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Syndol Headache Relief - 30 Tablets

Syndol Headache Relief - 30 Tablets

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  • ✔️ Combines four active ingredients for multi-mechanism headache relief
  • ✔️ Targets tension headaches with a mild muscle-relaxant component
  • ✔️ Caffeine enhances paracetamol and codeine absorption for faster relief
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ 30-tablet pack provides multiple doses for short-term pain management

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What Are Syndol Headache Relief Tablets?

 

Headaches can stop you in your tracks — whether it's a dull tension headache building through a long workday or a more persistent ache that paracetamol alone just isn't shifting. Syndol headache relief tablets are a well-established, over-the-counter option that combines four active ingredients to tackle headache pain from multiple angles at once. Each pack contains 30 tablets, priced at £6.79, making them a practical choice for adults who need reliable relief without a prescription. You can browse our full pain relief collection if you're looking for additional options alongside Syndol.

Syndol has been used in the UK for decades and remains one of the few OTC analgesics to include both codeine phosphate and doxylamine succinate alongside paracetamol and caffeine. That combination is what sets it apart from standard single-ingredient headache tablets. It's classified as a pharmacy (P) medicine in the UK, which means it's available without a prescription but must be sold under pharmacist supervision — including online, where a short suitability questionnaire is required.

 

How Does Syndol Work to Relieve Headaches?

 

Syndol's four-ingredient formula targets headache pain through complementary mechanisms, which is why it tends to work when simpler analgesics fall short. Here's how each component contributes:

  • Paracetamol (450mg): Inhibits the production of prostaglandins in the brain, reducing the perception of pain and lowering fever if present.
  • Codeine phosphate (10mg): A mild opioid analgesic that binds to opioid receptors in the central nervous system, enhancing pain relief beyond what paracetamol achieves alone.
  • Caffeine (30mg): Acts as an adjuvant analgesic — it improves the absorption and efficacy of both paracetamol and codeine, and causes mild vasoconstriction that can help relieve vascular headache pain.
  • Doxylamine succinate (5mg): An antihistamine with sedative and mild muscle-relaxant properties, particularly useful for tension headaches where muscle tightness around the scalp and neck plays a role.

Together, these ingredients address both the neurological and muscular components of tension-type headaches, which is why Syndol is often recommended when standard paracetamol or ibuprofen hasn't provided enough relief.

 

Who Is Syndol Suitable For?

 

Syndol is intended for adults and young people aged 12 and over who are experiencing mild to moderate pain, particularly tension headaches. It's especially useful when over-the-counter single-ingredient analgesics haven't been sufficient. That said, it's not appropriate for everyone — the codeine content means careful patient selection is essential.

Syndol may be suitable for you if:

  • You are aged 12 or over and in generally good health
  • You experience tension-type headaches that haven't responded adequately to paracetamol or ibuprofen alone
  • You do not have liver or kidney impairment
  • You are not pregnant, breastfeeding, or planning to become pregnant
  • You are not taking other codeine-containing medicines, MAOIs, or sedative drugs

 

How Does Syndol Compare to Other Headache Tablets?

 

Feature Syndol (30 Tablets) Standard Paracetamol (500mg)
Active ingredients Paracetamol, codeine, caffeine, doxylamine Paracetamol only
Suitable for tension headaches Yes — muscle-relaxant component included Partial — no muscle-relaxant action
Causes drowsiness Yes — doxylamine is sedating No
UK classification Pharmacy (P) medicine General Sale (GSL)

 

Is Syndol Safe to Store at Home?

 

Syndol headache relief tablets should be stored below 25°C in a dry place, away from direct sunlight and out of the reach and sight of children. Do not use the tablets after the expiry date printed on the packaging. Because the product contains codeine — a controlled drug component — it's important to keep it securely stored and never share it with others, even if they have similar symptoms. If you're managing multiple health conditions and need to keep various medicines at home, it's worth reviewing your storage arrangements with your pharmacist.

If you're looking for complementary health products, our vitamins and supplements range includes options that support general wellbeing alongside your pain management routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Syndol Headache Relief 30 Tablets specifications
Treatment category Headache and mild to moderate pain relief
Mechanism of action Analgesic, opioid receptor agonist, adjuvant analgesic, antihistamine/muscle relaxant
Effective for Tension headaches, mild to moderate pain
Suitable for Adults and children aged 12 and over
Active ingredients Paracetamol 450mg, Codeine phosphate 10mg, Caffeine 30mg, Doxylamine succinate 5mg
Pack size 30 tablets
UK classification Pharmacy (P) medicine
Drug class Compound analgesic
Preparation Film-coated tablet
Route of administration Oral

Specifications of Syndol Headache Relief 30 Tablets

 

What Is Syndol and What Is It Used For?

 

Syndol Headache Relief tablets are a compound analgesic medicine used to relieve tension headaches and mild to moderate pain in adults and young people aged 12 and over. Each tablet contains four active ingredients — paracetamol 450mg, codeine phosphate 10mg, caffeine 30mg, and doxylamine succinate 5mg — working together to provide multi-mechanism pain relief. It is classified as a Pharmacy (P) medicine in the UK, meaning it is available without a prescription but only through a registered pharmacy.

 

What Do You Need to Know Before Using Syndol?

 

Before taking Syndol, it's essential to check whether it is appropriate for you. The codeine content in particular carries specific risks and contraindications that you must be aware of.

Do not take Syndol if you:

  • Are under 12 years of age
  • Are pregnant or breastfeeding
  • Have liver disease, hepatitis, or significant kidney impairment
  • Are a known codeine ultra-rapid metaboliser (a genetic variation that causes codeine to convert to morphine too quickly, increasing overdose risk)
  • Have a history of alcohol dependence or drug misuse
  • Are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days
  • Are allergic to paracetamol, codeine, caffeine, doxylamine, or any other ingredient in the tablet
  • Have respiratory depression or severe asthma

Medicines that may interact with Syndol include:

  • Other paracetamol-containing products — risk of paracetamol overdose
  • Other codeine or opioid-containing medicines
  • Sedatives, sleeping tablets, or anxiolytics — increased drowsiness
  • Anticoagulants such as warfarin — paracetamol may enhance anticoagulant effect with prolonged use
  • Metoclopramide or domperidone — may alter paracetamol absorption
  • Alcohol — significantly increases sedation and liver risk

 

How Should You Take Syndol Tablets?

 

Always read the patient information leaflet supplied with your pack before taking Syndol. Follow these steps carefully:

  1. Swallow 2 tablets whole with a full glass of water.
  2. Do not crush or chew the tablets.
  3. Wait at least 4 hours before taking another dose.
  4. Do not take more than 8 tablets in any 24-hour period.
  5. Do not take for more than 3 days without seeking medical advice.
  6. Avoid alcohol while taking Syndol.
  7. Do not drive or operate machinery — doxylamine causes drowsiness.
Indication Age Group Dose Frequency
Tension headache / mild to moderate pain Adults and children aged 12+ 2 tablets Every 4–6 hours (max 8 tablets/24 hrs)
Not applicable Under 12 years Do not use — contraindicated

If you're also managing other conditions and need to keep track of multiple medicines, our first aid range includes useful home health essentials to support your wellbeing.

 

What Are the Possible Side Effects of Syndol?

 

Like all medicines, Syndol can cause side effects, although not everyone experiences them. The doxylamine and codeine components are the most likely sources of noticeable effects.

Common side effects:

  • Drowsiness or sedation
  • Dizziness
  • Constipation
  • Nausea
  • Dry mouth

Less common side effects:

  • Blurred vision
  • Difficulty urinating
  • Skin rash or itching
  • Headache on stopping the medicine (medication-overuse headache with prolonged use)
  • Dependence or withdrawal symptoms with prolonged or excessive use of codeine

Stop taking Syndol and seek immediate medical attention if you experience signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction. Codeine can cause breathing difficulties in rare cases, particularly in children and those with sleep apnoea.

 

How Should You Store Syndol Tablets?

 

Correct storage helps maintain the safety and effectiveness of your tablets. For those managing pain alongside other conditions, our cold and flu range offers additional symptom relief options that may complement your headache management.

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not store in a bathroom or near a sink
  • Do not share with others, even if they have similar symptoms
  • Return unused or expired tablets to your pharmacist for safe disposal — do not flush or bin them

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Syndol headache relief tablets online in the UK?

You can buy Syndol Headache Relief 30 Tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy, for £6.79. Because Syndol contains codeine, you'll need to complete a short suitability questionnaire before your order is approved — this is a legal requirement for all UK online pharmacies selling codeine-containing medicines. Once approved, your order is dispatched promptly to your door. You can find Syndol alongside other options in our pain relief collection.

How does Syndol work in the body?

Syndol works through four complementary mechanisms. Paracetamol reduces pain signals in the brain by inhibiting prostaglandin synthesis. Codeine phosphate binds to opioid receptors in the central nervous system to enhance analgesia. Caffeine acts as an adjuvant that improves the absorption and effectiveness of the other analgesics. Doxylamine succinate provides mild muscle relaxation and sedation, which is particularly helpful for tension headaches caused by muscle tightness in the scalp and neck.

How do I take Syndol tablets step by step?

Take 2 Syndol tablets with a full glass of water. Do not crush or chew them. Wait at least 4 hours before taking another dose, and never exceed 8 tablets in any 24-hour period. Because doxylamine causes drowsiness, avoid driving or operating machinery after taking Syndol, and do not drink alcohol while using this medicine.

What is the maximum daily dose of Syndol?

The maximum dose is 8 tablets in any 24-hour period for adults and young people aged 12 and over. Each dose is 2 tablets, taken every 4 to 6 hours as needed. Never exceed this limit — the paracetamol content (450mg per tablet, 3,600mg at maximum daily dose) can cause serious liver damage in overdose, even if you feel well initially.

What are the side effects of Syndol and how do I manage them?

The most common side effects are drowsiness, dizziness, constipation, nausea, and dry mouth — mainly caused by the doxylamine and codeine components. To manage drowsiness, avoid taking Syndol before driving or any activity requiring alertness. For constipation, increase your fluid and fibre intake. If side effects are severe or persistent, stop taking Syndol and speak to your pharmacist or GP.

Who should not take Syndol headache relief tablets?

Syndol is not suitable for children under 12, pregnant or breastfeeding women, people with liver or kidney disease, those who are codeine ultra-rapid metabolisers, or anyone taking MAOIs. It should also be avoided by people with a history of drug or alcohol dependence, respiratory depression, or severe asthma. Always complete the online suitability check before purchasing.

Can I take Syndol if I am pregnant or breastfeeding?

No — Syndol is not recommended during pregnancy or breastfeeding. Codeine can pass into breast milk and cause serious breathing problems in a nursing baby, particularly if the mother is a rapid metaboliser of codeine. Doxylamine also carries risks during pregnancy. Speak to your GP or midwife about safe alternatives for headache relief during pregnancy or while breastfeeding.

How long can I use Syndol for?

Syndol should not be used for more than 3 consecutive days without seeking medical advice. Prolonged use of codeine-containing medicines can lead to physical dependence and, paradoxically, medication-overuse headache — a condition where frequent analgesic use actually causes more frequent headaches. If your headaches are recurring or worsening, speak to your GP rather than continuing to self-medicate.

What happens if I miss a dose of Syndol?

Syndol is taken as needed for pain relief rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take your next dose when you need it, ensuring at least 4 hours have passed since your last dose. Never double up to compensate — this could take you over the safe daily limit for paracetamol and codeine.

Can I take Syndol with ibuprofen or other painkillers?

You should not take Syndol alongside other paracetamol-containing products, as this risks paracetamol overdose. Taking Syndol with ibuprofen is generally considered safe for short-term use in adults without contraindications to NSAIDs, but always check with your pharmacist first. Never combine Syndol with other codeine or opioid medicines, sedatives, or alcohol.

Does Syndol cause drowsiness — can I drive after taking it?

Yes, Syndol causes drowsiness due to the doxylamine succinate content. You must not drive, cycle, or operate heavy machinery after taking Syndol. Under UK law, driving while impaired by a medicine — even an OTC one — is an offence. Plan to rest after taking Syndol, particularly if you are taking it for the first time and are unsure how it will affect you.

What are the alternatives to Syndol for headache relief?

Alternatives include standard paracetamol (500mg), ibuprofen, aspirin, or combination products such as paracetamol with caffeine. For migraine specifically, triptans (available on prescription) may be more appropriate. If you're looking for a broader range of options, explore our pain relief collection for other OTC analgesics. Always speak to your pharmacist if you're unsure which product is right for your type of headache.

Is Syndol suitable for children?

Syndol is not suitable for children under 12 years of age. The codeine content poses a serious risk of respiratory depression in younger children, and the MHRA has restricted codeine use in under-12s entirely. For children's pain and fever relief, age-appropriate paracetamol or ibuprofen liquid formulations are the recommended options — speak to your pharmacist or check the NHS website for guidance.

Can Syndol become addictive?

Yes — codeine is an opioid and carries a risk of dependence, even at the low dose found in Syndol. The risk is higher with prolonged use, higher doses, or in people with a personal or family history of substance misuse. Syndol should only be used for short-term pain relief (no more than 3 days) and should never be taken more frequently or in higher doses than directed on the label.

What are the latest findings on codeine-containing headache tablets?

Regulatory bodies including the MHRA and NHS continue to highlight the risk of medication-overuse headache (MOH) with frequent use of codeine-containing analgesics. Clinical guidance recommends limiting use to no more than 10 to 15 days per month to avoid MOH. There is also ongoing emphasis on the risks of codeine in children and breastfeeding mothers, leading to tighter restrictions on OTC codeine products in recent years. Always follow current NHS and MHRA guidance when using Syndol headache relief tablets.

How Should You Use Syndol Headache Relief Tablets?

Syndol tablets are taken orally with water. Always read the patient information leaflet included in your pack before taking this medicine, and follow the steps below carefully to use it safely and effectively.

If your headache does not improve after taking Syndol, do not take an additional dose sooner than the 4-hour interval. Seek advice from your pharmacist or GP if pain persists or worsens.

What Is the Correct Dose of Syndol?

The recommended dose for adults and young people aged 12 and over is 2 tablets per dose. Do not adjust this dose without medical advice, and never take more than the maximum daily amount — the paracetamol content means exceeding the limit carries a serious risk of liver damage, even if you feel well at the time.

When Is the Best Time to Use Syndol?

Syndol is best taken at the onset of a headache, before the pain becomes severe. Taking it early tends to produce faster and more effective relief than waiting until the headache is fully established. Because doxylamine causes drowsiness, many people find it most convenient to take Syndol in the evening or when they are able to rest — this also allows the sedative effect to work in your favour rather than interfering with daily activities.

Avoid taking Syndol first thing in the morning if you need to drive or work, unless you have confirmed that it does not cause significant drowsiness for you personally. Taking it with or after food may help reduce any nausea.

How Long Can You Use Syndol For?

Syndol is intended for short-term use only. Do not take it for more than 3 consecutive days without seeking medical advice. Using codeine-containing medicines too frequently — more than 10 to 15 days per month — can lead to medication-overuse headache, a condition where the medicine itself begins to cause more frequent headaches over time. If you find yourself reaching for Syndol regularly, speak to your GP about investigating the underlying cause of your headaches and exploring longer-term management strategies.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Syndol?

Most people who take Syndol tolerate it well when used as directed, but side effects can occur. The most frequently reported effects are linked to the doxylamine and codeine components. If you experience any of the following, they are generally mild and tend to resolve once you stop taking the medicine.

  • Drowsiness or sedation
  • Dizziness or light-headedness
  • Constipation
  • Nausea or stomach discomfort
  • Dry mouth

What Are the Less Common Side Effects of Syndol?

Some people may experience less frequent side effects, particularly with repeated use or if they are more sensitive to any of the active ingredients. These are worth being aware of, even if they are unlikely to affect you.

  • Blurred vision
  • Difficulty passing urine (urinary retention)
  • Skin rash or itching
  • Confusion or difficulty concentrating
  • Medication-overuse headache with prolonged or frequent use
  • Dependence or withdrawal symptoms if codeine is used for extended periods

What Are the Serious Side Effects of Syndol?

Serious side effects are rare but require immediate medical attention. Stop taking Syndol straight away and call 999 or go to your nearest A&E if you experience any of the following:

  • Signs of a severe allergic reaction — swelling of the face, lips, tongue, or throat; difficulty breathing; widespread skin rash or hives
  • Difficulty breathing or slow, shallow breathing (respiratory depression — a known risk with codeine, particularly in children and those with sleep apnoea)
  • Yellowing of the skin or eyes, dark urine, or severe abdominal pain (signs of liver damage from paracetamol overdose)
  • Extreme drowsiness or loss of consciousness

What Should You Do If You Experience Side Effects?

For mild side effects such as drowsiness or nausea, rest and avoid driving until the effects wear off. Staying well hydrated and taking Syndol with food can help reduce stomach discomfort. If constipation is a problem, increase your fluid and dietary fibre intake. Do not take additional doses to try to counteract side effects — this will only increase your risk of further problems.

If you are concerned about any side effect, or if a side effect is severe, persistent, or unexpected, stop taking Syndol and contact your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Syndol Interact With Other Medicines?

Yes — Syndol has several clinically significant interactions. Taking it alongside other paracetamol-containing products risks exceeding the safe daily paracetamol limit. Combining it with other opioids, sedatives, sleeping tablets, or alcohol significantly increases the risk of respiratory depression and excessive sedation. Warfarin users should be aware that regular paracetamol use can enhance the anticoagulant effect, increasing bleeding risk. Always tell your pharmacist about all medicines, supplements, and herbal products you are taking before starting Syndol.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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