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Solpadeine Plus Soluble- 24 Tablets

Solpadeine Plus Soluble- 24 Tablets

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  • ✔️ Relieves moderate headache, migraine, and dental pain effectively
  • ✔️ Triple-action formula: paracetamol, codeine, and caffeine combined
  • ✔️ Soluble tablets absorb faster than standard solid analgesics
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Convenient 24-tablet pack for acute pain relief at home

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What Are Solpadeine Plus Soluble Tablets Used For?

 

If you've ever had a headache that just won't shift with ordinary paracetamol, you'll know how frustrating that can be. Solpadeine plus soluble tablets are an effervescent, triple-action analgesic designed for exactly those moments — when moderate pain needs something a little more targeted. Each pack contains 24 soluble tablets, making it a practical option to keep at home or in your bag for when pain strikes unexpectedly. You can browse our full pain relief collection if you're looking for other options alongside this product.

Each tablet contains three active ingredients: paracetamol 500 mg, codeine phosphate 8 mg, and caffeine 30 mg. This combination is specifically formulated to tackle moderate pain — including headaches, migraines, dental pain, period pain, and muscular aches — that hasn't responded adequately to paracetamol or ibuprofen alone. Because the tablets dissolve in water before you drink them, they're absorbed relatively quickly compared to standard solid tablets, which can be a real advantage when you need relief fast.

 

How Do Solpadeine Plus Soluble Tablets Work?

 

The three-ingredient formula works through complementary mechanisms, each contributing to overall pain relief:

  • Paracetamol (500 mg): Acts centrally in the brain to reduce the perception of pain and lower fever. It inhibits prostaglandin synthesis in the central nervous system, making it effective for a wide range of pain types.
  • Codeine phosphate (8 mg): A mild opioid analgesic that is converted to morphine in the body. It binds to opioid receptors in the brain and spinal cord, enhancing the pain-relieving effect of paracetamol for moderate pain that wouldn't otherwise respond.
  • Caffeine (30 mg): Thought to potentiate the analgesic effect of paracetamol by increasing its absorption and central activity. It also causes mild vasoconstriction, which may help with vascular headaches such as migraines.

Because the tablets are soluble, the active ingredients enter your bloodstream faster than a standard tablet — a meaningful benefit when you're dealing with a throbbing headache or acute pain.

 

Who Is Solpadeine Plus Suitable For?

 

This product is intended for adults and young people aged 16 and over who are experiencing moderate acute pain. It's particularly well-suited to people whose pain hasn't responded to single-ingredient analgesics. That said, it's not appropriate for everyone — and it's important to check suitability before use.

Solpadeine Plus may be suitable if you:

  • Are aged 16 or over and experiencing moderate pain such as headache, migraine, or dental pain
  • Have tried paracetamol or ibuprofen alone without adequate relief
  • Have no history of opioid dependence or substance misuse
  • Are not pregnant, breastfeeding, or taking medicines that interact with codeine or paracetamol

It is not suitable for children under 12, and should be used with caution in adolescents aged 12–15 only under medical supervision. People with liver disease, kidney impairment, or respiratory conditions should speak to a pharmacist or GP before use.

 

How Does Solpadeine Plus Compare to Solpadeine Max?

 

Feature Solpadeine Plus Soluble Solpadeine Max Soluble
Paracetamol per tablet 500 mg 500 mg
Codeine phosphate per tablet 8 mg 12.8 mg
Caffeine per tablet 30 mg 30 mg
Suitable for Moderate pain, adults 16+ Moderate to severe pain, adults 18+

 

How Should You Store Solpadeine Plus Soluble Tablets?

 

Store your solpadeine plus soluble tablets below 25°C in a dry place, away from direct sunlight and moisture. Because these are effervescent tablets, exposure to humidity can cause them to degrade — so keep the tube tightly closed after each use. Always store medicines out of the sight and reach of children.

Check the expiry date printed on the packaging before use. Do not use the tablets if the tube has been damaged or if the tablets appear discoloured or crumbled. If you're unsure whether a tablet is still suitable, speak to your pharmacist rather than taking a risk.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Solpadeine Plus Soluble 24 Tablets specifications
Treatment category Analgesic / Pain Relief
Mechanism of action Central analgesic (paracetamol + opioid receptor agonist codeine) with caffeine potentiation
Effective for Headache, migraine, dental pain, period pain, muscular pain
Suitable for Adults and young people aged 16 and over
Active ingredients Paracetamol 500 mg, Codeine Phosphate 8 mg, Caffeine 30 mg
Pack size 24 soluble tablets
UK classification Pharmacy (P) medicine
Drug class Opioid-combination analgesic
Preparation Effervescent tablet
Route of administration Oral (dissolved in water)

Specifications of Solpadeine Plus Soluble 24 Tablets

 

What Is Solpadeine Plus and What Is It Used For?

 

Solpadeine Plus Soluble Tablets are a licensed over-the-counter analgesic used for the short-term relief of moderate acute pain in adults and young people aged 16 and over. The product is classified as a Pharmacy (P) medicine in the UK, meaning it can be sold without a prescription but only under the supervision of a pharmacist. It is indicated for conditions including headache, migraine, toothache, period pain, rheumatic pain, and general muscular aches. If you're managing pain alongside other symptoms, you may also find relevant products in our cold and flu range.

 

What Do You Need to Know Before Using Solpadeine Plus?

 

Before taking these tablets, it's essential to check whether they are appropriate for you. There are several situations in which this product should not be used:

  • You are under 12 years of age — codeine is contraindicated in this age group
  • You are breastfeeding — codeine passes into breast milk and can harm a nursing infant
  • You are a known ultra-rapid CYP2D6 metaboliser — this genetic variation causes codeine to convert to morphine too quickly, increasing the risk of serious opioid toxicity
  • You have severe liver or kidney impairment
  • You have a history of opioid dependence or substance misuse
  • You have a condition causing respiratory depression or reduced lung function
  • You are allergic to paracetamol, codeine, caffeine, or any other ingredient in the formulation

The following medicines may interact with Solpadeine Plus. Always tell your pharmacist what you are taking:

  • Monoamine oxidase inhibitors (MAOIs) — serious interaction risk; do not use within 14 days of stopping an MAOI
  • Other opioid analgesics — increased risk of respiratory depression and sedation
  • CNS depressants including alcohol, benzodiazepines, and sedating antihistamines
  • Warfarin — regular use of paracetamol may enhance anticoagulant effect
  • Other paracetamol-containing products — risk of accidental paracetamol overdose
  • Metoclopramide or domperidone — may affect the rate of paracetamol absorption

 

How Should You Use Solpadeine Plus Soluble Tablets?

 

Always use this medicine exactly as described in the patient information leaflet or as directed by your pharmacist. Do not exceed the recommended dose.

  1. Drop one to two tablets into a glass containing at least 200 ml of water
  2. Wait for the tablets to fully dissolve — do not swallow them whole
  3. Drink the solution immediately once dissolved
  4. Leave at least four hours between doses
  5. Do not take more than eight tablets in any 24-hour period
  6. Use for the shortest time necessary — no more than three days without medical advice
Indication Age Group Dose Frequency
Moderate acute pain Adults and young people 16+ 1–2 tablets dissolved in water Every 4–6 hours; max 8 tablets/24 hrs
Moderate acute pain Children 12–15 (medical supervision only) 1 tablet dissolved in water Every 6 hours; max 4 tablets/24 hrs
Not applicable Children under 12 Contraindicated — do not use

 

What Are the Possible Side Effects of Solpadeine Plus?

 

Like all medicines, Solpadeine Plus can cause side effects, although not everyone will experience them. Knowing what to look out for helps you use the product safely.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or feeling sick
  • Constipation
  • Drowsiness or sedation
  • Dizziness

Less common side effects (may affect up to 1 in 100 people):

  • Vomiting
  • Headache caused by overuse of the medication (medication-overuse headache)
  • Skin rash or itching
  • Difficulty passing urine
  • Dependence or withdrawal symptoms with prolonged use

Stop taking the tablets and seek urgent medical attention if you experience signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin reaction.

 

How Should You Store Solpadeine Plus Soluble Tablets?

 

Correct storage helps maintain the quality and safety of your tablets. Follow these instructions carefully:

  • Store below 25°C in a dry place — avoid bathrooms or areas with high humidity
  • Keep the tube tightly closed after each use to prevent moisture getting in
  • Keep out of the sight and reach of children at all times
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacist for safe disposal

If you're looking for other health essentials to keep at home, our first aid collection has a range of useful products for everyday health needs.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Solpadeine Plus Soluble Tablets online in the UK?

You can order Solpadeine Plus Soluble 24 Tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy. Because this product contains codeine, you'll need to complete a brief online consultation to confirm it's suitable for you before purchase. Visit our pain relief collection to browse and order securely.

How does Solpadeine Plus work in the body?

Solpadeine Plus contains paracetamol, which reduces pain signals centrally in the brain; codeine phosphate, a mild opioid that binds to pain receptors in the brain and spinal cord; and caffeine, which is thought to enhance the analgesic effect of paracetamol. Together, these three ingredients tackle moderate pain more effectively than paracetamol alone. The soluble formulation means the active ingredients are absorbed relatively quickly once dissolved in water.

How do I take Solpadeine Plus Soluble Tablets step by step?

Drop one to two tablets into a glass of water (at least 200 ml), wait for them to fully dissolve, then drink the solution straight away. Never swallow the tablets whole or undissolved. Leave at least four hours between doses and do not take more than eight tablets in any 24-hour period.

What is the maximum dose of Solpadeine Plus in 24 hours?

The maximum dose for adults aged 16 and over is eight tablets in any 24-hour period, taken as one to two tablets every four to six hours. Never take more than two tablets at a single dose, and always leave at least four hours between doses. Exceeding the recommended dose increases the risk of serious side effects, including paracetamol overdose.

What are the side effects of Solpadeine Plus Soluble Tablets?

Common side effects include nausea, constipation, drowsiness, and dizziness — these are largely related to the codeine component. Less commonly, some people experience vomiting, skin rash, or difficulty urinating. If you notice any signs of a serious allergic reaction, such as facial swelling or difficulty breathing, stop taking the tablets and seek urgent medical attention.

Who should not take Solpadeine Plus Soluble Tablets?

This product is not suitable for children under 12, breastfeeding mothers, people with severe liver or kidney disease, or those with a history of opioid dependence. It is also contraindicated in people who are known ultra-rapid CYP2D6 metabolisers, as they convert codeine to morphine too quickly, raising the risk of serious toxicity. Always speak to a pharmacist if you're unsure whether this product is right for you.

Can I take Solpadeine Plus with other medicines?

You should not take Solpadeine Plus alongside other paracetamol-containing products, as this significantly increases the risk of accidental overdose. It also interacts with MAOIs, other opioids, CNS depressants (including alcohol), and warfarin. Always tell your pharmacist about every medicine, supplement, or herbal remedy you are taking before starting this product.

How long can I take Solpadeine Plus for?

Solpadeine Plus is intended for short-term use only — no more than three consecutive days without seeking medical advice. Using codeine-containing products for longer than this can lead to physical dependence and a condition called medication-overuse headache, where the painkiller itself starts to cause headaches. If your pain persists beyond three days, speak to your GP or pharmacist.

Is Solpadeine Plus suitable for migraines?

Yes, Solpadeine Plus is indicated for the relief of migraine headaches in adults aged 16 and over. The caffeine component may help by causing mild vasoconstriction, which can be beneficial in vascular headaches like migraines. However, if you experience frequent migraines, it's worth speaking to your GP about longer-term management options, as regular use of analgesics can worsen migraine frequency over time.

What happens if I miss a dose of Solpadeine Plus?

Solpadeine Plus is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take your next dose when pain returns, provided at least four hours have passed since your last dose. Never double up on doses to make up for one you've skipped.

Can I drink alcohol while taking Solpadeine Plus?

You should avoid alcohol while taking Solpadeine Plus. Alcohol combined with codeine increases the risk of sedation, dizziness, and respiratory depression. It also places additional strain on the liver alongside paracetamol. If you have any questions about alcohol and pain relief, your pharmacist can advise you further.

Can I take Solpadeine Plus if I am pregnant?

Solpadeine Plus is not recommended during pregnancy, particularly in the third trimester, as codeine can cause neonatal withdrawal symptoms and respiratory depression in the newborn. Paracetamol alone is generally considered the preferred analgesic during pregnancy, but you should always seek advice from your GP or midwife before taking any medicine while pregnant. Do not self-medicate with codeine-containing products during pregnancy.

What are the alternatives to Solpadeine Plus for headache relief?

Alternatives include standard paracetamol, ibuprofen, or aspirin for mild to moderate headaches. For migraines specifically, triptans such as sumatriptan may be more appropriate and are available from pharmacies. You can explore a range of options in our pain relief collection to find the most suitable product for your needs.

Does Solpadeine Plus cause dependence?

Yes, because Solpadeine Plus contains codeine — a mild opioid — there is a risk of physical and psychological dependence with prolonged or excessive use. This is why it should only be used for short periods (no more than three days) and at the lowest effective dose. If you find yourself needing it regularly, speak to your GP rather than continuing to self-medicate.

What are the latest guidelines on codeine-containing painkillers in the UK?

The MHRA and NHS advise that codeine-containing medicines should only be used for short-term relief of acute moderate pain that is not relieved by other analgesics such as paracetamol or ibuprofen alone. They are not recommended for chronic pain management, and their use in children under 12 is contraindicated. If you need ongoing pain management, a GP referral for a structured pain management plan is the recommended route. You may also find our IBS and cramps section helpful if your pain is related to abdominal cramping.

How Should You Use Solpadeine Plus Soluble Tablets?

Always read the patient information leaflet before taking Solpadeine Plus Soluble Tablets. This product is for oral use only — the tablets must be fully dissolved in water before you drink them; never swallow them whole or chew them.

Follow these steps each time you take a dose:

What Is the Correct Dose of Solpadeine Plus Soluble Tablets?

The correct dose depends on your age. Adults and young people aged 16 and over may take one to two tablets per dose, up to a maximum of eight tablets in any 24-hour period. Do not take more than two tablets at a time, and always leave at least four hours between doses.

When Is the Best Time to Use Solpadeine Plus Soluble Tablets?

Take Solpadeine Plus as soon as your pain begins — early treatment tends to be more effective than waiting until pain becomes severe. Because the tablets are soluble, they are absorbed relatively quickly, so you should begin to notice relief within 30 to 60 minutes of taking a dose.

You can take the tablets with or without food, though taking them with or after a light meal may help reduce the chance of nausea, particularly if your stomach is sensitive to codeine-containing medicines.

How Long Can You Use Solpadeine Plus Soluble Tablets For?

Solpadeine Plus is intended for short-term use only. You should not take it for more than three consecutive days without speaking to a doctor or pharmacist. Using codeine-containing medicines for longer than this increases the risk of physical dependence and can lead to medication-overuse headache — a condition where the painkiller itself begins to cause daily headaches.

If your pain has not improved after three days, or if it worsens at any point, stop taking the tablets and seek medical advice promptly. This product is not suitable for managing chronic or long-term pain conditions.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

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TC

Suffer with sciatica and hip pain and struggle to swallow tablets. These really help my mobility.

What Are the Most Common Side Effects of Solpadeine Plus?

The most frequently reported side effects of Solpadeine Plus are related to its codeine content. Most people tolerate the product well when taken at the recommended dose for a short period, but it's worth knowing what to look out for.

  • Nausea or feeling sick
  • Constipation
  • Drowsiness or sedation
  • Dizziness or light-headedness

What Are the Less Common Side Effects of Solpadeine Plus?

Less commonly, some people experience side effects that are more troublesome. These are still generally mild and tend to resolve once you stop taking the tablets, but you should mention them to your pharmacist if they persist.

  • Vomiting
  • Headache caused by overuse of the medication (medication-overuse headache)
  • Skin rash or itching
  • Difficulty passing urine (urinary retention)
  • Mood changes or feeling unusually euphoric or dysphoric
  • Dry mouth

What Are the Serious Side Effects of Solpadeine Plus?

Serious side effects are rare but require immediate medical attention. Stop taking Solpadeine Plus and call 999 or go to your nearest A&E if you experience any of the following:

  • Signs of a severe allergic reaction (anaphylaxis): swelling of the face, lips, tongue, or throat; difficulty breathing; rapid heartbeat; or a sudden drop in blood pressure
  • Severe skin reactions such as blistering or peeling
  • Slow or shallow breathing — a sign of opioid toxicity, particularly in ultra-rapid CYP2D6 metabolisers
  • Yellowing of the skin or eyes (jaundice) — a sign of liver damage, which can occur with paracetamol overdose

What Should You Do If You Experience Side Effects?

If you notice any side effect that concerns you, stop taking the tablets and speak to your pharmacist or GP as soon as possible. For mild side effects such as nausea, taking the tablets with a light meal may help. Constipation can often be managed by increasing your fluid and fibre intake while you are using the product.

If you suspect you or someone else has taken too much paracetamol — even if they feel well — go to A&E immediately or call 999. Paracetamol overdose can cause serious liver damage that may not be apparent for several days after the overdose occurs.

Can Solpadeine Plus Interact With Other Medicines?

Yes. Solpadeine Plus has several clinically significant interactions that you need to be aware of before taking it. The most important ones include:

  • Other paracetamol-containing products: Taking these alongside Solpadeine Plus can cause accidental paracetamol overdose — always check the ingredients of any other medicine you are taking
  • MAOIs: Serious and potentially life-threatening interaction; do not use within 14 days of stopping an MAOI
  • Alcohol and CNS depressants: Increase the risk of sedation and respiratory depression
  • Warfarin: Regular paracetamol use may enhance the anticoagulant effect, increasing bleeding risk
  • Other opioids: Additive risk of opioid toxicity and respiratory depression

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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