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Systane Ultra Lubricant Eye Drops 10ml

Systane Ultra Lubricant Eye Drops 10ml

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  • ✔️ Relieves dry, gritty, and irritated eyes on contact
  • ✔️ Forms a long-lasting lubricating film over the eye surface
  • ✔️ Suitable for daily use including during prolonged screen time
  • ✔️ Helps stabilise the tear film for extended comfort
  • ✔️ Convenient 10ml bottle — easy to use at home or on the go

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What Are Systane Ultra Dry Eye Drops?

 

If your eyes feel gritty, tired, or uncomfortably dry — especially after long hours at a screen or in air-conditioned environments — you are far from alone. Dry eye disease is one of the most common eye complaints seen by optometrists and GPs across the UK. Dry eye drops like Systane Ultra Lubricant Eye Drops 10ml are specifically designed to replicate the function of natural tears, providing fast, soothing relief when your eyes simply are not producing enough moisture on their own. You can explore our full range of products in our eye care collection if you are looking for additional support.

Systane Ultra is manufactured by Alcon, a globally recognised ophthalmic company. The 10ml bottle is a convenient, easy-to-use size suitable for everyday use at home or on the go. At just £8.99, it offers accessible relief without the need for a prescription.

 

How Do Systane Ultra Eye Drops Work?

 

The drops work by forming a protective, lubricating film across the ocular surface. This film helps stabilise the tear film, reduce friction between the eyelid and the eye, and restore moisture to the cornea and conjunctiva. The mechanism involves two key active ingredients working together:

  • Polyethylene glycol 400 (0.4%) — a water-retaining polymer that helps hold moisture on the eye surface
  • Propylene glycol (0.3%) — works alongside PEG 400 to enhance viscosity and extend contact time with the ocular surface
  • The drops also contain the patented POLYPROTECT technology, which helps the formula interact with the natural mucins on the eye surface for longer-lasting comfort
  • Upon blinking, the formula spreads evenly across the eye, mimicking the behaviour of a healthy natural tear film

The result is a drop that does not just temporarily wet the eye — it actively supports the tear film structure, which is why many people find relief lasts noticeably longer compared to simpler saline-based drops.

 

Who Should Use Systane Ultra Eye Drops?

 

Systane Ultra is suitable for adults and older children experiencing symptoms of dry eye syndrome. It is particularly useful for people whose symptoms are triggered by environmental or lifestyle factors. You might benefit from these drops if you:

  • Spend long hours looking at screens (computer, phone, or tablet)
  • Live or work in air-conditioned, heated, or windy environments
  • Wear contact lenses and experience end-of-day dryness
  • Have been diagnosed with dry eye disease by your optometrist or GP
  • Are over 50, as tear production naturally decreases with age
  • Take medications known to reduce tear production, such as antihistamines or antidepressants

It is worth noting that dry eye symptoms can sometimes overlap with those of eye allergies. If you are unsure whether your symptoms are allergy-related, you may also want to browse our allergy and hay fever range for additional options.

 

How Does Systane Ultra Compare to Other Lubricant Eye Drops?

 

Feature Systane Ultra 10ml HycoSan Extra 10ml
Active ingredient PEG 400 + Propylene glycol Sodium hyaluronate 0.2%
Preservative-free No (contains Polyquad) Yes
Suitable with soft contact lenses No — remove lenses first Yes
Duration of relief Long-lasting film formation Long-lasting hydration

 

How Should Systane Ultra Eye Drops Be Stored?

 

Store Systane Ultra below 25°C and keep it away from direct sunlight. Do not freeze the drops. Once opened, the bottle should be discarded after 28 days — even if there is product remaining — to reduce the risk of contamination and infection. Always replace the cap tightly after each use.

These dry eye drops are for external use only. Avoid touching the dropper tip to your eye, fingers, or any other surface. If you wear soft contact lenses, remove them before instilling the drops and wait at least 15 minutes before reinserting. This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Systane Ultra Lubricant Eye Drops 10ml specifications
Treatment category Dry eye relief / Ocular lubricant
Mechanism of action Forms a protective lubricating film over the ocular surface to stabilise the tear film
Effective for Dry, irritated, and uncomfortable eyes
Suitable for Adults and older children; not recommended for use with soft contact lenses in situ
Active ingredient Polyethylene glycol 400 0.4%, Propylene glycol 0.3%
Pack size 10ml
UK classification General Sale List (GSL)
Drug class Ocular lubricant
Preparation Sterile ophthalmic solution
Route of administration Topical ophthalmic (eye drops)

Specifications of Systane Ultra Lubricant Eye Drops 10ml

 

What Is Systane Ultra and What Is It Used For?

 

Systane Ultra Lubricant Eye Drops 10ml is an over-the-counter ophthalmic solution used to relieve the symptoms of dry eye syndrome. Dry eye occurs when the eyes do not produce enough tears, or when the tears evaporate too quickly, leaving the ocular surface inadequately lubricated. Common symptoms include a gritty or burning sensation, redness, sensitivity to light, and intermittent blurred vision. The NHS recognises dry eye as a very common condition, particularly in older adults and those who spend extended time using digital screens.

These lubricant eye drops are not a treatment for the underlying cause of dry eye — rather, they provide symptomatic relief by supplementing the natural tear film. They are suitable for use as often as needed throughout the day and are available without a prescription.

 

What Do You Need to Know Before Using Systane Ultra?

 

Before using these drops, it is important to be aware of the following contraindications and warnings:

  • Do not use if you are allergic to any of the ingredients, including polyethylene glycol 400, propylene glycol, or the preservative Polyquad (polidronium chloride)
  • Remove soft contact lenses before instilling the drops; wait at least 15 minutes before reinserting
  • Do not use if the bottle seal is broken before first use
  • Discard the bottle 28 days after opening, even if product remains
  • If you have an eye infection, eye injury, or have recently had eye surgery, consult your GP or optometrist before use
  • If symptoms persist or worsen after regular use, seek professional advice

Regarding drug interactions, Systane Ultra is a topical lubricant with no known clinically significant systemic interactions. However:

  • If you use other eye drops or eye ointments, allow at least 5 minutes between each product
  • Apply eye ointments last if using alongside drops

 

How Should You Use Systane Ultra Eye Drops?

 

Using eye drops correctly makes a real difference to how effective they are. Follow these steps each time you use Systane Ultra:

  1. Wash your hands thoroughly with soap and water before handling the bottle
  2. Remove soft contact lenses if you are wearing them
  3. Tilt your head back slightly and look upward
  4. Gently pull down your lower eyelid to create a small pocket
  5. Hold the bottle above your eye and squeeze gently to release one or two drops into the pocket
  6. Close your eye gently for a moment and blink a few times to spread the drops evenly
  7. Replace the cap immediately after use
  8. If treating both eyes, repeat the process for the second eye
Indication Age Group Dose Frequency
Dry eye symptom relief Adults 1–2 drops per eye As needed throughout the day
Dry eye symptom relief Older children (under supervision) 1 drop per eye As directed by a healthcare professional

 

What Are the Possible Side Effects of Systane Ultra?

 

Side effects with lubricant eye drops are generally mild and infrequent. Most people use Systane Ultra without any problems at all. That said, it is worth knowing what to look out for.

Common side effects (may affect up to 1 in 10 people):

  • Temporary blurred vision immediately after instillation — this usually clears within a minute or two
  • Mild stinging or burning sensation on application
  • A brief feeling of eye discomfort

Less common side effects (may affect fewer than 1 in 100 people):

  • Eye redness or irritation that persists beyond a few minutes
  • Sticky eyelids or discharge — this may indicate an allergic reaction to the preservative
  • Eyelid swelling or itching

If you experience persistent redness, pain, significant vision changes, or any signs of an allergic reaction, stop using the drops and seek medical advice promptly. You can also browse our first aid range if you need immediate support for minor eye irritation.

 

How Should You Store Systane Ultra Eye Drops?

 

  • Store below 25°C in a cool, dry place
  • Do not freeze
  • Keep out of direct sunlight
  • Keep the bottle tightly closed when not in use
  • Discard 28 days after first opening
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the bottle and carton

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Systane Ultra Eye Drops online in the UK?

You can buy Systane Ultra Lubricant Eye Drops 10ml directly from Cured Pharmacy online for £8.99 with no prescription required. It is a General Sale List (GSL) medicine, meaning it is available over the counter. Browse our full eye care collection for a wider range of eye health products.

How do Systane Ultra Eye Drops work in the eye?

Systane Ultra contains two active polymers — polyethylene glycol 400 and propylene glycol — that form a protective lubricating film over the surface of the eye. This film stabilises the tear film and reduces friction between the eyelid and the cornea. The result is longer-lasting comfort compared to simpler saline-based drops.

How do I use Systane Ultra Eye Drops step by step?

Wash your hands first, then tilt your head back and gently pull down your lower eyelid to create a small pocket. Squeeze one or two drops into the pocket, close your eye gently, and blink a few times to spread the solution. Replace the cap immediately and avoid touching the dropper tip to any surface.

How often can I use Systane Ultra Eye Drops each day?

Systane Ultra can be used as often as needed throughout the day — there is no strict maximum number of applications for most adults. If you find you need drops very frequently or your symptoms are not improving, it is worth speaking to your GP or optometrist. Persistent dry eye may have an underlying cause that needs addressing.

Can I use Systane Ultra Eye Drops with contact lenses?

No — you should remove soft contact lenses before applying Systane Ultra, as the preservative Polyquad can be absorbed by soft lens material and may cause irritation. After instilling the drops, wait at least 15 minutes before reinserting your lenses. Hard (rigid gas permeable) lenses should also be removed prior to use.

What are the side effects of Systane Ultra Eye Drops?

Most people tolerate Systane Ultra very well. The most commonly reported side effects include temporary blurred vision immediately after use and a mild stinging or burning sensation on instillation, both of which usually resolve within a minute or two. If you experience persistent redness, pain, or swelling, stop using the drops and seek medical advice.

Who is eligible to use Systane Ultra Eye Drops?

Systane Ultra is suitable for adults and older children who experience symptoms of dry eye syndrome, including grittiness, burning, and discomfort. It is particularly helpful for people who use screens for long periods, live in dry or air-conditioned environments, or have age-related tear deficiency. It is not recommended for people with known allergies to any of its ingredients.

What happens if I use too many drops of Systane Ultra?

Using more drops than needed is unlikely to cause serious harm, as the product is a topical lubricant with no systemic absorption. Excess solution will simply overflow from the eye. However, using the recommended one to two drops per application is sufficient for effective relief and avoids unnecessary waste.

How long can I use Systane Ultra Eye Drops for?

Systane Ultra can be used long-term as part of ongoing dry eye management — many people use lubricant eye drops daily for months or years without issue. The bottle must be discarded 28 days after opening regardless of how much product remains. If your symptoms change or worsen over time, consult your optometrist or GP for a review.

What are the alternatives to Systane Ultra Eye Drops?

Common alternatives include sodium hyaluronate-based drops such as HycoSan Extra or Hylo-Forte, which are preservative-free and can be used with soft contact lenses. Carbomer-based gels like Viscotears offer longer contact time and are often used at night. The right choice depends on your symptom severity and whether you need a preservative-free option.

Is Systane Ultra suitable during pregnancy or breastfeeding?

There is no evidence that topical ocular lubricants like Systane Ultra cause harm during pregnancy or breastfeeding, as systemic absorption is negligible. However, as with any medicine, it is always sensible to check with your GP or midwife before starting a new product during pregnancy. They can confirm it is appropriate for your individual circumstances.

Can Systane Ultra Eye Drops interact with other eye medicines?

Systane Ultra has no known clinically significant interactions with systemic medicines. If you use other eye drops or ointments, leave at least five minutes between each product to allow proper absorption. Always apply eye ointments last if you are using them alongside drops, as ointments can reduce the absorption of other topical eye preparations.

What is the best time of day to use Systane Ultra Eye Drops?

There is no single best time — use Systane Ultra whenever your eyes feel dry, uncomfortable, or irritated. Many people find they need drops most during prolonged screen use, in air-conditioned environments, or in the evening when eyes are most fatigued. Some people also use a lubricating gel or ointment at night for additional overnight comfort.

What does the latest research say about dry eye drops like Systane Ultra?

Research into dry eye management continues to evolve, with studies supporting the use of polymer-based lubricants for improving tear film stability and reducing ocular surface symptoms. Polyethylene glycol and propylene glycol combinations have been shown in clinical studies to provide meaningful symptom relief. If you are interested in broader eye health support, our vitamins and supplements range includes options that may support general eye health.

How should I store Systane Ultra Eye Drops after opening?

After opening, store Systane Ultra below 25°C in a cool, dry place away from direct sunlight — do not refrigerate or freeze. Always replace the cap tightly after each use to prevent contamination. Discard the bottle 28 days after first opening, even if there is still product remaining, to ensure sterility and safety.

How Should You Use Systane Ultra Eye Drops?

Using Systane Ultra correctly ensures you get the most effective relief from dry eye symptoms. Always wash your hands before handling the bottle, and make sure you remove soft contact lenses before applying the drops.

What Is the Correct Dose of Systane Ultra Eye Drops?

The standard dose is one to two drops per eye, applied as needed. There is no fixed maximum number of daily applications for adults, but using the drops only when symptoms occur is generally sufficient for most people.

When Is the Best Time to Use Systane Ultra Eye Drops?

Use Systane Ultra whenever your eyes feel dry, gritty, or uncomfortable — there is no single prescribed time of day. Many people find they need drops most during prolonged screen use, in air-conditioned or heated environments, or towards the end of the day when eyes are most fatigued. If you experience dryness overnight, a thicker lubricating gel or ointment used at bedtime may complement daytime use of these drops.

How Long Can You Use Systane Ultra Eye Drops For?

Systane Ultra is suitable for long-term use as part of an ongoing dry eye management routine. Many people use lubricant eye drops daily for extended periods without any problems. However, each bottle must be discarded 28 days after first opening to maintain sterility, even if product remains. If your symptoms change, worsen, or do not respond to regular use, consult your GP or optometrist for further assessment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Systane Ultra Eye Drops?

The majority of people who use Systane Ultra experience no side effects at all. When side effects do occur, they are usually mild and short-lived. The most frequently reported effects are directly related to the instillation of the drops rather than any systemic reaction.

  • Temporary blurred vision immediately after applying the drops — this typically clears within one to two minutes
  • Mild stinging or burning sensation on instillation
  • A brief feeling of eye discomfort or watering

What Are the Less Common Side Effects of Systane Ultra Eye Drops?

Less commonly, some people may notice more persistent effects, particularly if they are sensitive to the preservative Polyquad (polidronium chloride) contained in the formulation. If any of the following occur and do not resolve quickly, stop using the drops and seek advice from your pharmacist or GP.

  • Persistent eye redness or irritation lasting more than a few minutes after use
  • Itching or a feeling of something in the eye
  • Sticky eyelids or discharge
  • Eyelid swelling or puffiness

What Are the Serious Side Effects of Systane Ultra Eye Drops?

Serious side effects are rare with topical ocular lubricants. However, you should stop using Systane Ultra immediately and seek urgent medical attention if you experience any of the following, as they may indicate a more serious eye condition or allergic reaction:

  • Sudden or significant change in vision
  • Severe eye pain
  • Signs of a serious allergic reaction — including facial swelling, difficulty breathing, or a widespread rash
  • Increasing redness, discharge, or photophobia (sensitivity to light) that suggests possible eye infection

What Should You Do If You Experience Side Effects of Systane Ultra?

For mild, transient side effects such as brief stinging or temporary blurred vision, no action is usually needed — these resolve on their own within minutes. If you experience persistent or worsening symptoms, discontinue use and consult your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Systane Ultra Eye Drops Interact With Other Medicines?

Systane Ultra has no known clinically significant interactions with systemic medicines, as absorption through the eye into the bloodstream is negligible. If you use other eye drops or eye ointments, allow at least five minutes between each product to prevent dilution and ensure proper absorption. Always apply eye ointments last in your routine, as they can reduce the effectiveness of drops applied afterwards.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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