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Spedra (Avanafil) Tablets

Spedra (Avanafil) Tablets

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  • ✔️ Treats erectile dysfunction with onset in as little as 15 minutes
  • ✔️ Available in three strengths: 50mg, 100mg, and 200mg
  • ✔️ Clinically proven PDE5 inhibitor with up to 6 hours of effect
  • ✔️ Suitable for men with ED linked to diabetes or cardiovascular conditions
  • ✔️ Can be taken with or without food for flexible, on-demand use

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What Are Spedra Tablets and Can You Buy Spedra Tablets Online?

 

Erectile dysfunction (ED) affects a significant number of men in the UK — and it's far more common than many people realise. If you've been struggling to get or maintain an erection, you're not alone, and there are effective, clinically proven treatments available. Buy Spedra tablets online from Cured Pharmacy and access a fast-acting, prescription-strength treatment from the comfort of your home. Spedra contains avanafil, a selective phosphodiesterase type 5 (PDE5) inhibitor licensed in the UK for the treatment of erectile dysfunction in adult men. It's available in three strengths — 50mg, 100mg, and 200mg — and is taken on demand, roughly 15 to 30 minutes before sexual activity.

Spedra is a prescription-only medicine (POM) in the UK, which means you'll need a valid prescription before it can be dispensed. At Cured Pharmacy, our GPhC-registered team reviews your consultation carefully to ensure this treatment is appropriate for you. If you're also managing other aspects of your health, you might find our men's health range useful alongside your ED treatment.

 

How Does Spedra (Avanafil) Work in the Body?

 

Spedra works by targeting a specific enzyme called PDE5, which is found in the smooth muscle of the penis. During sexual stimulation, nitric oxide is released, which triggers the production of cyclic GMP (cGMP) — a chemical that relaxes smooth muscle and allows blood to flow into the erectile tissue. PDE5 normally breaks down cGMP, limiting this response. Avanafil inhibits PDE5, allowing cGMP to accumulate and sustain the relaxation needed for an erection.

  • Sexual stimulation triggers nitric oxide release in penile tissue
  • Nitric oxide increases cGMP levels, relaxing smooth muscle
  • Avanafil blocks PDE5, preventing cGMP breakdown
  • Blood flow to the penis increases, supporting an erection
  • Without sexual arousal, Spedra will not produce an erection

 

Who Is Spedra Suitable For?

 

Spedra is indicated for adult men (aged 18 and over) who experience erectile dysfunction — defined as the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It's particularly well-suited to men who want a fast-acting option, as it can begin working in as little as 15 minutes in some individuals.

  • Men with mild to severe erectile dysfunction
  • Men who prefer a fast-acting, on-demand treatment
  • Men who have not responded well to other PDE5 inhibitors
  • Men whose ED has a psychological or mixed aetiology

 

How Does Spedra Compare to Other ED Treatments?

 

Feature Spedra (Avanafil) Sildenafil (Viagra) Tadalafil (Cialis)
Onset of action As little as 15 minutes 30–60 minutes 30–60 minutes
Duration of effect Up to 6 hours 4–6 hours Up to 36 hours
Dosing frequency Once daily (on demand) Once daily (on demand) Once daily or on demand
Food interaction Minimal effect with food High-fat meals delay onset Minimal effect with food

 

How Should You Store Spedra and Is It Clinically Suitable for You?

 

Store Spedra tablets below 30°C in their original blister packaging, away from moisture and direct sunlight. Keep them out of the reach and sight of children. Do not use tablets past the expiry date printed on the pack. Before you buy Spedra tablets online, it's important to confirm that avanafil is appropriate for your individual health profile — particularly if you have cardiovascular disease, liver or kidney impairment, or are taking other medicines that may interact.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Spedra (Avanafil) Tablets specifications
Treatment category Erectile dysfunction
Active ingredient Avanafil
Mechanism of action Selective PDE5 inhibitor
Strengths 50mg, 100mg, 200mg
Pack sizes 4 tablets, 8 tablets
UK classification Prescription-only medicine (POM)
Drug class PDE5 inhibitor
Preparation Film-coated tablet
Route of administration Oral
Suitable for Adult men aged 18 and over
Effective In as little as 15 minutes

Specifications of Spedra (Avanafil) Tablets

 

What Is Spedra and What Is It Used For?

 

Spedra contains the active ingredient avanafil and belongs to a group of medicines called PDE5 inhibitors. It is used to treat erectile dysfunction in adult men — that is, when a man cannot get or keep an erection firm enough for sexual activity. Spedra does not cure erectile dysfunction, nor does it increase sexual desire. It works only when you are sexually stimulated. It is not intended for use in women or children.

 

What Do You Need to Know Before Using Spedra?

 

Do not take Spedra if any of the following apply to you:

  • You are taking nitrates (e.g. glyceryl trinitrate, isosorbide mononitrate) for chest pain — this combination can cause a dangerous drop in blood pressure
  • You are taking nitric oxide donors such as amyl nitrite ("poppers")
  • You have severe liver impairment
  • You have had a recent stroke, heart attack, or have unstable angina
  • You have low blood pressure (hypotension) or uncontrolled high blood pressure
  • You have a rare inherited eye condition such as retinitis pigmentosa
  • You are under 18 years of age

Tell your doctor or pharmacist if you are taking any of the following, as they may interact with Spedra:

  • Alpha-blockers (e.g. tamsulosin, doxazosin) — used for prostate problems or high blood pressure
  • Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, or clarithromycin
  • Moderate CYP3A4 inhibitors such as erythromycin, fluconazole, or diltiazem — dose adjustment may be needed
  • Other PDE5 inhibitors — do not combine
  • Antihypertensive medicines — increased risk of low blood pressure

 

How Should You Use Spedra?

 

Always use Spedra exactly as your doctor or pharmacist has told you. Do not take more than one tablet in any 24-hour period. Spedra can be taken with or without food, though a high-fat meal may slightly delay the onset of action.

  1. Take one Spedra tablet approximately 15–30 minutes before anticipated sexual activity
  2. Swallow the tablet whole with a glass of water
  3. Ensure you are sexually stimulated — the tablet will not work without arousal
  4. Do not take more than one tablet within 24 hours
  5. If you feel the effect is too strong or too weak, speak to your doctor about adjusting your dose
Indication Age Group Starting Dose Maximum Dose
Erectile dysfunction Adults (18+) 100mg 200mg per 24 hours
ED with moderate CYP3A4 inhibitor Adults (18+) 50mg 100mg per 24 hours
ED in elderly patients (≥65 years) 65 and over 50mg 200mg per 24 hours (with caution)

 

What Are the Possible Side Effects of Spedra?

 

Like all medicines, Spedra can cause side effects, although not everyone gets them. Most side effects are mild and short-lived. If you experience any side effect that concerns you, stop taking Spedra and speak to your doctor or pharmacist. You can also explore our condoms and sexual health range for complementary products to support your sexual wellbeing.

Common side effects (may affect up to 1 in 10 people):

  • Headache
  • Flushing (redness or warmth in the face, neck, or chest)
  • Nasal congestion or runny nose
  • Dizziness
  • Back pain

Less common side effects (may affect up to 1 in 100 people):

  • Nausea
  • Palpitations
  • Visual disturbances (blurred vision, changes in colour perception)
  • Fatigue
  • Low blood pressure (hypotension)

Seek immediate medical attention if you experience a prolonged erection lasting more than 4 hours (priapism), sudden loss of vision, or sudden hearing loss. These are rare but serious effects that require urgent care.

 

How Should You Store Spedra?

 

  • Store below 30°C
  • Keep in the original blister packaging to protect from moisture
  • Do not store in the bathroom or near a heat source
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you have any questions about your treatment or want to explore other aspects of your health, our vitamins and supplements collection may support your overall wellbeing alongside your prescribed treatment.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Spedra tablets online in the UK?

You can buy Spedra tablets online in the UK through a GPhC-registered online pharmacy such as Cured Pharmacy, after completing a short online consultation to confirm the treatment is suitable for you. Spedra is a prescription-only medicine, so a valid prescription or clinician-approved consultation is required before it can be dispensed. Our pharmacy team reviews every order to ensure your safety before dispatch.

How does Spedra (avanafil) work in the body?

Spedra works by selectively inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is found in the smooth muscle tissue of the penis. When you are sexually stimulated, nitric oxide is released, which increases levels of cyclic GMP — a chemical that relaxes smooth muscle and allows blood to flow into the erectile tissue. By blocking PDE5, avanafil prevents cGMP from breaking down too quickly, sustaining the blood flow needed for an erection.

How quickly does Spedra start working?

Spedra can begin working in as little as 15 minutes in some men, which makes it one of the fastest-acting oral ED treatments currently available in the UK. The effect can last for up to 6 hours, though individual response will vary depending on factors such as age, dose, and overall health. It will only work if you are sexually aroused — it does not produce an erection on its own.

What is the correct dose of Spedra to take?

The usual starting dose of Spedra is 100mg, taken approximately 15 to 30 minutes before sexual activity. Your doctor may lower this to 50mg if you experience side effects, or increase it to 200mg if the 100mg dose is not effective enough. You should never take more than one tablet in any 24-hour period.

Can I take Spedra with food or alcohol?

Spedra can be taken with or without food, and a light meal is unlikely to significantly affect how quickly it works. However, a high-fat meal may slightly delay the onset of action, so it's worth bearing this in mind if you want the fastest possible effect. Alcohol should be limited when taking Spedra, as it can increase the risk of side effects such as dizziness and low blood pressure.

Who is not suitable for Spedra?

Spedra is not suitable for men who take nitrates for chest pain, as the combination can cause a dangerous and potentially life-threatening drop in blood pressure. It is also not recommended for men with severe liver disease, recent stroke or heart attack, uncontrolled blood pressure, or those under 18 years of age. Always complete a full medical consultation before starting treatment.

What are the most common side effects of Spedra?

The most commonly reported side effects of Spedra include headache, flushing, nasal congestion, dizziness, and back pain. These effects are generally mild and tend to resolve on their own without any specific treatment. If side effects are persistent or troublesome, speak to your pharmacist or GP about adjusting your dose or switching to an alternative.

What should I do if I experience a prolonged erection after taking Spedra?

If you experience an erection lasting longer than 4 hours — a condition known as priapism — you should seek emergency medical attention immediately, as this can cause permanent damage to penile tissue if left untreated. This is a rare but serious side effect that requires urgent care. Do not take another dose of Spedra while waiting for medical help.

How does Spedra compare to Viagra (sildenafil)?

Spedra (avanafil) generally works faster than Viagra (sildenafil), with some men noticing an effect in as little as 15 minutes compared to 30 to 60 minutes for sildenafil. Both belong to the same class of medicines (PDE5 inhibitors) but differ in their selectivity, which may mean fewer off-target side effects with avanafil for some men. The right choice depends on your individual health profile and preferences — your prescriber can help you decide.

Can Spedra be taken alongside other medicines?

Spedra can interact with several medicines, including nitrates, alpha-blockers, and strong CYP3A4 inhibitors such as ketoconazole or ritonavir. If you are taking any of these, Spedra may be contraindicated or require a dose adjustment. Always tell your prescriber or pharmacist about all medicines, supplements, and herbal remedies you are currently taking before starting Spedra.

Is Spedra available on the NHS?

Spedra can be prescribed on the NHS in certain circumstances, particularly for men whose erectile dysfunction is linked to specific medical conditions such as diabetes, multiple sclerosis, or prostate cancer treatment. In other cases, it may be prescribed privately. Your GP can advise whether you qualify for NHS prescribing or whether a private prescription is more appropriate for your situation.

How long can I keep taking Spedra?

Spedra is an on-demand treatment, meaning you take it only when needed rather than every day, so there is no fixed treatment duration. Many men use it safely over the long term, but it is good practice to review your treatment with your GP periodically to ensure it remains appropriate. If your erectile dysfunction improves or changes, your doctor may recommend adjusting or stopping treatment.

What happens if I miss a dose of Spedra?

Because Spedra is taken on demand rather than on a fixed daily schedule, there is no concept of a "missed dose" in the traditional sense — you simply take it when you plan to be sexually active. Never take two tablets to make up for a missed one, and never take more than one tablet within any 24-hour period. If you are unsure about your dosing schedule, speak to your pharmacist.

Are there any lifestyle changes that can help alongside Spedra?

Yes — lifestyle factors play a significant role in erectile function, and making positive changes can improve how well treatments like Spedra work for you. The NHS recommends losing weight if you are overweight, stopping smoking, reducing alcohol intake, exercising regularly, and managing stress or anxiety. You might also find our men's health range helpful for supporting your overall wellbeing alongside your ED treatment.

What are the latest research findings on avanafil (Spedra)?

Clinical studies have consistently shown that avanafil is effective and well-tolerated in men with erectile dysfunction across a range of severities, including those with diabetes and cardiovascular risk factors. Research has highlighted its faster onset compared to other PDE5 inhibitors as a clinically meaningful advantage for many patients. If you'd like to explore other aspects of your sexual health, our condoms and sexual health collection offers a range of complementary products.

How Should You Use Spedra?

Spedra is taken by mouth as a film-coated tablet. Always follow the instructions given by your prescriber or pharmacist, and read the patient information leaflet supplied with your pack before you start treatment.

If you are unsure about any step, speak to your pharmacist before taking your first dose.

What Is the Correct Dose of Spedra?

The recommended starting dose for most adult men is 100mg. Your prescriber may adjust this based on how well you respond and whether you experience any side effects. The table below summarises the dosing guidance for different patient groups.

When Is the Best Time to Use Spedra?

Take Spedra approximately 15 to 30 minutes before anticipated sexual activity. Because it works faster than many other ED treatments, you do not need to plan as far in advance — making it a practical option for men who prefer spontaneity. Avoid taking it immediately after a large, high-fat meal, as this may delay how quickly it takes effect.

There is no fixed time of day that is "best" — simply take it when you need it, provided you have not already taken a dose within the previous 24 hours.

How Long Can You Use Spedra For?

Spedra is an on-demand treatment, so you only take it when needed rather than every day. There is no set maximum duration of use, and many men take it safely over the long term. However, it is good practice to review your treatment with your GP at least once a year to ensure it remains appropriate for your health needs.

If your erectile dysfunction improves significantly — for example, following lifestyle changes or treatment of an underlying condition — your doctor may advise reducing or stopping Spedra. Never stop or change your dose without speaking to your prescriber first.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Spedra?

Like all medicines, Spedra can cause side effects, though not everyone experiences them. The most commonly reported side effects tend to be mild and short-lived, often resolving on their own as your body adjusts to the medicine.

  • Headache
  • Flushing (redness or warmth in the face, neck, or chest)
  • Nasal congestion or runny nose
  • Dizziness
  • Back pain

What Are the Less Common Side Effects of Spedra?

Some men experience side effects that occur less frequently. These are still worth being aware of, particularly if you have other health conditions or are taking additional medicines.

  • Nausea or stomach discomfort
  • Palpitations (awareness of your heartbeat)
  • Visual disturbances, including blurred vision or changes in colour perception
  • Fatigue or tiredness
  • Low blood pressure (hypotension), particularly when standing up quickly
  • Skin redness or rash

What Are the Serious Side Effects of Spedra?

Serious side effects from Spedra are rare, but they do require immediate medical attention if they occur. Do not ignore these symptoms or wait to see if they resolve on their own.

  • Priapism — a prolonged, painful erection lasting more than 4 hours. This is a medical emergency and can cause permanent damage if not treated promptly
  • Sudden loss of vision in one or both eyes — stop taking Spedra immediately and seek urgent medical help
  • Sudden decrease or loss of hearing, sometimes accompanied by ringing in the ears or dizziness
  • Severe allergic reaction — symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread rash
  • Chest pain or irregular heartbeat — seek emergency care immediately

What Should You Do If You Experience Side Effects?

If you experience any side effect that worries you, stop taking Spedra and contact your GP or pharmacist as soon as possible. For serious or life-threatening reactions — such as priapism, sudden vision loss, or chest pain — call 999 or go to your nearest A&E department immediately. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Mild side effects such as headache or flushing often improve with continued use or a dose reduction. Your prescriber can help you find the right balance between effectiveness and tolerability.

Can Spedra Interact With Other Medicines?

Yes — Spedra has several clinically significant drug interactions that you must be aware of before starting treatment. Taking Spedra alongside nitrates (used for angina or chest pain) can cause a severe and potentially life-threatening drop in blood pressure. Alpha-blockers used for prostate conditions or hypertension can also lower blood pressure further when combined with avanafil. Strong CYP3A4 inhibitors — including ketoconazole, itraconazole, ritonavir, and clarithromycin — significantly increase avanafil blood levels and are contraindicated. Moderate CYP3A4 inhibitors such as erythromycin or fluconazole require a dose reduction. Always tell your prescriber and pharmacist about every medicine, supplement, or herbal remedy you are taking before using Spedra.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Frequently Asked Question

Spedra (Avanafil) is a quick-acting treatment for erectile dysfunction (ED), which means it is significantly faster than other types of ED medication.

Spedra works to change that – making it quicker and easier for you to get an erection through improved blood flow where it counts. Most users report feeling more confident, relaxed, and satisfied — without the stress or pressure that ED can cause. 

Spedra is taken only when needed, so you don’t have to worry about missed doses.

No, it’s not recommended for men with certain heart conditions, very low blood pressure, or those taking nitrate medicines. Always check with your pharmacist before starting.

Yes, but they may start on a lower dose (such as 50mg) to minimize side effects.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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What is Spedra used for? 

Spedra (Avanafil) is a quick-acting treatment for erectile dysfunction (ED), which means it is significantly faster than other types of ED medication.

How does Spedra work? 

Spedra works to change that – making it quicker and easier for you to get an erection through improved blood flow where it counts. Most users report feeling more confident, relaxed, and satisfied — without the stress or pressure that ED can cause. 

What should I do if I forget to take it? 

Spedra is taken only when needed, so you don’t have to worry about missed doses.

Is Spedra suitable for everyone? 

No, it’s not recommended for men with certain heart conditions, very low blood pressure, or those taking nitrate medicines. Always check with your pharmacist before starting.

Can older men take Spedra?  Yes, but they may start on a lower dose (such as 50mg) to minimize side effects.