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Paramol - 24 Tablets

Paramol - 24 Tablets

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  • ✔️ Combines paracetamol and dihydrocodeine for moderate pain relief
  • ✔️ Effective for headaches, migraines, dental pain, and fever
  • ✔️ Dual-action formula targets pain via two different pathways
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Each pack contains 24 tablets for convenient short-term use

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What Are Paramol Tablets and How Do They Relieve Pain?

 

If you're dealing with a throbbing headache, a stubborn migraine, or general aches that just won't shift, Paramol tablets offer a dual-action approach to pain relief. Each tablet contains two active ingredients — paracetamol 500 mg and dihydrocodeine tartrate 7.46 mg — working together to tackle moderate pain that hasn't responded to paracetamol or ibuprofen alone. Paramol is available over the counter in the UK for adults and young people aged 12 and over, making it a practical option when everyday pain relief isn't quite cutting it. You can browse our full pain relief collection if you'd like to compare other options alongside Paramol.

Paramol 24 tablets are priced at £8.69 and are classified as a Pharmacy (P) medicine in the UK, meaning they're sold under pharmacist supervision. That classification exists for good reason — dihydrocodeine is a mild opioid, and it's important to use this medicine correctly and only for short-term relief.

 

How Do Paramol Tablets Work to Relieve Pain?

 

The two active ingredients in Paramol work through different but complementary mechanisms, which is why the combination tends to be more effective than either ingredient on its own.

  • Paracetamol (500 mg per tablet): Inhibits the production of prostaglandins in the brain, reducing the perception of pain and lowering elevated body temperature (fever).
  • Dihydrocodeine tartrate (7.46 mg per tablet): A mild opioid analgesic that binds to opioid receptors in the central nervous system, dampening pain signals travelling to the brain.
  • Combined effect: The two ingredients act on different pain pathways simultaneously, providing relief that is meaningfully stronger than standard paracetamol alone for moderate pain.

It's worth noting that dihydrocodeine can cause drowsiness, so you should avoid driving or operating machinery until you know how Paramol affects you.

 

Who Is Paramol Suitable For?

 

Paramol is designed for people who need something a step up from standard over-the-counter pain relief. It's particularly useful when paracetamol or ibuprofen alone hasn't been sufficient. That said, it isn't right for everyone.

Paramol may be suitable if you:

  • Are aged 12 years or over
  • Experience moderate pain such as headaches, migraines, dental pain, or muscular aches
  • Have a fever that needs managing alongside pain
  • Are not taking other opioid-containing medicines or medicines that interact with dihydrocodeine

It is not suitable for children under 12, people with respiratory depression, those with a known hypersensitivity to paracetamol or opioids, or anyone currently taking monoamine oxidase inhibitors (MAOIs).

 

How Does Paramol Compare to Standard Paracetamol?

 

Feature Paramol Tablets Standard Paracetamol 500 mg
Active ingredients Paracetamol 500 mg + Dihydrocodeine 7.46 mg Paracetamol 500 mg only
Pain level targeted Mild to moderate pain Mild pain
Suitable for migraines Yes Sometimes
Risk of dependence Yes (opioid component) No
UK classification Pharmacy (P) medicine General Sale (GSL)

 

How Should You Store Paramol Tablets?

 

Store Paramol tablets below 25°C in a dry place, away from direct sunlight. Always keep them out of the sight and reach of children. Do not use the tablets after the expiry date printed on the packaging — if in doubt, return them to your pharmacy for safe disposal. If you're managing multiple health conditions and keeping a range of medicines at home, it's worth checking our first aid collection for storage accessories and other essentials.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Paramol 24 Tablets specifications
Treatment category Pain relief, fever, migraine
Mechanism of action Paracetamol (prostaglandin inhibition) + Dihydrocodeine (opioid receptor agonist)
Effective for Headaches, migraines, dental pain, muscular aches, fever
Suitable for Adults and children aged 12 and over
Active ingredient Paracetamol 500 mg, Dihydrocodeine tartrate 7.46 mg
Pack size 24 tablets
UK classification Pharmacy (P) medicine
Drug class Analgesic combination (opioid + non-opioid)
Preparation Tablet
Route of administration Oral

Specifications of Paramol 24 Tablets

 

What Is Paramol and What Is It Used For?

 

Paramol is a combination analgesic tablet containing paracetamol 500 mg and dihydrocodeine tartrate 7.46 mg. It is used for the short-term relief of moderate pain that has not responded adequately to paracetamol or ibuprofen alone. Conditions it is commonly used for include headaches, migraines, toothache, period pain, muscular pain, and fever. Paramol tablets are for oral use and are available over the counter as a Pharmacy (P) medicine in the UK.

 

What Do You Need to Know Before Using Paramol?

 

Before taking Paramol, it's important to check whether it is appropriate for you. Do not take Paramol if any of the following apply:

  • You are allergic to paracetamol, dihydrocodeine, or any other ingredient in the tablet
  • You have severe liver or kidney disease
  • You have a condition causing respiratory depression (slowed or difficult breathing)
  • You are under 12 years of age
  • You are currently taking or have recently taken monoamine oxidase inhibitors (MAOIs)
  • You have a head injury or raised intracranial pressure
  • You are in the third trimester of pregnancy

Speak to your pharmacist or GP before taking Paramol if you have liver problems, kidney problems, an underactive thyroid, or a history of substance dependence. Dihydrocodeine can cause dependence even at the doses found in over-the-counter products — this is why Paramol should only be used for short periods.

The following medicines may interact with Paramol:

  • Other opioid analgesics (e.g. codeine, tramadol) — increased risk of side effects
  • MAOIs — potentially serious interaction; do not use together
  • CNS depressants including alcohol, sedatives, and anxiolytics — increased drowsiness
  • Other paracetamol-containing products — risk of paracetamol overdose
  • Warfarin — regular use of paracetamol may enhance anticoagulant effect
  • Metoclopramide or domperidone — may affect absorption of paracetamol

 

How Should You Use Paramol?

 

Always use Paramol exactly as directed on the packaging or as advised by your pharmacist. Do not exceed the recommended dose.

  1. Check the packaging to confirm you are not allergic to any ingredient.
  2. Swallow the tablets whole with a full glass of water.
  3. Do not crush or chew the tablets.
  4. Take with or without food — food may help if you experience nausea.
  5. Allow at least 4 hours between doses.
  6. Do not take more than 8 tablets in any 24-hour period.
  7. Do not use for more than 3 days without seeking medical advice.
Age Group Dose Frequency Maximum in 24 hours
Adults and children aged 12+ 1–2 tablets Every 4–6 hours 8 tablets
Children under 12 Not suitable — do not use

If you are looking for pain relief options suitable for younger children, our baby and toddler collection includes age-appropriate products.

 

What Are the Possible Side Effects of Paramol?

 

Like all medicines, Paramol can cause side effects, although not everyone experiences them. The dihydrocodeine component is responsible for most of the side effects listed below.

Common side effects:

  • Nausea or vomiting
  • Constipation
  • Dizziness or light-headedness
  • Drowsiness or sedation
  • Headache (with prolonged use — medication-overuse headache)

Less common side effects:

  • Dry mouth
  • Sweating
  • Difficulty urinating (urinary retention)
  • Skin rash or itching
  • Mood changes

Serious but rare reactions include severe allergic reactions (anaphylaxis), liver damage (in overdose), and respiratory depression. If you experience difficulty breathing, swelling of the face or throat, or severe skin reactions, seek emergency medical help immediately. If you're managing symptoms like nausea alongside pain, you may find our sickness and nausea collection helpful for supportive products.

 

How Should You Store Paramol?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep in the original packaging until use
  • Keep out of the sight and reach of children at all times
  • Do not use after the expiry date printed on the carton
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Paramol tablets online in the UK?

You can buy Paramol 24 tablets online from Cured Pharmacy, a GPhC-registered UK online pharmacy. No prescription is needed — it is available as a Pharmacy (P) medicine for adults and young people aged 12 and over. Simply add it to your basket and complete a short health questionnaire at checkout to ensure it is suitable for you.

How do Paramol tablets work in the body?

Paramol works through two complementary mechanisms. Paracetamol reduces pain signals and lowers fever by inhibiting prostaglandin synthesis in the brain, while dihydrocodeine — a mild opioid — binds to opioid receptors in the central nervous system to further dampen pain perception. Together, they provide stronger relief than paracetamol alone for moderate pain.

How do I take Paramol tablets step by step?

Swallow 1 to 2 tablets whole with a full glass of water. You can take them with or without food, though taking them with food may reduce the chance of nausea. Allow at least 4 hours between doses and never take more than 8 tablets in any 24-hour period.

What is the correct dose of Paramol for adults?

The recommended dose for adults and children aged 12 and over is 1 to 2 tablets every 4 to 6 hours when needed. The maximum dose is 8 tablets in 24 hours. Do not use for more than 3 consecutive days without speaking to a pharmacist or GP.

Can I take Paramol for a migraine?

Yes, Paramol is indicated for migraine relief and can be effective when taken at the first sign of a migraine attack. However, if you are using pain relief for migraines more than 10 to 15 days per month, you may be at risk of medication-overuse headache — speak to your GP for a longer-term management plan.

What are the side effects of Paramol and how do I manage them?

The most common side effects are nausea, constipation, dizziness, and drowsiness — these are largely due to the dihydrocodeine component. Taking Paramol with food can help reduce nausea, and staying well hydrated and eating fibre-rich foods may ease constipation. If side effects are troublesome or persistent, stop use and speak to your pharmacist.

Who is eligible to take Paramol tablets?

Paramol is suitable for adults and young people aged 12 and over who need relief from moderate pain or fever. It is not suitable for children under 12, people with severe liver or kidney disease, those with respiratory depression, or anyone taking MAOIs. Always read the label and speak to a pharmacist if you are unsure.

Can I take Paramol if I am pregnant or breastfeeding?

Paramol is not recommended during pregnancy, particularly in the third trimester, because dihydrocodeine can affect the baby's breathing. It is also not recommended during breastfeeding as dihydrocodeine passes into breast milk. Speak to your GP or midwife before taking any pain relief during pregnancy or while breastfeeding.

What happens if I miss a dose of Paramol?

Paramol is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take your next dose when pain returns, ensuring at least 4 hours have passed since your last dose. Never double up to compensate for a missed dose.

How long can you take Paramol for?

Paramol should not be used for more than 3 days without medical advice. Prolonged use of opioid-containing medicines like Paramol can lead to physical dependence and, in the case of headache treatment, medication-overuse headache. If your pain persists beyond 3 days, consult your GP for further assessment.

Can I drink alcohol while taking Paramol?

You should avoid alcohol while taking Paramol. Alcohol enhances the sedative effects of dihydrocodeine, increasing the risk of drowsiness, dizziness, and impaired coordination. Combining alcohol with paracetamol also increases the risk of liver damage, particularly if you drink regularly or in large amounts.

What are the alternatives to Paramol tablets?

For milder pain, standard paracetamol or ibuprofen may be sufficient. For headaches and migraines, aspirin-based products or triptans (on prescription) are also options. You can explore a range of over-the-counter options in our pain relief collection. Always choose the lowest effective dose for the shortest necessary time.

Can I take Paramol with other medicines?

Paramol can interact with several medicines, including other opioids, MAOIs, sedatives, and other paracetamol-containing products. Taking it alongside these medicines can increase the risk of serious side effects including respiratory depression or paracetamol overdose. Always tell your pharmacist about all medicines you are currently taking before starting Paramol.

Is Paramol suitable for period pain?

Yes, Paramol can be used for the relief of period pain (dysmenorrhoea) in adults and young people aged 12 and over. If period pain is severe, recurring, or significantly affecting your daily life, it is worth speaking to your GP, as there may be an underlying cause that needs investigation. You can also find relevant products in our women's health collection.

What are the latest findings on dihydrocodeine-paracetamol combinations?

Clinical evidence consistently supports the use of paracetamol-opioid combinations for moderate pain where single-agent therapy is insufficient. However, regulatory bodies including the MHRA continue to emphasise the importance of short-term use only, given the risk of opioid dependence even at low doses found in over-the-counter products. Always follow the recommended dose and duration on the packaging.

How Should You Use Paramol?

Paramol tablets are taken orally with a full glass of water. You can take them with or without food, though taking them alongside a light meal or snack may help reduce the chance of nausea — a common side effect of the dihydrocodeine component. Always read the patient information leaflet inside the pack before use.

What Is the Correct Dose of Paramol?

The dose of Paramol depends on your age. The table below summarises the recommended dosing. Never exceed the maximum stated dose, and always leave at least 4 hours between doses to avoid accidental overdose of paracetamol.

When Is the Best Time to Use Paramol?

Paramol is most effective when taken at the earliest sign of pain or fever, rather than waiting until symptoms become severe. For migraines in particular, taking Paramol as soon as you notice the onset of a headache — ideally before the pain peaks — tends to give the best results. If you experience nausea with migraines, taking the tablets with a small amount of food may help.

Avoid taking Paramol late at night unless necessary, as dihydrocodeine can cause drowsiness that may affect your sleep quality or leave you feeling groggy the following morning.

How Long Can You Use Paramol For?

Paramol is intended for short-term use only. Do not use it for more than 3 consecutive days without seeking advice from your pharmacist or GP. Using opioid-containing medicines like Paramol for extended periods carries a risk of physical dependence, and using any pain relief for headaches or migraines too frequently can lead to medication-overuse headache — a condition where the very medicine you're taking starts to cause more headaches.

If your pain has not improved after 3 days, or if it worsens, stop taking Paramol and consult a healthcare professional. They can help identify the underlying cause and recommend a more appropriate treatment plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Paramol?

The most frequently reported side effects of Paramol are related to its dihydrocodeine component. Most people tolerate the medicine well when taken at the recommended dose for a short period, but it's important to know what to look out for.

  • Nausea or vomiting
  • Constipation
  • Dizziness or light-headedness
  • Drowsiness or sedation
  • Headache (particularly with prolonged use — see medication-overuse headache below)

What Are the Less Common Side Effects of Paramol?

Some people experience side effects that are less frequent but still worth being aware of. These tend to occur more often in people who are sensitive to opioids or who take higher doses.

  • Dry mouth
  • Sweating
  • Difficulty urinating (urinary retention)
  • Skin rash or itching
  • Mood changes or feelings of euphoria
  • Abdominal discomfort

What Are the Serious Side Effects of Paramol?

Serious side effects are rare but require immediate medical attention. Paracetamol overdose — which can occur if you accidentally take too much or combine Paramol with other paracetamol-containing products — can cause severe liver damage, which may not be immediately apparent. Symptoms of overdose include nausea, vomiting, and abdominal pain in the first 24 hours, followed by signs of liver failure.

Dihydrocodeine can cause respiratory depression (dangerously slow or shallow breathing) in overdose or in people with pre-existing respiratory conditions. Severe allergic reactions (anaphylaxis), characterised by swelling of the face, lips, or throat, difficulty breathing, and a sudden drop in blood pressure, are rare but life-threatening. Call 999 immediately if you suspect a serious reaction.

What Should You Do If You Experience Side Effects of Paramol?

For mild side effects such as nausea or constipation, taking Paramol with food and staying well hydrated can help. If drowsiness is a problem, avoid driving or operating machinery until you know how the medicine affects you. If side effects are persistent, worsening, or causing significant distress, stop taking Paramol and speak to your pharmacist or GP as soon as possible.

In the event of a suspected overdose — even if you feel well — go to your nearest A&E department immediately or call 999. Do not wait for symptoms to develop, as paracetamol overdose damage can be irreversible if treatment is delayed.

Can Paramol Interact With Other Medicines?

Yes. Paramol has several clinically significant interactions. Taking it alongside other opioid analgesics, sedatives, or alcohol increases the risk of excessive sedation and respiratory depression. Combining it with other paracetamol-containing products — including many cold and flu remedies — risks paracetamol overdose. MAOIs interact seriously with dihydrocodeine and must not be taken together. Warfarin users should be aware that regular paracetamol use may enhance the anticoagulant effect, increasing bleeding risk. Always inform your pharmacist of all medicines, supplements, and herbal remedies you are taking before starting Paramol.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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