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Lyclear Lotion 100ml

Lyclear Lotion 100ml

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  • ✔️ Kills head lice with permethrin 1% in just 10 minutes
  • ✔️ Suitable for adults and children aged 6 months and over
  • ✔️ Two-dose course targets both live lice and newly hatched eggs
  • ✔️ Clinically established permethrin formula recommended by pharmacists
  • ✔️ Convenient 100ml bottle — enough for a full two-dose treatment course

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What Is Lyclear Lotion — the Head Lice Treatment That Works?

 

Head lice are one of the most common childhood complaints in the UK, affecting millions of families every year. They spread easily through direct head-to-head contact and can cause persistent itching, discomfort, and no small amount of stress. Lyclear Lotion 100ml is a clinically established, over-the-counter head lice treatment containing permethrin 1% w/v — a synthetic pyrethroid that targets lice directly at the source. Available from our head lice collection at Cured Pharmacy, it offers a straightforward, pharmacist-recommended option for the whole family.

Permethrin has been used in head lice management for decades and remains one of the most studied topical insecticides available without a prescription. Lyclear Lotion is suitable for adults and children aged 6 months and over, making it a practical choice for households dealing with an active infestation.

 

How Does Lyclear Lotion Work Against Lice?

 

Permethrin works by interfering with the sodium channel function in the nerve cell membranes of head lice. This disrupts normal nerve signal transmission, leading to paralysis and death of the louse. Unlike some physical treatments that rely on suffocation, permethrin acts chemically — which means it can be effective even when applied for a relatively short contact time.

  • Permethrin binds to voltage-gated sodium channels in louse nerve cells
  • Sodium channels are held open, causing continuous nerve firing
  • This leads to paralysis of the louse within minutes of contact
  • Dead lice and loosened eggs can then be removed with a fine-toothed nit comb

 

Who Should Use Lyclear Lotion and Is It Right for You?

 

Lyclear Lotion is designed for anyone with a confirmed head lice infestation. The NHS recommends only treating head lice when a live louse has been found — not as a preventative measure. It is suitable for:

  • Adults and children aged 6 months and over
  • Individuals who prefer a chemical insecticide-based approach
  • Households where multiple family members need treatment simultaneously
  • Those who have not responded to wet combing alone

Children under 2 years of age should only be treated under the supervision of a healthcare professional. If you are pregnant or breastfeeding, speak to your pharmacist or GP before using this product.

 

How Does Lyclear Lotion Compare to Other Head Lice Treatments?

 

Feature Lyclear Lotion (Permethrin 1%) Dimeticone Lotion (e.g. Hedrin)
Mechanism Chemical — disrupts louse nervous system Physical — coats and suffocates lice
Contact time 10 minutes 8 hours (overnight)
Age suitability 6 months and over 6 months and over
Resistance risk Some reported permethrin resistance in UK lice populations No known resistance (physical mode of action)

 

Is Lyclear Lotion Suitable for Sensitive Scalps and How Should It Be Stored?

 

If you or your child has a sensitive scalp, eczema, or a history of skin reactions, speak to your pharmacist before using any head lice treatment. Lyclear Lotion should not be applied to broken, infected, or inflamed skin. Avoid contact with the eyes — if accidental contact occurs, rinse immediately with plenty of water. You can browse our skin care range for products that may help soothe the scalp after treatment.

Store Lyclear Lotion below 25°C, away from direct heat and naked flames. The lotion is flammable — do not use near an open fire or while smoking. Keep out of reach and sight of children. Do not use after the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Lotion 100ml specifications
Treatment category Head lice (Pediculosis capitis)
Mechanism of action Synthetic pyrethroid — disrupts sodium channels in louse nerve cells causing paralysis
Effective against Head lice (Pediculus humanus capitis) and their eggs (nits)
Suitable for Adults and children aged 6 months and over
Active ingredient Permethrin 1% w/v
Pack size 100ml
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Synthetic pyrethroid insecticide
Preparation Topical lotion
Route of administration Topical (applied to scalp and hair)

Specifications of Lyclear Lotion 100ml

 

What Is Lyclear Lotion and What Is It Used For?

 

Lyclear Lotion 100ml is a topical insecticide lotion used to treat infestations of head lice (Pediculus humanus capitis) in adults and children aged 6 months and over. Its active ingredient, permethrin 1% w/v, is a synthetic pyrethroid that kills lice by disrupting their nervous system. It is available over the counter without a prescription and is one of the chemical treatment options recommended for managing head lice in the UK.

Head lice do not jump or fly — they spread only through prolonged, direct head-to-head contact. They are not a sign of poor hygiene. The NHS advises that treatment should only begin once a live louse has been detected by wet combing or visual inspection.

 

What Do You Need to Know Before Using Lyclear Lotion?

 

Before applying Lyclear Lotion, read the following contraindications and warnings carefully:

  • Do not use if you are allergic to permethrin, any pyrethroid, pyrethrin, or any other ingredient in the lotion
  • Do not apply to broken, infected, or inflamed skin
  • Do not use on infants under 6 months of age without medical advice
  • Children under 2 years should only be treated under medical supervision
  • Avoid contact with eyes, nose, and mouth — rinse immediately with water if contact occurs
  • Do not use near naked flames or while smoking — the lotion is flammable
  • Speak to your GP or pharmacist if you are pregnant or breastfeeding before use

Known drug interactions with topical permethrin are not clinically significant. However, inform your pharmacist of any other topical products you are using on the scalp or hair, including medicated shampoos.

  • No significant systemic drug interactions are currently documented for topical permethrin at 1% concentration
  • Avoid using alongside other insecticide-based scalp treatments simultaneously

 

How Should You Use Lyclear Lotion?

 

Always use Lyclear Lotion exactly as described in the patient information leaflet. Do not apply more than directed. For families managing an active infestation, you may also find it helpful to explore our hair care range for nit combs and supporting products.

  1. Ensure hair is dry before application — do not apply to wet hair
  2. Apply the lotion directly to the scalp, working it through the hair from root to tip
  3. Pay particular attention to the area behind the ears and at the nape of the neck
  4. Leave the lotion on for 10 minutes — do not exceed this contact time
  5. Rinse the hair thoroughly with warm water and a mild shampoo
  6. While hair is still damp, comb through with a fine-toothed nit comb to remove dead lice and eggs
  7. Repeat the treatment after 7 days to kill any lice that may have hatched from surviving eggs
Indication Age Group Dose Frequency
Head lice infestation Adults and children 6 months+ Sufficient lotion to cover scalp and all hair Apply once, repeat after 7 days
Head lice infestation Children under 2 years Under medical supervision only As directed by a healthcare professional

 

What Are the Possible Side Effects of Lyclear Lotion?

 

Like all medicines, Lyclear Lotion can cause side effects, although not everyone experiences them. Most reactions are mild and localised to the scalp.

Common side effects:

  • Mild scalp itching or irritation after application
  • Temporary burning or stinging sensation on the scalp
  • Redness or tingling of the skin

Less common side effects:

  • Skin rash or hives (urticaria)
  • Swelling of the face, lips, or throat — this may indicate an allergic reaction and requires immediate medical attention
  • Numbness or altered sensation on the scalp

If you experience signs of a severe allergic reaction — including difficulty breathing, swelling of the face or throat, or a widespread rash — stop using the product immediately and seek emergency medical help. You can also contact NHS 111 for guidance.

 

How Should You Store Lyclear Lotion?

 

Correct storage helps maintain the effectiveness and safety of Lyclear Lotion. Follow these instructions carefully:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight, heat sources, and naked flames — the lotion is flammable
  • Keep the bottle tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the bottle or outer carton
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacist for safe disposal

If you have any concerns about storing this product safely, particularly in households with young children, our team at Cured Pharmacy is happy to advise. You might also find useful information in our baby and toddler section for child-safe storage tips and family health products.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Lotion 100ml online in the UK?

You can buy Lyclear Lotion 100ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £6.99. It is available without a prescription as an over-the-counter medicine. Browse our full head lice collection for additional treatment options and nit combs.

How does Lyclear Lotion work in the body?

Lyclear Lotion contains permethrin 1% w/v, a synthetic pyrethroid that works by binding to voltage-gated sodium channels in the nerve cells of head lice. This keeps the channels open, causing continuous nerve firing, paralysis, and ultimately death of the louse. Because it acts chemically rather than physically, it requires only a 10-minute contact time on the scalp.

How do I use Lyclear Lotion step by step?

Apply Lyclear Lotion to dry hair, working it thoroughly through from the scalp to the tips, paying close attention to the area behind the ears and the nape of the neck. Leave it on for exactly 10 minutes, then rinse with warm water and shampoo. While the hair is still damp, comb through with a fine-toothed nit comb to remove dead lice and loosened eggs.

How long do I leave Lyclear Lotion on my hair?

Lyclear Lotion should remain on the hair and scalp for 10 minutes before rinsing — no longer. Leaving it on for longer than directed does not improve effectiveness and may increase the risk of scalp irritation. Always follow the instructions in the patient information leaflet included with the product.

Is Lyclear Lotion safe for children?

Lyclear Lotion is suitable for adults and children aged 6 months and over. Children under 2 years of age should only be treated under the supervision of a healthcare professional. Always keep the lotion away from the eyes, nose, and mouth during application, and rinse immediately with water if accidental contact occurs.

Do I need to repeat the treatment with Lyclear Lotion?

Yes — a second application is recommended 7 days after the first treatment. This is because permethrin may not kill all louse eggs (nits) in the first application, and a second dose targets any lice that have hatched in the intervening week. This two-dose approach is consistent with NHS guidance on head lice treatment.

What are the side effects of Lyclear Lotion?

The most common side effects include mild scalp itching, a temporary burning or stinging sensation, and slight redness after application — these are usually short-lived. Less commonly, some people may experience a skin rash or, rarely, signs of an allergic reaction such as swelling of the face or difficulty breathing. If you experience a severe reaction, stop use immediately and seek medical help.

Can I use Lyclear Lotion if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your GP or pharmacist before using Lyclear Lotion. Systemic absorption of topically applied permethrin is very low, but a healthcare professional should assess whether the benefits outweigh any potential risks in your individual situation. Do not self-treat without seeking advice first.

What are alternatives to Lyclear Lotion for head lice?

Alternatives include dimeticone-based products such as Hedrin, which work by physically coating and suffocating lice rather than using a chemical insecticide — making them useful if permethrin resistance is suspected. Wet combing with a fine-toothed nit comb every few days over two weeks is also a non-chemical option recommended by the NHS. You can explore further options in our hair care range.

Is there any resistance to Lyclear Lotion in UK head lice?

Some resistance to permethrin has been reported in head lice populations in the UK, which means Lyclear Lotion may be less effective in certain cases. If you complete two full courses of treatment and live lice are still found, speak to your pharmacist about switching to a product with a different mechanism of action, such as a dimeticone-based lotion. The NHS recommends rotating treatment types if resistance is suspected.

How long does it take for Lyclear Lotion to kill head lice?

Permethrin begins to act on lice within minutes of contact, causing paralysis relatively quickly. However, you should still leave the lotion on for the full 10 minutes as directed to ensure maximum effectiveness. Dead lice and loosened eggs should then be removed by combing through damp hair with a fine-toothed nit comb immediately after rinsing.

Can Lyclear Lotion be used on coloured or chemically treated hair?

There is no specific clinical evidence that Lyclear Lotion damages coloured or chemically treated hair, but the lotion's formulation may interact with certain hair treatments. If you have recently had a perm, colour, or chemical straightening treatment, it is advisable to speak to your pharmacist before use. Always perform a patch test on a small area of skin if you have a history of scalp sensitivity.

What happens if I accidentally get Lyclear Lotion in my eyes?

If Lyclear Lotion comes into contact with the eyes, rinse immediately and thoroughly with plenty of clean, cool water for several minutes. If irritation, redness, or pain persists after rinsing, seek medical advice promptly. To prevent accidental eye contact, apply the lotion carefully and keep the head tilted back during application.

How should I store Lyclear Lotion safely at home?

Store Lyclear Lotion below 25°C in a cool, dry place away from direct sunlight, heat sources, and naked flames — the lotion is flammable. Always keep the bottle tightly closed and out of the reach and sight of children. Do not use the product after the expiry date printed on the packaging.

What is the latest guidance on head lice treatment in the UK?

Current NHS guidance recommends treating head lice only when a live louse has been confirmed by wet combing or direct inspection — not as a precautionary measure. Both chemical treatments (such as permethrin-based lotions) and physical treatments (such as dimeticone) are considered effective first-line options. The NHS also advises checking and treating all household members simultaneously to prevent re-infestation.

How Should You Use Lyclear Lotion?

Lyclear Lotion should always be applied to dry hair — not wet or damp hair — to ensure the permethrin makes proper contact with the scalp and hair shaft. Before you begin, make sure you have a fine-toothed nit comb to hand, as combing after rinsing is an essential part of the treatment process.

What Is the Correct Dose of Lyclear Lotion?

There is no fixed volume dose for Lyclear Lotion — you should use enough lotion to cover the entire scalp and all the hair thoroughly. For longer or thicker hair, you may need more of the product to ensure complete coverage. Do not apply more than necessary, and do not use more frequently than directed.

When Is the Best Time to Use Lyclear Lotion?

There is no specific time of day that is clinically superior for applying Lyclear Lotion, but many people find it easiest to apply during a bath or shower routine — remembering that the hair must be dry before application. Applying in the evening can be practical, as it allows time for careful combing afterwards without rushing. Ensure the room is well ventilated during application, as the lotion is flammable.

Treat all affected household members on the same day where possible, to reduce the risk of re-infestation between family members. Check all household contacts by wet combing before deciding whether treatment is needed.

How Long Can You Use Lyclear Lotion For?

Lyclear Lotion is intended for short-term use only — a standard course consists of two applications, seven days apart. If live lice are still found after completing both applications, do not apply a third course of the same product. Instead, speak to your pharmacist, who may recommend switching to a treatment with a different mechanism of action, such as a dimeticone-based lotion, in case of permethrin resistance.

Lyclear Lotion is not intended for use as a preventative treatment. Only use it when a live louse has been confirmed by wet combing or direct visual inspection, in line with NHS guidance.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Lyclear Lotion?

Most people tolerate Lyclear Lotion well, and side effects are generally mild and temporary. Because the lotion is applied topically to the scalp, any reactions tend to be localised rather than systemic. The most frequently reported effects include:

  • Mild itching or irritation of the scalp during or after application
  • A temporary burning or stinging sensation on the skin
  • Slight redness or tingling of the scalp

These effects usually resolve on their own within a short time after rinsing the product off. If they persist or worsen, contact your pharmacist for advice.

What Are the Less Common Side Effects of Lyclear Lotion?

Less commonly, some individuals may experience more noticeable skin reactions. These are not typical but are worth being aware of before you begin treatment.

  • Skin rash or hives (urticaria) on the scalp or surrounding skin
  • Numbness or altered sensation on the scalp
  • Dryness or flaking of the scalp skin following use
  • Swelling or puffiness around the hairline

If you notice any of these effects and they do not resolve quickly, stop using the product and speak to your pharmacist or GP.

What Are the Serious Side Effects of Lyclear Lotion?

Serious side effects from topical permethrin at 1% concentration are rare but can occur, particularly in individuals with a known allergy to pyrethroids or pyrethrins. Signs of a serious allergic reaction (anaphylaxis) include:

  • Sudden swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • A widespread skin rash or severe hives
  • Dizziness, rapid heartbeat, or feeling faint

If you experience any of these symptoms, stop using Lyclear Lotion immediately and call 999 or go to your nearest A&E department. Do not wait to see if symptoms improve on their own.

What Should You Do If You Experience Side Effects of Lyclear Lotion?

For mild side effects such as scalp irritation or temporary stinging, rinsing the hair thoroughly with cool water is usually sufficient. Avoid scratching the scalp, as this can worsen irritation and increase the risk of skin infection. If you are concerned that a reaction is more than mild, contact your pharmacist or GP for guidance. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Lyclear Lotion Interact With Other Medicines?

No clinically significant drug interactions have been documented for topical permethrin at 1% concentration, as systemic absorption through intact skin is very low. However, you should avoid using Lyclear Lotion at the same time as other insecticide-based scalp treatments, as this may increase the risk of skin irritation. Always inform your pharmacist of any other topical products you are currently using on your scalp or hair, including medicated shampoos or conditioners.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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