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Olopatadine Eye Drops

Olopatadine Eye Drops

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  • ✔️ Relieves allergic conjunctivitis itching, redness, and watering
  • ✔️ Dual-action antihistamine and mast cell stabiliser formula
  • ✔️ Symptom relief begins within minutes of instillation
  • ✔️ Suitable for adults and children aged 3 years and over
  • ✔️ Convenient twice-daily dosing for all-day eye allergy control

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What Are Olopatadine Eye Drops and How Do They Help?

 

If your eyes itch, water, and turn red every time pollen season arrives — or whenever you're around cats, dust, or mould — you'll know how disruptive allergic conjunctivitis can be. Olopatadine eye drops offer targeted, fast-acting relief directly at the source of the problem. Available from our eye care collection, these drops combine two mechanisms in a single formulation, making them one of the most clinically studied topical treatments for eye allergy symptoms in the UK.

Olopatadine hydrochloride is the active ingredient. It belongs to a class of medicines known as selective histamine H1-receptor antagonists with mast cell stabilising properties. The NHS recognises allergic conjunctivitis as an extremely common condition, particularly in people who also suffer from hay fever or other atopic conditions such as asthma or eczema. Symptoms typically include itching, redness, tearing, and a gritty or burning sensation in the eyes.

 

How Do Olopatadine Eye Drops Work in the Eye?

 

The mechanism behind olopatadine is dual-action, which is what sets it apart from older single-action antihistamine drops. Here's how it works step by step:

  • Histamine blockade: Olopatadine selectively blocks H1 histamine receptors on the conjunctival cells, preventing histamine from triggering the itch and redness response.
  • Mast cell stabilisation: It inhibits the degranulation of mast cells in the conjunctiva, reducing the release of histamine and other inflammatory mediators before they can cause symptoms.
  • Rapid onset: Clinical studies show symptom relief can begin within minutes of instillation.
  • Sustained effect: The twice-daily dosing schedule maintains a consistent therapeutic level throughout the day.

This dual approach means olopatadine doesn't just treat symptoms after they appear — it also helps prevent them from worsening. That's particularly useful during high-pollen days or prolonged allergen exposure.

 

Who Should Use Olopatadine Eye Drops?

 

These drops are suitable for adults and children aged 3 years and over who experience signs and symptoms of allergic conjunctivitis. Whether your allergy is seasonal (triggered by pollen) or perennial (triggered year-round by dust mites, pet dander, or mould), olopatadine eye drops can help. They're also commonly used alongside oral antihistamines for people who also experience nasal or skin allergy symptoms — you can explore our allergy and hay fever range for complementary options.

Olopatadine eye drops are particularly well-suited for:

  • Adults and children (3+) with seasonal allergic conjunctivitis
  • People with perennial allergic conjunctivitis due to dust mites or pet allergens
  • Those who find oral antihistamines insufficient for eye symptoms
  • Patients looking for a preservative-containing drop with a well-established safety profile

 

How Do Olopatadine Eye Drops Compare to Other Antihistamine Eye Drops?

 

Feature Olopatadine Eye Drops Sodium Cromoglicate Eye Drops
Mechanism Antihistamine + mast cell stabiliser Mast cell stabiliser only
Dosing frequency Twice daily Four times daily
Onset of action Within minutes Several days of regular use
Suitable age 3 years and over 6 years and over (varies by brand)

 

How Should You Store Olopatadine Eye Drops?

 

Store your olopatadine eye drops below 25°C, away from direct sunlight and out of reach of children. Do not freeze the solution. Once opened, the bottle should be discarded after four weeks — even if there is solution remaining — to reduce the risk of eye infection from contamination. Always check the expiry date printed on the packaging before use.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Olopatadine Eye Drops specifications
Treatment category Allergic conjunctivitis
Mechanism of action Selective H1-receptor antagonist and mast cell stabiliser
Effective for Itching, redness, and watering caused by eye allergies
Suitable for Adults and children aged 3 years and over
Active ingredient Olopatadine hydrochloride
Strengths 0.1% w/v
UK classification Pharmacy (P) medicine
Drug class Antihistamine / mast cell stabiliser
Preparation Sterile ophthalmic solution
Route of administration Topical ophthalmic (eye drops)

Specifications of Olopatadine Eye Drops

 

What Are Olopatadine Eye Drops and What Are They Used For?

 

Olopatadine eye drops contain olopatadine hydrochloride 0.1% w/v as the active ingredient. They are used to treat the signs and symptoms of allergic conjunctivitis — an inflammation of the conjunctiva (the thin membrane covering the white of the eye and inner eyelids) triggered by allergens such as pollen, dust mites, animal dander, or mould spores. Symptoms include itching, redness, watering, and a gritty or burning sensation. The NHS describes allergic conjunctivitis as one of the most common eye conditions in the UK, frequently occurring alongside hay fever.

Olopatadine eye drops are licensed for use in adults and children aged 3 years and over. They are a Pharmacy (P) medicine, meaning you can purchase them without a prescription from a registered pharmacy.

 

What Do You Need to Know Before Using Olopatadine Eye Drops?

 

Before using these drops, read the following carefully. Do not use olopatadine eye drops if any of the contraindications below apply to you.

Do not use if you:

  • Are allergic to olopatadine hydrochloride or any other ingredient in the formulation (including benzalkonium chloride as preservative)
  • Are under 3 years of age
  • Have a known hypersensitivity to any component of the product

Warnings and precautions — tell your pharmacist or doctor if you:

  • Wear soft (hydrophilic) contact lenses — benzalkonium chloride can discolour soft lenses; remove lenses before use and wait at least 15 minutes before reinserting
  • Are pregnant or breastfeeding — seek medical advice before use
  • Have any other eye condition or are using other eye drops or eye ointments
  • Experience any sudden change in vision after using the drops

Drug interactions:

  • No clinically significant interactions have been reported for topical ophthalmic olopatadine at the recommended dose
  • If using multiple eye preparations, allow at least 5 minutes between each product
  • Apply eye ointments last if using alongside drops

 

How Should You Use Olopatadine Eye Drops Correctly?

 

Always use olopatadine eye drops exactly as described in this leaflet or as directed by your pharmacist. Do not use more than the recommended dose.

  1. Wash your hands thoroughly before handling the bottle.
  2. Remove soft contact lenses if worn.
  3. Tilt your head back slightly and gently pull down your lower eyelid to create a small pocket.
  4. Hold the dropper tip close to your eye without touching it, and instil one drop into the pocket.
  5. Close your eye gently and press lightly on the inner corner (nasolacrimal duct) for one to two minutes to reduce systemic absorption.
  6. Repeat in the other eye if both are affected.
  7. Replace the cap immediately after use.
Indication Age Group Dose Frequency
Allergic conjunctivitis Adults and children aged 3+ 1 drop per affected eye Twice daily (approx. 6–8 hours apart)
Allergic conjunctivitis Under 3 years Not recommended

 

What Are the Possible Side Effects of Olopatadine Eye Drops?

 

Like all medicines, olopatadine eye drops can cause side effects, although not everyone gets them. Most side effects are mild and localised to the eye.

Common side effects (may affect up to 1 in 10 people):

  • Transient stinging or burning sensation immediately after instillation
  • Headache
  • Eye discomfort or irritation
  • Dry eye sensation

Less common side effects (may affect up to 1 in 100 people):

  • Blurred vision (usually temporary — do not drive until vision clears)
  • Increased sensitivity to light (photophobia)
  • Eyelid swelling or redness
  • Unusual taste in the mouth
  • Runny nose

Stop using the drops and seek medical advice promptly if you develop signs of a serious allergic reaction, such as severe eye swelling, difficulty breathing, or a widespread skin rash. If you experience persistent or worsening eye symptoms, consult your GP or pharmacist. You can also browse our broader allergy and hay fever range for additional symptom management options.

 

How Should You Store Olopatadine Eye Drops?

 

  • Store below 25°C in a cool, dry place
  • Do not freeze
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the label
  • Discard the bottle 4 weeks after first opening, even if solution remains
  • Do not share your eye drops with anyone else
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

For a wider range of eye health products, visit our dedicated eye care collection at Cured Pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy olopatadine eye drops online in the UK?

You can buy olopatadine eye drops directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, without needing a prescription. They are classified as a Pharmacy (P) medicine, so a short online consultation may be required to confirm suitability. Simply add to your basket and complete the checkout — delivery is fast and discreet.

How do olopatadine eye drops work in the body?

Olopatadine works via two complementary mechanisms: it selectively blocks histamine H1 receptors in the conjunctiva, stopping histamine from triggering itch and redness, and it stabilises mast cells to prevent further release of inflammatory chemicals. This dual action means it both treats existing symptoms and helps prevent them from escalating. The effect begins within minutes of instillation.

How do I use olopatadine eye drops step by step?

Wash your hands, remove contact lenses if worn, tilt your head back, and gently pull down your lower eyelid to form a small pocket. Instil one drop into the pocket without touching the dropper tip to your eye, then close your eye gently and press lightly on the inner corner for one to two minutes. Repeat in the other eye if needed, then replace the cap immediately.

What is the correct dose of olopatadine eye drops?

The recommended dose for adults and children aged 3 years and over is one drop in each affected eye, twice daily — ideally spaced approximately 6 to 8 hours apart. Do not instil more than one drop per dose or use more frequently than twice daily unless specifically advised by a healthcare professional. Using more than the recommended amount will not improve results and may increase the risk of side effects.

When is the best time to use olopatadine eye drops?

Most people find it helpful to use one dose in the morning and one in the evening, roughly 6 to 8 hours apart, to maintain consistent symptom control throughout the day. If your symptoms are worse at particular times — for example, during outdoor activities in high-pollen conditions — try to time your morning dose before you go outside. Consistency matters more than the exact time of day.

What are the side effects of olopatadine eye drops and how do I manage them?

The most common side effect is a brief stinging or burning sensation immediately after instillation, which usually settles within a minute or two. Headache and mild eye discomfort are also reported by some users. If you experience blurred vision after applying the drops, wait until your vision clears before driving or operating machinery — this is usually temporary and resolves quickly.

Can I use olopatadine eye drops if I wear contact lenses?

Yes, but you must remove your soft contact lenses before applying the drops and wait at least 15 minutes before reinserting them. This is because the preservative benzalkonium chloride can be absorbed by soft lens material and may cause irritation or lens discolouration. Hard (rigid gas-permeable) lenses should also be removed prior to instillation.

Who is eligible to use olopatadine eye drops?

Olopatadine eye drops are suitable for adults and children aged 3 years and over who have been diagnosed with, or are experiencing symptoms consistent with, allergic conjunctivitis. They are not recommended for children under 3. People who are pregnant, breastfeeding, or have other eye conditions should speak to their pharmacist or GP before use.

What happens if I miss a dose of olopatadine eye drops?

If you forget a dose, apply it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case simply skip the missed one and carry on as normal. Never apply two doses at once to make up for a missed one. Missing an occasional dose is unlikely to significantly affect your overall symptom control.

What are the alternatives to olopatadine eye drops?

Common alternatives include sodium cromoglicate eye drops (a mast cell stabiliser requiring four-times-daily dosing), ketotifen eye drops (another antihistamine), and azelastine eye drops. Oral antihistamines such as cetirizine or loratadine can also help with eye symptoms as part of a broader allergy management plan — explore our allergy and hay fever collection for more options. Your pharmacist can advise on the most appropriate choice for your specific situation.

How long can you use olopatadine eye drops for?

Olopatadine eye drops can be used for the duration of the allergy season or for as long as symptoms persist, but you should not use a single bottle for more than four weeks after opening due to contamination risk. If your symptoms continue beyond a few weeks without improvement, or if they worsen, consult your GP or pharmacist. Long-term use should be reviewed periodically by a healthcare professional.

Can olopatadine eye drops be used for hay fever eyes?

Yes — olopatadine eye drops are specifically indicated for allergic conjunctivitis, which is the eye component of hay fever. They target the itching, redness, and watering that pollen triggers in the eyes. Many people use them alongside nasal sprays or oral antihistamines for full hay fever symptom control during the pollen season.

Are olopatadine eye drops safe during pregnancy?

There is limited data on the use of olopatadine eye drops during pregnancy. Although topical ophthalmic absorption is low, you should always consult your GP or midwife before using any medicine during pregnancy or whilst breastfeeding. They can help you weigh up the potential benefits against any theoretical risks and suggest the safest option for you.

What are the latest studies on olopatadine eye drops?

Olopatadine has been extensively studied since its introduction and remains one of the most clinically validated topical antihistamines for allergic conjunctivitis. Published research consistently demonstrates its dual mechanism — H1 blockade and mast cell stabilisation — provides faster and more sustained relief compared to single-action agents. It continues to be recommended in clinical guidelines for the management of allergic eye disease.

Can children use olopatadine eye drops?

Yes — olopatadine eye drops are licensed for use in children aged 3 years and over at the same dose as adults: one drop in each affected eye twice daily. They are not recommended for children under 3 years of age. If your child is very young or has other health conditions, always check with your GP or paediatrician before starting treatment. You can also browse our baby and toddler section for age-appropriate health products.

How Should You Use Olopatadine Eye Drops?

Using olopatadine eye drops correctly makes a real difference to how well they work. Always wash your hands before handling the bottle, and never allow the dropper tip to touch your eye, eyelid, or any other surface — this prevents contamination. If you wear soft contact lenses, remove them before instilling the drops and wait at least 15 minutes before putting them back in.

Follow these steps each time you use the drops:

What Is the Correct Dose of Olopatadine Eye Drops?

The standard dose is one drop in each affected eye, twice daily. Doses should be spaced approximately 6 to 8 hours apart to maintain consistent symptom control throughout the day. Do not instil more than one drop per dose — using extra drops will not improve the effect and may increase the likelihood of side effects such as stinging or blurred vision.

When Is the Best Time to Use Olopatadine Eye Drops?

Most people find a morning and evening routine works well — for example, once after waking and once before bed. If your symptoms are particularly bad during high-pollen periods, applying your morning dose before going outdoors can help reduce the impact of allergen exposure. The key is consistency: using the drops at roughly the same times each day helps maintain a steady level of protection.

If you are also using other eye drops or ointments, leave at least 5 minutes between each product. Apply eye ointments last. Avoid rubbing your eyes after instillation, as this can reduce the effectiveness of the drops and potentially introduce bacteria.

How Long Can You Use Olopatadine Eye Drops For?

You can use olopatadine eye drops for as long as your allergy symptoms persist — typically throughout the pollen season for seasonal sufferers, or on an ongoing basis for those with perennial allergic conjunctivitis. However, each bottle must be discarded four weeks after first opening, regardless of how much solution remains, to prevent the risk of eye infection from microbial contamination.

If your symptoms have not improved after a few weeks of regular use, or if they worsen at any point, stop using the drops and consult your GP or pharmacist. Long-term use should be reviewed periodically by a healthcare professional to ensure the treatment remains appropriate for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Olopatadine Eye Drops?

Most people tolerate olopatadine eye drops well, and side effects are generally mild and short-lived. The most frequently reported issue is a transient stinging or burning sensation in the eye immediately after instillation — this usually settles within a minute or two and is not a reason to stop treatment. Headache is also commonly reported, though it is difficult to determine whether this is directly caused by the drops or by the underlying allergy itself.

  • Stinging or burning sensation after instillation
  • Headache
  • Eye discomfort or irritation
  • Dry eye sensation

What Are the Less Common Side Effects of Olopatadine Eye Drops?

Less commonly, some people experience side effects that are still mild but worth being aware of. Blurred vision can occur shortly after applying the drops — this is usually temporary and clears within a few minutes. Do not drive or operate machinery until your vision has fully returned to normal. If blurred vision persists, seek medical advice.

  • Temporary blurred vision
  • Increased sensitivity to light (photophobia)
  • Eyelid swelling or redness
  • Unusual or unpleasant taste in the mouth
  • Runny nose
  • Keratitis (inflammation of the cornea) — rare

What Are the Serious Side Effects of Olopatadine Eye Drops?

Serious side effects are rare with olopatadine eye drops when used as directed. However, you should stop using the drops immediately and seek urgent medical attention if you experience any of the following, as they may indicate a serious allergic reaction (hypersensitivity):

  • Severe swelling of the eye, eyelid, face, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or hives
  • Sudden and significant worsening of eye redness or pain

If you develop signs of an eye infection — such as increased discharge, crusting, or significant pain — stop using the drops and consult your GP promptly. Do not share your eye drops with anyone else, as this can spread infection.

What Should You Do If You Experience Side Effects?

For mild side effects such as brief stinging, simply close your eye gently after instillation and press lightly on the inner corner for a minute or two — this can reduce both the discomfort and the amount of medicine absorbed systemically. If a side effect is persistent, worsening, or causing you concern, stop using the drops and speak to your pharmacist or GP before continuing.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting side effects helps improve the safety information available for all medicines.

Can Olopatadine Eye Drops Interact With Other Medicines?

No clinically significant drug interactions have been identified for olopatadine eye drops at the recommended topical ophthalmic dose. Because systemic absorption from eye drops is very low, the risk of interactions with oral medicines is minimal. However, if you are using other eye drops or eye ointments at the same time, leave at least 5 minutes between each product and apply ointments last. Always tell your pharmacist about all medicines you are taking, including herbal remedies and supplements, before starting a new treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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