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Motusol 1% Diclofenac Gel 100g

Motusol 1% Diclofenac Gel 100g

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  • ✔️ Targets joint and muscle pain directly at the source
  • ✔️ Reduces inflammation with clinically proven diclofenac sodium 1%
  • ✔️ Suitable for osteoarthritis, sprains, and soft tissue injuries
  • ✔️ Lower systemic absorption than oral NSAID tablets
  • ✔️ Convenient 100g tube for extended topical pain management

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What Is Diclofenac Gel and How Does It Relieve Pain?

 

If you're dealing with aching joints, sore muscles, or the nagging discomfort of a soft tissue injury, Motusol 1% Diclofenac Gel could be exactly what you need. This 100g topical gel contains diclofenac sodium 1% as its active ingredient — a well-established non-steroidal anti-inflammatory drug (NSAID) that targets pain and inflammation directly at the source. Available over the counter for just £7.49, it offers a practical, targeted approach to everyday pain without the need for a prescription. You can browse our full range of pain relief products if you'd like to explore other options alongside this gel.

Diclofenac is one of the most widely used topical analgesics in the UK. It's trusted by patients and healthcare professionals alike for managing localised musculoskeletal pain — from osteoarthritis flare-ups to sports-related strains. Because it's applied directly to the skin, it works where you need it most, with far less systemic exposure than taking an oral NSAID tablet.

 

How Does Motusol 1% Diclofenac Gel Work?

 

Topical NSAIDs like diclofenac work by penetrating the skin and reaching the underlying tissues, where they get to work on the inflammatory process. Here's a simplified breakdown of the mechanism:

  • Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes in the affected tissue.
  • This reduces the synthesis of prostaglandins — the chemical messengers responsible for triggering pain, swelling, and heat at the site of injury or inflammation.
  • With fewer prostaglandins present, the pain signal is dampened and local inflammation subsides.
  • Because the gel is applied topically, systemic absorption is significantly lower than with oral diclofenac, reducing the risk of gastrointestinal side effects.

It's a targeted mechanism. Rather than flooding your whole system with an anti-inflammatory, the gel concentrates its effect where you actually feel the pain.

 

Who Is Motusol 1% Diclofenac Gel Suitable For?

 

This gel is suitable for adults and adolescents aged 14 and over who are experiencing localised pain and inflammation. It's particularly useful for people who prefer not to take oral pain relief, or those who find tablets cause stomach upset. That said, it's not appropriate for everyone — always read the label carefully.

Motusol 1% Diclofenac Gel is well suited for:

  • Adults with osteoarthritis of the knee or hand joints
  • People recovering from soft tissue injuries such as sprains, strains, or tendinitis
  • Those with localised back pain or muscle soreness
  • Individuals who cannot tolerate oral NSAIDs due to gastrointestinal sensitivity

 

How Does Motusol Diclofenac Gel Compare to Ibuprofen Gel?

 

Feature Motusol 1% Diclofenac Gel Ibuprofen Gel (e.g. 5%)
Active ingredient Diclofenac sodium 1% Ibuprofen 5%
Application frequency 3–4 times daily 3–4 times daily
Suitable for osteoarthritis Yes Yes
Minimum age 14 years 12 years (varies by brand)

 

Is Motusol 1% Diclofenac Gel Safe to Store at Home?

 

Diclofenac gel should be stored below 25°C, away from direct heat and sunlight. Keep the cap tightly closed when not in use, and always store it out of the reach and sight of children. Do not use the gel after the expiry date printed on the tube or carton. If you're managing multiple health conditions and keeping several medicines at home, it's worth checking our creams and ointments section for other topical treatments you might find useful.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Motusol 1% Diclofenac Gel 100g specifications
Treatment category Pain relief / Anti-inflammatory
Mechanism of action COX-1 and COX-2 inhibition, reducing prostaglandin synthesis
Effective for Joint pain, muscle pain, soft tissue injuries, osteoarthritis
Suitable for Adults and adolescents aged 14 and over
Active ingredient Diclofenac sodium 1%
Pack size 100g
Strength 1% w/w
UK classification P (Pharmacy medicine)
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Topical gel
Route of administration Topical (cutaneous)

Specifications of Motusol 1% Diclofenac Gel 100g

 

What Is Motusol 1% Diclofenac Gel and What Is It Used For?

 

Motusol 1% Diclofenac Gel is a topical non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation in muscles, joints, and soft tissues. It contains diclofenac sodium 1% w/w as its active ingredient. It is used for the symptomatic relief of pain associated with:

  • Osteoarthritis of superficial joints such as the knee and hand
  • Acute soft tissue injuries including sprains, strains, and contusions
  • Localised musculoskeletal pain and inflammation
  • Tendinitis and periarthritis

This is an over-the-counter (OTC) medicine suitable for short-term use in adults and adolescents aged 14 and over.

 

What Do You Need to Know Before Using Motusol 1% Diclofenac Gel?

 

Before applying this gel, it's important to check whether it's appropriate for you. Do not use Motusol 1% Diclofenac Gel if any of the following apply:

  • You are allergic to diclofenac, aspirin, ibuprofen, or any other NSAID
  • You have ever experienced asthma, urticaria, or allergic rhinitis triggered by aspirin or other NSAIDs
  • You are in the third trimester of pregnancy
  • You are under 14 years of age
  • The skin at the application site is broken, damaged, infected, or affected by eczema or dermatitis
  • You have a known hypersensitivity to any of the excipients in the formulation

Take care and speak to your pharmacist or GP before using this gel if you:

  • Are in the first or second trimester of pregnancy or are breastfeeding
  • Have a history of peptic ulcer disease or gastrointestinal bleeding (though topical use carries lower risk than oral NSAIDs)
  • Have impaired kidney or liver function
  • Are using other topical products on the same area of skin

Drug interactions to be aware of:

  • Anticoagulants such as warfarin — topical diclofenac may slightly increase bleeding risk in rare cases
  • Other NSAIDs (oral or topical) — concurrent use is not recommended
  • Ciclosporin or tacrolimus — potential for increased nephrotoxicity if significant systemic absorption occurs

 

How Should You Use Motusol 1% Diclofenac Gel?

 

Always use this gel exactly as directed on the label or as advised by your pharmacist. Do not apply more than the recommended amount, and do not use it on large areas of the body simultaneously.

  1. Wash and dry the affected area before application.
  2. Squeeze approximately 2–4g of gel (roughly the size of a 50p coin) onto your fingertips.
  3. Gently massage the gel into the skin over the painful area until fully absorbed.
  4. Wash your hands thoroughly after application, unless your hands are the area being treated.
  5. Allow the gel to dry before covering with clothing. Do not apply under occlusive (airtight) dressings.
  6. Avoid contact with eyes, mouth, and mucous membranes. If accidental contact occurs, rinse with water immediately.
Indication Age Group Dose Frequency
Joint and muscle pain Adults and adolescents ≥14 years 2–4g per application 3–4 times daily
Soft tissue injury Adults and adolescents ≥14 years 2–4g per application 3–4 times daily
Children under 14 Not recommended

 

What Are the Possible Side Effects of Motusol 1% Diclofenac Gel?

 

Like all medicines, this gel can cause side effects, although not everyone experiences them. Most side effects are localised to the skin at the application site.

Common side effects (may affect up to 1 in 10 people):

  • Skin redness (erythema) at the application site
  • Itching or pruritus
  • Dry or flaking skin
  • A mild burning or stinging sensation after application

Less common side effects (may affect up to 1 in 100 people):

  • Contact dermatitis or eczema-like reaction
  • Skin rash or urticaria
  • Photosensitivity (increased sensitivity to sunlight at the treated area)
  • Localised swelling or oedema

Stop using the gel and seek medical advice immediately if you develop signs of a serious allergic reaction, such as facial swelling, difficulty breathing, or widespread skin reactions. You can also find other topical treatment options in our first aid collection if you need alternatives for skin-related concerns.

 

How Should You Store Motusol 1% Diclofenac Gel?

 

  • Store below 25°C in a cool, dry place away from direct sunlight and heat sources.
  • Keep the tube tightly closed when not in use.
  • Do not freeze.
  • Keep out of the reach and sight of children.
  • Do not use after the expiry date printed on the tube and carton.
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy for safe disposal.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Motusol 1% Diclofenac Gel online in the UK?

You can buy Motusol 1% Diclofenac Gel directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £7.49 per 100g tube. It is available without a prescription as an over-the-counter pharmacy medicine. Browse our full pain relief collection for related products.

How does diclofenac gel work on joint and muscle pain?

Diclofenac gel works by inhibiting COX-1 and COX-2 enzymes in the tissue beneath the skin, which reduces the production of prostaglandins — the chemicals responsible for pain, swelling, and inflammation. Applied topically, it delivers its anti-inflammatory effect locally with much lower systemic absorption than oral diclofenac tablets. This makes it a practical option for people who want targeted relief without affecting the whole body.

How do I apply Motusol 1% Diclofenac Gel step by step?

Clean and dry the affected area first, then squeeze approximately 2–4g of gel onto your fingertips and gently massage it into the skin until absorbed. Wash your hands after application unless your hands are the area being treated, and avoid applying under tight or occlusive dressings. Do not let the gel come into contact with your eyes or mouth.

How many times a day should I use diclofenac gel?

Motusol 1% Diclofenac Gel should be applied three to four times daily to the affected area. Space applications evenly throughout the day and do not exceed the recommended daily amount. If you are unsure about frequency for your specific condition, speak to your pharmacist.

What are the side effects of Motusol 1% Diclofenac Gel?

The most common side effects are localised skin reactions at the application site, including redness, itching, dryness, or a mild burning sensation. Less commonly, some people experience contact dermatitis, a skin rash, or increased sensitivity to sunlight on the treated area. Serious allergic reactions are rare but require immediate medical attention — stop using the gel and seek help if you develop facial swelling or difficulty breathing.

Who should not use Motusol 1% Diclofenac Gel?

This gel is not suitable for people who are allergic to diclofenac, aspirin, ibuprofen, or any other NSAID. It should not be applied to broken, infected, or damaged skin, and it is not recommended during the third trimester of pregnancy. Children under 14 years of age should not use this product.

What happens if I accidentally apply too much diclofenac gel?

Applying more than the recommended amount may increase the risk of skin irritation at the application site. If you accidentally ingest any of the gel or apply it to a very large area of skin, contact NHS 111 or your nearest pharmacist for advice. Systemic side effects from topical overuse are uncommon but possible with excessive application.

Can I use diclofenac gel during pregnancy?

Motusol 1% Diclofenac Gel is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and uterine inertia. Use during the first and second trimesters should only be considered after discussion with a doctor or pharmacist. Always seek medical advice before using any NSAID if you are pregnant or trying to conceive.

Is diclofenac gel better than ibuprofen gel for arthritis?

Both diclofenac gel and ibuprofen gel are topical NSAIDs with evidence supporting their use in osteoarthritis and soft tissue pain. Clinical studies suggest diclofenac gel has good skin penetration and is specifically licensed for osteoarthritis of superficial joints such as the knee. The best choice depends on your individual circumstances — speak to your pharmacist if you're unsure which is more appropriate for you.

How long can I use Motusol 1% Diclofenac Gel for?

For over-the-counter use, this gel should not be used for more than 14 days without consulting a doctor or pharmacist. If your symptoms persist, worsen, or change in character during this time, stop using the gel and seek medical advice. Long-term use should only be continued under the supervision of a healthcare professional.

Can I use diclofenac gel alongside oral pain relief?

Using diclofenac gel alongside paracetamol is generally considered acceptable, but combining it with oral NSAIDs such as ibuprofen or naproxen is not recommended as this increases the risk of side effects. Always tell your pharmacist about all medicines you are currently taking before starting a new treatment. If you need additional pain management options, our pain relief range includes a variety of alternatives.

Does diclofenac gel interact with warfarin?

There is a small theoretical risk that topical diclofenac may slightly enhance the anticoagulant effect of warfarin, particularly if applied to large areas of skin over a prolonged period. If you are taking warfarin or any other anticoagulant, speak to your GP or pharmacist before using this gel. Regular INR monitoring may be advisable in some cases.

Can I use diclofenac gel on my back?

Yes, diclofenac gel can be applied to areas of localised back pain, provided the skin is intact and not broken or infected. Apply a small amount to the painful area and massage in gently. Bear in mind that the gel is most effective for superficial musculoskeletal pain — deep-seated back pain may require additional assessment and treatment from a healthcare professional.

What are the latest studies on topical diclofenac for pain?

Research continues to support the efficacy of topical diclofenac for osteoarthritis and soft tissue pain, with studies showing meaningful pain reduction and improved function compared to placebo. Topical NSAIDs are increasingly recommended as a first-line option for knee osteoarthritis in clinical guidelines due to their favourable safety profile versus oral NSAIDs. The NHS and NICE both recognise topical NSAIDs as an appropriate treatment option for localised joint pain.

How should I store Motusol 1% Diclofenac Gel at home?

Store the gel below 25°C in a cool, dry place away from direct sunlight and heat. Keep the tube tightly closed between uses and always store it out of the reach of children. Do not use the gel after the expiry date printed on the packaging, and return any unused medicine to your pharmacy for safe disposal. You can also explore our creams and ointments section for other topical treatments to keep in your medicine cabinet.

How Should You Use Motusol 1% Diclofenac Gel?

Using Motusol 1% Diclofenac Gel correctly ensures you get the most benefit while minimising the risk of skin irritation. Always apply it to clean, dry, intact skin — never to broken, infected, or damaged areas.

Follow these steps each time you apply the gel:

What Is the Correct Dose of Motusol 1% Diclofenac Gel?

The correct dose depends on the size of the area being treated and the nature of your pain. Always use the smallest effective amount and do not apply to large areas of the body simultaneously.

When Is the Best Time to Use Motusol 1% Diclofenac Gel?

There is no single "best" time — the key is consistency. Spreading your applications evenly throughout the day (for example, morning, midday, afternoon, and evening) helps maintain a steady anti-inflammatory effect at the site of pain.

Many people find it helpful to apply the gel after washing or bathing, when the skin is clean and circulation is slightly increased. Applying before physical activity or before bed can also help manage pain at the times it tends to be most noticeable.

How Long Can You Use Motusol 1% Diclofenac Gel For?

For over-the-counter use, Motusol 1% Diclofenac Gel should not be used for more than 14 consecutive days without consulting a doctor or pharmacist. Most acute soft tissue injuries respond within this timeframe.

If your symptoms have not improved after 14 days, or if they worsen at any point, stop using the gel and seek medical advice. Longer-term use for conditions such as osteoarthritis should only be continued under the guidance of a healthcare professional who can monitor your response and overall health.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Motusol 1% Diclofenac Gel?

Most side effects associated with this gel are localised to the skin at the application site and are generally mild. They tend to resolve on their own once you stop using the product or reduce the frequency of application.

  • Skin redness (erythema) at the treated area
  • Itching or pruritus
  • Dry or flaking skin
  • A mild burning or stinging sensation immediately after application

What Are the Less Common Side Effects of Motusol 1% Diclofenac Gel?

Some people experience less frequent reactions that may require you to stop using the gel and seek advice from a pharmacist or GP. These are not common, but it's worth knowing what to look out for.

  • Contact dermatitis — an eczema-like reaction with redness, blistering, or weeping skin
  • Urticaria (hives) or a generalised skin rash
  • Photosensitivity — increased sensitivity to sunlight on the treated area
  • Localised swelling or oedema at the application site
  • Papules or vesicles (small raised spots or fluid-filled blisters)

What Are the Serious Side Effects of Motusol 1% Diclofenac Gel?

Serious side effects from topical diclofenac are rare, particularly because systemic absorption is much lower than with oral NSAIDs. However, they can occur, especially if the gel is applied to large areas of skin, used under occlusive dressings, or used for prolonged periods.

Seek immediate medical attention if you experience any of the following, as these may indicate a serious allergic reaction (anaphylaxis) or systemic NSAID effect:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or wheezing
  • Severe skin reactions such as widespread blistering or peeling
  • Signs of kidney problems such as reduced urine output or ankle swelling

What Should You Do If You Experience Side Effects of Motusol 1% Diclofenac Gel?

If you notice mild skin irritation at the application site, try reducing the amount of gel you apply or the frequency of use. If the irritation persists or worsens, stop using the gel and speak to your pharmacist. For any signs of a serious reaction, stop using the product immediately and call 999 or go to your nearest A&E department.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. Reporting side effects helps improve the safety information available for all medicines.

Can Motusol 1% Diclofenac Gel Interact With Other Medicines?

Although topical diclofenac has lower systemic absorption than oral forms, interactions are still possible — particularly with certain medicines. The most clinically relevant interactions include:

  • Anticoagulants (e.g. warfarin): A small increase in bleeding risk has been reported. Monitor INR if you are on anticoagulant therapy.
  • Other NSAIDs (oral or topical): Concurrent use is not recommended as it may increase the risk of side effects without additional benefit.
  • Ciclosporin or tacrolimus: Potential for increased nephrotoxicity if significant systemic absorption occurs.
  • Lithium or methotrexate: Topical NSAIDs may theoretically increase plasma levels of these medicines, though the risk with topical use is low.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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