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Nutramigen 2 With LGG - 400g

Nutramigen 2 With LGG - 400g

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What Is Nutramigen 2 With LGG and Who Is It For?

 

If your baby has been diagnosed with cow's milk allergy (CMA), finding the right formula can feel overwhelming. Nutramigen 2 with LGG is a hypoallergenic, extensively hydrolysed follow-on formula designed for infants from 6 months of age who cannot tolerate standard cow's milk-based feeds. It is one of the most widely recommended formulas for managing CMA in the UK, and it is available both on prescription and to purchase directly from our baby and toddler range here at Cured Pharmacy.

Cow's milk allergy affects an estimated 2–3% of infants in the UK, according to NHS guidance. Symptoms can range from skin rashes and digestive discomfort to more serious reactions. Nutramigen 2 with LGG is clinically formulated to provide complete nutrition while minimising the allergenic proteins that trigger these responses.

 

How Does Nutramigen 2 With LGG Work in the Body?

 

The formula works through a process called extensive hydrolysis. Rather than containing whole or partially broken-down milk proteins, Nutramigen 2 with LGG uses casein that has been hydrolysed into very small peptide fragments. These fragments are too small for the immune system to recognise as a threat, which is why this type of formula is classified as hypoallergenic.

  • Extensively hydrolysed casein: Cow's milk protein is broken down into tiny peptides, dramatically reducing allergenicity.
  • LGG probiotic (Lactobacillus rhamnosus GG): A clinically studied probiotic strain added to support gut microbiome health and help manage allergy symptoms over time.
  • Complete nutritional profile: Formulated to meet the nutritional requirements of infants from 6 months, including iron, calcium, and vitamins D and C.
  • Lactose-free: Contains no lactose, making it suitable for infants who also have lactose intolerance alongside CMA.

 

Who Should Use Nutramigen 2 With LGG?

 

This formula is intended for infants aged 6 months and over who have a confirmed or clinically suspected cow's milk allergy. It should be used under the guidance of a healthcare professional — typically a GP, health visitor, or paediatric dietitian. It is not a general-purpose formula for healthy infants without allergy concerns.

  • Infants aged 6 months or older with confirmed cow's milk allergy
  • Babies with multiple food protein allergies where cow's milk is a trigger
  • Infants who have not responded adequately to partially hydrolysed formulas
  • Babies requiring a lactose-free, hypoallergenic follow-on formula as part of a dietitian-led plan

 

How Does Nutramigen 2 With LGG Compare to Nutramigen 1 With LGG?

 

Feature Nutramigen 2 With LGG Nutramigen 1 With LGG
Age range 6 months and over From birth to 6 months
Protein source Extensively hydrolysed casein Extensively hydrolysed casein
Contains LGG probiotic Yes Yes
Lactose-free Yes Yes
Nutritional composition Adjusted for older infants (higher iron, adjusted energy) Formulated for newborn nutritional needs

 

How Should You Store Nutramigen 2 With LGG?

 

Store the unopened tin in a cool, dry place below 25°C, away from direct sunlight. Once opened, keep the lid tightly closed and use within 4 weeks. Never store opened powder in the fridge — moisture can affect the formula's quality. Prepared feeds should be used immediately or stored in the back of the fridge (not the door) and used within 24 hours. Discard any unused feed after 2 hours at room temperature.

If you are managing your baby's allergy alongside other health concerns — for example, if your infant also experiences digestive discomfort — you may find it helpful to explore our vitamins and supplements range for additional nutritional support products suitable for families.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nutramigen 2 With LGG 400g specifications
Treatment category Hypoallergenic infant formula / Dietary management of cow's milk allergy
Mechanism of action Extensive hydrolysis of casein protein reduces allergenicity; LGG probiotic supports gut microbiome
Effective for Cow's milk allergy (CMA) in infants from 6 months
Suitable for Infants aged 6 months and over with confirmed or suspected CMA
Active ingredient Extensively hydrolysed casein protein; Lactobacillus rhamnosus GG (LGG)
Pack size 400g
UK classification Food for Special Medical Purposes (FSMP)
Drug class Hypoallergenic formula (FSMP)
Preparation Powder for oral solution (reconstituted with water)
Route of administration Oral

Specifications of Nutramigen 2 With LGG 400g

 

What Is Nutramigen 2 With LGG and What Is It Used For?

 

Nutramigen 2 with LGG is a Food for Special Medical Purposes (FSMP) — a follow-on formula specifically designed for the dietary management of cow's milk allergy (CMA) in infants aged 6 months and over. It is not a standard infant formula and should only be used under medical supervision. The formula provides complete nutrition for older infants who cannot tolerate the proteins found in standard cow's milk-based feeds, whether they are breastfed, formula-fed, or mixed-fed.

CMA is one of the most common food allergies in infancy in the UK. The NHS advises that infants with CMA require a suitable alternative formula to ensure they receive adequate nutrition during a critical period of growth and development.

 

What Do You Need to Know Before Using Nutramigen 2 With LGG?

 

Before starting your baby on this formula, it is essential to discuss it with your GP, health visitor, or paediatric dietitian. Do not switch formulas without professional guidance.

Do not use this formula if your baby:

  • Has galactosaemia (a rare metabolic disorder affecting galactose processing)
  • Has a known allergy to any of the ingredients listed on the tin
  • Is under 6 months of age (use Nutramigen 1 with LGG instead)
  • Has been advised by a clinician to use an amino acid-based formula (for severe or complex allergies)

Warnings and precautions:

  • This formula is not suitable as the sole source of nutrition for infants under 6 months
  • Always prepare feeds using freshly boiled water cooled to no less than 70°C to reduce the risk of bacterial contamination
  • Do not add extra scoops — incorrect preparation can harm your baby's health
  • Breastfeeding is still recommended where possible; discuss with your healthcare team

Known interactions:

  • No significant drug interactions are known for this formula
  • If your baby is taking any prescribed medicines, always check with your pharmacist or GP before changing their formula

 

How Should You Use Nutramigen 2 With LGG?

 

Always follow the preparation instructions printed on the tin. Incorrect preparation — whether too concentrated or too dilute — can be harmful to your baby. Wash your hands thoroughly before preparing any feed.

  1. Boil fresh tap water and allow it to cool for no more than 30 minutes (water should remain at or above 70°C).
  2. Pour the required amount of cooled boiled water into a sterilised bottle.
  3. Using the scoop provided, add the correct number of level scoops as directed on the tin for your baby's age and weight.
  4. Replace the bottle cap and shake well until the powder is fully dissolved.
  5. Cool the feed to a safe feeding temperature by holding the bottle under cold running water or placing it in a bowl of cold water.
  6. Test the temperature on the inside of your wrist before feeding.
  7. Discard any unused feed within 2 hours if kept at room temperature, or within 24 hours if refrigerated.
Age Group Approximate Feeds Per Day Approximate Volume Per Feed Notes
6–9 months 3–5 feeds 150–200 ml Alongside introduction of solid foods
9–12 months 2–4 feeds 150–200 ml Formula remains important alongside weaning
12 months+ As directed by dietitian As directed Review with healthcare professional

Feed volumes are a guide only. Your baby's individual needs will vary. Always follow the advice of your healthcare team. If you are also managing weaning and looking for additional support products, our vitamins and supplements range includes options relevant to infant and family nutrition.

 

What Are the Possible Side Effects of Nutramigen 2 With LGG?

 

Most infants tolerate Nutramigen 2 with LGG well, but some changes in digestion are normal when first starting the formula. These are usually temporary.

Common side effects:

  • Looser or more frequent stools during the first few days
  • Change in stool colour (may appear greener or darker)
  • Different stool odour compared to standard formula
  • Mild wind or bloating as the gut adjusts

Less common side effects:

  • Temporary reduction in feed acceptance (some babies dislike the taste initially)
  • Constipation in a small number of infants
  • Skin reactions — if a rash develops after starting the formula, contact your GP promptly

If your baby shows signs of a severe allergic reaction — including swelling of the face or throat, difficulty breathing, or sudden collapse — call 999 immediately. While extensively hydrolysed formulas are tolerated by the vast majority of infants with CMA, a very small number may require an amino acid-based formula instead.

 

How Should You Store Nutramigen 2 With LGG?

 

  • Store the unopened tin in a cool, dry place below 25°C
  • Keep away from direct sunlight and sources of heat
  • Once opened, seal the lid tightly and use within 4 weeks
  • Do not store opened powder in the refrigerator — moisture can degrade the formula
  • Prepared feeds should be stored in the back of the fridge and used within 24 hours
  • Discard any feed left at room temperature after 2 hours
  • Keep out of reach of children

For families managing infant allergies alongside other health concerns, you may also find our allergy and hay fever range useful for older family members dealing with allergic conditions.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nutramigen 2 with LGG online in the UK?

You can buy Nutramigen 2 with LGG 400g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. It is also stocked in some high street pharmacies and may be available on NHS prescription if your baby has a confirmed diagnosis of cow's milk allergy. Ordering online is a convenient option for families who need regular supplies without visiting a pharmacy in person.

How does Nutramigen 2 with LGG work in the body?

Nutramigen 2 with LGG works by providing cow's milk protein in an extensively hydrolysed form — meaning the proteins are broken down into very small peptide fragments that the immune system is unlikely to recognise as allergens. The added LGG probiotic (Lactobacillus rhamnosus GG) supports the gut microbiome and may help the immune system manage allergic responses over time. Together, these two components make it one of the most clinically studied hypoallergenic formulas available in the UK.

What age is Nutramigen 2 with LGG suitable for?

Nutramigen 2 with LGG is designed for infants from 6 months of age onwards as a follow-on formula. For babies under 6 months with cow's milk allergy, Nutramigen 1 with LGG is the appropriate choice. Always confirm the correct formula for your baby's age and needs with your GP or paediatric dietitian before switching.

How do I prepare Nutramigen 2 with LGG step by step?

Boil fresh tap water and allow it to cool for no more than 30 minutes so it remains at or above 70°C, then pour the required volume into a sterilised bottle. Add the correct number of level scoops as directed on the tin, replace the cap, and shake well until fully dissolved. Cool the feed to a safe temperature before offering it to your baby, and discard any unused feed within 2 hours at room temperature or 24 hours if refrigerated.

What is the correct dose of Nutramigen 2 with LGG for my baby?

The number of scoops and volume of water required per feed is printed on the tin and varies according to your baby's age and weight. As a general guide, infants aged 6–9 months typically need 3–5 feeds per day of approximately 150–200 ml each, alongside the introduction of solid foods. Always follow the tin instructions and your healthcare team's advice rather than estimating.

What are the side effects of Nutramigen 2 with LGG?

The most commonly reported changes when starting Nutramigen 2 with LGG include looser stools, a change in stool colour (often greener), and a different odour — these are generally temporary and settle within a few days. A small number of infants may initially be reluctant to accept the formula due to its taste, which differs from standard milk-based feeds. If your baby develops a skin rash, persistent vomiting, or any signs of a severe allergic reaction, contact your GP or call 999 immediately.

Is Nutramigen 2 with LGG available on prescription in the UK?

Yes, Nutramigen 2 with LGG can be prescribed by a GP or paediatric dietitian for infants with a confirmed diagnosis of cow's milk allergy, and it is listed as a Food for Special Medical Purposes (FSMP). If your baby has been diagnosed with CMA, speak to your GP about whether a prescription is appropriate, as this can reduce the cost to your family. It is also available to purchase over the counter from registered pharmacies including Cured Pharmacy.

How does Nutramigen 2 with LGG compare to Aptamil Pepti 2?

Both Nutramigen 2 with LGG and Aptamil Pepti 2 are extensively hydrolysed follow-on formulas for infants with cow's milk allergy, but they differ in their protein source and probiotic content — Nutramigen uses hydrolysed casein with LGG, while Aptamil Pepti 2 uses hydrolysed whey protein. The choice between them is usually guided by your baby's clinical response and your healthcare team's recommendation. Neither should be selected without professional advice.

How long does a baby stay on Nutramigen 2 with LGG?

The duration of use depends on your baby's individual allergy management plan, as determined by your GP or paediatric dietitian. Most infants with cow's milk allergy are reviewed regularly — often every 6 months — to assess whether they are developing tolerance to cow's milk proteins. Many children naturally outgrow CMA by the age of 3–5 years, but this varies considerably between individuals.

Who is eligible to use Nutramigen 2 with LGG?

Nutramigen 2 with LGG is intended for infants aged 6 months and over who have a confirmed or clinically suspected cow's milk allergy, as assessed by a healthcare professional. It is not suitable for infants with galactosaemia, those with a known allergy to any of its ingredients, or babies who require an amino acid-based formula for severe or complex allergies. Always seek a clinical diagnosis before starting any hypoallergenic formula. You can browse our baby and toddler range for related products.

What happens if I make up a feed incorrectly?

Preparing feeds with too much or too little powder can be harmful — over-concentrated feeds can put strain on your baby's kidneys, while under-concentrated feeds may not provide adequate nutrition. Always use the scoop provided in the tin, level off each scoop carefully, and follow the exact water-to-powder ratio on the tin. If you are unsure, speak to your pharmacist or health visitor before preparing the next feed.

Can I use Nutramigen 2 with LGG if my baby is also being breastfed?

Yes, Nutramigen 2 with LGG can be used alongside breastfeeding as part of a mixed-feeding approach, if recommended by your healthcare team. The NHS advises that breastfeeding is still the preferred option where possible, even for infants with cow's milk allergy, as the breastfeeding parent can modify their own diet to exclude dairy. Discuss the best feeding strategy for your baby's specific situation with your GP or health visitor.

What are the alternatives to Nutramigen 2 with LGG for cow's milk allergy?

Alternatives include other extensively hydrolysed formulas such as Aptamil Pepti 2 and SMA Althéra, or — for infants with severe CMA who do not tolerate hydrolysed formulas — amino acid-based formulas such as Neocate or Nutramigen Puramino. Soya-based formulas are generally not recommended for infants under 6 months and should only be used on medical advice. Your paediatric dietitian is best placed to recommend the most appropriate alternative for your baby. If your family also manages other allergic conditions, our allergy and hay fever range may be of interest.

What are the latest studies on Nutramigen 2 with LGG?

Clinical research has shown that extensively hydrolysed casein formulas containing LGG may help infants with cow's milk allergy develop tolerance more quickly compared to those on standard hypoallergenic formulas without the probiotic. Studies published in peer-reviewed journals have supported the role of LGG in modulating the gut immune response in infants with CMA. Your GP or dietitian can discuss the current evidence base and what it means for your baby's individual management plan.

How should I transition my baby onto Nutramigen 2 with LGG?

Some babies accept the formula immediately, while others — particularly those used to standard milk-based feeds — may take a little time to adjust to the different taste. Your healthcare team may suggest a gradual transition, mixing increasing proportions of Nutramigen 2 with LGG with the previous formula over several days. Persistence is often needed, and most babies adapt within one to two weeks. If your baby consistently refuses the formula, speak to your dietitian before trying an alternative approach.

How Should You Use Nutramigen 2 With LGG?

Always prepare feeds fresh using the instructions printed on the tin. Hygiene is critical — sterilise all bottles, teats, and equipment before each use, and wash your hands thoroughly before preparing any feed. Never use a microwave to heat prepared feeds, as this can create hot spots that may burn your baby's mouth.

Follow these steps each time you prepare a feed:

What Is the Correct Dose of Nutramigen 2 With LGG?

The correct number of scoops and volume of water per feed is specified on the tin and is based on your baby's age and weight. The table below provides a general guide, but always defer to the tin instructions and your healthcare team's specific advice for your baby.

When Is the Best Time to Use Nutramigen 2 With LGG?

Nutramigen 2 with LGG can be offered at any time of day in place of a standard formula feed, following your baby's usual feeding routine. As your baby progresses through weaning, formula feeds typically shift to morning, mid-afternoon, and bedtime, though this varies between infants. Consistency in feeding times can help your baby settle into a routine and make it easier to monitor their intake.

Prepare each feed fresh immediately before use where possible. If you need to prepare feeds in advance — for example, for overnight or when out — store them in the back of the fridge (not the door) and use within 24 hours. Never reheat a feed that has already been partially consumed.

How Long Can You Use Nutramigen 2 With LGG For?

The duration of use is determined by your baby's individual allergy management plan, as reviewed by your GP or paediatric dietitian. Most infants with cow's milk allergy are assessed at regular intervals — typically every 6 months — to evaluate whether they are developing tolerance. Many children naturally outgrow CMA between the ages of 3 and 5 years, at which point a supervised milk ladder reintroduction may be recommended.

Do not stop using the formula or attempt to reintroduce cow's milk without guidance from your healthcare team, as this can trigger allergic reactions. Regular reviews ensure your baby continues to receive appropriate nutrition as their needs change.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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