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Nurofen Plus 200mg -24 Tablets

Nurofen Plus 200mg -24 Tablets

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  • ✔️ Combines ibuprofen and codeine for dual-action pain relief
  • ✔️ Targets moderate headaches, migraines, and musculoskeletal pain
  • ✔️ Ibuprofen reduces inflammation; codeine eases central pain signals
  • ✔️ Suitable for adults needing stronger relief than single analgesics
  • ✔️ 24-tablet pack provides convenient short-term pain management at home

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What Are Nurofen Plus Tablets and How Do They Relieve Pain?

 

Nurofen Plus tablets combine two active ingredients — ibuprofen 200mg and codeine phosphate 12.8mg — to tackle moderate pain that hasn't responded to a single analgesic alone. Whether you're dealing with a persistent headache, a migraine that's knocked you off your feet, or general musculoskeletal discomfort, this dual-action formula is designed to address pain from two different angles at once. You can find it alongside other trusted options in our pain relief collection.

Each pack contains 24 tablets, making it a practical choice to keep at home for those moments when pain strikes unexpectedly. It's available over the counter in the UK for adults aged 18 and over, though there are important restrictions on how long you should use it — more on that below.

 

How Does Nurofen Plus Work to Reduce Pain?

 

The two active ingredients in Nurofen Plus work through distinct but complementary mechanisms. Understanding how they function can help you use the product safely and effectively.

  • Ibuprofen (200mg): A non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, reducing the production of prostaglandins — the chemicals responsible for pain, inflammation, and fever.
  • Codeine phosphate (12.8mg): An opioid analgesic that binds to mu-opioid receptors in the brain and spinal cord, altering the perception of pain signals travelling through the central nervous system.
  • Combined effect: By targeting both peripheral inflammation and central pain pathways, the two ingredients together provide a broader analgesic effect than either would achieve alone.

It's worth noting that codeine is a prodrug — it's converted to morphine in the liver. This conversion varies between individuals depending on their genetic makeup, which is one reason why the response to codeine can differ from person to person.

 

Who Is Nurofen Plus Suitable For?

 

Nurofen Plus is intended for adults aged 18 and over who need short-term relief from moderate pain that hasn't been adequately controlled by ibuprofen or paracetamol alone. It's particularly well-suited to:

  • Adults experiencing moderate to severe headaches or migraines
  • People with dental pain, period pain, or musculoskeletal aches
  • Those who have already tried a single analgesic without sufficient relief
  • Adults who need a short-term (up to 3 days) pain management option

It is not appropriate for children under 12, and those aged 12–17 should only use it on medical advice. If you're pregnant, breastfeeding, or managing a long-term health condition, always speak to your GP or pharmacist before taking it.

 

How Does Nurofen Plus Compare to Standard Ibuprofen?

 

Feature Nurofen Plus 200mg Standard Ibuprofen 400mg
Active ingredients Ibuprofen 200mg + Codeine 12.8mg Ibuprofen 400mg only
Pain level targeted Moderate pain unresponsive to single analgesic Mild to moderate pain
Dependence risk Yes — codeine carries dependence risk No opioid dependence risk
Maximum duration (OTC) 3 days without medical advice Up to 10 days for pain (NHS guidance)

 

Is Nurofen Plus Suitable for Long-Term Use?

 

No — and this is an important point. Nurofen Plus tablets should not be used for more than three consecutive days without speaking to a doctor or pharmacist. Prolonged use of codeine-containing medicines carries a real risk of dependence, and overuse of any analgesic can paradoxically worsen headaches over time — a condition known as medication overuse headache (MOH). If you find yourself reaching for pain relief more than a few days a week, that's a signal to seek professional advice rather than continue self-medicating.

Storage is straightforward: keep the tablets below 25°C in a dry place, away from direct sunlight, and out of reach of children. If you're managing other health concerns alongside pain, our vitamins and supplements collection may support your overall wellbeing.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen Plus 200mg 24 Tablets specifications
Treatment category Pain relief / Analgesic
Mechanism of action NSAID (ibuprofen) + Opioid analgesic (codeine phosphate)
Effective for Headaches, migraines, dental pain, period pain, musculoskeletal pain
Suitable for Adults aged 18 and over
Active ingredient Ibuprofen 200mg, Codeine Phosphate 12.8mg
Pack size 24 tablets
Strengths Ibuprofen 200mg / Codeine Phosphate 12.8mg per tablet
UK classification Pharmacy (P) medicine
Drug class NSAID + Opioid analgesic combination
Preparation Film-coated tablet
Route of administration Oral

Specifications of Nurofen Plus 200mg 24 Tablets

 

What Is Nurofen Plus and What Is It Used For?

 

Nurofen Plus 200mg tablets are a combination analgesic medicine containing ibuprofen and codeine phosphate. They are used for the short-term relief of moderate pain in adults — particularly when pain has not responded adequately to ibuprofen or paracetamol taken alone. Approved indications include headaches, migraines, dental pain, period pain (dysmenorrhoea), backache, rheumatic and muscular pain, and the pain of non-serious arthritic conditions.

Nurofen Plus tablets are classified as a Pharmacy (P) medicine in the UK, meaning they can be purchased without a prescription but only from a registered pharmacy under the supervision of a pharmacist. They are not intended for long-term use.

 

What Do You Need to Know Before Using Nurofen Plus?

 

Before taking Nurofen Plus, it's essential to check whether it is safe for you. Do not take these tablets if any of the following apply:

  • You are allergic to ibuprofen, codeine, aspirin, or any other NSAID
  • You have or have had a stomach ulcer, gastrointestinal bleeding, or perforation
  • You have severe kidney, liver, or heart failure
  • You are in the last trimester of pregnancy
  • You are under 12 years of age
  • You are a known ultra-rapid metaboliser of codeine (CYP2D6 ultra-rapid metaboliser)
  • You are breastfeeding
  • You have a condition causing increased intracranial pressure

The following medicines may interact with Nurofen Plus. Always tell your pharmacist or GP what you are taking:

  • Anticoagulants (e.g. warfarin) — increased bleeding risk
  • Other NSAIDs or aspirin — increased risk of gastrointestinal side effects
  • Antidepressants (SSRIs, SNRIs, tricyclics) — increased risk of gastrointestinal bleeding
  • Lithium — ibuprofen may increase lithium plasma levels
  • Methotrexate — ibuprofen may increase methotrexate toxicity
  • Diuretics and antihypertensives — ibuprofen may reduce their effectiveness
  • Other opioid medicines or sedatives — additive CNS depression with codeine

 

How Should You Use Nurofen Plus Correctly?

 

Always take Nurofen Plus exactly as directed on the label or as advised by your pharmacist. Swallow the tablets whole with a full glass of water. Taking them with food or milk can help reduce the chance of stomach upset.

  1. Check you are not allergic to ibuprofen, codeine, or aspirin before taking.
  2. Take 1 to 2 tablets with a full glass of water.
  3. If possible, take with food or milk to protect your stomach.
  4. Wait at least 4 hours before taking your next dose.
  5. Do not exceed 6 tablets in any 24-hour period.
  6. Do not use for more than 3 consecutive days without medical advice.
  7. If pain persists or worsens, consult your GP or pharmacist.
Indication Age Group Dose Frequency
Headache / Migraine Adults 18+ 1–2 tablets Every 4–6 hours (max 6 tablets/24 hrs)
Dental / Period pain Adults 18+ 1–2 tablets Every 4–6 hours (max 6 tablets/24 hrs)
Musculoskeletal pain Adults 18+ 1–2 tablets Every 4–6 hours (max 6 tablets/24 hrs)
Children under 12 Under 12 Not suitable — do not use

 

What Are the Possible Side Effects of Nurofen Plus?

 

Like all medicines, Nurofen Plus can cause side effects, although not everyone experiences them. If you're also managing digestive discomfort, you may find our indigestion collection helpful alongside your pain management plan.

Common side effects (may affect up to 1 in 10 people):

  • Nausea and vomiting
  • Constipation
  • Dizziness or lightheadedness
  • Stomach discomfort or indigestion
  • Headache (paradoxically, with overuse)

Less common side effects (may affect up to 1 in 100 people):

  • Drowsiness or sedation
  • Skin rash or itching
  • Fluid retention (oedema)
  • Raised blood pressure
  • Gastrointestinal bleeding (seek immediate medical attention if you notice black or tarry stools)
  • Allergic reactions including facial swelling or difficulty breathing — stop use immediately and call 999

Codeine can cause dependence even at therapeutic doses if used regularly. If you notice you need to take it more frequently or in higher amounts to achieve the same effect, speak to your GP promptly.

 

How Should You Store Nurofen Plus Safely?

 

Correct storage helps maintain the integrity of the tablets and keeps your household safe. If you have children at home, this is especially important given that codeine-containing medicines can be dangerous in accidental ingestion. You might also want to explore our first aid collection for other household safety essentials.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Store in the original packaging until use
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen Plus tablets online in the UK?

You can buy Nurofen Plus 200mg 24 Tablets from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. It is available as a Pharmacy (P) medicine for adults aged 18 and over without a prescription. Browse our full pain relief collection for more analgesic options.

How do Nurofen Plus tablets work in the body?

Nurofen Plus contains ibuprofen, which inhibits COX enzymes to reduce prostaglandin production and ease inflammation and pain, alongside codeine phosphate, which binds to opioid receptors in the brain and spinal cord to alter pain perception. The two ingredients work through different pathways, providing a combined analgesic effect for moderate pain. This dual mechanism makes it more suitable than either ingredient alone for pain that hasn't responded to a single analgesic.

How do I take Nurofen Plus step by step?

Take 1 to 2 tablets with a full glass of water, ideally with food or milk to reduce stomach irritation. Wait at least 4 hours before taking your next dose, and never exceed 6 tablets in a 24-hour period. Do not use for more than 3 consecutive days without speaking to a pharmacist or GP.

What is the correct dose of Nurofen Plus for adults?

The standard adult dose is 1 to 2 tablets every 4 to 6 hours as needed for pain relief. The maximum dose is 6 tablets in any 24-hour period. Always use the lowest effective dose for the shortest time necessary.

Can I take Nurofen Plus for a migraine?

Yes, Nurofen Plus is indicated for migraine relief in adults aged 18 and over. Ibuprofen helps reduce the inflammation associated with migraines, while codeine provides additional pain relief for moderate migraine pain. If your migraines are frequent or severe, speak to your GP about longer-term management options.

What are the common side effects of Nurofen Plus?

Common side effects include nausea, constipation, dizziness, and stomach discomfort. These are generally mild and often improve when the tablets are taken with food. If you experience severe stomach pain, black stools, or signs of an allergic reaction such as facial swelling or difficulty breathing, stop taking the tablets and seek urgent medical attention.

How do I manage side effects of Nurofen Plus?

Taking the tablets with food or milk can help reduce gastrointestinal side effects such as nausea and indigestion. Staying well hydrated and avoiding alcohol while taking Nurofen Plus can also reduce the risk of dizziness and stomach irritation. If side effects persist or feel severe, contact your pharmacist or GP for advice.

Who should not take Nurofen Plus tablets?

Nurofen Plus is not suitable for children under 12, people allergic to ibuprofen, aspirin, or codeine, those with active peptic ulcers, severe kidney or liver disease, or those in the third trimester of pregnancy. People who are breastfeeding should also avoid it, as codeine can pass into breast milk and cause serious harm to infants. Always read the full patient information leaflet before use.

Can Nurofen Plus become habit-forming or addictive?

Yes — codeine phosphate, one of the active ingredients in Nurofen Plus tablets, carries a recognised risk of dependence with regular use. This is why it should only be used for short-term pain relief of up to 3 days. If you find yourself needing it more frequently or in larger amounts, speak to your GP as soon as possible.

What happens if I miss a dose of Nurofen Plus?

If you miss a dose and are still in pain, take it as soon as you remember — provided at least 4 hours have passed since your last dose. Never double up doses to compensate for a missed one. If you are unsure, ask your pharmacist for guidance.

What are the alternatives to Nurofen Plus for pain relief?

Alternatives include standard ibuprofen tablets, paracetamol, co-codamol (paracetamol with codeine), or aspirin depending on the type and severity of your pain. For mild to moderate pain, a single analgesic is often sufficient and carries fewer risks. Explore our pain relief collection to compare available options.

How long can you take Nurofen Plus for?

Nurofen Plus should not be used for more than 3 consecutive days without medical advice. Using codeine-containing medicines for longer periods increases the risk of dependence and can also lead to medication overuse headache, where pain actually worsens with continued analgesic use. If your pain persists beyond 3 days, consult your GP.

Can I take Nurofen Plus with other medicines?

Nurofen Plus can interact with several medicines including anticoagulants like warfarin, other NSAIDs, antidepressants, lithium, methotrexate, and other opioid or sedative medicines. Always tell your pharmacist or GP about all medicines you are currently taking, including herbal remedies and supplements, before starting Nurofen Plus.

Is Nurofen Plus safe to take during pregnancy?

No — Nurofen Plus is contraindicated in the third trimester of pregnancy and should be avoided in the first and second trimesters unless specifically advised by a doctor. Ibuprofen can affect foetal kidney development and may cause premature closure of the ductus arteriosus. If you are pregnant and in pain, speak to your midwife or GP about safer alternatives such as paracetamol.

What are the latest guidelines on using codeine-containing medicines in the UK?

The MHRA and NHS advise that codeine-containing medicines should only be used for short-term pain relief in adults, and are not recommended for children under 12 or for breastfeeding mothers. Pharmacists are required to counsel patients on the risk of dependence at the point of sale. If you have concerns about your use of codeine-containing products, your GP or pharmacist can provide personalised guidance. You may also find our sleep aid collection useful if pain is affecting your sleep.

How Should You Use Nurofen Plus?

Always read the patient information leaflet supplied with your pack before taking Nurofen Plus. Swallow the tablets whole with a full glass of water — do not crush or chew them. Taking them with food or milk is strongly recommended to reduce the risk of stomach irritation.

Follow these steps each time you take a dose:

What Is the Correct Dose of Nurofen Plus?

The dose of Nurofen Plus varies by age. It is not suitable for children under 12 years of age under any circumstances. For those aged 12 to 17, it should only be used on the advice of a doctor. The table below summarises the recommended dosing for adults.

When Is the Best Time to Use Nurofen Plus?

Nurofen Plus works best when taken at the onset of pain rather than waiting until symptoms become severe. For migraines in particular, taking it early — as soon as you notice the headache developing — tends to produce better results than waiting until the pain is at its peak. If you experience nausea alongside your migraine, taking the tablets with a light snack may help.

Avoid taking Nurofen Plus on an empty stomach wherever possible, as ibuprofen can irritate the gastric lining. If you are taking it for period pain, starting at the first sign of discomfort rather than waiting for pain to escalate is generally more effective.

How Long Can You Use Nurofen Plus For?

Nurofen Plus is intended for short-term use only. Do not take it for more than 3 consecutive days without seeking advice from your GP or pharmacist. Using codeine-containing medicines beyond this period significantly increases the risk of physical dependence and can also trigger medication overuse headache — a condition where the very medicine you're taking to relieve pain begins to cause it.

If your pain has not improved after 3 days, or if it worsens at any point, stop taking the tablets and seek medical advice promptly. This product is not a substitute for investigating and treating the underlying cause of persistent pain.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Nurofen Plus?

Most people tolerate Nurofen Plus well when taken as directed, but like all medicines, it can cause side effects. The most frequently reported ones are related to the gastrointestinal tract and the central nervous system — both of which are affected by ibuprofen and codeine respectively.

  • Nausea or feeling sick
  • Constipation
  • Dizziness or lightheadedness
  • Stomach discomfort, indigestion, or heartburn
  • Headache (particularly with overuse — see medication overuse headache)
  • Drowsiness or mild sedation

Taking the tablets with food or milk can significantly reduce the likelihood of stomach-related side effects. Staying well hydrated and avoiding alcohol while taking Nurofen Plus is also advisable.

What Are the Less Common Side Effects of Nurofen Plus?

Less common side effects occur in fewer people but are still worth being aware of, particularly if you are taking Nurofen Plus for the first time or have underlying health conditions.

  • Skin rash, itching, or hives
  • Fluid retention causing swelling in the ankles or feet
  • Raised blood pressure
  • Vomiting
  • Flatulence or bloating
  • Difficulty sleeping (insomnia)
  • Mild visual disturbances

If any of these persist or feel particularly troublesome, stop taking the tablets and speak to your pharmacist or GP before continuing.

What Are the Serious Side Effects of Nurofen Plus?

Serious side effects are rare but require immediate medical attention. Do not ignore the following warning signs — they can indicate a potentially life-threatening reaction or complication.

  • Black, tarry, or blood-streaked stools — may indicate gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Severe stomach pain or cramping
  • Swelling of the face, lips, tongue, or throat (angioedema)
  • Difficulty breathing or wheezing — may indicate a serious allergic reaction
  • Chest pain or tightness
  • Signs of kidney problems: reduced urination, swelling, or unusual fatigue
  • Severe skin reactions such as blistering or peeling

If you experience any of the above, stop taking Nurofen Plus immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or constipation, taking the tablets with food and increasing your fluid intake often helps. If dizziness occurs, avoid driving or operating machinery until it passes. Do not take additional doses to try to counteract side effects — this will only increase your risk of further problems.

You can report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines in real-world use. Your pharmacist can also advise on managing mild side effects or suggest an alternative analgesic if Nurofen Plus is not suiting you.

Can Nurofen Plus Interact With Other Medicines?

Yes — Nurofen Plus has several clinically significant drug interactions that you must be aware of before taking it. Ibuprofen can increase the plasma levels of lithium and methotrexate to potentially toxic levels, and can reduce the effectiveness of antihypertensive and diuretic medicines. Codeine, when combined with other CNS depressants such as sedatives, sleeping tablets, or other opioids, can cause excessive sedation or respiratory depression.

Taking Nurofen Plus alongside anticoagulants such as warfarin increases the risk of bleeding, and combining it with other NSAIDs or aspirin raises the likelihood of gastrointestinal side effects. Always inform your pharmacist or GP of every medicine you are taking — including over-the-counter products, herbal remedies, and supplements — before starting Nurofen Plus.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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