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Solpadeine Plus (Codeine/Paracetamol) - 32 Capsules

Solpadeine Plus (Codeine/Paracetamol) - 32 Capsules

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  • ✔️ Combines paracetamol and codeine for moderate pain relief
  • ✔️ Targets pain unresponsive to single analgesics alone
  • ✔️ Suitable for headache, dental pain, and period pain
  • ✔️ Convenient 32-capsule pack for short-term pain management
  • ✔️ Pharmacy-only formula with clinically established analgesic combination

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What Is Solpadeine Plus Codeine Paracetamol?

 

When everyday pain gets in the way — whether it's a stubborn headache, dental discomfort, or muscular ache that won't shift — you need something that actually works. Solpadeine plus codeine paracetamol is a pharmacy-only combination analgesic containing two active ingredients: paracetamol 500 mg and codeine phosphate 8 mg per capsule. It's specifically designed for short-term relief of moderate pain that hasn't responded to paracetamol, ibuprofen, or aspirin alone. You can browse our full pain relief collection if you're comparing options before deciding.

Each pack contains 32 capsules, making it a practical choice for managing acute pain episodes at home. As a pharmacy (P) medicine in the UK, it's available without a prescription — but it does require a brief suitability check to ensure it's appropriate for you. This is standard practice for any medicine containing codeine.

 

How Does Solpadeine Plus Work to Relieve Pain?

 

The two active ingredients in Solpadeine Plus work through different but complementary mechanisms, which is why the combination tends to be more effective than either ingredient on its own.

  • Paracetamol (500 mg per capsule): Acts centrally in the brain to reduce the perception of pain and lower fever. Its exact mechanism isn't fully understood, but it's thought to inhibit prostaglandin synthesis in the central nervous system.
  • Codeine phosphate (8 mg per capsule): An opioid analgesic that is partially converted to morphine in the liver. It binds to opioid receptors in the brain and spinal cord, reducing the transmission of pain signals and altering how pain is perceived.
  • Combined effect: Together, these two ingredients provide a synergistic analgesic effect — meaning the combined relief is greater than you'd get from either alone at these doses.

It's worth knowing that codeine's effectiveness varies between individuals. People who are "ultra-rapid metabolisers" of codeine convert it to morphine very quickly, which can increase the risk of side effects. Conversely, "poor metabolisers" may find codeine less effective. This is a genetic variation, and it's one reason why codeine-containing medicines require careful use.

 

Who Is Solpadeine Plus Suitable For?

 

Solpadeine Plus is intended for adults and adolescents aged 12 and over who are experiencing moderate pain that hasn't been adequately controlled by a single analgesic. It's particularly useful for:

  • Headaches and migraines (short-term use only)
  • Dental pain, including toothache and post-extraction discomfort
  • Muscular pain, back pain, and rheumatic aches
  • Period pain (dysmenorrhoea)
  • Cold and flu-related aches and pains

It is not suitable for everyone. Children under 12 must never take codeine-containing medicines. People who are breastfeeding, have liver or kidney impairment, or have a history of opioid dependence should avoid this product. Always check with your pharmacist if you're unsure whether it's right for you.

 

How Does Solpadeine Plus Compare to Paracetamol Alone?

 

Feature Solpadeine Plus (Codeine/Paracetamol) Paracetamol Alone (500 mg)
Active ingredients Paracetamol 500 mg + Codeine 8 mg Paracetamol 500 mg
Pain level targeted Moderate pain unresponsive to single analgesics Mild to moderate pain
Risk of dependence Yes — codeine carries dependence risk No
UK classification Pharmacy (P) medicine General Sale List (GSL)
Suitable for under 12s No Yes (age-appropriate formulations)

 

How Should Solpadeine Plus Be Stored?

 

Store Solpadeine Plus below 25°C in a dry place, away from direct sunlight and moisture. Keep the capsules in their original packaging until you need them. As with all medicines, keep this product out of the sight and reach of children — this is especially important given that it contains codeine.

Do not use the capsules after the expiry date printed on the pack. If you have unused or expired capsules, return them to your local pharmacy for safe disposal — do not put them in household waste or flush them down the toilet. If you're managing multiple health conditions and need to keep track of various medicines, our first aid collection includes useful storage and organisational products.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Solpadeine Plus (Codeine/Paracetamol) - 32 Capsules specifications
Treatment category Pain relief / Analgesia
Mechanism of action Central analgesic (paracetamol) + opioid receptor agonist (codeine)
Effective for Moderate pain unresponsive to single analgesics
Suitable for Adults and adolescents aged 12 and over
Active ingredient Paracetamol 500 mg, Codeine Phosphate 8 mg
Pack size 32 capsules
Strengths Paracetamol 500 mg / Codeine Phosphate 8 mg per capsule
UK classification Pharmacy (P) medicine
Drug class Opioid combination analgesic
Preparation Capsule
Route of administration Oral

Specifications of Solpadeine Plus (Codeine/Paracetamol) - 32 Capsules

 

What Is Solpadeine Plus and What Is It Used For?

 

Solpadeine Plus capsules are a combination analgesic medicine used for the short-term relief of moderate pain. Each capsule contains paracetamol 500 mg and codeine phosphate 8 mg. It is indicated when pain has not been adequately controlled by paracetamol, ibuprofen, or aspirin used alone. Typical uses include headache, dental pain, period pain, muscular aches, and cold or flu-related discomfort. It is classified as a pharmacy (P) medicine in the UK, meaning it can be purchased without a prescription but only through a registered pharmacy.

 

What Do You Need to Know Before Using Solpadeine Plus?

 

Before taking Solpadeine Plus, it's important to check whether it is safe for you. Do not take this medicine if any of the following apply:

  • You are under 12 years of age
  • You are breastfeeding — codeine passes into breast milk and can harm a nursing infant
  • You have severe liver or kidney disease
  • You have a known hypersensitivity to paracetamol, codeine, or any other ingredient in the capsules
  • You are a known ultra-rapid metaboliser of codeine (a genetic variation that increases morphine levels in the blood)
  • You have respiratory depression or obstructive airways disease
  • You have a history of opioid dependence or substance misuse

The following medicines may interact with Solpadeine Plus. Tell your pharmacist or doctor if you are taking:

  • Monoamine oxidase inhibitors (MAOIs) — serious interaction risk; do not use within 14 days of stopping an MAOI
  • Other medicines containing paracetamol — risk of accidental overdose
  • Other opioid analgesics or CNS depressants (including sedatives, sleeping tablets, or alcohol) — increased risk of drowsiness and respiratory depression
  • Anticoagulants such as warfarin — regular use of paracetamol may enhance anticoagulant effect
  • Metoclopramide or domperidone — may affect the rate of paracetamol absorption

 

How Should You Use Solpadeine Plus Correctly?

 

Always take Solpadeine Plus exactly as directed on the label or as advised by your pharmacist. Swallow the capsules whole with a full glass of water. Do not crush or chew them.

  1. Take 2 capsules as a single dose.
  2. Wait at least 4 hours before taking your next dose.
  3. Do not take more than 4 doses (8 capsules) in any 24-hour period.
  4. Do not use for more than 3 consecutive days without seeking medical advice.
  5. If pain persists or worsens, speak to your GP or pharmacist.
Indication Age Group Dose Frequency
Moderate pain (headache, dental, muscular) Adults and adolescents 12+ 2 capsules Up to 4 times daily (min. 4 hrs apart)
Children under 12 Under 12 years NOT suitable — do not use

If you're also managing symptoms such as cold and flu alongside your pain, you may find it helpful to explore our cold and flu range for complementary products.

 

What Are the Possible Side Effects of Solpadeine Plus?

 

Like all medicines, Solpadeine Plus can cause side effects, although not everyone experiences them. Knowing what to look out for helps you use this medicine safely.

Common side effects (may affect up to 1 in 10 people):

  • Constipation — particularly with repeated use
  • Nausea or feeling sick
  • Drowsiness or sedation
  • Dizziness or light-headedness

Less common side effects (may affect up to 1 in 100 people):

  • Vomiting
  • Headache (paradoxically, with overuse — known as medication-overuse headache)
  • Skin rash or itching
  • Difficulty passing urine
  • Mood changes or confusion

Stop taking Solpadeine Plus and seek immediate medical attention if you develop signs of a serious allergic reaction, such as swelling of the face, lips, or throat, difficulty breathing, or a severe skin rash. Paracetamol overdose is a medical emergency — if you or someone else has taken too much, go to A&E immediately even if you feel well, as liver damage may not be apparent for several days.

 

How Should You Store Solpadeine Plus?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep in the original blister packaging until use
  • Keep out of the sight and reach of children at all times
  • Do not use after the expiry date printed on the pack
  • Return unused or expired capsules to your pharmacy — do not dispose of via household waste or drains

If you're looking for additional support products to manage pain-related conditions, our vitamins and supplements collection includes options such as magnesium, which some people find helpful alongside conventional pain management strategies.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Solpadeine Plus online in the UK?

You can buy Solpadeine Plus 32 capsules from Cured Pharmacy, a GPhC-registered online pharmacy. Because it contains codeine, it is a pharmacy (P) medicine and requires a brief suitability check before purchase. You can find it alongside other options in our pain relief collection.

How does Solpadeine Plus work in the body?

Solpadeine Plus contains two active ingredients that work together. Paracetamol reduces pain signals in the brain, while codeine phosphate — an opioid — is converted to morphine in the liver and binds to opioid receptors to further dampen pain perception. The combination provides greater relief than either ingredient alone for moderate pain.

What is the correct dose of Solpadeine Plus for adults?

The recommended adult dose is 2 capsules taken up to 4 times a day, with at least 4 hours between each dose. You must not exceed 8 capsules in any 24-hour period. Always follow the instructions on the pack or as directed by your pharmacist.

How long can I use Solpadeine Plus for?

Solpadeine Plus is intended for short-term use only — a maximum of 3 consecutive days. Using it for longer than this without medical supervision significantly increases the risk of codeine dependence and can cause medication-overuse headache. If your pain persists beyond 3 days, speak to your GP.

Can I take Solpadeine Plus with ibuprofen?

Solpadeine Plus does not contain ibuprofen, so taking both together is generally considered acceptable for short-term pain relief in adults. However, you should always check with your pharmacist first, as ibuprofen is not suitable for everyone — particularly those with stomach problems, kidney issues, or certain cardiovascular conditions.

Who should not take Solpadeine Plus?

Solpadeine Plus is not suitable for children under 12, people who are breastfeeding, those with severe liver or kidney disease, or anyone with a history of opioid dependence. It is also contraindicated in people who are known ultra-rapid metabolisers of codeine, as this increases the risk of serious opioid toxicity. Always read the full patient information leaflet before use.

What are the most common side effects of Solpadeine Plus?

The most commonly reported side effects include constipation, nausea, and drowsiness — all of which are related to the codeine component. Dizziness can also occur, particularly if you stand up quickly. These effects are more likely with repeated or prolonged use, which is why the 3-day limit is important.

What should I do if I miss a dose of Solpadeine Plus?

If you miss a dose, simply take the next dose when your pain returns, provided at least 4 hours have passed since your last dose. Do not double up to make up for a missed dose. Never take more than 8 capsules in 24 hours under any circumstances.

Can I drink alcohol while taking Solpadeine Plus?

You should avoid alcohol while taking Solpadeine Plus. Both codeine and alcohol are central nervous system depressants, and combining them increases the risk of excessive drowsiness, dizziness, and in serious cases, respiratory depression. This is a genuine safety concern, not just a precautionary note.

Is Solpadeine Plus safe to take during pregnancy?

Solpadeine Plus is not recommended during pregnancy, particularly in the third trimester, as codeine can cause neonatal withdrawal symptoms and respiratory depression in the newborn. Paracetamol alone is generally considered the preferred analgesic during pregnancy, but you should always seek advice from your GP or midwife before taking any medicine when pregnant.

What are the alternatives to Solpadeine Plus?

If Solpadeine Plus isn't suitable for you, alternatives include paracetamol alone, ibuprofen, or aspirin for mild to moderate pain. For more targeted relief — such as for period pain or muscular discomfort — your pharmacist can advise on the most appropriate option. You can explore a range of alternatives in our pain relief collection.

Can Solpadeine Plus cause dependence?

Yes. Codeine is an opioid and carries a recognised risk of physical and psychological dependence, even at the low doses found in over-the-counter products like Solpadeine Plus. This risk increases significantly with prolonged use or use beyond the recommended 3-day limit. If you find yourself relying on it regularly, speak to your GP.

Can I drive after taking Solpadeine Plus?

Codeine can cause drowsiness and impair your ability to drive or operate machinery safely. You should not drive if you feel drowsy, dizzy, or less alert than usual after taking Solpadeine Plus. Under UK drug-driving laws, driving while impaired by codeine is a criminal offence regardless of whether the medicine was taken legally.

What happens if I take too much Solpadeine Plus?

Taking too much Solpadeine Plus is a medical emergency, primarily because of the paracetamol content. Paracetamol overdose can cause severe liver damage that may not be immediately apparent. If you or someone else has taken more than the recommended dose, go to your nearest A&E immediately or call 999 — do not wait for symptoms to appear.

What is the latest guidance on codeine use in the UK?

The MHRA and NHS have issued updated guidance emphasising that codeine-containing medicines should only be used for short-term pain relief (maximum 3 days) and are not appropriate for children under 12 or breastfeeding mothers. There is also growing awareness of codeine dependence as a public health concern, with pharmacists trained to identify and support patients who may be misusing these products. If you have concerns about your use of codeine, your GP or pharmacist can help.

How Should You Use Solpadeine Plus?

Solpadeine Plus capsules are taken orally with a full glass of water. Swallow each capsule whole — do not crush, chew, or open the capsules, as this can affect how the medicine is absorbed and increase the risk of side effects.

What Is the Correct Dose of Solpadeine Plus?

The dose of Solpadeine Plus depends on your age. It is not suitable for children under 12 years of age under any circumstances. For adults and adolescents aged 12 and over, the standard dose is 2 capsules per dose. Always use the lowest effective dose for the shortest time necessary.

When Is the Best Time to Use Solpadeine Plus?

Take Solpadeine Plus as soon as your pain begins — early intervention tends to be more effective than waiting until pain becomes severe. If you are taking it for a predictable pain such as period pain, you may find it helpful to take the first dose at the onset of discomfort rather than waiting for it to peak. Taking capsules with or after food may help reduce the likelihood of nausea, particularly if your stomach is sensitive.

Avoid taking your last dose of the day too close to bedtime if you need to remain alert, as codeine can cause drowsiness. Space your doses evenly throughout the day to maintain consistent pain relief.

How Long Can You Use Solpadeine Plus For?

Solpadeine Plus is intended for short-term use only. You should not take it for more than 3 consecutive days without seeking advice from your GP or pharmacist. Prolonged use of codeine-containing medicines carries a real risk of physical dependence, and regular use of any analgesic for more than a few days can lead to medication-overuse headache — a condition where the very medicine you're taking to relieve pain begins to cause it.

If your pain is ongoing or recurring, it's important to identify and address the underlying cause rather than relying on repeated courses of Solpadeine Plus. Your GP can help explore longer-term pain management strategies appropriate for your situation.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Solpadeine Plus?

The most frequently reported side effects of Solpadeine Plus are linked to its codeine content. Codeine acts on opioid receptors throughout the body — not just in the brain — which is why it can affect the digestive system and cause sedation alongside its pain-relieving effects.

  • Constipation — the most common opioid-related side effect; drink plenty of water and eat fibre-rich foods to help manage this
  • Nausea or feeling sick — more likely on an empty stomach; taking capsules with food may help
  • Drowsiness or sedation — do not drive or operate machinery if affected
  • Dizziness or light-headedness — particularly when standing up quickly

What Are the Less Common Side Effects of Solpadeine Plus?

Less frequently, some people experience side effects that are still worth being aware of. These are not common, but they can occur — particularly with repeated use or in people who are more sensitive to codeine or paracetamol.

  • Vomiting
  • Headache — paradoxically, overuse of analgesics can cause medication-overuse headache
  • Skin rash or itching
  • Difficulty passing urine (urinary retention)
  • Mood changes, confusion, or feeling unusually euphoric
  • Dry mouth

What Are the Serious Side Effects of Solpadeine Plus?

Serious side effects are rare but require immediate medical attention. Stop taking Solpadeine Plus and seek emergency help if you experience any of the following:

  • Signs of a severe allergic reaction (anaphylaxis): swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash or hives
  • Slow or shallow breathing — a sign of opioid toxicity, particularly in ultra-rapid metabolisers of codeine
  • Yellowing of the skin or eyes (jaundice) — may indicate liver damage, particularly in cases of paracetamol overdose
  • Extreme drowsiness or loss of consciousness

Paracetamol overdose is a particular concern because liver damage may not produce obvious symptoms for 24–72 hours. If you suspect an overdose, go to A&E immediately — do not wait for symptoms.

What Should You Do If You Experience Side Effects of Solpadeine Plus?

For mild side effects such as constipation or nausea, simple measures — staying hydrated, eating fibre-rich foods, or taking capsules with food — can help. If drowsiness is affecting your daily activities, avoid driving and consider whether you need to continue taking the medicine. If any side effect is troubling you or does not resolve, stop use and speak to your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Solpadeine Plus Interact With Other Medicines?

Yes. Solpadeine Plus has several clinically significant interactions. The most serious is with monoamine oxidase inhibitors (MAOIs) — do not take Solpadeine Plus within 14 days of stopping an MAOI. Taking it alongside other paracetamol-containing products risks accidental overdose, so always check the ingredients of any other medicines you are using. Combining codeine with alcohol, sedatives, sleeping tablets, or other opioids increases the risk of dangerous CNS and respiratory depression. Warfarin users should be aware that regular paracetamol use may enhance the anticoagulant effect, increasing bleeding risk. Always tell your pharmacist about all medicines, supplements, and herbal products you are taking before starting Solpadeine Plus.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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