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Nizoral Anti-dandruff Shampoo- 100ml

Nizoral Anti-dandruff Shampoo- 100ml

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  • ✔️ Targets Malassezia fungus — the root cause of dandruff
  • ✔️ Contains clinically proven 2% ketoconazole antifungal
  • ✔️ Treats and prevents seborrhoeic dermatitis of the scalp
  • ✔️ Visible reduction in flaking within two to four weeks
  • ✔️ Suitable for adults and young people aged 12 and over

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Is Ketoconazole Shampoo Right for Your Dandruff?

 

Dandruff affects roughly half of all adults at some point in their lives, and for many people it can be persistent, embarrassing, and frustrating to manage. Nizoral Anti-Dandruff Shampoo 100ml contains ketoconazole shampoo at a 2% concentration — the same active ingredient used in prescription-strength treatments, now available over the counter. It is one of the few medicated shampoos that directly targets the fungal cause of dandruff rather than simply washing away flakes. If you have been cycling through regular shampoos without lasting results, this could be the change your scalp needs. You can browse the full range of hair care products at Cured Pharmacy alongside this treatment.

Dandruff is not just a cosmetic issue. It is often linked to a condition called seborrhoeic dermatitis, which causes the scalp to become flaky, itchy, and sometimes inflamed. The NHS recognises seborrhoeic dermatitis as a common skin condition that can affect the scalp, face, and other oily areas of the body. Nizoral is clinically indicated for both the treatment and prevention of dandruff and seborrhoeic dermatitis of the scalp in adults.

 

How Does Nizoral Anti-Dandruff Shampoo Work?

 

The active ingredient, ketoconazole 2%, is an imidazole antifungal. It works by targeting a yeast called Malassezia (formerly known as Pityrosporum ovale), which naturally lives on the scalp but can overgrow in some people, triggering the flaking and irritation associated with dandruff. Here is how it works step by step:

  • Ketoconazole binds to fungal cell membranes and inhibits the synthesis of ergosterol, a key component that keeps fungal cells intact.
  • Without ergosterol, the fungal cell membrane becomes leaky and the cell dies.
  • This reduces the Malassezia population on the scalp, which in turn reduces the inflammatory response causing flaking and itching.
  • Regular preventative use keeps fungal levels low, reducing the chance of dandruff returning.

Because it works at the root cause — the fungus — rather than just masking symptoms, Nizoral tends to produce more sustained results than cosmetic anti-dandruff shampoos.

 

Who Should Use Nizoral Anti-Dandruff Shampoo?

 

Nizoral Anti-Dandruff Shampoo is suitable for adults who experience recurrent or persistent dandruff, or who have been diagnosed with seborrhoeic dermatitis of the scalp. It is available without a prescription, making it accessible for most adults. That said, it is not appropriate for everyone.

This shampoo may be suitable for you if:

  • You have visible scalp flaking that has not responded to standard cosmetic shampoos.
  • You experience scalp itching, redness, or irritation alongside dandruff.
  • You have been told by a healthcare professional that you have seborrhoeic dermatitis.
  • You want a preventative treatment to stop dandruff from recurring after a course of treatment.

It is not recommended for use in children under 12 without medical supervision, and you should avoid it if you have a known allergy to ketoconazole or any other ingredient in the formulation.

 

How Does Nizoral Compare to Other Dandruff Shampoos?

 

Feature Nizoral Anti-Dandruff Shampoo Zinc Pyrithione Shampoo
Active ingredient Ketoconazole 2% Zinc pyrithione 1–2%
Mechanism Antifungal — targets Malassezia directly Antimicrobial — broad-spectrum
Use frequency Twice weekly (treatment); fortnightly (prevention) Daily or every other day
OTC availability in UK Yes Yes

 

Is Nizoral Shampoo Safe to Store and Use Long Term?

 

Nizoral Anti-Dandruff Shampoo should be stored below 25°C, away from direct sunlight, and kept out of the reach of children. The 100ml bottle is compact enough for everyday bathroom storage. Once opened, check the expiry date on the packaging and do not use beyond it. If you are also managing a fungal skin condition elsewhere on the body, you may find it helpful to explore our range of athletes foot and fungal infection treatments for complementary options.

Long-term preventative use of ketoconazole shampoo is generally considered safe when used as directed. However, if your symptoms worsen, spread beyond the scalp, or do not improve after four weeks of treatment, you should consult your GP or pharmacist for further assessment.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Nizoral Anti-Dandruff Shampoo 100ml specifications
Treatment category Antifungal / Scalp treatment
Active ingredient Ketoconazole 2% w/v
Mechanism of action Inhibits ergosterol synthesis in fungal cell membranes
Effective against Dandruff, seborrhoeic dermatitis of the scalp
Suitable for Adults and children aged 12 and over
Pack size 100ml
UK classification P (Pharmacy medicine)
Drug class Imidazole antifungal
Preparation Medicated shampoo
Route of administration Topical (scalp)

Specifications of Nizoral Anti-Dandruff Shampoo 100ml

 

What Is Nizoral Anti-Dandruff Shampoo and What Is It Used For?

 

Nizoral Anti-Dandruff Shampoo 100ml is a medicated scalp treatment containing ketoconazole 2% w/v as its active ingredient. It belongs to a class of medicines called imidazole antifungals. It is used to treat dandruff and seborrhoeic dermatitis of the scalp — conditions caused or worsened by an overgrowth of the Malassezia yeast on the scalp. It can also be used as a preventative treatment once symptoms have cleared, to reduce the likelihood of recurrence. The NHS describes dandruff as a common condition that causes the skin on the scalp to flake, and notes that it is not contagious or serious, but can be difficult to manage without the right treatment.

 

What Do You Need to Know Before Using Nizoral Anti-Dandruff Shampoo?

 

Before using this shampoo, read the following carefully. There are certain situations where you should not use Nizoral, or where you should seek advice first.

Do not use Nizoral Anti-Dandruff Shampoo if:

  • You are allergic to ketoconazole or any other ingredient in the formulation.
  • You have broken, raw, or severely inflamed skin on your scalp without first consulting a doctor.
  • You are under 12 years of age, unless directed by a healthcare professional.

Speak to your pharmacist or GP before use if:

  • You are pregnant or breastfeeding.
  • You have a history of liver problems (relevant if you are also using oral ketoconazole).
  • You are using any other scalp treatments or medicated products at the same time.
  • Your symptoms have not been previously assessed by a healthcare professional.

Known interactions:

  • No clinically significant drug interactions are expected with topical ketoconazole shampoo used as directed, as systemic absorption is minimal.
  • Avoid using alongside other medicated scalp products unless advised by a pharmacist.

 

How Should You Use Nizoral Anti-Dandruff Shampoo?

 

Always use this shampoo exactly as described in the patient information leaflet or as directed by your pharmacist. Do not use more than recommended, and do not apply to areas other than the scalp unless specifically advised.

  1. Wet your hair and scalp thoroughly with warm water.
  2. Apply a sufficient amount of Nizoral shampoo to cover the entire scalp.
  3. Lather gently and leave the shampoo in contact with the scalp for 3 to 5 minutes.
  4. Rinse thoroughly with water.
  5. Repeat if necessary, depending on hair length and thickness.
  6. Avoid contact with eyes — if contact occurs, rinse immediately with water.
Indication Age Group Dose Frequency
Treatment of dandruff / seborrhoeic dermatitis Adults and children ≥12 Sufficient amount to cover scalp Twice weekly for 2–4 weeks
Prevention of recurrence Adults and children ≥12 Sufficient amount to cover scalp Once every 1–2 weeks

 

What Are the Possible Side Effects of Nizoral Anti-Dandruff Shampoo?

 

Like all medicines, Nizoral Anti-Dandruff Shampoo can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the scalp. If you are also managing other skin conditions, our skin care range includes a variety of supportive products that may help.

Common side effects (may affect up to 1 in 10 people):

  • Mild scalp irritation or burning sensation
  • Itching of the scalp
  • Temporary change in hair texture or dryness
  • Oiliness or dryness of the scalp

Less common side effects (may affect up to 1 in 100 people):

  • Hair loss or thinning (usually temporary)
  • Skin rash or contact dermatitis
  • Discolouration of chemically treated or grey hair (rare)
  • Allergic reaction — symptoms may include rash, swelling, or difficulty breathing (seek immediate medical attention)

Stop using the shampoo and contact your pharmacist or GP if you experience any unexpected or worsening symptoms. If you are concerned about hair thinning alongside dandruff, you may also wish to explore our female hair loss collection for additional support options.

 

How Should You Store Nizoral Anti-Dandruff Shampoo?

 

  • Store below 25°C in a cool, dry place.
  • Keep away from direct sunlight and heat sources.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the bottle and carton.
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Nizoral Anti-Dandruff Shampoo online in the UK?

You can buy Nizoral Anti-Dandruff Shampoo 100ml directly from Cured Pharmacy, a UK GPhC-registered online pharmacy. It is classified as a Pharmacy (P) medicine and is available without a prescription. Simply add it to your basket and it will be dispensed and dispatched by our qualified pharmacy team.

How does ketoconazole shampoo treat dandruff?

Ketoconazole 2% works by inhibiting the production of ergosterol, a vital component of the fungal cell membrane of Malassezia — the yeast responsible for dandruff. Without ergosterol, the fungal cells cannot survive, which reduces the overgrowth that triggers scalp flaking and irritation. This targeted antifungal action makes it more effective for fungal-driven dandruff than many cosmetic shampoos.

How do I use Nizoral Anti-Dandruff Shampoo step by step?

Wet your hair thoroughly, apply enough shampoo to cover the scalp, and lather gently. Leave it on for 3 to 5 minutes before rinsing well — this contact time is important for the ketoconazole to work. For treatment, use twice a week for 2 to 4 weeks; for prevention, once every one to two weeks is sufficient.

How often should I use Nizoral shampoo each week?

During an active dandruff episode, use Nizoral twice a week for up to four weeks. Once your symptoms have cleared, you can switch to a maintenance dose of once every one to two weeks to prevent dandruff from coming back. Do not use it more frequently than recommended without pharmacist advice.

What are the side effects of Nizoral Anti-Dandruff Shampoo?

The most common side effects include mild scalp irritation, itching, and temporary changes in hair texture. Less commonly, some people notice temporary hair thinning or, rarely, a skin rash. If you experience any signs of an allergic reaction — such as swelling, hives, or difficulty breathing — stop use immediately and seek medical attention.

Can I use Nizoral shampoo if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your doctor or pharmacist before using Nizoral Anti-Dandruff Shampoo. Although systemic absorption from topical use is minimal, it is always sensible to seek professional advice before using any medicine during pregnancy or whilst nursing.

How long does it take for Nizoral shampoo to work?

Most people begin to notice a reduction in flaking and scalp irritation within the first two weeks of twice-weekly use. Full improvement is typically seen after a complete 2 to 4 week treatment course. If your symptoms have not improved after four weeks, consult your pharmacist or GP for further assessment.

Is Nizoral shampoo suitable for colour-treated or chemically processed hair?

Nizoral can, in rare cases, cause discolouration of chemically treated, bleached, or grey hair. If your hair has been chemically processed, it is worth doing a patch test or speaking to your pharmacist before starting regular use. The risk is uncommon, but it is worth being aware of before you begin treatment.

Who is eligible to use Nizoral Anti-Dandruff Shampoo?

Nizoral Anti-Dandruff Shampoo is suitable for adults and young people aged 12 and over who have dandruff or seborrhoeic dermatitis of the scalp. It should not be used in children under 12 without medical supervision. People with known allergies to ketoconazole or any other ingredient in the formulation should not use this product.

What happens if I miss a dose of Nizoral shampoo?

If you forget to use Nizoral on a scheduled wash day, simply use it at your next hair wash — do not double up by applying it twice in one day to compensate. Consistency matters more than strict timing, so just continue with your regular twice-weekly schedule. Missing the occasional wash is unlikely to significantly affect your results.

What are the alternatives to Nizoral Anti-Dandruff Shampoo?

Alternatives include zinc pyrithione shampoos, selenium sulphide shampoos, and coal tar-based shampoos, all of which are available over the counter. Nizoral is distinct in that it contains 2% ketoconazole, which specifically targets the Malassezia fungus. If you are exploring other scalp or hair care options, Cured Pharmacy stocks a range of treatments to suit different needs.

Can Nizoral shampoo be used to prevent dandruff from coming back?

Yes — once your dandruff has cleared with the twice-weekly treatment course, you can continue using Nizoral once every one to two weeks as a preventative measure. This maintenance approach helps keep Malassezia levels on the scalp under control and reduces the chance of symptoms returning. Many people find this long-term strategy very effective.

How long can you use Nizoral Anti-Dandruff Shampoo for?

The treatment phase lasts 2 to 4 weeks with twice-weekly use. After that, preventative use once every one to two weeks can be continued longer term. If you feel you need to use it more frequently than recommended, or if symptoms persist beyond four weeks, speak to your pharmacist or GP.

Does Nizoral shampoo help with hair loss caused by dandruff?

Severe dandruff and seborrhoeic dermatitis can contribute to temporary hair shedding due to scalp inflammation. By treating the underlying fungal cause, Nizoral may help reduce this inflammation-related hair loss. However, if you are experiencing significant or ongoing hair thinning, it is worth exploring our female hair loss collection or speaking to a healthcare professional for a full assessment.

What is the latest research on ketoconazole shampoo for dandruff?

Ketoconazole 2% shampoo has been studied extensively and remains one of the most well-evidenced topical antifungal treatments for dandruff and seborrhoeic dermatitis. Clinical studies have consistently shown it to be effective at reducing Malassezia colonisation and associated scalp symptoms. The NHS and BNF both recognise ketoconazole as a first-line topical option for seborrhoeic dermatitis of the scalp.

How Should You Use Nizoral Anti-Dandruff Shampoo?

Using Nizoral correctly is key to getting the best results from your treatment. Unlike regular shampoos, this is a medicated product — the contact time on your scalp matters just as much as the application itself. Follow these steps each time you use it:

You do not need to use your regular shampoo alongside Nizoral on treatment days. If your hair feels dry after use, a separate conditioner applied to the lengths (not the scalp) can be used after rinsing.

What Is the Correct Dose of Nizoral Anti-Dandruff Shampoo?

There is no fixed volume dose for Nizoral — you simply apply enough to cover your scalp fully. The key variable is how often you use it, which depends on whether you are treating active dandruff or preventing it from returning. The table below summarises the recommended dosing schedule.

Do not use more frequently than recommended. If symptoms persist after four weeks of treatment, consult your pharmacist or GP.

When Is the Best Time to Use Nizoral Anti-Dandruff Shampoo?

There is no specific time of day that is clinically superior for using Nizoral — morning or evening showers are both fine. What matters most is that you leave the shampoo on your scalp for the full 3 to 5 minutes before rinsing, so choose a time when you are not rushing. Many people find it easiest to incorporate it into their regular shower routine on set days of the week, such as Monday and Thursday, to maintain the twice-weekly schedule during the treatment phase.

If you are using Nizoral for prevention, picking a consistent day each week or fortnight helps you stay on track without having to think about it.

How Long Can You Use Nizoral Anti-Dandruff Shampoo For?

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What Are the Most Common Side Effects of Nizoral Anti-Dandruff Shampoo?

Most people tolerate Nizoral Anti-Dandruff Shampoo well, and side effects are generally mild and short-lived. The most frequently reported effects are localised to the scalp and tend to resolve on their own without stopping treatment.

  • Mild scalp irritation or a slight burning sensation after application
  • Itching of the scalp
  • Temporary dryness or oiliness of the scalp
  • Changes in hair texture, such as increased dryness or brittleness

What Are the Less Common Side Effects of Nizoral Anti-Dandruff Shampoo?

Less commonly, some people experience side effects that are more noticeable or that may require you to stop using the product. These are not typical, but it is worth knowing what to look out for.

  • Temporary hair thinning or increased hair shedding
  • Contact dermatitis — a localised skin rash on the scalp or hairline
  • Discolouration of chemically treated, bleached, or grey hair (rare)
  • Folliculitis — inflammation around hair follicles

If you notice significant hair loss or a worsening rash, stop using the shampoo and speak to your pharmacist or GP before continuing.

What Are the Serious Side Effects of Nizoral Anti-Dandruff Shampoo?

Serious side effects from topical ketoconazole shampoo are rare, as systemic absorption through the scalp is minimal when used as directed. However, allergic reactions can occur in a small number of people. Symptoms of a serious allergic reaction (anaphylaxis) include:

  • Sudden swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or hives
  • Dizziness or feeling faint

If you experience any of these symptoms, stop using the shampoo immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects of Nizoral Shampoo?

For mild side effects such as scalp irritation or dryness, you may find that symptoms settle after the first few uses as your scalp adjusts. Reducing the contact time slightly (to 3 minutes rather than 5) may also help. If side effects are persistent, uncomfortable, or worsening, stop use and consult your pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Nizoral Anti-Dandruff Shampoo Interact With Other Medicines?

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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