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Nytol One-A-Night 50mg - 20 Tablets

Nytol One-A-Night 50mg - 20 Tablets

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Nytol One-A-Night 50mg Tablets for Sleep Support

 

You can rely on Nytol One-A-Night 50mg tablets when you need help falling asleep and staying asleep through the night. Each tablet contains 50mg of diphenhydramine hydrochloride, an antihistamine that causes drowsiness as a side effect, making it effective for temporary sleep difficulties.

This pack contains 20 tablets, providing you with a convenient supply for occasional sleepless nights. The tablets are designed to be taken once daily before bedtime, helping you establish a more regular sleep pattern when stress, travel, or other factors disrupt your normal rest.

 

How Diphenhydramine Helps You Sleep

 

Diphenhydramine works by blocking histamine receptors in your brain, which naturally makes you feel drowsy. This antihistamine crosses the blood-brain barrier and affects the central nervous system, reducing the time it takes you to fall asleep.

The sedating effect typically begins within 30 to 60 minutes after taking the tablet, helping you transition into sleep more easily. The effects can last for several hours, supporting you through a full night's rest without frequent awakening.

 

Who Can Benefit from These Sleep Tablets

 

These nytol one a night tablets are suitable for adults and children over 16 years who experience occasional sleeplessness. You might find them helpful if you're dealing with temporary sleep disruption due to stress, shift work, or travel across time zones.

The tablets work well for people who:

  • Have difficulty falling asleep at bedtime
  • Wake frequently during the night
  • Experience temporary insomnia due to life changes
  • Need sleep support during stressful periods

If you're looking for additional support with sleep difficulties, you might also consider browsing our sleep aid collection for complementary products.

 

Why Choose Single-Dose Convenience

 

The one-a-night formulation means you only need to take one tablet before bedtime, eliminating the need for multiple doses throughout the day. This reduces the risk of daytime drowsiness that can occur with some sleep medications taken more frequently.

Each 50mg tablet provides a consistent dose of the active ingredient, helping you maintain predictable sleep support when you need it most. The convenient tablet form makes them easy to take with water and suitable for travel or keeping by your bedside.

 

Storage and Shelf Life Information

 

You should store these tablets in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep them in their original packaging to protect from light and maintain their effectiveness throughout the shelf life.

Always keep medicines out of reach and sight of children. Check the expiry date on the packaging before use and do not take tablets that have passed their expiry date, as their effectiveness may be reduced.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

 

Recommended Dosage for Adults

You should take one tablet 20 to 30 minutes before you plan to go to bed. Swallow the tablet whole with a glass of water - do not crush, chew, or break the tablet as this may affect how the medicine works.

Take the tablet only when you can dedicate at least 7 to 8 hours to sleep, as the drowsy effects can last several hours. This ensures you wake up feeling refreshed rather than groggy the next morning.

Important Administration Guidelines

Do not exceed one tablet in any 24-hour period, even if you wake up during the night. Taking more than the recommended dose will not improve your sleep but may increase the risk of side effects and next-day drowsiness.

You should not use these tablets for more than two weeks continuously without consulting your doctor or pharmacist. If your sleep problems persist beyond this time, seek medical advice to identify any underlying causes that may need different treatment.

Customer Reviews

Based on 7 reviews
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S
Shirley Davies

VERY OBLIGING, WOULD BUY AGAIN, SWIFT DELIVERY

A
Anonymous

Great service and fast delivery

A
Anonymous

Helping me get.to sleep well

J
James Baldock

Thank you for a very nice delivery as well

M
Margaret

They really work for me

Understanding Potential Side Effects

Like all medicines, Nytol One-A-Night can have side effects, although not everyone will experience them. If you're managing other health conditions, you may want to explore our vitamins and supplements range for additional wellness support.

The most common side effects include drowsiness that may persist into the next day, dry mouth, and mild dizziness. These effects are usually mild and tend to decrease as your body adjusts to the medication.

You may experience any of the following side effects:

  • Drowsiness or grogginess the next morning
  • Dry mouth or throat
  • Dizziness or unsteadiness
  • Blurred vision
  • Difficulty concentrating
  • Constipation
  • Nausea or stomach upset
  • Headache
  • Confusion, particularly in elderly users
  • Difficulty urinating
  • Skin rash or itching
  • Restlessness or agitation

If you experience these or any other side effects, speak to your doctor or pharmacist right away. For more information about reporting side effects please see the MHRA Yellow Card Scheme.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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