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Panadol Extra Soluble - 24 Tablets

Panadol Extra Soluble - 24 Tablets

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  • ✔️ Relieves headache, migraine, and dental pain effectively
  • ✔️ Contains paracetamol 500mg plus caffeine 65mg per tablet
  • ✔️ Soluble format for faster absorption than standard tablets
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ 24-tablet pack provides a practical at-home pain relief supply

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What Are Panadol Extra Soluble Tablets?

 

If you've ever needed fast relief from a headache and wanted something that gets to work quickly, panadol extra soluble tablets are worth knowing about. Each effervescent tablet contains two active ingredients — paracetamol 500mg and caffeine 65mg — working together to tackle mild to moderate pain. The soluble format means you dissolve the tablets in water before drinking, which can help the medicine absorb faster than a standard tablet you swallow whole. You can find this and other options across our pain relief collection at Cured Pharmacy.

Panadol Extra Soluble is an over-the-counter medicine, so you don't need a prescription to buy it. It's licensed in the UK for the relief of headache, migraine headache, dental pain, period pain, rheumatic pain, muscular aches, and the symptoms of cold and flu including fever. Each pack contains 24 tablets, giving you a practical supply to keep at home or in your bag.

 

How Do Panadol Extra Soluble Tablets Work?

 

Understanding how a medicine works helps you use it more confidently. Here's what happens when you take Panadol Extra Soluble:

  • Paracetamol (500mg per tablet) — inhibits the production of prostaglandins in the brain and spinal cord, which are chemicals involved in transmitting pain signals and raising body temperature. This reduces both pain perception and fever.
  • Caffeine (65mg per tablet) — acts as an adjuvant analgesic. It enhances the pain-relieving effect of paracetamol, meaning you may get more effective relief than from paracetamol alone at the same dose.
  • Soluble delivery — dissolving the tablet in water creates a solution that the body can absorb rapidly through the gastrointestinal tract, potentially speeding up the onset of action compared to solid oral tablets.

The combination of paracetamol and caffeine is well established in clinical practice. The NHS notes that paracetamol is one of the most commonly used pain relievers in the UK and is generally well tolerated when taken at the correct dose.

 

Who Is Panadol Extra Soluble Suitable For?

 

Panadol Extra Soluble is suitable for most adults and young people aged 12 and over. It's a particularly good choice if you find standard tablets difficult to swallow, or if you want a pain reliever that gets to work without delay. That said, it isn't right for everyone.

It may be suitable for you if you:

  • Are aged 12 or over and weigh at least 32kg
  • Experience regular tension headaches or migraines
  • Need relief from dental pain, period pain, or muscular aches
  • Prefer a soluble format over swallowing tablets

 

How Does Panadol Extra Soluble Compare to Standard Panadol?

 

Feature Panadol Extra Soluble Standard Panadol (500mg Tablets)
Active ingredients Paracetamol 500mg + Caffeine 65mg Paracetamol 500mg only
Format Effervescent soluble tablet Solid oral tablet
Onset of action Potentially faster (dissolved in water) Standard absorption rate
Suitable for ages 12 years and over Varies by product; some from 6 years

 

How Should You Store Panadol Extra Soluble Tablets?

 

Store your panadol extra soluble tablets below 25°C in a dry place, away from direct sunlight and moisture. Because these are effervescent tablets, humidity can cause them to degrade more quickly than standard tablets — so keep the tube tightly closed after each use. Always store medicines out of the sight and reach of children.

Check the expiry date printed on the packaging before use. Do not use the tablets if the tube has been damaged or if the tablets appear discoloured or crumbled. If you need to dispose of unused tablets, take them to your local pharmacy — never flush them down the toilet or put them in household waste.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Panadol Extra Soluble 24 Tablets specifications
Treatment category Pain relief / Analgesic
Mechanism of action Prostaglandin synthesis inhibition (paracetamol) + adjuvant analgesic (caffeine)
Effective for Headache, migraine, dental pain, period pain, muscular aches, cold and flu symptoms, fever
Suitable for Adults and children aged 12 years and over
Active ingredient Paracetamol 500mg, Caffeine 65mg per tablet
Pack size 24 tablets
UK classification General Sale List (GSL)
Drug class Non-opioid analgesic / Xanthine
Preparation Effervescent tablet
Route of administration Oral (dissolved in water)

Specifications of Panadol Extra Soluble 24 Tablets

 

What Is Panadol Extra Soluble and What Is It Used For?

 

Panadol Extra Soluble is an effervescent analgesic tablet containing paracetamol 500mg and caffeine 65mg per tablet. It is used for the short-term relief of mild to moderate pain, including headache, migraine headache, dental pain, period pain, rheumatic and muscular pain, and for reducing fever associated with colds and flu. The soluble format is designed to dissolve fully in water before you drink it, making it a practical option if you struggle with swallowing solid tablets.

 

What Do You Need to Know Before Using Panadol Extra Soluble?

 

Before taking this medicine, read the following carefully. Some people should not use Panadol Extra Soluble, and others may need to take extra care.

Do not take Panadol Extra Soluble if you:

  • Are allergic to paracetamol, caffeine, or any other ingredient in the tablet
  • Are under 12 years of age
  • Have severe liver disease or severe kidney impairment
  • Are already taking other medicines containing paracetamol — this can lead to accidental overdose
  • Have phenylketonuria (PKU) — check the PIL for excipient information

Take care and speak to your pharmacist or doctor first if you:

  • Regularly drink alcohol (more than 3 units per day)
  • Have liver or kidney problems, even mild ones
  • Are underweight or malnourished
  • Are pregnant or breastfeeding — paracetamol is generally considered safe in pregnancy at the lowest effective dose, but always seek advice first
  • Are sensitive to caffeine

Known drug interactions — tell your pharmacist if you take:

  • Warfarin or other anticoagulants — regular paracetamol use may increase bleeding risk
  • Metoclopramide or domperidone — these can speed up paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken at the same time
  • Other caffeine-containing products — combining sources of caffeine can cause jitteriness, palpitations, or difficulty sleeping
  • Any other paracetamol-containing product — always check labels carefully

 

How Should You Use Panadol Extra Soluble?

 

Always follow the dosage instructions on the packaging or as directed by your pharmacist. Never exceed the stated dose.

  1. Drop 2 tablets into a full glass of water (at least 200ml).
  2. Wait for the tablets to fully dissolve — do not swallow them whole.
  3. Stir gently if needed, then drink the entire solution.
  4. Repeat every 4 to 6 hours if pain or fever continues.
  5. Do not take more than 4 doses (8 tablets) in any 24-hour period.
  6. Leave at least 4 hours between each dose.
Age Group Dose Frequency Maximum in 24 hours
Adults and children aged 12+ 1–2 tablets Every 4–6 hours 8 tablets (4 doses)
Children under 12 Not suitable — do not use

If you are looking for pain relief options for younger children, our baby and toddler range includes age-appropriate products recommended for younger patients.

 

What Are the Possible Side Effects of Panadol Extra Soluble?

 

Like all medicines, Panadol Extra Soluble can cause side effects, although not everyone experiences them. Most people tolerate it well when taken at the recommended dose.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or stomach discomfort
  • Restlessness or difficulty sleeping (related to caffeine content)
  • Increased heart rate or palpitations

Less common or rare side effects:

  • Skin rash, itching, or hives
  • Swelling of the face, lips, or throat (signs of an allergic reaction — seek emergency help immediately)
  • Blood disorders such as thrombocytopenia (very rare)
  • Liver damage — this is a serious risk if you take more than the recommended dose

If you experience any signs of a serious allergic reaction or liver problems (such as yellowing of the skin or eyes, dark urine, or severe abdominal pain), stop taking the tablets and seek urgent medical attention. The NHS advises that paracetamol overdose is a medical emergency — if you think you or someone else has taken too much, call 999 or go to A&E immediately, even if you feel well.

 

How Should You Store Panadol Extra Soluble?

 

  • Store below 25°C in a dry place away from moisture and direct sunlight
  • Keep the tube tightly closed after each use to prevent humidity damage
  • Keep out of the sight and reach of children at all times
  • Do not use after the expiry date printed on the packaging
  • Do not dispose of medicines via household waste — return unused tablets to your local pharmacy

If you're managing multiple health conditions and need to keep a range of medicines at home, it's worth exploring our first aid collection for other useful products to have on hand.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Panadol Extra Soluble tablets online in the UK?

You can buy Panadol Extra Soluble 24 Tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, without a prescription. It is classified as a General Sale List (GSL) medicine, so no consultation is required. Simply add it to your basket and it will be dispatched to your door.

How do Panadol Extra Soluble tablets work in the body?

Panadol Extra Soluble contains paracetamol, which works by blocking the production of prostaglandins — chemicals in the brain that transmit pain signals and raise body temperature. The added caffeine acts as an adjuvant, enhancing the analgesic effect of paracetamol so you may experience more effective relief. The soluble format allows the active ingredients to be absorbed quickly once the dissolved solution reaches your stomach.

How do I take Panadol Extra Soluble step by step?

Taking Panadol Extra Soluble correctly is straightforward. Follow these steps:

  1. Drop 2 tablets into a full glass of water (at least 200ml).
  2. Allow the tablets to dissolve completely — do not swallow them whole.
  3. Drink the full solution once dissolved.
  4. Repeat every 4 to 6 hours if needed, but take no more than 8 tablets in 24 hours.
What is the correct dose of Panadol Extra Soluble for adults?

The recommended adult dose is 2 tablets (providing paracetamol 1000mg and caffeine 130mg) taken every 4 to 6 hours as needed. You should not take more than 4 doses — that is, 8 tablets — in any 24-hour period. Always leave at least 4 hours between doses.

When is the best time to take Panadol Extra Soluble?

Take Panadol Extra Soluble as soon as your pain or fever begins — early treatment tends to be more effective than waiting until symptoms worsen. Because the tablets contain caffeine, it's worth being mindful of taking them late in the evening, as caffeine can interfere with sleep in some people. If you need pain relief at night, speak to your pharmacist about a caffeine-free alternative.

What are the side effects of Panadol Extra Soluble and how do I manage them?

Most people tolerate Panadol Extra Soluble well at the recommended dose. Possible side effects include nausea, restlessness, palpitations (linked to caffeine), and rarely skin rash or allergic reactions. If you experience nausea, try taking the dissolved solution with a small amount of food. If you notice signs of an allergic reaction — such as swelling of the face or difficulty breathing — stop taking the tablets and seek emergency medical help immediately.

Who should not take Panadol Extra Soluble tablets?

Panadol Extra Soluble is not suitable for children under 12 years of age, people with a known allergy to paracetamol or caffeine, or those with severe liver or kidney disease. You should also avoid it if you are already taking other paracetamol-containing medicines, as this significantly increases the risk of overdose. Always check with your pharmacist if you are unsure whether this product is right for you.

Can I take Panadol Extra Soluble if I am pregnant or breastfeeding?

Paracetamol is generally considered the pain reliever of choice during pregnancy when used at the lowest effective dose for the shortest time, but the caffeine content in Panadol Extra Soluble means you should seek advice from your midwife, GP, or pharmacist before using it. High caffeine intake during pregnancy is associated with risks including low birth weight. A caffeine-free paracetamol product may be more appropriate.

Can I take Panadol Extra Soluble with other medicines?

You must not take Panadol Extra Soluble alongside any other product containing paracetamol, as this can lead to accidental overdose — a serious and potentially life-threatening situation. It may also interact with warfarin (increasing bleeding risk with regular use), metoclopramide, domperidone, and cholestyramine. Always tell your pharmacist about all medicines you are taking, including herbal remedies and supplements. You can browse our vitamins and supplements collection for products that are less likely to interact with paracetamol.

What happens if I miss a dose of Panadol Extra Soluble?

Panadol Extra Soluble is taken as needed for pain or fever, rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. If you need pain relief and it has been at least 4 hours since your last dose, you can take your next dose as normal. Never double up on doses to make up for one you forgot.

What are the alternatives to Panadol Extra Soluble?

If Panadol Extra Soluble isn't suitable for you, there are several alternatives available. Standard paracetamol 500mg tablets provide the same analgesic effect without caffeine. Ibuprofen is another option for pain and inflammation, though it is not suitable for everyone. You can explore the full range of options in our pain relief collection to find the most appropriate product for your needs.

How long can I take Panadol Extra Soluble for?

Panadol Extra Soluble is intended for short-term use only. You should not use it for more than 3 consecutive days for pain, or more than 3 days for fever, without speaking to a doctor or pharmacist. If your symptoms persist beyond this time, or if they worsen, seek medical advice rather than continuing to self-treat.

Is Panadol Extra Soluble suitable for children?

No — Panadol Extra Soluble is not suitable for children under 12 years of age. The caffeine content and the adult-strength paracetamol dose make it inappropriate for younger children. For pain and fever relief in babies and toddlers, age-appropriate liquid paracetamol formulations are available — you can find suitable options in our baby and toddler collection.

Does Panadol Extra Soluble contain caffeine and will it keep me awake?

Yes — each tablet contains 65mg of caffeine, so a standard 2-tablet dose provides 130mg of caffeine, which is roughly equivalent to one to two cups of coffee. This can cause restlessness, palpitations, or difficulty sleeping in people who are sensitive to caffeine, particularly if taken in the evening. If you need pain relief at night, consider a caffeine-free paracetamol product instead.

What is the latest evidence on paracetamol and caffeine combinations for headache?

Clinical evidence supports the use of paracetamol combined with caffeine for the treatment of tension-type headache and migraine. Studies published in peer-reviewed literature have found that the combination is more effective than paracetamol alone for headache relief. The NHS recognises paracetamol as a first-line treatment for headache, and caffeine is an established adjuvant analgesic used in several licensed combination products available in the UK.

How Should You Use Panadol Extra Soluble?

Panadol Extra Soluble must always be dissolved in water before you take it — never swallow the tablets whole or chew them. Using the correct method ensures the medicine works as intended and reduces the risk of stomach discomfort.

Follow these steps each time you take a dose:

What Is the Correct Dose of Panadol Extra Soluble?

The dose you take depends on your age. Adults and young people aged 12 and over should take 1 to 2 tablets per dose. Never exceed 8 tablets in any 24-hour period, and always leave at least 4 hours between doses. Panadol Extra Soluble is not suitable for children under 12 years of age.

When Is the Best Time to Use Panadol Extra Soluble?

Take Panadol Extra Soluble as soon as your pain or fever starts — acting early generally leads to better relief than waiting until symptoms become severe. Because each dose contains 130mg of caffeine (from 2 tablets), try to avoid taking it close to bedtime if you are sensitive to caffeine, as it may affect your ability to fall asleep. If you need pain relief during the night, a caffeine-free paracetamol product may be more suitable.

You can take Panadol Extra Soluble with or without food, though taking it with a light snack may help if you find it causes mild stomach discomfort.

How Long Can You Use Panadol Extra Soluble For?

Panadol Extra Soluble is intended for short-term use only. For pain relief, do not use it for more than 3 consecutive days without speaking to a doctor or pharmacist. For fever, the same 3-day limit applies. If your symptoms have not improved within this time, or if they worsen at any point, stop using the tablets and seek medical advice promptly.

Long-term or excessive use of paracetamol can cause serious liver damage. If you find you are regularly relying on pain relief, it is worth discussing the underlying cause with your GP.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Panadol Extra Soluble?

Panadol Extra Soluble is well tolerated by most people when taken at the recommended dose. However, the caffeine content means some people may notice stimulant-related effects, particularly if they are sensitive to caffeine or have consumed other caffeine-containing drinks or products on the same day.

  • Nausea or mild stomach discomfort
  • Restlessness or feeling jittery
  • Difficulty sleeping, particularly if taken in the evening
  • Increased heart rate or palpitations
  • Headache on stopping — if taken regularly, abrupt discontinuation of caffeine can trigger a withdrawal headache

What Are the Less Common Side Effects of Panadol Extra Soluble?

Less common side effects are rare at therapeutic doses but can occur. If you notice any of the following, stop taking the tablets and speak to your pharmacist or GP.

  • Skin rash, itching, or hives (urticaria)
  • Flushing or sweating
  • Dizziness or light-headedness
  • Unusual bruising or bleeding (very rare — may indicate a blood disorder)

What Are the Serious Side Effects of Panadol Extra Soluble?

Serious side effects from Panadol Extra Soluble are uncommon when the medicine is used correctly, but they can occur — particularly if the recommended dose is exceeded. Paracetamol overdose is a medical emergency. Even if you feel well initially, liver damage from overdose may not become apparent for several days. If you think you or someone else has taken too much, call 999 or go to your nearest A&E immediately — do not wait for symptoms to appear.

Signs of a serious allergic reaction (anaphylaxis) include swelling of the face, lips, tongue, or throat, difficulty breathing, and a sudden drop in blood pressure. This requires emergency treatment. Signs of liver problems include yellowing of the skin or whites of the eyes (jaundice), dark urine, and severe upper abdominal pain.

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or restlessness, try taking your next dose with a light snack and reducing your caffeine intake from other sources. If side effects are troublesome or persistent, stop taking the tablets and speak to your pharmacist, who can suggest an alternative pain reliever. For any serious or unexpected reaction, seek medical attention without delay.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting side effects helps improve medicine safety for everyone.

Can Panadol Extra Soluble Interact With Other Medicines?

Yes — interactions are possible, and some are clinically significant. Taking Panadol Extra Soluble alongside other paracetamol-containing products is the most important risk to avoid, as it can lead to accidental overdose without you realising. Warfarin users should be aware that regular paracetamol use (more than a few days) can enhance the anticoagulant effect, increasing bleeding risk. Medicines that speed up stomach emptying, such as metoclopramide and domperidone, can increase the rate of paracetamol absorption. Cholestyramine, used to lower cholesterol, can reduce paracetamol absorption if taken at the same time — separate doses by at least one hour. Always tell your pharmacist about every medicine, supplement, or herbal remedy you are taking before starting Panadol Extra Soluble.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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