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Nurofen Migraine Pain - 12 Caplets

Nurofen Migraine Pain - 12 Caplets

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  • ✔️ Specifically licensed for migraine headache relief in adults
  • ✔️ Contains ibuprofen 400mg for targeted migraine pain relief
  • ✔️ Works best when taken at the very first sign of migraine
  • ✔️ Suitable for adults aged 18 and over with migraine
  • ✔️ Convenient 12-caplet pack for home or on-the-go use

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What Are Nurofen Migraine Pain Caplets?

 

If you've ever been floored by a migraine, you'll know it's far more than just a bad headache. Throbbing pain, sensitivity to light, nausea — it can stop your day completely. Nurofen migraine pain caplets are a licensed, over-the-counter medicine specifically indicated for the treatment of migraine headaches in adults. Each caplet contains 400mg of ibuprofen, a well-established non-steroidal anti-inflammatory drug (NSAID) with a long track record in pain management. You can find this product and other options in our pain relief collection at Cured Pharmacy.

This pack contains 12 caplets, making it a practical option to keep at home or in your bag for when a migraine strikes. At just £3.19, it's an accessible choice for adults who need targeted migraine relief without a prescription.

 

How Do Nurofen Migraine Pain Caplets Work?

 

Ibuprofen works by inhibiting cyclooxygenase (COX) enzymes — specifically COX-1 and COX-2. These enzymes are responsible for producing prostaglandins, which are chemical messengers that trigger inflammation, pain, and fever. By reducing prostaglandin synthesis, ibuprofen helps to ease the throbbing pain and associated discomfort of a migraine attack.

  • Blocks COX-1 and COX-2 enzymes to reduce prostaglandin production
  • Reduces neurogenic inflammation thought to contribute to migraine pain
  • Provides analgesic (pain-relieving) and anti-inflammatory effects
  • Begins to take effect within 20–30 minutes of ingestion in most people

It's worth noting that ibuprofen is most effective when taken at the first sign of a migraine, rather than waiting until the pain becomes severe.

 

Who Is Nurofen Migraine Pain Suitable For?

 

This product is intended for adults aged 18 and over who experience migraine headaches. It is not suitable for children or adolescents under 18. Before using, it's important to confirm that your symptoms are consistent with migraine — if you're unsure, speak to your GP or pharmacist first.

  • Adults aged 18 and over with diagnosed or self-identified migraine
  • People who experience migraine with or without aura
  • Those who need a fast-acting OTC option at the onset of an attack
  • Individuals who have previously tolerated ibuprofen without adverse effects

It is not appropriate for people with a history of peptic ulcers, severe kidney or liver impairment, or those in the third trimester of pregnancy. Always read the label carefully.

 

How Does Nurofen Migraine Pain Compare to Standard Ibuprofen?

 

Feature Nurofen Migraine Pain (400mg) Standard Ibuprofen (200mg)
Ibuprofen strength per caplet 400mg 200mg
Licensed indication Migraine headaches General pain, fever, inflammation
Starting dose 2 caplets (800mg) 1–2 tablets (200–400mg)
Maximum daily dose 6 caplets (2,400mg) 6 tablets (1,200mg OTC)

 

Is Nurofen Migraine Pain Safe to Store at Home?

 

Yes — Nurofen migraine pain caplets should be stored below 25°C in a dry place, away from direct sunlight. Keep them out of reach and sight of children at all times. Do not use after the expiry date printed on the packaging. If you're managing multiple health conditions and keeping various medicines at home, it's a good idea to check our first aid collection for other essentials you might want to have on hand.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen Migraine Pain 12 Caplets specifications
Treatment category Migraine pain relief
Active ingredient Ibuprofen 400mg
Mechanism of action COX-1 and COX-2 inhibitor (NSAID)
Effective for Migraine headaches in adults
Suitable for Adults aged 18 and over
Pack size 12 caplets
Strength 400mg ibuprofen per caplet
UK classification General Sale List (GSL)
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Caplet (film-coated tablet)
Route of administration Oral

Specifications of Nurofen Migraine Pain 12 Caplets

 

What Is Nurofen Migraine Pain and What Is It Used For?

 

Nurofen Migraine Pain 12 Caplets is an over-the-counter medicine containing ibuprofen 400mg per caplet. It is specifically licensed for the treatment of migraine headaches in adults aged 18 and over. Migraine is a neurological condition characterised by moderate to severe throbbing head pain, often accompanied by nausea, vomiting, and sensitivity to light or sound. The NHS recognises migraine as one of the most common neurological conditions in the UK, affecting around one in five women and one in fifteen men.

Nurofen migraine pain caplets are designed to be taken at the earliest sign of a migraine attack, when they are most likely to be effective. They are not intended for the prevention of migraine or for the treatment of other types of headache such as tension headache or cluster headache, unless advised by a healthcare professional.

 

What Do You Need to Know Before Using Nurofen Migraine Pain?

 

Do not take this medicine if any of the following apply to you:

  • You are allergic to ibuprofen, aspirin, or any other NSAID
  • You have or have had a peptic ulcer or gastrointestinal bleeding
  • You are in the third trimester of pregnancy (weeks 28 onwards)
  • You have severe heart failure, severe kidney disease, or severe liver disease
  • You are under 18 years of age
  • You have been told by a doctor to avoid NSAIDs

Speak to your pharmacist or GP before taking this medicine if you have asthma, high blood pressure, a history of heart disease, inflammatory bowel disease, or if you are in the first or second trimester of pregnancy.

The following medicines may interact with ibuprofen:

  • Aspirin or other NSAIDs (increased risk of side effects)
  • Warfarin or other anticoagulants (increased bleeding risk)
  • Antihypertensives (ibuprofen may reduce their effectiveness)
  • SSRIs such as fluoxetine (increased risk of gastrointestinal bleeding)
  • Lithium (ibuprofen may increase lithium levels in the blood)
  • Methotrexate (ibuprofen may increase toxicity)

 

How Should You Use Nurofen Migraine Pain?

 

Always take this medicine exactly as described on the label. Taking it with food or milk can help reduce the risk of stomach upset. Swallow the caplets whole with a full glass of water — do not crush or chew them.

  1. Take 2 caplets (800mg ibuprofen) at the first sign of a migraine attack
  2. Swallow with a full glass of water, preferably with food or milk
  3. If symptoms persist after 4 hours, take a further 2 caplets
  4. Do not take more than 6 caplets (2,400mg) in any 24-hour period
  5. Do not use for more than 3 days without speaking to a doctor
Indication Age Group Dose Frequency
Migraine headache Adults 18+ 2 caplets (800mg) Every 4 hours, max 6 caplets/24hrs
Migraine headache Under 18 Not suitable Not applicable

If you find you are regularly relying on pain relief for migraines more than 10–15 days per month, this can lead to medication overuse headache. Speak to your GP if this is the case. You may also find it helpful to explore our sickness and nausea collection if you experience nausea alongside your migraines.

 

What Are the Possible Side Effects of Nurofen Migraine Pain?

 

Like all medicines, ibuprofen can cause side effects, although not everyone experiences them. The following lists cover the most commonly reported effects.

Common side effects:

  • Nausea or vomiting
  • Indigestion or heartburn
  • Stomach pain or discomfort
  • Diarrhoea

Less common side effects:

  • Headache or dizziness
  • Skin rash or itching
  • Fluid retention (swelling of ankles or feet)
  • Raised blood pressure
  • Worsening of asthma symptoms (in susceptible individuals)

Stop taking this medicine and seek immediate medical attention if you experience signs of a serious allergic reaction (such as facial swelling, difficulty breathing, or severe skin reaction), black or bloody stools, or severe stomach pain.

 

How Should You Store Nurofen Migraine Pain?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the carton
  • Do not store in a bathroom or near a sink — moisture can degrade the caplets
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you're looking to support your overall wellbeing alongside migraine management, our vitamins and supplements collection includes products such as magnesium, which some research suggests may support migraine prevention when taken regularly.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen Migraine Pain caplets online in the UK?

You can buy Nurofen Migraine Pain 12 Caplets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.19. No prescription is required as it is an over-the-counter medicine. Simply add it to your basket and it will be dispatched quickly to your door. Browse our full pain relief collection for more options.

How does Nurofen Migraine Pain work in the body?

Nurofen Migraine Pain contains ibuprofen 400mg, which works by inhibiting COX-1 and COX-2 enzymes that produce prostaglandins — the chemicals responsible for triggering pain and inflammation during a migraine. By reducing prostaglandin levels, ibuprofen helps to ease the throbbing head pain, sensitivity to light, and associated discomfort of a migraine attack. It is most effective when taken at the very first sign of symptoms.

How do I take Nurofen Migraine Pain step by step?

Take 2 caplets (800mg ibuprofen) at the first sign of a migraine, swallowed whole with a full glass of water. It is advisable to take them with food or milk to reduce the chance of stomach upset. If your migraine persists after 4 hours, you may take a further 2 caplets, but do not exceed 6 caplets in any 24-hour period.

What is the correct dose of Nurofen Migraine Pain for adults?

The recommended starting dose for adults aged 18 and over is 2 caplets (800mg ibuprofen) taken at the onset of a migraine. This can be repeated every 4 hours if needed, up to a maximum of 6 caplets (2,400mg) in 24 hours. Do not exceed this dose and do not use for more than 3 consecutive days without medical advice.

What is the best time to take Nurofen Migraine Pain?

The best time to take Nurofen Migraine Pain is at the very first sign of a migraine attack — ideally before the pain becomes severe. Early intervention gives ibuprofen the best chance of working effectively. Waiting until the migraine is fully established can reduce how well the medicine works.

What are the side effects of Nurofen Migraine Pain and how do I manage them?

Common side effects include nausea, indigestion, stomach discomfort, and diarrhoea. Taking the caplets with food or milk can help reduce gastrointestinal upset. Less commonly, you may experience dizziness, skin rash, or fluid retention. If you experience any severe or unusual symptoms, stop taking the medicine and contact your pharmacist or GP promptly.

Who should not take Nurofen Migraine Pain?

This medicine is not suitable for anyone under 18, people allergic to ibuprofen or aspirin, those with a current or previous peptic ulcer, or anyone in the third trimester of pregnancy. People with severe heart, kidney, or liver conditions should also avoid it. Always check with your pharmacist if you are unsure whether this product is right for you.

Can I take Nurofen Migraine Pain if I am pregnant?

Nurofen Migraine Pain must not be taken during the third trimester of pregnancy (from 28 weeks onwards) as ibuprofen can harm the unborn baby. Use during the first and second trimesters should only be considered on medical advice, as it is generally not recommended. If you are pregnant and experiencing migraines, speak to your GP or midwife about safe alternatives.

What happens if I take too many Nurofen Migraine Pain caplets?

Taking more than the recommended dose of ibuprofen can cause serious side effects including stomach bleeding, kidney problems, and in severe cases, loss of consciousness. If you think you or someone else has taken too many caplets, contact NHS 111 or go to your nearest A&E immediately. Always keep medicines out of reach of children.

What happens if I miss a dose of Nurofen Migraine Pain?

Because Nurofen Migraine Pain is taken as needed rather than on a fixed daily schedule, the concept of a missed dose does not apply in the traditional sense. Simply take it at the onset of your next migraine, following the recommended dosage instructions. Never double up doses to compensate.

Can I take Nurofen Migraine Pain with other medicines?

Ibuprofen can interact with several medicines, including aspirin, warfarin, antihypertensives, SSRIs, lithium, and methotrexate. Taking ibuprofen alongside other NSAIDs increases the risk of side effects. Always tell your pharmacist about all medicines you are currently taking before starting Nurofen Migraine Pain.

What are the alternatives to Nurofen Migraine Pain?

OTC alternatives include paracetamol, aspirin, or combination products containing caffeine, which can enhance pain relief. For people who cannot tolerate NSAIDs, paracetamol-based options may be more suitable. If OTC medicines are not controlling your migraines, speak to your GP — prescription treatments such as triptans may be more appropriate. You can also explore our wider pain relief collection for other options.

How long can I use Nurofen Migraine Pain for?

Nurofen Migraine Pain should not be used for more than 3 consecutive days without seeking medical advice. Using pain relief medicines — including ibuprofen — on more than 10 to 15 days per month can lead to medication overuse headache, which can make migraines worse over time. If you find yourself needing pain relief this frequently, speak to your GP.

Is Nurofen Migraine Pain the same as regular ibuprofen?

Nurofen Migraine Pain contains the same active ingredient as standard ibuprofen — but at a higher dose of 400mg per caplet, compared to the 200mg found in many standard ibuprofen tablets. It is also specifically licensed for migraine headaches, whereas standard ibuprofen is licensed for general pain, fever, and inflammation. The higher starting dose (800mg) is what makes it particularly suited to migraine treatment.

What does the latest research say about ibuprofen for migraine?

Clinical evidence consistently supports ibuprofen as an effective first-line OTC treatment for migraine in adults. Studies published in peer-reviewed literature and referenced by the NHS confirm that ibuprofen at doses of 400–800mg provides meaningful pain relief for many migraine sufferers. However, for those with frequent or severe attacks, prescription treatments such as triptans may offer greater efficacy, and a GP referral is advisable.

How Should You Use Nurofen Migraine Pain?

Always read the label before taking this medicine. Nurofen Migraine Pain caplets should be swallowed whole — do not crush or chew them. Taking them with food or a glass of milk can help protect your stomach lining and reduce the risk of indigestion.

Follow these steps each time you take Nurofen Migraine Pain:

What Is the Correct Dose of Nurofen Migraine Pain?

The dose of Nurofen Migraine Pain is specifically designed for adults experiencing a migraine attack. It is higher than standard OTC ibuprofen doses because migraine typically requires a stronger analgesic response. The table below summarises the recommended dosing by age group and indication.

When Is the Best Time to Use Nurofen Migraine Pain?

Timing really does matter with migraine treatment. Ibuprofen is most effective when taken at the earliest possible sign of a migraine — this might be the onset of an aura, a feeling of pressure behind the eyes, or the very beginning of head pain. Waiting until the migraine is fully established can significantly reduce how well the medicine works, as absorption may be slower once nausea sets in.

If you regularly experience warning signs before a migraine (known as a prodrome), use these as your cue to take the caplets promptly. Do not take them as a preventative measure before symptoms begin.

How Long Can You Use Nurofen Migraine Pain For?

Nurofen Migraine Pain is intended for short-term use only. Do not use it for more than 3 consecutive days without seeking advice from your GP or pharmacist. If you find yourself reaching for migraine pain relief on more than 10 to 15 days per month, this is a sign that you should speak to your doctor — frequent use of analgesics can itself cause medication overuse headache, sometimes called rebound headache, which can make migraines more frequent and harder to treat over time.

Your GP can help you explore longer-term migraine management strategies, including preventative treatments if appropriate.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Nurofen Migraine Pain?

Like all medicines containing ibuprofen, Nurofen Migraine Pain can cause side effects in some people, though not everyone will experience them. The most commonly reported side effects relate to the gastrointestinal system, particularly when the medicine is taken on an empty stomach.

  • Nausea or feeling sick
  • Indigestion or heartburn
  • Stomach pain or abdominal discomfort
  • Diarrhoea
  • Vomiting

Taking the caplets with food or milk can significantly reduce the likelihood of these effects. If stomach discomfort is persistent, speak to your pharmacist.

What Are the Less Common Side Effects of Nurofen Migraine Pain?

Some people may experience side effects that are less frequent but still worth being aware of. These tend to occur more often in people who take ibuprofen regularly or at higher doses over a prolonged period.

  • Headache or dizziness
  • Skin rash or itching
  • Fluid retention, causing swelling of the ankles or feet
  • Raised blood pressure
  • Worsening of asthma symptoms in susceptible individuals
  • Flatulence or bloating

If you notice any of these effects and they are troublesome or persistent, stop taking the medicine and consult your pharmacist or GP.

What Are the Serious Side Effects of Nurofen Migraine Pain?

Serious side effects from ibuprofen are uncommon when the medicine is used as directed, but they can occur. You should stop taking Nurofen Migraine Pain immediately and seek urgent medical attention if you experience any of the following:

  • Signs of a serious allergic reaction — facial swelling, difficulty breathing, severe skin rash, or anaphylaxis
  • Black, tarry, or blood-stained stools, which may indicate gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Severe stomach pain
  • Chest pain, shortness of breath, or sudden weakness — which may indicate cardiovascular events
  • Significant reduction in urine output, which may suggest kidney problems

These effects are rare but serious. Do not ignore them.

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as nausea or indigestion, try taking the caplets with food and plenty of water. For more troublesome or persistent effects, stop taking the medicine and speak to your pharmacist or GP as soon as possible. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Never take more than the recommended dose in an attempt to improve effectiveness — this only increases the risk of side effects without providing additional benefit.

Can Nurofen Migraine Pain Interact With Other Medicines?

Yes. Ibuprofen has several clinically significant drug interactions that you should be aware of before taking this medicine. Always inform your pharmacist of all medicines you are currently taking, including over-the-counter products and herbal remedies.

  • Aspirin or other NSAIDs: Increased risk of gastrointestinal side effects
  • Warfarin or anticoagulants: Ibuprofen may increase bleeding risk
  • Antihypertensives (blood pressure medicines): Ibuprofen may reduce their effectiveness
  • SSRIs (e.g. fluoxetine, sertraline): Increased risk of gastrointestinal bleeding
  • Lithium: Ibuprofen may raise lithium blood levels, increasing toxicity risk
  • Methotrexate: Ibuprofen may increase methotrexate toxicity

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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