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Numark Paracetamol Plus - 500mg/65mg - 16 Caplets

Numark Paracetamol Plus - 500mg/65mg - 16 Caplets

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  • ✔️ Combines paracetamol 500mg with caffeine 65mg for enhanced relief
  • ✔️ Targets headache, back pain, period pain, and sore throat
  • ✔️ Caffeine adjuvant increases paracetamol's analgesic effectiveness
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Convenient 16-caplet pack for on-the-go pain management

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What Are Paracetamol With Caffeine Tablets?

 

Numark Paracetamol Plus 500mg/65mg caplets are a combination analgesic containing two active ingredients: paracetamol and caffeine. Each caplet delivers 500mg of paracetamol alongside 65mg of caffeine — a well-established pairing used to treat mild to moderate pain. Whether you're dealing with a nagging headache, back pain, joint discomfort, or period pain, this product offers a convenient, affordable option available without a prescription. You can find it alongside other trusted options in our pain relief collection.

At just £1.99 for 16 caplets, it's one of the more accessible OTC analgesics on the market. The caplet format makes it easy to swallow, and the pack size is practical for keeping at home or in your bag for when pain strikes unexpectedly.

 

How Does Numark Paracetamol Plus Work?

 

The two active ingredients work together to deliver more effective pain relief than paracetamol alone. Here's how each one contributes:

  • Paracetamol (500mg): Inhibits the synthesis of prostaglandins in the central nervous system, reducing the perception of pain and helping to lower elevated body temperature.
  • Caffeine (65mg): Acts as an adjuvant analgesic — it enhances the pain-relieving effect of paracetamol, meaning the combination can be more effective than paracetamol on its own at the same dose.
  • Together: Clinical evidence supports that adding caffeine to paracetamol increases the proportion of patients who achieve meaningful pain relief, particularly for headache and musculoskeletal pain.

It's worth noting that caffeine itself does not directly relieve pain. Its role is to boost the efficacy of the paracetamol component, which is why this combination is widely used in OTC analgesics across the UK.

 

Who Should Use Numark Paracetamol Plus?

 

This product is suitable for adults and young people aged 16 and over who need short-term relief from mild to moderate pain. It is particularly useful for:

  • Headaches and migraines (mild to moderate)
  • Period pain and menstrual cramps
  • Back pain and joint pain
  • Sore throat discomfort
  • Cold and flu-related aches

It is not suitable for children under 12, and those aged 12–15 should only use it under medical supervision. If you are pregnant, breastfeeding, or have a liver or kidney condition, speak to your pharmacist or GP before use.

 

How Does Numark Paracetamol Plus Compare to Standard Paracetamol?

 

Feature Numark Paracetamol Plus (500mg/65mg) Standard Paracetamol (500mg)
Active ingredients Paracetamol + Caffeine Paracetamol only
Analgesic efficacy Enhanced (adjuvant effect of caffeine) Standard
Suitable for headache Yes — caffeine may improve response Yes
Suitable for children under 12 No Age-appropriate formulations available
Caffeine content 65mg per caplet None

 

Is Numark Paracetamol Plus Suitable for Long-Term Use?

 

Paracetamol with caffeine tablets are intended for short-term use only. Using caffeine-containing analgesics regularly — more than 10–15 days per month — can paradoxically worsen headaches over time, a condition known as medication-overuse headache (MOH). If you find yourself reaching for pain relief most days, it's important to speak to your GP.

Store this product below 25°C in a dry place, away from direct sunlight and out of reach of children. If you're managing ongoing pain alongside other health concerns, our women's health collection includes additional products that may support your wellbeing.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Numark Paracetamol Plus 500mg/65mg 16 Caplets specifications
Treatment category Analgesic / Pain Relief
Mechanism of action Prostaglandin synthesis inhibition (paracetamol) + adjuvant analgesic (caffeine)
Effective for Headache, period pain, back pain, joint pain, sore throat, cold and flu aches
Suitable for Adults and young people aged 16 and over
Active ingredient Paracetamol 500mg, Caffeine 65mg
Pack size 16 caplets
Strengths 500mg paracetamol / 65mg caffeine per caplet
UK classification General Sale List (GSL)
Drug class Non-opioid analgesic with xanthine adjuvant
Preparation Caplet (film-coated tablet)
Route of administration Oral

Specifications of Numark Paracetamol Plus 500mg/65mg 16 Caplets

 

What Is Numark Paracetamol Plus and What Is It Used For?

 

Numark Paracetamol Plus 500mg/65mg caplets are an over-the-counter combination analgesic used for the short-term relief of mild to moderate pain. Each caplet contains paracetamol 500mg — one of the most widely used pain relievers in the UK — and caffeine 65mg, which enhances the analgesic effect. This product is indicated for headache, migraine, period pain, back pain, joint pain, sore throat, and the aches associated with colds and flu. It is classified as a General Sale List (GSL) medicine in the UK, meaning it can be purchased without a prescription.

 

What Do You Need to Know Before Using Numark Paracetamol Plus?

 

Before taking this medicine, read the following carefully. Do not take Numark Paracetamol Plus if any of the following apply to you:

  • You are allergic to paracetamol, caffeine, or any other ingredient in the product
  • You have severe liver or kidney disease
  • You are under 12 years of age
  • You are already taking other paracetamol-containing medicines (risk of overdose)
  • You have phenylketonuria (if the product contains aspartame — check the label)

Talk to your pharmacist or GP before use if you:

  • Are pregnant or breastfeeding
  • Have a history of alcohol dependence or liver problems
  • Are taking warfarin (paracetamol can affect anticoagulant control at higher doses)
  • Are taking monoamine oxidase inhibitors (MAOIs)
  • Regularly consume large amounts of caffeine from other sources (coffee, energy drinks)

Drug interactions to be aware of:

  • Warfarin and other anticoagulants — regular paracetamol use may enhance anticoagulant effect
  • Other paracetamol-containing products — do not combine; risk of accidental overdose
  • MAOIs — avoid concurrent use
  • Metoclopramide and domperidone — may increase the rate of paracetamol absorption
  • Cholestyramine — may reduce paracetamol absorption if taken within one hour

 

How Should You Use Numark Paracetamol Plus?

 

Always take this medicine exactly as described. Swallow the caplets whole with a glass of water. Do not crush or chew them.

  1. Take 2 caplets for adults (aged 16 and over)
  2. Swallow with a full glass of water
  3. Wait at least 4 hours before taking the next dose
  4. Do not take more than 4 doses (8 caplets) in any 24-hour period
  5. Do not use for more than 3 days without medical advice
Indication Age Group Dose Frequency
Headache, back pain, period pain Adults and young people 16+ 2 caplets Up to 4 times daily (every 4 hours)
All indications Under 12 Not suitable Not applicable
All indications 12–15 years Medical supervision only Seek advice

 

What Are the Possible Side Effects of Numark Paracetamol Plus?

 

Like all medicines, this product can cause side effects, although not everyone will experience them. If you're managing pain alongside digestive discomfort, you may also want to explore our IBS and cramps collection for complementary support.

Common side effects (may affect up to 1 in 10 people):

  • Nausea
  • Stomach discomfort
  • Restlessness or difficulty sleeping (due to caffeine content)
  • Increased heart rate (palpitations)

Less common side effects (may affect up to 1 in 100 people):

  • Skin rash or itching
  • Headache on stopping use (caffeine withdrawal)
  • Allergic reactions including urticaria

Serious but rare: Paracetamol overdose can cause severe liver damage. If you accidentally take too much, go to A&E immediately — even if you feel well, as symptoms of liver damage may be delayed.

 

How Should You Store Numark Paracetamol Plus?

 

Proper storage helps maintain the safety and effectiveness of this medicine. If you're building a home medicine cabinet, our first aid collection has everything you need alongside your pain relief essentials.

  • Store below 25°C in a dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the packaging
  • Do not store in a bathroom or near a sink
  • Return unused or expired medicines to your pharmacist for safe disposal — do not flush or bin them

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Numark Paracetamol Plus online in the UK?

You can buy Numark Paracetamol Plus 500mg/65mg 16 caplets directly from Cured Pharmacy online for just £1.99, with no prescription required. It is a General Sale List (GSL) medicine, so it is legally available to purchase over the counter. Browse our full pain relief collection for more analgesic options.

How does paracetamol with caffeine work differently from plain paracetamol?

Paracetamol reduces pain by inhibiting prostaglandin synthesis in the central nervous system, while caffeine acts as an adjuvant — it enhances the analgesic effect of paracetamol without directly relieving pain itself. Research suggests that adding 65mg of caffeine to a standard paracetamol dose increases the number of people who achieve meaningful pain relief. This makes the combination particularly useful for headaches and musculoskeletal pain.

How do I take Numark Paracetamol Plus step by step?

Take 2 caplets with a full glass of water, swallowing them whole without crushing or chewing. Wait at least 4 hours before taking your next dose, and never exceed 8 caplets (4 doses) in any 24-hour period. If your symptoms persist beyond 3 days, stop taking the medicine and consult your pharmacist or GP.

What is the correct dose of Numark Paracetamol Plus for adults?

The recommended dose for adults and young people aged 16 and over is 2 caplets, taken up to 4 times a day with at least 4 hours between each dose. This means the maximum daily dose is 8 caplets, providing 4,000mg of paracetamol and 520mg of caffeine in total. Never exceed this amount, as paracetamol overdose can cause serious liver damage.

Can I take Numark Paracetamol Plus for period pain?

Yes — Numark Paracetamol Plus is indicated for the relief of period pain (dysmenorrhoea) and is a suitable OTC option for mild to moderate menstrual discomfort. The caffeine component may help by enhancing the paracetamol's pain-relieving effect. If your period pain is severe or not responding to OTC treatment, speak to your GP, as there may be an underlying cause worth investigating.

What are the side effects of Numark Paracetamol Plus?

At recommended doses, side effects are uncommon but can include nausea, stomach discomfort, restlessness, and palpitations — largely attributable to the caffeine content. Skin rash or allergic reactions are less common. Serious liver damage can occur if you take more than the recommended dose of paracetamol, so always stick to the stated amount.

How do I manage side effects of Numark Paracetamol Plus?

If you experience nausea, try taking the caplets with a small amount of food. Restlessness or difficulty sleeping caused by caffeine can be minimised by avoiding taking a dose close to bedtime. If you develop a skin rash, swelling, or difficulty breathing, stop taking the medicine immediately and seek urgent medical attention, as these may indicate an allergic reaction.

Is Numark Paracetamol Plus suitable for children?

No — this product is not suitable for children under 12 years of age. For children aged 12–15, it should only be used under medical supervision. If you need pain relief for a younger child, speak to your pharmacist about age-appropriate paracetamol formulations available in our baby and toddler collection.

Can I take Numark Paracetamol Plus with other medicines?

You must not take this product alongside other paracetamol-containing medicines — including many cold and flu remedies — as this significantly increases the risk of paracetamol overdose. It may also interact with warfarin, MAOIs, metoclopramide, and domperidone. Always tell your pharmacist about all medicines you are currently taking before starting a new one.

Who is eligible to use Numark Paracetamol Plus?

This product is suitable for adults and young people aged 16 and over who need short-term relief from mild to moderate pain. It is not suitable for those with severe liver or kidney disease, those allergic to paracetamol or caffeine, or those already taking other paracetamol-containing products. Pregnant or breastfeeding individuals should seek pharmacist advice before use.

What happens if I miss a dose of Numark Paracetamol Plus?

If you miss a dose, simply take the next one when needed — as long as at least 4 hours have passed since your last dose. Do not double up to compensate for a missed dose. This product is taken as needed for pain rather than on a fixed schedule, so missing a dose is generally not a concern.

How long can you take Numark Paracetamol Plus for?

You should not use this product for more than 3 consecutive days without speaking to a doctor or pharmacist. Regular use of caffeine-containing analgesics beyond 10–15 days per month can lead to medication-overuse headache, where the treatment itself begins to cause the very symptom it is meant to relieve. If your pain is ongoing, seek professional advice about longer-term management.

What are the alternatives to Numark Paracetamol Plus?

Alternatives include standard paracetamol 500mg tablets (without caffeine), ibuprofen 200mg or 400mg tablets (suitable for those without contraindications to NSAIDs), or aspirin 300mg tablets for adults. The right choice depends on your individual health profile and the type of pain you're experiencing — your pharmacist can help you decide. Explore the full range in our pain relief collection for more options.

Can I drink alcohol while taking Numark Paracetamol Plus?

You should avoid drinking alcohol while taking paracetamol-containing medicines, particularly if you drink regularly or in large amounts, as this increases the risk of liver damage. The NHS advises that people who drink more than the recommended weekly limits should seek medical advice before taking paracetamol. Occasional, moderate alcohol consumption is generally considered lower risk, but caution is always advisable.

What are the latest findings on paracetamol and caffeine combinations?

Published clinical evidence, including Cochrane reviews, consistently supports the use of caffeine as an adjuvant to paracetamol, showing that the combination produces meaningfully better pain relief than paracetamol alone for headache and postoperative pain. The 65mg caffeine dose used in products like Numark Paracetamol Plus is the most studied and widely accepted adjuvant dose. Regulatory bodies including the MHRA continue to recognise this combination as safe and effective when used as directed.

How Should You Use Numark Paracetamol Plus?

Numark Paracetamol Plus caplets are taken orally with a full glass of water. Swallow each caplet whole — do not crush, chew, or break them. Taking them with or after a light snack may help if you have a sensitive stomach.

Follow these steps each time you take a dose:

What Is the Correct Dose of Numark Paracetamol Plus?

The dose varies by age. Always follow the guidance below and never exceed the stated maximum daily dose. Taking more paracetamol than recommended can cause serious liver damage, even if you feel well at the time.

When Is the Best Time to Use Numark Paracetamol Plus?

Take Numark Paracetamol Plus as soon as your pain begins — early intervention tends to be more effective than waiting until discomfort becomes severe. Because the product contains 65mg of caffeine per caplet, avoid taking a dose in the evening or close to bedtime if you are sensitive to caffeine, as it may interfere with your sleep.

If you are using it for period pain, starting at the first sign of cramping rather than waiting for pain to peak can help you stay more comfortable throughout the day. Space your doses evenly across the day to maintain consistent pain relief.

How Long Can You Use Numark Paracetamol Plus For?

This product is intended for short-term use only. Do not take it for more than 3 consecutive days without seeking advice from your pharmacist or GP. If your symptoms persist, worsen, or change in character, it is important to get them properly assessed rather than continuing to self-medicate.

Using caffeine-containing analgesics too frequently — typically more than 10 to 15 days per month — can lead to medication-overuse headache, a condition where the pain relief medicine itself begins to trigger headaches. If you find you are relying on pain relief most days, speak to your GP about alternative management strategies.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

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Madeleinefjames

Very happy with these tablets, much cheaper than the named brands and do exactly the same , fine for headaches and other aches and pains. I’m pleased and will buy more soon.

What Are the Most Common Side Effects of Numark Paracetamol Plus?

When taken at the recommended dose, Numark Paracetamol Plus is generally well tolerated. However, some people do experience side effects, particularly related to the caffeine component. Common side effects may include:

  • Nausea or stomach discomfort
  • Restlessness or difficulty sleeping (insomnia)
  • Increased heart rate (palpitations)
  • Headache on stopping use (caffeine withdrawal)

These effects are usually mild and resolve on their own. Taking the caplets with a small amount of food can help reduce stomach discomfort, and avoiding evening doses can minimise sleep disruption.

What Are the Less Common Side Effects of Numark Paracetamol Plus?

Less commonly, some individuals may experience reactions that require attention. These include:

  • Skin rash, itching, or hives (urticaria)
  • Flushing
  • Mild allergic reactions
  • Dizziness

If you notice any skin changes or unusual symptoms after taking this medicine, stop use and speak to your pharmacist. These reactions, while uncommon, should not be ignored.

What Are the Serious Side Effects of Numark Paracetamol Plus?

Serious side effects are rare when the product is used correctly, but they can occur if the recommended dose is exceeded. The most significant risk is paracetamol-induced liver damage, which can occur even without obvious symptoms in the early stages. If you or someone else has taken more than the recommended amount, go to your nearest A&E immediately — do not wait for symptoms to appear.

Severe allergic reactions (anaphylaxis) are extremely rare but require emergency medical attention. Signs include swelling of the face, lips, or throat, difficulty breathing, and a sudden drop in blood pressure.

What Should You Do If You Experience Side Effects of Numark Paracetamol Plus?

For mild side effects such as nausea or restlessness, adjusting when you take the medicine — for example, with food or earlier in the day — may help. If side effects are persistent or troublesome, stop taking the product and consult your pharmacist. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

In the event of a suspected overdose, do not wait for symptoms. Seek emergency medical help immediately, as early treatment is critical in preventing serious liver damage from paracetamol toxicity.

Can Numark Paracetamol Plus Interact With Other Medicines?

Yes — interactions are possible and some are clinically significant. Do not take this product at the same time as other paracetamol-containing medicines, including many cold and flu remedies, as this can lead to accidental overdose. Paracetamol can also enhance the anticoagulant effect of warfarin when taken regularly, so those on blood thinners should seek pharmacist advice. MAOIs, metoclopramide, domperidone, and cholestyramine may also interact with this product.

Always inform your pharmacist or GP of all medicines, supplements, and herbal remedies you are taking before starting Numark Paracetamol Plus.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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