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Nurofen 342mg for Migraine - 12 Caplets

Nurofen 342mg for Migraine - 12 Caplets

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  • ✔️ Targets migraine pain with fast-absorbing ibuprofen lysine formula
  • ✔️ Specifically indicated for migraine headache, not general pain
  • ✔️ Works best when taken at the very first sign of attack
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ Convenient 12-caplet pack for acute migraine relief

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Is Ibuprofen for Migraine Right for You?

 

Migraines are more than just a bad headache. The throbbing pain, sensitivity to light and sound, and sometimes nausea can leave you unable to function for hours. Ibuprofen for migraine is one of the most widely recommended first-line treatments for mild to moderate migraine attacks, and Nurofen 342mg for Migraine caplets are specifically formulated to get to work quickly. Each caplet contains 342mg of ibuprofen lysine — a salt form of ibuprofen that is absorbed faster than standard ibuprofen tablets, making it particularly suited to migraine relief. If you're looking for a trusted, pharmacy-quality option, you can browse our full pain relief collection for more choices.

Nurofen 342mg for Migraine is a General Sale List (GSL) medicine available without a prescription. Each pack contains 12 caplets, priced at just £3.49, making it an accessible option for adults who experience occasional migraines.

 

How Do Nurofen Migraine Caplets Work?

 

The active ingredient, ibuprofen lysine, belongs to the non-steroidal anti-inflammatory drug (NSAID) class. It works by blocking the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are responsible for producing prostaglandins — chemical messengers that trigger inflammation, pain, and fever. During a migraine, prostaglandins contribute to the dilation of blood vessels and sensitisation of pain receptors in the brain. By reducing prostaglandin production, ibuprofen helps to ease the throbbing pain and associated discomfort.

  • Ibuprofen lysine is absorbed more rapidly than standard ibuprofen, reaching peak plasma concentration sooner
  • Reduces inflammation around cranial blood vessels involved in migraine pathophysiology
  • Provides analgesic (pain-relieving) and antipyretic (fever-reducing) effects
  • Works best when taken at the earliest sign of a migraine attack

 

Who Is Nurofen Migraine Suitable For?

 

These caplets are intended for adults and young people aged 12 and over who experience migraine headaches. They are particularly useful for those who need fast-acting relief and prefer a targeted migraine formulation over a standard ibuprofen tablet. That said, they are not suitable for everyone.

  • Adults aged 18 and over experiencing mild to moderate migraine attacks
  • Young people aged 12–17 (under medical supervision where appropriate)
  • Those who have previously tolerated ibuprofen without adverse effects
  • People who prefer a non-prescription option for occasional migraine management

They are not suitable for people with a known allergy to ibuprofen or aspirin, those with active peptic ulcers, or anyone in the third trimester of pregnancy. Always read the label carefully before use.

 

How Does Nurofen Migraine Compare to Standard Ibuprofen?

 

Feature Nurofen 342mg for Migraine Standard Ibuprofen 200mg Tablet
Active ingredient Ibuprofen lysine 342mg (= 200mg ibuprofen) Ibuprofen 200mg
Absorption speed Faster (lysine salt form) Standard absorption rate
Indicated specifically for migraine Yes No (general pain relief)
Dose per administration 2 caplets (400mg ibuprofen equivalent) 1–2 tablets (200–400mg ibuprofen)

 

How Should You Store Nurofen Migraine Caplets?

 

Store Nurofen 342mg for Migraine below 25°C in a dry place, away from direct sunlight. Keep the pack out of reach and sight of children at all times. Do not use the caplets after the expiry date printed on the packaging. If you're managing multiple health conditions alongside migraines, it's worth exploring our vitamins and supplements range, as certain nutritional deficiencies have been associated with increased migraine frequency.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nurofen 342mg for Migraine 12 Caplets specifications
Treatment category Migraine and headache relief
Active ingredient Ibuprofen lysine 342mg (equivalent to ibuprofen 200mg)
Mechanism of action COX-1 and COX-2 inhibitor; reduces prostaglandin synthesis
Effective for Migraine headache with or without aura
Suitable for Adults and young people aged 12 and over
Pack size 12 caplets
Strength 342mg ibuprofen lysine per caplet
UK classification General Sale List (GSL)
Drug class NSAID (Non-steroidal anti-inflammatory drug)
Preparation Caplet (film-coated tablet)
Route of administration Oral

Specifications of Nurofen 342mg for Migraine 12 Caplets

 

What Is Nurofen 342mg for Migraine and What Is It Used For?

 

Nurofen 342mg for Migraine caplets are an over-the-counter medicine used to treat migraine headaches in adults and young people aged 12 and over. The active ingredient is ibuprofen lysine 342mg, which is equivalent to 200mg of ibuprofen. Ibuprofen lysine is a salt form of ibuprofen that dissolves and is absorbed into the bloodstream more quickly than standard ibuprofen, making it well-suited to the acute treatment of migraine. Each pack contains 12 caplets and is available without a prescription.

These caplets are indicated specifically for the treatment of migraine headache. They are not intended for general everyday pain relief or for use as a preventative migraine treatment. If your migraines are frequent, severe, or not responding to over-the-counter medicines, you should speak to your GP.

 

What Do You Need to Know Before Using Nurofen Migraine Caplets?

 

Before taking these caplets, it is important to check whether they are appropriate for you. Do not take Nurofen 342mg for Migraine if any of the following apply:

  • You are allergic to ibuprofen, aspirin, or any other NSAID
  • You have or have had a peptic ulcer or gastrointestinal bleeding
  • You are in the third trimester of pregnancy (weeks 28 onwards)
  • You have severe heart failure, severe kidney disease, or severe liver disease
  • You are under 12 years of age
  • You have been told by a doctor to avoid NSAIDs

Speak to your pharmacist or GP before taking these caplets if you have asthma, high blood pressure, a history of heart disease, inflammatory bowel disease, or if you are in the first or second trimester of pregnancy.

The following medicines may interact with ibuprofen lysine:

  • Aspirin or other NSAIDs (increased risk of side effects)
  • Warfarin or other anticoagulants (increased bleeding risk)
  • SSRIs such as fluoxetine (increased risk of gastrointestinal bleeding)
  • Antihypertensives including ACE inhibitors and diuretics (reduced effectiveness)
  • Lithium (ibuprofen may increase lithium plasma levels)
  • Methotrexate (ibuprofen may increase toxicity)

 

How Should You Use Nurofen 342mg for Migraine?

 

Always take Nurofen 342mg for Migraine exactly as described in the patient information leaflet. Taking it at the earliest sign of a migraine gives you the best chance of effective relief. Swallow the caplets whole with a full glass of water — do not crush or chew them.

  1. Take 2 caplets at the first sign of a migraine attack
  2. Swallow with a full glass of water
  3. Do not take more than 2 caplets in any 24-hour period
  4. Do not take for more than 2 days without speaking to a doctor
  5. If symptoms persist or worsen, seek medical advice promptly
Indication Age Group Dose Frequency
Migraine headache Adults (18+) 2 caplets (684mg ibuprofen lysine) Once in 24 hours
Migraine headache 12–17 years 2 caplets (under medical supervision) Once in 24 hours
Migraine headache Under 12 years Not suitable

Be aware that taking ibuprofen for migraine too frequently — more than 10 days per month — can itself cause medication overuse headache (MOH), sometimes called a rebound headache. If you find yourself needing pain relief very regularly, speak to your GP. You might also find it helpful to explore our sickness and nausea range if you experience nausea alongside your migraines.

 

What Are the Possible Side Effects of Nurofen Migraine Caplets?

 

Like all medicines, Nurofen 342mg for Migraine can cause side effects, although not everyone experiences them. The following lists cover the most commonly reported effects.

Common side effects

  • Nausea or feeling sick
  • Indigestion or stomach discomfort
  • Diarrhoea
  • Abdominal pain

Less common side effects

  • Dizziness or headache
  • Flatulence
  • Constipation
  • Skin rash or itching
  • Fluid retention (oedema)

Stop taking the caplets and seek immediate medical attention if you experience signs of a serious allergic reaction (swelling of the face, lips, or throat, difficulty breathing), black or bloody stools, severe stomach pain, or chest pain. These are rare but serious effects that require urgent assessment.

 

How Should You Store Nurofen 342mg for Migraine?

 

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

If you are managing other health conditions alongside migraines, our cold and flu range includes additional products that may help if your migraine is accompanied by cold-like symptoms. Always check for interactions before combining medicines.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nurofen 342mg for Migraine online in the UK?

You can buy Nurofen 342mg for Migraine caplets online from Cured Pharmacy, a UK GPhC-registered online pharmacy. It is available without a prescription as a General Sale List medicine. You can also find it in most UK pharmacies, supermarkets, and health retailers.

How does ibuprofen for migraine work in the body?

Ibuprofen lysine works by inhibiting COX-1 and COX-2 enzymes, which reduces the production of prostaglandins — chemicals that cause inflammation, pain, and blood vessel dilation during a migraine. The lysine salt form is absorbed faster than standard ibuprofen, helping to ease migraine pain more quickly. It is most effective when taken at the very first sign of an attack.

How do I use Nurofen Migraine caplets step by step?

Take 2 caplets at the first sign of a migraine with a full glass of water. Do not crush or chew the caplets — swallow them whole. Do not take more than 2 caplets in any 24-hour period, and do not use for more than 2 consecutive days without speaking to a doctor.

What is the correct dose of Nurofen 342mg for Migraine for adults?

The recommended adult dose is 2 caplets taken as a single dose, providing 684mg of ibuprofen lysine (equivalent to 400mg of ibuprofen). This dose should not be repeated within 24 hours. Do not exceed 2 caplets in any 24-hour period.

When is the best time to take Nurofen Migraine caplets?

Take Nurofen Migraine at the very first sign of a migraine attack — the earlier you take it, the more effective it is likely to be. Waiting until the headache is at its peak may reduce how well the medicine works. Taking it with food or milk can help reduce the chance of stomach upset.

What are the side effects of Nurofen 342mg for Migraine?

Common side effects include nausea, indigestion, stomach discomfort, and diarrhoea. Less commonly, you may experience dizziness, skin rash, or fluid retention. Stop taking the caplets and seek urgent medical advice if you notice signs of a serious allergic reaction, black stools, or severe stomach pain.

Who should not take Nurofen Migraine caplets?

These caplets are not suitable for people who are allergic to ibuprofen or aspirin, have an active peptic ulcer, are in the third trimester of pregnancy, or have severe heart, kidney, or liver disease. They are also not suitable for children under 12 years of age. Always read the patient information leaflet before use.

Can I take Nurofen Migraine if I am pregnant?

Nurofen Migraine must not be taken during the third trimester of pregnancy (from week 28 onwards) as it may harm the unborn baby. Use during the first and second trimesters should only be considered after speaking to a doctor or pharmacist. If you are pregnant and experiencing migraines, always seek medical advice before taking any medicine.

What happens if I take too many Nurofen Migraine caplets?

Taking more than the recommended dose increases the risk of serious side effects including stomach bleeding, kidney problems, and dizziness. If you think you or someone else has taken too much, contact NHS 111 or go to your nearest A&E immediately. Always keep medicines out of reach of children.

Can Nurofen Migraine cause medication overuse headache?

Yes — using ibuprofen for migraine on more than 10 days per month can lead to medication overuse headache (MOH), also known as rebound headache. This is a recognised risk with all acute migraine treatments, including NSAIDs and triptans. If you find yourself needing pain relief very frequently, speak to your GP about preventative migraine management.

What are alternatives to Nurofen 342mg for Migraine?

Alternatives for mild to moderate migraine include paracetamol, aspirin 300mg, or standard ibuprofen 400mg tablets. For more severe or frequent migraines, a GP may prescribe triptans such as sumatriptan. You can explore our broader pain relief range for other options.

Can I take Nurofen Migraine with other medicines?

Nurofen Migraine can interact with several medicines including aspirin, warfarin, SSRIs, antihypertensives, lithium, and methotrexate. Always tell your pharmacist or GP about all medicines you are taking, including herbal remedies and supplements. Do not take alongside other ibuprofen-containing products.

How long can I use Nurofen Migraine for?

Nurofen Migraine is intended for short-term, acute use only — do not use for more than 2 consecutive days without medical advice. If your migraines are frequent or not responding to treatment, consult your GP. Long-term or frequent use of NSAIDs carries risks including gastrointestinal and cardiovascular effects.

Is Nurofen Migraine suitable for teenagers?

Nurofen 342mg for Migraine can be used by young people aged 12 and over, though medical supervision is advisable for those under 18. It is not suitable for children under 12 years of age. If a teenager experiences frequent migraines, a GP should be consulted to rule out underlying causes.

What are the latest findings on using ibuprofen for migraine treatment?

Ibuprofen remains one of the most studied and recommended over-the-counter treatments for acute migraine, with evidence supporting its use at 400mg doses for mild to moderate attacks. Current NHS guidance continues to recommend NSAIDs as a first-line option for migraine. Research also highlights the importance of early treatment and avoiding medication overuse to achieve the best outcomes. If you're also managing nausea during migraines, our sickness and nausea range may offer additional support.

How Should You Use Nurofen 342mg for Migraine?

Nurofen 342mg for Migraine caplets are designed for oral use and should be swallowed whole with a full glass of water. Taking them with food or milk can help reduce the likelihood of stomach discomfort. Always follow the instructions in the patient information leaflet supplied with the pack.

What Is the Correct Dose of Nurofen 342mg for Migraine?

The dose varies by age group. It is important not to exceed the stated dose, as doing so increases the risk of side effects without providing additional benefit. The table below summarises the recommended dosing.

When Is the Best Time to Use Nurofen 342mg for Migraine?

The most effective time to take Nurofen Migraine is at the very first sign of a migraine — whether that is the onset of head pain, visual disturbances (aura), or other warning symptoms you recognise. Early intervention gives the ibuprofen lysine the best opportunity to reduce inflammation and pain before the attack fully develops. Waiting until the migraine is at its worst may significantly reduce how well the medicine works.

How Long Can You Use Nurofen 342mg for Migraine For?

These caplets are intended for short-term, acute use only. Do not use for more than 2 consecutive days without seeking medical advice. Using ibuprofen for migraine on more than 10 days per month can lead to medication overuse headache, which can make migraines more frequent and harder to treat. If you find yourself needing this medicine regularly, speak to your GP about longer-term migraine management strategies, which may include preventative treatments.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Nurofen 342mg for Migraine?

Like all NSAIDs, Nurofen Migraine caplets can cause gastrointestinal side effects in some people. These are generally mild and often resolve on their own. Taking the caplets with food or milk can help reduce stomach-related effects.

  • Nausea or feeling sick
  • Indigestion or heartburn
  • Stomach pain or discomfort
  • Diarrhoea
  • Flatulence (wind)

What Are the Less Common Side Effects of Nurofen Migraine Caplets?

Some people may experience side effects that are less frequent but still worth being aware of. If any of the following persist or concern you, stop taking the caplets and speak to your pharmacist or GP.

  • Dizziness or light-headedness
  • Headache (separate from the migraine being treated)
  • Skin rash or itching
  • Fluid retention or mild swelling
  • Constipation
  • Fatigue

What Are the Serious Side Effects of Nurofen 342mg for Migraine?

Serious side effects are rare but require immediate medical attention. Stop taking the caplets straight away and seek urgent help if you experience any of the following. These effects are more likely in people who take NSAIDs at high doses or for prolonged periods.

  • Signs of a serious allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing; severe skin rash
  • Black, tarry, or bloody stools — a sign of gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Severe stomach pain
  • Chest pain, shortness of breath, or sudden weakness — possible signs of cardiovascular events
  • Significant reduction in urine output — possible sign of kidney problems

What Should You Do If You Experience Side Effects of Nurofen Migraine?

For mild side effects such as nausea or indigestion, try taking the caplets with food and plenty of water. If side effects are moderate or persistent, stop taking the medicine and consult your pharmacist. For any serious or unexpected reaction, stop use immediately and contact NHS 111 or attend your nearest A&E. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Nurofen Migraine Interact With Other Medicines?

Yes — ibuprofen lysine can interact with a number of commonly used medicines. Always inform your pharmacist or GP of everything you are taking before starting Nurofen Migraine. Key interactions include aspirin and other NSAIDs (increased gastrointestinal risk), warfarin and anticoagulants (increased bleeding risk), SSRIs (increased risk of gastrointestinal bleeding), antihypertensives including ACE inhibitors and diuretics (reduced blood pressure control), lithium (raised plasma levels), and methotrexate (increased toxicity risk). Do not take alongside other ibuprofen-containing products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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