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Orajel Extra Strength Dental Gel - 5.3g

Orajel Extra Strength Dental Gel - 5.3g

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  • ✔️ Contains 20% benzocaine for fast-acting topical oral pain relief
  • ✔️ Temporarily numbs toothache, teething pain, and sore gums
  • ✔️ Suitable for adults and children aged 2 years and over
  • ✔️ Compact 5.3g tube — easy to store in a medicine cabinet or bag
  • ✔️ Works within minutes of application directly to the affected area

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What Is Orajel Extra Strength Dental Gel and How Does It Help?

 

Toothache can strike at the worst possible moment — a weekend, a bank holiday, or the middle of the night when your dentist is unavailable. That is where orajel extra strength dental gel comes in. This 5.3g tube contains 20% benzocaine, a well-established local anaesthetic used to provide temporary relief from toothache, teething discomfort, and other sources of oral pain. At just £4.49, it is a practical first-response option to keep in your medicine cabinet. You can browse our full range of dental products at Cured Pharmacy for more oral care solutions.

Orajel has been a trusted name in oral pain relief for decades. The extra strength formulation is designed for adults and older children who need a higher concentration of active ingredient than standard teething gels provide. It is applied directly to the gum or affected area, meaning it gets to work locally rather than systemically — which is reassuring for many people who prefer not to take oral tablets.

 

How Does Orajel Extra Strength Dental Gel Work?

 

The active ingredient, benzocaine 20%, is a topical local anaesthetic. It works by temporarily blocking the sodium channels in nerve cell membranes at the site of application. When those channels are blocked, the nerve cannot transmit pain signals to the brain — so you feel numbness rather than pain. The effect is localised, meaning it does not affect the rest of your body.

  • Benzocaine is applied directly to the oral mucosa (gum or inner cheek tissue)
  • It penetrates the surface tissue and inhibits nerve signal transmission
  • Numbness typically begins within a few minutes of application
  • The effect is temporary — usually lasting 15–30 minutes depending on the individual

It is worth remembering that this gel manages pain temporarily. It does not treat the underlying cause of toothache, such as decay or infection. You should still see a dentist as soon as possible if you have persistent dental pain.

 

Who Should Use Orajel Extra Strength Dental Gel?

 

This gel is suitable for adults and children aged 2 years and over who need short-term relief from oral pain. It is particularly useful in situations where dental treatment is not immediately available. If you are also managing other discomforts, our pain relief collection includes a wide range of complementary options.

  • Adults experiencing toothache while awaiting a dental appointment
  • Parents managing teething discomfort in children aged 2 and over
  • People with sore gums caused by dentures or orthodontic appliances
  • Those with minor mouth ulcers or irritation on the gum tissue

 

How Does Orajel Extra Strength Compare to Standard Orajel Gel?

 

Feature Orajel Extra Strength Dental Gel Standard Orajel Dental Gel
Benzocaine concentration 20% 10%
Suitable for Adults and children 2+ Adults and children 2+
Intended use Toothache, teething, gum pain Mild toothache, teething
Pack size 5.3g 5.3g

 

How Should You Store Orajel Extra Strength Dental Gel?

 

Store the gel below 25°C in a dry place, away from direct sunlight. Keep the cap tightly closed when not in use. As with all medicines, keep it out of the reach and sight of children. Do not use the gel after the expiry date printed on the tube. If you are unsure whether the product is still suitable to use, ask your pharmacist.

The orajel extra strength dental gel tube is compact and easy to store in a bathroom cabinet or first aid kit. Check the tube regularly for any signs of damage or leakage. If you notice any changes in colour or consistency, do not use it and dispose of it safely.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Orajel Extra Strength Dental Gel 5.3g specifications
Treatment category Oral pain relief / Dental anaesthetic
Mechanism of action Topical local anaesthetic — sodium channel blockade
Effective for Toothache, teething pain, gum soreness, mouth ulcers
Suitable for Adults and children aged 2 years and over
Active ingredient Benzocaine 20%
Pack size 5.3g
Strength 20% w/w benzocaine
UK classification General Sale Medicine (GSL)
Drug class Topical local anaesthetic
Preparation Gel
Route of administration Topical (oral mucosa)

Specifications of Orajel Extra Strength Dental Gel 5.3g

 

What Is Orajel Extra Strength Dental Gel and What Is It Used For?

 

Orajel Extra Strength Dental Gel is a topical anaesthetic gel containing 20% benzocaine. It is used for the temporary relief of pain associated with toothache, teething, sore gums, and minor mouth irritations. It is classified as a General Sale Medicine (GSL) in the UK, meaning it can be purchased without a prescription. It is not a cure for dental problems — it is a short-term pain management tool while you arrange professional dental care.

If you are looking for broader oral health support alongside this product, our oral health collection includes a range of complementary products for everyday dental care.

 

What Do You Need to Know Before Using Orajel Extra Strength Dental Gel?

 

Before using this gel, read the following carefully. There are some situations where this product may not be appropriate for you.

Do not use this product if you:

  • Are allergic to benzocaine, other local anaesthetics, or any other ingredient in the gel
  • Have a condition called methaemoglobinaemia (a rare blood disorder)
  • Are applying it to a child under 2 years of age
  • Have open wounds or severely broken skin inside the mouth

Drug interactions to be aware of:

  • No clinically significant interactions are expected at topical doses
  • If you are taking medicines that can cause methaemoglobinaemia (such as certain antibiotics or nitrates), speak to your pharmacist before use
  • Always tell your pharmacist about all medicines you are currently taking, including herbal remedies

If you are pregnant, breastfeeding, or trying to conceive, speak to your GP or pharmacist before using this gel as a precaution.

 

How Should You Use Orajel Extra Strength Dental Gel?

 

Using this gel correctly is important for both safety and effectiveness. Follow these steps carefully each time you apply it.

  1. Wash your hands thoroughly before and after application
  2. Using a clean fingertip or cotton bud, apply a small pea-sized amount of gel to the affected area
  3. Gently massage the gel into the gum or painful area
  4. Allow the gel to remain in place — do not rinse immediately
  5. Repeat up to four times daily as needed
  6. Do not swallow the gel
Indication Age Group Dose Frequency
Toothache Adults and children 2+ Small pea-sized amount Up to 4 times daily
Teething pain Children aged 2 and over Small pea-sized amount Up to 4 times daily
Gum soreness Adults Small pea-sized amount Up to 4 times daily

Do not use more than directed. If symptoms persist beyond 7 days, or worsen at any point, stop using the gel and consult your dentist or GP.

 

What Are the Possible Side Effects of Orajel Extra Strength Dental Gel?

 

Like all medicines, Orajel Extra Strength Dental Gel can cause side effects, although not everyone will experience them. Most side effects are mild and localised to the area of application.

Common side effects:

  • Mild stinging or burning sensation immediately after application
  • Temporary numbness spreading slightly beyond the target area
  • Mild local irritation or redness of the gum tissue

Less common side effects:

  • Allergic contact reaction — rash, itching, or swelling at the application site
  • In very rare cases, benzocaine has been associated with methaemoglobinaemia, a serious condition where the blood's ability to carry oxygen is reduced — seek emergency medical help immediately if you notice blue-tinged lips, shortness of breath, or unusual fatigue after use

If you experience any signs of a serious allergic reaction — including swelling of the face, lips, or throat, or difficulty breathing — stop using the product immediately and call 999 or go to your nearest A&E. You can find further guidance on managing minor health concerns through our baby and toddler section if you are using this product for a child's teething discomfort.

 

How Should You Store Orajel Extra Strength Dental Gel?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Always replace the cap firmly after use
  • Keep out of the reach and sight of children at all times
  • Do not use after the expiry date printed on the tube
  • Do not freeze
  • Dispose of unused or expired medicine safely — return to your local pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Orajel Extra Strength Dental Gel online in the UK?

You can buy Orajel Extra Strength Dental Gel 5.3g directly from Cured Pharmacy online for £4.49 with fast UK delivery. It is a General Sale Medicine, so no prescription is needed. It is also available from some high street pharmacies and supermarkets across the UK.

How does Orajel Extra Strength Dental Gel work in the body?

The gel contains 20% benzocaine, a topical local anaesthetic that works by blocking sodium channels in the nerve endings at the site of application. This prevents pain signals from being transmitted to the brain, producing a numbing effect. The action is entirely localised to the area where you apply the gel — it does not enter your bloodstream in significant amounts at normal topical doses.

How do I apply Orajel Extra Strength Dental Gel step by step?

Wash your hands first, then apply a small pea-sized amount of gel to the affected gum or tooth area using a clean fingertip or cotton bud. Gently massage it in and allow it to sit — do not rinse straight away. You can repeat this up to four times daily as needed.

How quickly does Orajel Extra Strength Dental Gel start working?

Most people notice a numbing effect within a few minutes of applying the gel to the affected area. The duration of relief varies between individuals but typically lasts around 15 to 30 minutes. If pain is severe or persistent, you should contact your dentist rather than relying solely on the gel.

Is Orajel Extra Strength Dental Gel safe for children?

Orajel Extra Strength Dental Gel is not recommended for children under 2 years of age. For children aged 2 and over, it can be used in small amounts up to four times daily. If you are managing teething in a younger infant, speak to your pharmacist or GP — you can also explore our baby and toddler range for age-appropriate alternatives.

Can I use Orajel Extra Strength Dental Gel during pregnancy?

If you are pregnant or breastfeeding, you should speak to your GP or pharmacist before using this gel as a precaution. While topical benzocaine is not expected to cause harm at the doses used in this product, professional guidance is always advisable during pregnancy. Your pharmacist can help you weigh up the options.

What are the side effects of Orajel Extra Strength Dental Gel?

Side effects are uncommon but can include mild stinging, local irritation, or redness at the application site. In very rare cases, benzocaine has been linked to a serious condition called methaemoglobinaemia — symptoms include blue-tinged lips, shortness of breath, and unusual fatigue. Stop use immediately and seek emergency help if you notice these signs.

What happens if I accidentally swallow Orajel Extra Strength Dental Gel?

Swallowing a small amount of the gel accidentally is unlikely to cause serious harm in adults, but you should contact NHS 111 or your pharmacist for advice if this happens. Keep the product away from children to prevent accidental ingestion. Do not deliberately swallow the gel — it is intended for topical use only.

How long can I use Orajel Extra Strength Dental Gel for?

This gel is intended for short-term use only. If your symptoms have not improved after 7 days of use, or if they worsen at any point, stop using the gel and consult your dentist or GP. Prolonged use without addressing the underlying dental cause is not recommended.

Who should not use Orajel Extra Strength Dental Gel?

You should not use this gel if you are allergic to benzocaine or any other local anaesthetic. It is also not suitable for children under 2 years of age, or for people with a condition called methaemoglobinaemia. Always check the full ingredient list before use if you have known allergies.

What are the alternatives to Orajel Extra Strength Dental Gel?

Alternatives include other topical anaesthetic gels such as Anbesol or Bonjela, which contain different active ingredients. Oral pain relief medicines such as paracetamol or ibuprofen can also help manage toothache. You can browse our full pain relief collection for more options suited to your needs.

Can I use Orajel Extra Strength Dental Gel for mouth ulcers?

Yes, the gel can provide temporary numbing relief for minor mouth ulcers and gum irritation. However, if your mouth ulcer has not healed within 2 weeks, you should see your GP or dentist to rule out any underlying cause. The gel does not treat the ulcer itself — it only manages the pain temporarily.

Does Orajel Extra Strength Dental Gel interact with other medicines?

No clinically significant drug interactions are expected at the topical doses used in this product. However, if you are taking medicines associated with methaemoglobinaemia — such as certain antibiotics or nitrate-based medicines — speak to your pharmacist before use. Always inform your pharmacist of all medicines you are currently taking.

What is the difference between Orajel Extra Strength and regular Orajel?

The key difference is the concentration of benzocaine — Orajel Extra Strength contains 20% benzocaine, while standard Orajel formulations typically contain 10%. The higher concentration is intended for more significant dental pain where a stronger numbing effect is needed. Both products are applied in the same way and are suitable for adults and children aged 2 and over.

Is there any research supporting the use of benzocaine gels for toothache?

Benzocaine is a well-established topical local anaesthetic that has been used in dentistry and oral care for many decades. Its mechanism of action — sodium channel blockade — is well documented in pharmacological literature. The NHS recognises topical anaesthetics as a short-term option for managing dental pain while awaiting professional treatment.

How Should You Use Orajel Extra Strength Dental Gel?

Using Orajel Extra Strength Dental Gel correctly ensures you get the most effective relief with the least risk of irritation. Always read the label before use and follow these steps each time you apply the gel.

Avoid eating or drinking for at least 30 minutes after applying the gel where possible, as this allows the benzocaine to remain in contact with the tissue for longer. Do not apply the gel to broken or bleeding gum tissue without first seeking advice from your dentist or pharmacist.

What Is the Correct Dose of Orajel Extra Strength Dental Gel?

The correct dose depends on the age of the person being treated and the indication. Always use the smallest effective amount. Do not apply more gel than directed, as this will not increase the numbing effect and may increase the risk of side effects.

Do not use in children under 2 years of age. If you are unsure about the appropriate dose for your child, speak to your pharmacist before use.

When Is the Best Time to Use Orajel Extra Strength Dental Gel?

Apply the gel whenever you experience oral pain or discomfort, up to a maximum of four times per day. Many people find it most helpful to apply the gel before meals to reduce discomfort while eating, and again before bed if toothache is disrupting sleep. Try to space applications evenly throughout the day rather than applying multiple doses in quick succession.

If you are using the gel for a child's teething discomfort, applying it before nap time or bedtime can help settle them more comfortably. Always supervise children during application and ensure they do not swallow the gel.

How Long Can You Use Orajel Extra Strength Dental Gel For?

This gel is intended for short-term use only. Do not use it for more than 7 consecutive days without consulting your dentist or GP. Persistent toothache or gum pain is a sign that you need professional dental assessment — the gel manages symptoms temporarily but does not address the underlying cause.

If your symptoms worsen at any point during use, or if you develop swelling, fever, or difficulty swallowing, stop using the gel immediately and seek urgent dental or medical advice. Prolonged self-treatment with topical anaesthetics is not a substitute for proper dental care.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Orajel Extra Strength Dental Gel?

Most people use Orajel Extra Strength Dental Gel without experiencing any significant side effects. When side effects do occur, they are usually mild and limited to the area where the gel has been applied.

  • Mild stinging or burning sensation immediately after application
  • Temporary numbness spreading slightly beyond the intended area
  • Mild redness or irritation of the gum tissue
  • A bitter or unusual taste in the mouth

These effects are generally short-lived and resolve on their own without any treatment. If the stinging is particularly uncomfortable, you may be applying too much gel — try using a smaller amount next time.

What Are the Less Common Side Effects of Orajel Extra Strength Dental Gel?

Less commonly, some people may experience a localised allergic reaction to benzocaine or one of the other ingredients in the gel. This is more likely if you have a known sensitivity to local anaesthetics or para-aminobenzoic acid (PABA) derivatives.

  • Contact dermatitis or allergic reaction at the application site
  • Swelling of the gum or surrounding tissue
  • Itching or hives inside the mouth
  • Prolonged or excessive numbness beyond the expected duration

If you notice any of these effects, stop using the gel and speak to your pharmacist or GP. They can advise on whether an alternative product would be more suitable for you.

What Are the Serious Side Effects of Orajel Extra Strength Dental Gel?

Serious side effects from topical benzocaine are rare but can occur. The most significant risk is methaemoglobinaemia — a condition in which the blood's ability to carry oxygen is reduced. This is more likely if large amounts of the gel are used, if it is swallowed, or in individuals with certain genetic conditions or who are taking specific medicines.

  • Blue or grey discolouration of the lips, fingernails, or skin (cyanosis)
  • Shortness of breath or difficulty breathing
  • Rapid heart rate
  • Unusual fatigue, dizziness, or confusion
  • Severe allergic reaction (anaphylaxis) — swelling of the face, lips, tongue, or throat

If you or someone else experiences any of these symptoms after using the gel, call 999 immediately or go to your nearest A&E department. Do not wait to see if symptoms improve on their own.

What Should You Do If You Experience Side Effects?

For mild side effects such as local irritation or stinging, simply reduce the amount of gel you are applying and ensure you are not using it more frequently than four times per day. Rinsing your mouth gently with water after the gel has had time to work can also help reduce any residual irritation.

For any side effect that concerns you — or that does not resolve quickly — stop using the gel and contact your pharmacist or GP. You should also report suspected side effects through the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk, which helps monitor the safety of medicines in the UK.

Can Orajel Extra Strength Dental Gel Interact With Other Medicines?

At the topical doses used in this product, clinically significant drug interactions are not expected. However, people taking medicines that are known to increase the risk of methaemoglobinaemia — such as certain antibiotics (including dapsone), nitrate-based medicines, or some antimalarials — should speak to their pharmacist before using benzocaine-containing products. Always inform your pharmacist of all medicines you are currently taking, including over-the-counter products and herbal supplements.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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