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Peptac Liquid 500ml

Peptac Liquid 500ml

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  • ✔️ Forms a protective alginate raft to block acid reflux
  • ✔️ Relieves heartburn, indigestion and acid reflux symptoms
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Liquid formulation ideal for those who avoid tablets
  • ✔️ 500ml bottle provides multiple doses for ongoing relief

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What Is Peptac Liquid Heartburn Relief?

 

Heartburn is something most of us have felt at some point — that uncomfortable burning sensation rising from your stomach into your chest or throat. It happens when stomach acid escapes upward into the oesophagus, a process known as acid reflux. Peptac liquid heartburn relief is a well-established, over-the-counter alginate-antacid suspension designed to tackle exactly this. Available in a convenient 500ml bottle, it provides soothing relief from heartburn, acid reflux, and indigestion without the need for a prescription. If you're looking for more digestive health options, browse our full indigestion range at Cured Pharmacy.

Each dose contains three active ingredients working together: sodium alginate, sodium bicarbonate, and calcium carbonate. These are not new or experimental compounds — they have a long track record of safe use in the UK. The liquid formulation makes it particularly useful for people who struggle to swallow tablets, and the 500ml size means you won't be running out in a hurry.

 

How Does Peptac Liquid Work to Relieve Heartburn?

 

The mechanism behind Peptac Liquid is elegantly straightforward. Rather than simply neutralising acid throughout the stomach, it creates a physical barrier — often called an "alginate raft" — that sits on top of the stomach contents and prevents acid from splashing back up into the oesophagus. Here's how it happens step by step:

  • Sodium alginate reacts with stomach acid to form a thick, gel-like substance.
  • Sodium bicarbonate produces carbon dioxide during this reaction, which causes the gel to become buoyant and float on the stomach contents.
  • This floating raft acts as a physical plug, blocking the lower oesophageal sphincter from being breached by acid.
  • Calcium carbonate provides additional antacid action, helping to neutralise excess stomach acid directly.

The result? Rapid, localised relief that targets the root cause of that burning feeling rather than just masking it temporarily.

 

Who Should Use Peptac Liquid and Is It Right for You?

 

Peptac Liquid is suitable for a broad range of people experiencing common digestive complaints. It's particularly well suited to those who find tablet-based antacids inconvenient or difficult to take. That said, it's not appropriate for everyone, so it's worth checking the list below before you buy.

Peptac Liquid is generally appropriate for:

  • Adults and young people aged 12 and over with occasional heartburn or acid reflux.
  • Pregnant women experiencing heartburn — though always check with your midwife or GP first.
  • People who prefer a liquid antacid over tablets or chewable options.
  • Those managing symptoms of gastro-oesophageal reflux disease (GORD) alongside other treatments.

 

How Does Peptac Liquid Compare to Other Antacid Options?

 

Feature Peptac Liquid 500ml Standard Antacid Tablets
Mechanism Alginate raft + antacid neutralisation Antacid neutralisation only
Form Oral liquid suspension Chewable or swallowable tablet
Suitable for 12+ Yes Varies by product
Pregnancy use Often suitable (seek advice) Varies — check individual product

 

How Should You Store Peptac Liquid and Is It Clinically Suitable for You?

 

Store Peptac Liquid below 25°C and keep it away from direct sunlight. Do not freeze the bottle — freezing can affect the consistency of the suspension and reduce its effectiveness. Once opened, check the expiry date on the label and discard any unused liquid after the stated period. Keep it out of the reach and sight of children at all times.

From a clinical suitability perspective, Peptac liquid heartburn relief contains sodium, which is worth noting if you're on a low-sodium diet or have been advised to restrict your salt intake due to conditions such as heart failure or kidney disease. If you're unsure whether this product is right for you, speak to your pharmacist before use. You might also find it helpful to explore our IBS and cramps collection if your digestive symptoms are more complex.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Peptac Liquid 500ml specifications
Treatment category Heartburn, acid reflux, indigestion
Mechanism of action Alginate raft formation + antacid neutralisation
Effective for Heartburn, gastro-oesophageal reflux, indigestion
Suitable for Adults and children aged 12 and over
Active ingredients Sodium alginate 250mg/5ml, Sodium bicarbonate 133.5mg/5ml, Calcium carbonate 80mg/5ml
Pack size 500ml
UK classification General Sale List (GSL)
Drug class Alginate antacid
Preparation Oral suspension (liquid)
Route of administration Oral

Specifications of Peptac Liquid 500ml

 

What Is Peptac Liquid 500ml and What Is It Used For?

 

Peptac Liquid 500ml is an over-the-counter alginate-antacid oral suspension used to relieve the symptoms of heartburn, acid reflux, and indigestion. It works by forming a protective raft on top of stomach contents, preventing acid from rising into the oesophagus. It is classified as a General Sale List (GSL) medicine in the UK, meaning you can buy it without a prescription. It is used to treat:

  • Heartburn — the burning sensation in the chest caused by acid reflux.
  • Gastro-oesophageal reflux — where stomach acid regularly flows back into the oesophagus.
  • Indigestion (dyspepsia) — discomfort or pain in the upper abdomen after eating.
  • Symptoms of reflux during pregnancy.

 

What Do You Need to Know Before Using Peptac Liquid 500ml?

 

Before taking Peptac Liquid, it's important to check whether it is appropriate for you. Do not use this product if any of the following apply:

  • You are allergic to sodium alginate, sodium bicarbonate, calcium carbonate, or any other ingredient in the formulation.
  • You have been told to follow a low-sodium (low-salt) diet — each 10ml dose contains a significant amount of sodium.
  • You have severe kidney (renal) impairment.
  • You have hypercalcaemia (raised calcium levels in the blood).
  • The patient is a child under 12 years of age — do not use without medical advice.

You should also be aware of the following warnings:

  • If your symptoms persist for more than two weeks, or if you experience difficulty swallowing, unexplained weight loss, or vomiting blood, see your GP promptly.
  • Use with caution if you have heart failure or are on a medically supervised sodium-restricted diet.
  • Speak to your pharmacist or GP before use if you are pregnant or breastfeeding.

Drug interactions: Peptac Liquid may affect the absorption of other medicines if taken at the same time. Known interactions include:

  • Tetracycline antibiotics — calcium carbonate can reduce their absorption.
  • Iron supplements — antacids can impair iron absorption.
  • Some antifungals (e.g. itraconazole) — absorption may be reduced.
  • Bisphosphonates (e.g. alendronic acid) — leave at least a 2-hour gap.

As a general rule, leave at least 2 hours between taking Peptac Liquid and any other oral medicines. If you take regular prescribed medication, check with your pharmacist first.

 

How Should You Use Peptac Liquid 500ml?

 

Always use Peptac Liquid exactly as directed on the label. Shake the bottle well before each use to ensure the suspension is evenly mixed. Use the measuring cup or medicine spoon provided to measure your dose accurately — do not estimate.

  1. Shake the bottle thoroughly before opening.
  2. Measure the correct dose using the measuring cup or a 5ml medicine spoon.
  3. Take the liquid after meals and at bedtime.
  4. Swallow the dose directly — do not dilute with water.
  5. Replace the cap securely after use and store upright.
Indication Age Group Dose Frequency
Heartburn / acid reflux Adults & children 12+ 10–20ml After meals and at bedtime (up to 4 times daily)
Indigestion Adults & children 12+ 10–20ml After meals and at bedtime (up to 4 times daily)
Children under 12 Under 12 Not recommended Seek medical advice

 

What Are the Possible Side Effects of Peptac Liquid 500ml?

 

Peptac Liquid is generally well tolerated when used as directed. However, like all medicines, it can cause side effects in some people. If you experience anything that concerns you, stop use and speak to your pharmacist or GP. You might also find it useful to explore our pain relief collection if you're managing associated discomfort alongside your digestive symptoms.

Common side effects (may affect up to 1 in 10 people):

  • Mild nausea
  • Flatulence (wind)
  • Constipation

Less common side effects (may affect up to 1 in 100 people):

  • Diarrhoea
  • Stomach cramps or bloating
  • Allergic reactions — rash, itching, or swelling (seek medical attention immediately if this occurs)

 

How Should You Store Peptac Liquid 500ml?

 

Correct storage helps maintain the effectiveness and safety of Peptac Liquid. Follow these instructions carefully:

  • Store below 25°C in a cool, dry place.
  • Do not freeze — freezing alters the suspension and may reduce effectiveness.
  • Keep away from direct sunlight and heat sources.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the label.
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy.

If you're managing multiple health conditions alongside heartburn, our vitamins and supplements collection may also be of interest for supporting your overall wellbeing.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Peptac Liquid 500ml online in the UK?

You can buy Peptac Liquid 500ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, without needing a prescription. It is classified as a General Sale List (GSL) medicine, so it is available over the counter. Simply add it to your basket and select your preferred delivery option at checkout for fast, discreet dispatch.

How does Peptac Liquid work in the body?

Peptac Liquid works through a dual mechanism: sodium alginate reacts with stomach acid to form a buoyant gel raft that physically sits on top of stomach contents, preventing acid from rising into the oesophagus. At the same time, calcium carbonate and sodium bicarbonate neutralise excess stomach acid directly. This combination provides both a physical barrier and chemical neutralisation for effective heartburn relief.

How do I use Peptac Liquid step by step?

Shake the bottle well before each use, then measure 10–20ml using the measuring cup or a 5ml medicine spoon. Take the dose after meals and at bedtime — swallow it directly without diluting with water. Replace the cap tightly after use and store the bottle upright below 25°C.

What is the correct dose of Peptac Liquid for adults?

The recommended adult dose is 10–20ml (2–4 teaspoons) taken after meals and at bedtime, up to four times per day. The maximum daily dose is 80ml in 24 hours — do not exceed this. If you are unsure about the right dose for your situation, speak to your pharmacist before use.

When is the best time to take Peptac Liquid?

Peptac Liquid is most effective when taken after meals and at bedtime, as this is when stomach acid production is highest and reflux is most likely to occur. Taking it on an empty stomach is less effective because the alginate raft needs stomach contents to float on. Consistency matters — try to take it at the same times each day for the best results.

What are the side effects of Peptac Liquid?

Peptac Liquid is generally well tolerated, but some people may experience mild side effects such as nausea, flatulence, or constipation. Less commonly, diarrhoea or stomach cramps may occur. Rarely, allergic reactions such as rash or swelling can happen — if this occurs, stop use immediately and seek medical attention.

How do I manage side effects of Peptac Liquid?

Most side effects of Peptac Liquid are mild and tend to resolve on their own without any specific treatment. If you experience constipation, staying well hydrated and increasing dietary fibre can help — you may also find our constipation range useful. If side effects are persistent or severe, stop taking the liquid and speak to your pharmacist or GP.

Who is Peptac Liquid suitable for?

Peptac Liquid is suitable for adults and young people aged 12 and over who experience heartburn, acid reflux, or indigestion. It is often recommended during pregnancy for heartburn relief, though you should always check with your midwife or GP first. It is not suitable for children under 12, or for people with severe kidney impairment, hypercalcaemia, or those on a strict low-sodium diet without medical supervision.

Can I take Peptac Liquid during pregnancy?

Peptac Liquid is frequently used during pregnancy to relieve heartburn, which is a very common symptom, particularly in the second and third trimesters. However, because it contains sodium, you should always speak to your midwife, GP, or pharmacist before taking it while pregnant. They can confirm it is appropriate for your individual circumstances and advise on the correct dose.

Does Peptac Liquid interact with other medicines?

Yes, Peptac Liquid can affect the absorption of certain medicines if taken at the same time. Known interactions include tetracycline antibiotics, iron supplements, some antifungals, and bisphosphonates such as alendronic acid. As a general precaution, leave at least a 2-hour gap between taking Peptac Liquid and any other oral medicines, and always check with your pharmacist if you take regular prescribed medication.

How long can you use Peptac Liquid for?

Peptac Liquid is intended for short-term relief of heartburn and indigestion symptoms. If your symptoms persist for more than two weeks, or if they worsen, you should see your GP to rule out an underlying condition such as gastro-oesophageal reflux disease (GORD) or a peptic ulcer. Do not use it continuously for extended periods without seeking medical advice.

What happens if I take too much Peptac Liquid?

Taking more than the recommended dose of Peptac Liquid may increase the risk of side effects such as nausea, bloating, or electrolyte imbalance due to the sodium content. If you accidentally take a large overdose, contact NHS 111 or go to your nearest A&E department. Always keep medicines out of the reach of children to prevent accidental ingestion.

What are the alternatives to Peptac Liquid for heartburn?

There are several alternatives available for heartburn relief, including other alginate-antacid liquids (such as Gaviscon Advance), standard antacid tablets containing calcium carbonate or magnesium trisilicate, and proton pump inhibitors (PPIs) such as omeprazole for more persistent symptoms. Browse our full indigestion collection to compare options. Your pharmacist can help you choose the most appropriate product for your symptoms.

Is Peptac Liquid the same as Gaviscon?

Peptac Liquid and Gaviscon Original Liquid share a very similar formulation — both contain sodium alginate, sodium bicarbonate, and calcium carbonate as active ingredients and work via the same alginate raft mechanism. They are considered therapeutically equivalent for most patients. The main difference is branding and price, with Peptac Liquid often being a more cost-effective option.

What are the latest findings on alginate antacids for heartburn?

Alginate-antacid preparations like Peptac Liquid have been studied extensively and are well supported by clinical evidence for the short-term relief of heartburn and gastro-oesophageal reflux symptoms. The NHS recommends alginate-containing antacids as a first-line option for managing mild to moderate reflux symptoms, including during pregnancy. Research continues to confirm their safety and effectiveness when used as directed, with a well-established tolerability profile across diverse patient groups.

How Should You Use Peptac Liquid 500ml?

Using Peptac Liquid correctly makes a real difference to how well it works. The liquid suspension needs to be shaken thoroughly before each use, as the active ingredients can settle at the bottom of the bottle between doses. Always measure your dose carefully — guessing can lead to taking too little (and getting poor relief) or too much (increasing the risk of side effects).

What Is the Correct Dose of Peptac Liquid 500ml?

The dose varies depending on your age and the severity of your symptoms. Always follow the label instructions or the advice of your pharmacist. Do not exceed the maximum daily dose of 80ml in any 24-hour period.

When Is the Best Time to Use Peptac Liquid 500ml?

Timing is everything with Peptac Liquid. It works best when taken after meals and at bedtime — this is when stomach acid levels are at their highest and reflux is most likely to occur. Taking it on an empty stomach is far less effective, because the alginate raft needs stomach contents to float on in order to form properly. If you experience nighttime heartburn in particular, the bedtime dose is especially important.

How Long Can You Use Peptac Liquid 500ml For?

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What Are the Most Common Side Effects of Peptac Liquid 500ml?

Peptac Liquid is generally well tolerated by most people when used as directed. Common side effects are usually mild and tend to resolve on their own without any specific treatment. You don't need to stop taking the medicine unless they become bothersome.

  • Mild nausea
  • Flatulence (wind or bloating)
  • Constipation

What Are the Less Common Side Effects of Peptac Liquid 500ml?

Less commonly, some people may experience gastrointestinal side effects that are slightly more disruptive. These are still generally mild and short-lived, but worth being aware of before you start using the product.

  • Diarrhoea
  • Stomach cramps or abdominal discomfort
  • Feeling of fullness or bloating after taking the dose

What Are the Serious Side Effects of Peptac Liquid 500ml?

Serious side effects from Peptac Liquid are rare, but they do exist and should not be ignored. Because the product contains sodium, people who take it in large quantities over a long period — particularly those with kidney disease or heart failure — may be at risk of sodium overload or electrolyte imbalance. Allergic reactions, though uncommon, can also occur. Signs of a serious allergic reaction (anaphylaxis) include:

  • Sudden rash, hives, or itching
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Dizziness or feeling faint

If you experience any of these symptoms, stop taking Peptac Liquid immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects of Peptac Liquid 500ml?

For mild side effects such as nausea or constipation, reducing your dose slightly or ensuring you take the medicine after food (rather than on an empty stomach) may help. Staying well hydrated is also important, particularly if you experience constipation. If side effects persist or are affecting your daily life, stop using the product and speak to your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Peptac Liquid 500ml Interact With Other Medicines?

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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