mild clobetasone butyrate — suitable for sensitive skin
  • ✔️ Effective against Candida and common skin bacteria simultaneously
  • ✔️ Convenient 30g tube for targeted, short-term topical treatment

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What Is Trimovate Cream and How Does It Help Infected Skin?

 

Trimovate cream is a triple-action topical treatment that combines three active ingredients in a single formulation: clobetasone butyrate 0.05% (a mild corticosteroid), oxytetracycline 3% (a broad-spectrum antibiotic), and nystatin 100,000 units/g (an antifungal agent). It is used to treat inflammatory skin conditions where bacterial or fungal infection is present or suspected. If you have ever dealt with a patch of eczema that just won't settle — or one that seems to be getting worse rather than better — there is a good chance secondary infection is involved, and that is exactly where this cream steps in. You can browse our full range of creams and ointments if you are looking for other topical treatments alongside this one.

This cream is classified as a Pharmacy (P) medicine in the UK, meaning it is available without a prescription but should be purchased through a registered pharmacy. It is supplied in a 30g tube and is intended for short-term use on affected skin areas in adults and children over two years of age.

 

How Does Trimovate Cream Work on Inflamed and Infected Skin?

 

The three ingredients in Trimovate cream each target a different aspect of infected skin inflammation. Here is how they work together:

  • Clobetasone butyrate 0.05% — a mild topical corticosteroid that reduces redness, swelling, and itching by suppressing the local inflammatory response in the skin.
  • Oxytetracycline 3% — a tetracycline-class antibiotic that inhibits bacterial protein synthesis, helping to clear bacterial infections such as those caused by Staphylococcus aureus, which commonly colonise eczematous skin.
  • Nystatin 100,000 units/g — a polyene antifungal that binds to ergosterol in fungal cell membranes, disrupting their integrity and killing organisms such as Candida species.

Because inflamed skin is often colonised by both bacteria and fungi simultaneously, using a product that addresses all three components — inflammation, bacterial infection, and fungal infection — can be more effective than treating each separately.

 

Who Is Trimovate Cream Suitable For?

 

Trimovate cream is suitable for adults and children over two years of age who have inflammatory skin conditions complicated by, or at risk of, bacterial or fungal infection. It is particularly useful for conditions affecting skin folds, where warmth and moisture create an environment that encourages mixed infections.

  • Adults with infected or secondarily infected eczema (atopic, contact, or seborrhoeic)
  • People with intertrigo — a rash that develops in skin folds such as the groin, underarms, or beneath the breasts
  • Individuals with otitis externa (outer ear inflammation) where infection is a factor, under medical guidance
  • Patients with prurigo or other inflammatory dermatoses where infection complicates the picture

It is not suitable for people with known hypersensitivity to any of the active ingredients, those with viral skin infections (such as herpes simplex or chickenpox), or those with tuberculosis of the skin. If you are managing a broader skin condition, our skin care collection includes a range of supportive products that may complement your treatment plan.

 

How Does Trimovate Cream Compare to Similar Topical Treatments?

 

Feature Trimovate Cream Hydrocortisone 1% Cream
Active ingredients Steroid + antibiotic + antifungal Steroid only
Treats infection Yes (bacterial and fungal) No
Steroid potency Mild (clobetasone butyrate 0.05%) Mild (hydrocortisone 1%)
Suitable for infected eczema Yes Not recommended if infected

 

How Should Trimovate Cream Be Stored and Is It Clinically Appropriate for You?

 

Store Trimovate cream below 25°C in a dry place, away from direct sunlight. Do not refrigerate. Keep the tube tightly closed when not in use and keep it out of the reach and sight of children. Check the expiry date on the tube before each use — do not use the cream after the printed expiry date.

Before starting treatment, it is worth considering whether Trimovate cream is the right choice for your specific skin concern. If you are unsure whether your skin condition involves infection, a pharmacist can help you assess this. People with conditions such as rosacea, perioral dermatitis, or acne should avoid using this product, as topical steroids can worsen these conditions. If you are also managing a fungal skin condition separately, you may find our athletes foot and fungal infections collection useful for additional antifungal options.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Trimovate Cream 30g specifications
Treatment category Infected inflammatory skin conditions
Mechanism of action Anti-inflammatory (steroid), antibacterial (tetracycline), antifungal (polyene)
Effective for Infected eczema, intertrigo, seborrhoeic dermatitis
Suitable for Adults and children over 2 years
Active ingredients Clobetasone butyrate 0.05%, Oxytetracycline 3%, Nystatin 100,000 units/g
Pack size 30g
UK classification Pharmacy (P) medicine
Drug class Topical corticosteroid / antibiotic / antifungal combination
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Trimovate Cream 30g

 

What Is Trimovate Cream and What Is It Used For?

 

Trimovate cream is a topical combination medicine used to treat inflammatory skin conditions that are infected or at risk of becoming infected. It contains three active ingredients working together: clobetasone butyrate (a mild steroid to reduce inflammation), oxytetracycline (an antibiotic to treat bacterial infection), and nystatin (an antifungal to treat or prevent fungal infection). It is licensed for use in conditions such as infected eczema, intertrigo, and seborrhoeic dermatitis in adults and children over two years of age. The NHS advises that topical corticosteroids should be used at the lowest effective potency for the shortest possible time to minimise the risk of side effects.

 

What Do You Need to Know Before Using Trimovate Cream?

 

Do not use Trimovate cream if any of the following apply to you:

  • You are allergic to clobetasone butyrate, oxytetracycline, nystatin, or any other ingredient in the cream
  • You have a viral skin infection, including herpes simplex (cold sores), chickenpox, or shingles
  • You have tuberculosis of the skin
  • You have rosacea, acne vulgaris, or perioral dermatitis
  • You have a fungal infection other than one caused by Candida species (nystatin does not cover all fungi)
  • The affected area is near the eyes — avoid contact with eyes entirely
  • You are treating a child under two years of age

Tell your pharmacist or doctor if you are pregnant, breastfeeding, or planning to become pregnant. Topical corticosteroids should be used with caution during pregnancy. The oxytetracycline component means this product should not be used in children under 12 years of age on large areas of skin or for prolonged periods, as tetracyclines can affect developing teeth and bones if absorbed systemically in significant amounts.

Regarding drug interactions, topical use of Trimovate cream carries minimal systemic absorption under normal conditions. However, be aware of the following:

  • Avoid using other topical preparations on the same area simultaneously unless directed by a doctor
  • Concurrent use of other corticosteroid-containing products on different body areas may increase total steroid load

 

How Should You Use Trimovate Cream?

 

Always use Trimovate cream exactly as directed by your pharmacist or as described in the patient information leaflet. Do not apply more than recommended, and do not use it for longer than advised.

  1. Wash your hands thoroughly before and after applying the cream.
  2. Clean and gently dry the affected skin area.
  3. Squeeze a small amount of cream onto your fingertip — a thin layer is sufficient.
  4. Apply gently to the affected area and smooth in lightly. Do not rub vigorously.
  5. Do not cover the treated area with an airtight dressing unless specifically instructed by your doctor, as occlusion increases steroid absorption.
  6. Wash hands again after application.
Indication Age Group Dose Frequency
Infected eczema / intertrigo Adults Thin layer to affected area 2–4 times daily
Infected eczema / intertrigo Children over 2 years Thin layer to affected area 2–4 times daily (short-term only)
Seborrhoeic dermatitis Adults Thin layer to affected area 2–4 times daily

 

What Are the Possible Side Effects of Trimovate Cream?

 

Like all medicines, Trimovate cream can cause side effects, although not everyone experiences them. Most side effects are local and related to the application site. If you notice any unexpected skin changes, stop using the cream and speak to your pharmacist or GP.

Common side effects (may affect up to 1 in 10 people):

  • Mild burning or stinging sensation at the application site
  • Itching or skin irritation
  • Skin dryness

Less common side effects (may affect up to 1 in 100 people, particularly with prolonged use):

  • Skin thinning (atrophy) — more likely with long-term or occlusive use
  • Stretch marks (striae) in skin fold areas
  • Skin discolouration
  • Increased hair growth at the application site (hypertrichosis)
  • Allergic contact dermatitis — a worsening of the skin condition rather than improvement
  • Secondary infection with organisms not covered by the antibiotic or antifungal components

If you are managing other skin concerns alongside this treatment, our skin care collection includes emollients and barrier creams that can support skin recovery.

 

How Should You Store Trimovate Cream?

 

  • Store below 25°C in a cool, dry place
  • Do not refrigerate or freeze
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube and carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist for safe disposal

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Trimovate cream online in the UK?

You can buy Trimovate cream 30g online from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is available as a Pharmacy (P) medicine, meaning no prescription is required but it is sold under pharmacist supervision. Simply add it to your basket and complete a short health questionnaire at checkout to ensure it is appropriate for you.

What is Trimovate cream used for?

Trimovate cream is used to treat inflammatory skin conditions that are infected or at risk of infection, including infected eczema, intertrigo (rash in skin folds), and seborrhoeic dermatitis. Its triple-action formula targets inflammation, bacterial infection, and fungal infection simultaneously. It is not suitable for treating viral skin infections such as cold sores or chickenpox.

How does Trimovate cream work in the body?

Trimovate cream works through three distinct mechanisms applied directly to the skin. Clobetasone butyrate reduces inflammation by suppressing local immune responses; oxytetracycline kills bacteria by inhibiting their protein synthesis; and nystatin disrupts fungal cell membranes to eliminate Candida species. Together, these three ingredients address the most common causes of infected skin inflammation in a single application.

How do I apply Trimovate cream step by step?

Wash your hands, then clean and gently dry the affected skin area. Apply a thin layer of cream to the affected area two to four times daily, smoothing it in gently without rubbing. Always wash your hands again after application and avoid getting the cream in your eyes or on broken skin.

How many times a day should I use Trimovate cream?

The standard recommended frequency is two to four times daily, applied as a thin layer to the affected area. You should use the smallest amount that provides effective relief and avoid applying more frequently than directed. If your symptoms have not improved after seven days, consult your pharmacist or GP before continuing.

How long can I use Trimovate cream for?

Trimovate cream is intended for short-term use only, typically up to seven days. Prolonged use of topical corticosteroids can cause skin thinning, stretch marks, and other local side effects. If your condition has not resolved within a week, seek medical advice rather than continuing to self-treat.

What are the side effects of Trimovate cream?

Common side effects include mild burning, stinging, or itching at the application site, which usually settle quickly. With prolonged use, skin thinning, discolouration, or stretch marks may develop, particularly in skin fold areas. If you notice your skin condition worsening rather than improving, stop using the cream and speak to your pharmacist or GP.

Can I use Trimovate cream on my face?

Trimovate cream should only be used on the face under medical supervision and for the shortest possible time, as facial skin is thinner and more susceptible to steroid-related side effects such as skin thinning and rosacea-like reactions. It must not be used near the eyes. If you have a facial skin condition, speak to your GP or pharmacist before applying this cream to your face.

Is Trimovate cream safe to use during pregnancy?

You should consult your doctor or pharmacist before using Trimovate cream if you are pregnant or breastfeeding. Topical corticosteroids are generally used with caution during pregnancy, and the oxytetracycline component requires careful consideration. Your healthcare professional can advise on the safest option for your individual circumstances.

Can children use Trimovate cream?

Trimovate cream can be used in children over two years of age, but only for short periods and under pharmacist or medical guidance. It should not be used in children under two years old. Because children's skin absorbs topical medicines more readily than adult skin, extra care is needed to use the smallest effective amount for the shortest possible time.

Who should not use Trimovate cream?

Trimovate cream is not suitable for people with viral skin infections (such as herpes simplex or chickenpox), tuberculosis of the skin, rosacea, acne, or perioral dermatitis. It should also be avoided by anyone with a known allergy to any of its active ingredients. Children under two years of age should not use this product.

What happens if I miss an application of Trimovate cream?

If you forget to apply Trimovate cream at your usual time, apply it as soon as you remember — unless it is nearly time for your next application, in which case simply skip the missed dose. Do not apply a double amount to make up for a missed application. Consistency is helpful, but doubling up is not necessary or recommended.

What are the alternatives to Trimovate cream?

Alternatives depend on the nature of your skin condition. If infection is not present, a plain mild topical steroid such as hydrocortisone 1% cream may be sufficient. For purely fungal infections, an antifungal cream from our athletes foot and fungal infections range may be more appropriate. Your pharmacist can help you choose the most suitable product based on your symptoms.

Can I use Trimovate cream under a bandage or dressing?

You should not cover the treated area with an airtight (occlusive) dressing unless specifically instructed by your doctor. Occlusive dressings significantly increase the absorption of the corticosteroid through the skin, which raises the risk of systemic side effects and local skin thinning. A light, non-occlusive dressing may be used if needed for protection.

Are there any medicines that interact with Trimovate cream?

Trimovate cream has minimal systemic absorption under normal conditions, so significant drug interactions are uncommon. However, you should avoid applying other topical preparations to the same area at the same time unless directed by a healthcare professional. If you are using other corticosteroid-containing products on different areas of your body, mention this to your pharmacist, as combined steroid exposure can add up. You can also explore our skin care collection for complementary, non-steroidal skin support products.

How Should You Use Trimovate Cream?

Trimovate cream is applied directly to the affected area of skin. Always wash your hands before and after use, and make sure the skin is clean and gently dried before applying the cream.

Avoid getting the cream in your eyes, mouth, or nose. If accidental contact occurs, rinse thoroughly with water. Do not apply to large areas of the body without medical advice.

What Is the Correct Dose of Trimovate Cream?

The correct dose is a thin layer applied to the affected area. Using more cream than necessary does not improve results and increases the risk of side effects, particularly skin thinning with prolonged use.

When Is the Best Time to Use Trimovate Cream?

There is no single fixed time of day that is clinically superior for applying Trimovate cream. What matters most is consistency — try to space your applications evenly throughout the day, for example morning, midday, late afternoon, and evening if using four times daily. Applying after washing or bathing, once the skin is clean and dry, can help the cream absorb more effectively and reduce the risk of washing it off too soon after application.

If you are applying to a skin fold area such as the groin or underarm, ensure the area is fully dry before application to reduce the risk of maceration and to allow the cream to work properly.

How Long Can You Use Trimovate Cream For?

Trimovate cream is designed for short-term use only. The recommended maximum duration is seven days for most conditions. Using it for longer than this without medical supervision increases the risk of skin thinning, stretch marks, and other steroid-related side effects, particularly in skin fold areas where absorption is higher.

If your symptoms have not improved after seven days, or if they worsen at any point during treatment, stop using the cream and consult your GP or pharmacist. Do not restart a course without seeking advice first. Long-term management of chronic skin conditions such as eczema should be supervised by a healthcare professional.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Trimovate Cream?

Most people who use Trimovate cream do not experience serious side effects, particularly when it is used correctly for a short period. The most common reactions are local and occur at the site of application. They are usually mild and tend to settle as your skin adjusts to the treatment.

  • Mild burning or stinging sensation immediately after application
  • Itching at the application site
  • Skin dryness or flaking
  • Mild redness around the treated area

What Are the Less Common Side Effects of Trimovate Cream?

Less common side effects are more likely to occur with prolonged use, use under occlusive dressings, or application to large areas of skin. These effects are related primarily to the corticosteroid component of the cream.

  • Skin thinning (atrophy) — particularly in skin fold areas or with extended use
  • Stretch marks (striae) in areas where the skin is under tension
  • Skin discolouration (hypopigmentation or hyperpigmentation)
  • Increased hair growth at the application site (hypertrichosis)
  • Allergic contact dermatitis — a paradoxical worsening of the skin condition
  • Secondary infection with organisms not covered by oxytetracycline or nystatin

What Are the Serious Side Effects of Trimovate Cream?

Serious side effects from Trimovate cream are rare when it is used as directed for short periods. However, if the cream is applied to large areas of skin, used under occlusion, or used for extended periods — particularly in children — there is a small risk of systemic absorption of the corticosteroid. This can, in rare cases, lead to adrenal suppression or Cushing's syndrome-like features. Signs to watch for include unusual weight gain, facial puffiness, or extreme fatigue. Stop using the cream and seek medical advice immediately if you notice any of these symptoms.

Tetracycline-class antibiotics such as oxytetracycline can, in rare cases, cause photosensitivity. Avoid prolonged sun exposure on treated areas and use sun protection if the treated skin will be exposed to sunlight.

What Should You Do If You Experience Side Effects?

If you experience mild local reactions such as stinging or itching, these often settle within a few days. If they persist or worsen, stop using the cream and speak to your pharmacist. If you notice your skin condition getting worse rather than better — which may indicate an allergic reaction or a secondary infection — discontinue use immediately and seek medical advice. For any serious or unexpected reaction, contact your GP or call NHS 111.

You can report suspected side effects of any medicine in the UK directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Trimovate Cream Interact With Other Medicines?

Because Trimovate cream is applied topically and systemic absorption is low under normal conditions, clinically significant drug interactions are uncommon. However, you should avoid applying other topical preparations to the same skin area at the same time, as this may alter absorption or cause local reactions. If you are using other corticosteroid-containing products on different parts of your body, inform your pharmacist, as the combined steroid load may be relevant. Always tell your pharmacist about all medicines you are currently using, including over-the-counter products and supplements.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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