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Nurofen Plus 200mg - 32 Tablets

Nurofen Plus 200mg - 32 Tablets

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  • ✔️ Combines ibuprofen and codeine for dual-action moderate pain relief
  • ✔️ Effective for headache, migraine, dental and muscle pain
  • ✔️ Codeine acts centrally to reduce pain perception in the brain
  • ✔️ Each pack contains 32 tablets for multi-day short-term relief
  • ✔️ Suitable for adults and adolescents aged 12 and over

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What Are Nurofen Plus Ibuprofen Codeine Tablets?

 

Nurofen Plus 200mg tablets are a combination analgesic containing two active ingredients: ibuprofen 200mg and codeine phosphate 12.8mg. Together, they work on pain from two different angles — making this one of the more effective over-the-counter options for moderate pain that hasn't responded to single-ingredient painkillers alone. Whether you're dealing with a stubborn headache, a migraine, dental pain, or aching muscles, Nurofen Plus ibuprofen codeine tablets are formulated to tackle pain that ordinary ibuprofen or paracetamol might not fully address. You can browse our full pain relief collection if you'd like to compare options before deciding.

Because this product contains codeine — a controlled opioid analgesic — it is classified as a Pharmacy (P) medicine in the UK. That means it's available without a prescription, but only through a registered pharmacy following a suitability check. It is not suitable for everyone, and it must not be used for more than three consecutive days without medical advice.

 

How Does Nurofen Plus Work to Relieve Pain?

 

The two active ingredients in Nurofen Plus work through distinct but complementary mechanisms:

  • Ibuprofen 200mg is a non-steroidal anti-inflammatory drug (NSAID). It inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which reduces the production of prostaglandins — the chemicals responsible for triggering pain, inflammation, and fever at the site of tissue damage.
  • Codeine phosphate 12.8mg is an opioid analgesic. Once absorbed, codeine is partially converted to morphine in the liver. It then binds to mu-opioid receptors in the brain and spinal cord, reducing the perception of pain signals travelling through the central nervous system.
  • Together, these two mechanisms provide both peripheral (at the pain site) and central (in the brain) pain relief — which is why the combination can be more effective for moderate pain than either ingredient alone.

It's worth noting that around 7–10% of the population are poor metabolisers of codeine due to CYP2D6 enzyme variation, meaning they may experience reduced analgesic effect. Conversely, ultra-rapid metabolisers may convert codeine to morphine too quickly, increasing the risk of opioid-related side effects.

 

Who Is Nurofen Plus Suitable For?

 

Nurofen Plus is intended for adults and adolescents aged 12 and over who are experiencing moderate pain that has not been adequately relieved by ibuprofen or paracetamol alone. It is particularly suited to:

  • Adults with tension headaches or migraines
  • People experiencing dental pain or post-procedural discomfort
  • Those with muscle pain, back pain, or joint pain
  • Adults with period pain (dysmenorrhoea) that hasn't responded to standard analgesics

It is not appropriate for children under 12, pregnant women (especially in the third trimester), breastfeeding mothers, or anyone with a history of peptic ulcers, severe kidney or liver disease, or NSAID-induced asthma. Always read the full patient information leaflet before use.

 

How Does Nurofen Plus Compare to Standard Ibuprofen?

 

Feature Nurofen Plus 200mg Standard Ibuprofen 400mg
Active ingredients Ibuprofen 200mg + Codeine 12.8mg Ibuprofen 400mg only
Pain types addressed Moderate pain, migraine, dental, muscle Mild to moderate pain, inflammation
Central nervous system action Yes (via codeine) No
Risk of dependency Yes (codeine component) No
UK classification Pharmacy (P) medicine General Sale List (GSL)
Maximum duration without medical advice 3 days 10 days (pain)

 

How Should You Store Nurofen Plus and Is It Clinically Suitable for You?

 

Store Nurofen Plus below 25°C in a dry place, away from direct sunlight and out of the reach and sight of children. Do not use after the expiry date printed on the packaging. Keep tablets in their original blister pack until needed.

Before purchasing, consider whether Nurofen Plus ibuprofen codeine tablets are right for your situation. If you have a history of gastrointestinal problems, cardiovascular disease, or are taking other medicines — including blood thinners or antidepressants — speak to your pharmacist first. If you're also managing a condition that affects your digestive system, you might find our indigestion collection helpful for managing any stomach-related discomfort alongside pain relief.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen Plus 200mg - 32 Tablets specifications
Treatment category Analgesic / Pain Relief
Mechanism of action COX inhibition (ibuprofen) + opioid receptor agonism (codeine)
Effective for Headache, migraine, dental pain, muscle pain, period pain
Suitable for Adults and adolescents aged 12 and over
Active ingredient Ibuprofen 200mg, Codeine Phosphate 12.8mg
Pack size 32 tablets
Strengths Ibuprofen 200mg / Codeine Phosphate 12.8mg per tablet
UK classification Pharmacy (P) medicine
Drug class NSAID + Opioid analgesic combination
Preparation Film-coated tablet
Route of administration Oral

Specifications of Nurofen Plus 200mg - 32 Tablets

 

What Is Nurofen Plus and What Is It Used For?

 

Nurofen Plus 200mg tablets contain two active ingredients — ibuprofen and codeine phosphate — and are used to relieve moderate pain that has not responded adequately to ibuprofen or paracetamol alone. Approved indications include headache, migraine, dental pain, neuralgia, period pain, rheumatic and muscular pain, and the pain associated with colds and flu. It is a short-term treatment only and should not be used continuously without medical supervision.

 

What Do You Need to Know Before Using Nurofen Plus?

 

Do not take Nurofen Plus if any of the following apply to you:

  • You are allergic to ibuprofen, codeine, aspirin, or any other NSAID
  • You have or have had a stomach ulcer or gastrointestinal bleeding
  • You have severe heart failure, kidney failure, or liver failure
  • You are in the last three months of pregnancy
  • You have asthma, urticaria, or rhinitis triggered by aspirin or other NSAIDs
  • You are under 12 years of age
  • You are breastfeeding (codeine passes into breast milk and can harm infants)
  • You have a condition causing breathing difficulties or respiratory depression
  • You are known to be an ultra-rapid metaboliser of codeine (CYP2D6)

The following medicines may interact with Nurofen Plus. Tell your pharmacist or doctor if you are taking:

  • Anticoagulants such as warfarin (increased bleeding risk)
  • Other NSAIDs or aspirin (increased risk of side effects)
  • SSRIs or SNRIs (increased risk of gastrointestinal bleeding)
  • Lithium (ibuprofen may increase lithium plasma levels)
  • Methotrexate (ibuprofen may increase toxicity)
  • Antihypertensives and diuretics (ibuprofen may reduce their effectiveness)
  • Other opioid medicines or sedatives (additive CNS depression with codeine)
  • MAOIs — do not take within 14 days of stopping an MAOI

 

How Should You Use Nurofen Plus?

 

Always use Nurofen Plus exactly as directed on the label or as advised by your pharmacist. Taking it with food or milk can help reduce the chance of stomach upset.

  1. Check you are not allergic to ibuprofen, codeine, or aspirin before taking.
  2. Swallow 1 to 2 tablets whole with a full glass of water.
  3. Take with food or milk to reduce the risk of stomach irritation.
  4. Wait at least 4 hours before taking your next dose.
  5. Do not exceed 6 tablets in any 24-hour period.
  6. Do not use for more than 3 consecutive days without speaking to a doctor or pharmacist.
  7. If pain persists or worsens, seek medical advice promptly.
Indication Age Group Dose Frequency
Moderate pain (headache, dental, muscle) Adults & adolescents 12+ 1–2 tablets Every 4–6 hours (max 6 tablets/24 hrs)
Migraine Adults 18+ 1–2 tablets Every 4–6 hours (max 6 tablets/24 hrs)
Children under 12 Under 12 NOT suitable — do not use

 

What Are the Possible Side Effects of Nurofen Plus?

 

Like all medicines, Nurofen Plus can cause side effects, although not everyone experiences them. If you're also managing other health concerns alongside pain, you may find it useful to explore our first aid collection for supportive products.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or vomiting
  • Constipation
  • Drowsiness or sedation
  • Stomach discomfort or indigestion
  • Dizziness or light-headedness

Less common side effects (may affect up to 1 in 100 people):

  • Headache (paradoxically, with overuse)
  • Skin rash or itching
  • Fluid retention or oedema
  • Raised blood pressure
  • Confusion or mood changes
  • Difficulty urinating

Stop taking Nurofen Plus and seek immediate medical attention if you experience: signs of a severe allergic reaction (swelling of the face, lips, or throat, difficulty breathing), black or bloody stools, severe stomach pain, or chest pain. Prolonged use of codeine-containing medicines can lead to dependence — this is a serious risk and one reason why the three-day limit exists.

 

How Should You Store Nurofen Plus?

 

Correct storage helps maintain the safety and effectiveness of your tablets. Follow these guidelines:

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep in the original blister packaging until ready to use
  • Keep out of the reach and sight of children at all times
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you're managing multiple health conditions and need to keep a range of medicines at home, it's worth reviewing your storage arrangements regularly. For those also taking supplements alongside pain relief, our vitamins and supplements collection includes products that may support general wellbeing.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen Plus online in the UK?

You can buy Nurofen Plus 200mg 32 Tablets from Cured Pharmacy, a GPhC-registered online pharmacy. Because it contains codeine, you'll need to complete a short suitability questionnaire before your order is approved. This ensures the product is safe and appropriate for your needs before it's dispensed.

How does Nurofen Plus work in the body?

Nurofen Plus contains ibuprofen, which blocks COX enzymes to reduce prostaglandin production and ease inflammation and pain at the source. It also contains codeine phosphate, which is converted to morphine in the liver and acts on opioid receptors in the brain and spinal cord to reduce the perception of pain. The dual mechanism makes it more effective for moderate pain than either ingredient alone.

How do I take Nurofen Plus step by step?

Follow these steps for safe use:

  1. Take 1 to 2 tablets with a full glass of water.
  2. Take with food or milk to protect your stomach.
  3. Wait at least 4 hours before your next dose.
  4. Do not take more than 6 tablets in 24 hours.
  5. Do not use for more than 3 consecutive days without medical advice.
What is the correct dose of Nurofen Plus for adults?

The standard adult dose is 1 to 2 tablets every 4 to 6 hours as needed for pain relief. The maximum dose is 6 tablets in any 24-hour period. Do not exceed this limit, and always leave at least 4 hours between doses to reduce the risk of side effects.

When is the best time to take Nurofen Plus?

Take Nurofen Plus as soon as pain begins — early intervention tends to be more effective, particularly for migraines. Always take it with food or a glass of milk to minimise the risk of stomach irritation. Avoid taking it late at night if drowsiness from the codeine component could be a concern for your daily activities.

What are the side effects of Nurofen Plus and how do I manage them?

Common side effects include nausea, constipation, drowsiness, and stomach discomfort. Taking the tablets with food can help reduce stomach upset, and staying well hydrated can ease constipation. If you experience severe stomach pain, difficulty breathing, or signs of an allergic reaction, stop taking the tablets immediately and seek medical attention.

Who should not take Nurofen Plus?

Nurofen Plus is not suitable for children under 12, pregnant women (especially in the third trimester), breastfeeding mothers, or people with a history of peptic ulcers, NSAID-induced asthma, or severe kidney or liver disease. It is also contraindicated in people with respiratory depression or known hypersensitivity to ibuprofen or codeine. Always check with your pharmacist if you are unsure.

Can Nurofen Plus cause dependency or addiction?

Yes — because Nurofen Plus contains codeine, an opioid, regular or prolonged use can lead to physical and psychological dependence. This is why it must not be used for more than 3 consecutive days without medical supervision. If you find yourself needing it frequently, speak to your GP about alternative pain management strategies.

What happens if I miss a dose of Nurofen Plus?

Nurofen Plus is taken as needed for pain rather than on a fixed schedule, so there is no "missed dose" in the traditional sense. Simply take your next dose when pain returns, ensuring at least 4 hours have passed since your last dose. Never double up to compensate for a missed dose.

Can I take Nurofen Plus for migraines?

Yes, Nurofen Plus is indicated for migraine relief. The ibuprofen component helps reduce the inflammation associated with migraine, while codeine provides additional central pain relief. However, if you are using it more than 10 days per month for migraines, you may be at risk of medication overuse headache — speak to your GP for a longer-term management plan.

What are the alternatives to Nurofen Plus?

Alternatives include standard ibuprofen tablets, paracetamol, co-codamol (paracetamol with codeine), or naproxen for inflammatory pain. The right choice depends on your pain type, medical history, and any other medicines you're taking. You can explore our pain relief collection to compare available options.

How long can you take Nurofen Plus for?

Nurofen Plus should not be used for more than 3 consecutive days without speaking to a doctor or pharmacist. It is intended for short-term relief of moderate pain only. Prolonged use increases the risk of gastrointestinal side effects, kidney strain, and codeine dependence.

Can I take Nurofen Plus with other medicines?

Nurofen Plus can interact with several medicines, including warfarin, SSRIs, lithium, methotrexate, other NSAIDs, and sedatives. Always tell your pharmacist about all medicines you are currently taking — including herbal remedies and supplements — before starting Nurofen Plus. Do not take it within 14 days of stopping an MAOI antidepressant.

Is Nurofen Plus safe during pregnancy or breastfeeding?

No. Nurofen Plus is not recommended during pregnancy, particularly in the third trimester, as ibuprofen can harm the developing baby. Codeine is also contraindicated during breastfeeding because it passes into breast milk and can cause serious harm to infants. Speak to your midwife or GP for safe pain relief alternatives during pregnancy.

What are the latest guidelines on codeine-containing medicines in the UK?

The MHRA has issued guidance reinforcing that codeine-containing medicines should only be used for short-term pain relief (up to 3 days) and are not suitable for children under 12. There are also restrictions on use in adolescents aged 12–18 with breathing problems. If you're managing ongoing pain, our IBS and cramps collection may offer supportive options for abdominal discomfort, while your GP can advise on longer-term pain strategies.

How Should You Use Nurofen Plus?

Nurofen Plus is taken orally and works best when used at the first sign of pain. Always swallow tablets whole with a full glass of water, and take them with food or milk to reduce the chance of stomach irritation. Never crush or chew the tablets.

What Is the Correct Dose of Nurofen Plus?

The dose varies depending on the indication and the patient's age. Always follow the dosage instructions on the pack or as directed by your pharmacist. Do not adjust the dose without professional guidance, particularly given the codeine content.

When Is the Best Time to Use Nurofen Plus?

Take Nurofen Plus as soon as pain begins — acting early generally produces better results, especially for migraines where early treatment can prevent escalation. Always take it with food to protect your stomach, and avoid taking it on an empty stomach or immediately before lying down. If drowsiness from the codeine component is a concern, avoid taking it before driving or operating machinery.

How Long Can You Use Nurofen Plus For?

Nurofen Plus is intended for short-term use only. Do not use it for more than 3 consecutive days without speaking to a doctor or pharmacist. Using codeine-containing medicines beyond this period significantly increases the risk of dependence and medication overuse headache. If your pain is ongoing or recurring, your GP can help identify the underlying cause and recommend a longer-term management plan.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Nurofen Plus?

Most people tolerate Nurofen Plus well when taken as directed, but some do experience side effects. The most frequently reported ones are linked to either the ibuprofen or codeine component of the tablet.

  • Nausea or vomiting
  • Constipation
  • Drowsiness or sedation
  • Stomach discomfort or indigestion
  • Dizziness or light-headedness

What Are the Less Common Side Effects of Nurofen Plus?

Less common side effects occur in a smaller proportion of users but are still worth being aware of. If any of the following persist or become troublesome, speak to your pharmacist or GP.

  • Headache (particularly with overuse — known as medication overuse headache)
  • Skin rash, itching, or hives
  • Fluid retention or ankle swelling
  • Raised blood pressure
  • Confusion or mood changes
  • Difficulty urinating
  • Dry mouth

What Are the Serious Side Effects of Nurofen Plus?

Although rare, serious side effects can occur and require immediate medical attention. Stop taking Nurofen Plus straight away and call 999 or go to A&E if you experience any of the following:

  • Signs of a severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash
  • Black, tarry, or bloody stools — which may indicate gastrointestinal bleeding
  • Severe stomach or abdominal pain
  • Chest pain or shortness of breath (possible cardiovascular event)
  • Yellowing of the skin or eyes (jaundice — possible liver damage)
  • Significant reduction in urine output (possible kidney impairment)

Can Nurofen Plus Interact With Other Medicines?

Yes — both ibuprofen and codeine can interact with a range of other medicines. Ibuprofen may increase the effects of anticoagulants such as warfarin, raising the risk of bleeding. It can also reduce the effectiveness of antihypertensives and diuretics, and increase the toxicity of methotrexate and lithium. Codeine combined with other sedatives, opioids, or alcohol can cause excessive drowsiness and respiratory depression. SSRIs taken alongside ibuprofen increase the risk of gastrointestinal bleeding. Always inform your pharmacist of all medicines you are taking before starting Nurofen Plus.

What Should You Do If You Experience Side Effects of Nurofen Plus?

For mild side effects such as nausea or constipation, taking the tablets with food and staying well hydrated can help. If drowsiness is affecting your daily activities, avoid driving or operating machinery. For any side effect that is severe, persistent, or unexpected, stop taking the tablets and contact your pharmacist or GP promptly. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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