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Lyclear Extra Strong 100ml

Lyclear Extra Strong 100ml

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  • ✔️ Kills live head lice and eggs with permethrin 1% w/v
  • ✔️ Works in just 10 minutes per application
  • ✔️ Suitable for adults and children aged 6 months and over
  • ✔️ Two-dose course eliminates newly hatched lice effectively
  • ✔️ Clinically proven insecticide-based lotion for confirmed infestations

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Is Lyclear Extra Strong Head Lice Treatment Right for You?

 

Head lice are one of the most common childhood nuisances in the UK, affecting millions of families every year. If you've spotted the telltale signs — persistent scalp itching, tiny white eggs clinging to hair shafts, or live lice moving through the hair — you'll want something that actually works. Lyclear Extra Strong head lice treatment is a clinically proven, permethrin-based lotion designed to tackle infestations quickly and effectively. Available over the counter, it's a trusted choice for parents and adults alike. You can find it alongside other treatments in our head lice collection.

Each 100ml bottle contains permethrin 1% w/v as the active ingredient. Permethrin is a synthetic pyrethroid — a compound derived from the chrysanthemum plant — that has been used in head lice treatments for decades. It's well-studied, widely recommended, and available without a prescription for use in adults and children aged 6 months and over.

 

How Does Lyclear Extra Strong Work Against Lice?

 

Understanding how a treatment works helps you use it with confidence. Permethrin targets the nervous system of head lice specifically, making it highly effective at the concentrations used in this lotion.

  • Permethrin binds to sodium channels in the nerve cell membranes of lice.
  • This disrupts normal nerve impulse transmission, causing prolonged nerve firing.
  • The result is paralysis of the louse, followed by death.
  • The lotion also has ovicidal activity — meaning it can kill lice eggs (nits) as well as live lice.
  • A second application after 7 days is recommended to eliminate any lice that may have hatched from eggs surviving the first treatment.

It's worth noting that resistance to permethrin has been reported in some louse populations in the UK. If you've used a permethrin-based product recently without success, speak to your pharmacist about alternative treatment options.

 

Who Is Lyclear Extra Strong Suitable For?

 

This lotion is suitable for a wide range of people, but there are some groups who should take extra care or seek advice before using it. It is generally appropriate for:

  • Adults and children aged 6 months and over
  • Individuals with a confirmed or suspected head lice infestation
  • Household contacts of someone with head lice, as part of a coordinated treatment approach
  • Those who prefer an insecticide-based treatment over physical (dimeticone) alternatives

Children under 2 years of age should only be treated under medical supervision. If you are pregnant, breastfeeding, or have a known allergy to permethrin, chrysanthemums, or any other ingredient in the formulation, consult your pharmacist or GP before use.

 

How Does Lyclear Extra Strong Compare to Dimeticone Treatments?

 

Feature Lyclear Extra Strong (Permethrin 1%) Dimeticone-based (e.g. Hedrin)
Mechanism Neurotoxic — disrupts louse nervous system Physical — coats and suffocates lice
Resistance risk Some resistance reported in UK louse populations No resistance reported (physical action)
Application time 10 minutes 8 hours (or overnight)
Suitable age 6 months and over 6 months and over (varies by product)

 

How Should You Store Lyclear Extra Strong and Is It Safe to Use?

 

Lyclear Extra Strong head lice treatment should be stored below 25°C, away from direct heat and open flames — permethrin-based lotions are flammable. Keep the bottle tightly closed and out of reach of children when not in use. Do not store in a bathroom cabinet where heat and humidity can affect the product's stability.

From a safety perspective, this lotion is for external use only. Avoid contact with the eyes, mouth, and broken or infected skin. If accidental eye contact occurs, rinse thoroughly with water. If you experience signs of a serious allergic reaction — such as swelling of the face, difficulty breathing, or a widespread rash — stop use immediately and seek urgent medical attention. If you're browsing other topical treatments, our creams and ointments collection has a range of options for various skin conditions.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Extra Strong 100ml specifications
Treatment category Head lice (pediculosis capitis)
Active ingredient Permethrin 1% w/v
Mechanism of action Synthetic pyrethroid — disrupts sodium channels in louse nerve cell membranes
Effective against Live head lice and eggs (nits)
Suitable for Adults and children aged 6 months and over
Pack size 100ml
Strength 1% w/v permethrin
UK classification Pharmacy (P) medicine
Drug class Synthetic pyrethroid insecticide
Preparation Lotion
Route of administration Topical (scalp and hair)

Specifications of Lyclear Extra Strong 100ml

 

What Is Lyclear Extra Strong and What Is It Used For?

 

Lyclear Extra Strong is a topical lotion containing permethrin 1% w/v, used to treat head lice infestations (pediculosis capitis). Head lice are tiny parasitic insects that live on the scalp and feed on blood. They spread easily through direct head-to-head contact and are particularly common among school-age children, though anyone can be affected. The NHS recommends treating all affected household members at the same time to prevent re-infestation.

This lotion is applied directly to the hair and scalp, left for 10 minutes, and then rinsed off. A second application is required 7 days later. It is not a preventative treatment — it should only be used when a live louse has been confirmed by wet combing or visual inspection.

 

What Do You Need to Know Before Using Lyclear Extra Strong?

 

Before using this lotion, read the following carefully. There are certain situations where you should not use it, or where you should seek advice first.

Do not use Lyclear Extra Strong if you:

  • Are allergic to permethrin, any synthetic pyrethroid, pyrethrin, or any other ingredient in the lotion
  • Have an allergy to chrysanthemums or related plants
  • Have broken, infected, or inflamed skin on the scalp
  • Are treating a child under 6 months of age (seek medical advice first)

Take extra care and speak to your pharmacist or GP if you:

  • Are pregnant or breastfeeding
  • Are treating a child under 2 years of age
  • Have asthma — the lotion contains alcohol, which may trigger symptoms in some individuals
  • Have previously used a permethrin-based treatment without success, as resistance may be a factor

Drug interactions:

  • No clinically significant drug interactions are known at the topical doses used in this product.
  • If you are using any other scalp or hair treatments, allow them to be fully rinsed out before applying Lyclear Extra Strong.

 

How Should You Use Lyclear Extra Strong?

 

Always follow the instructions in the patient information leaflet. The steps below reflect standard guidance for this product.

  1. Wash the hair with an ordinary shampoo and rinse thoroughly. Do not use a conditioning shampoo or conditioner, as this can reduce the effectiveness of the lotion.
  2. Towel-dry the hair so it is damp but not dripping wet.
  3. Apply the lotion generously to the hair and scalp, working from the roots to the tips. Ensure all areas are covered, including behind the ears and at the nape of the neck.
  4. Leave the lotion on for 10 minutes.
  5. Rinse the hair thoroughly with warm water.
  6. Comb through the hair with a fine-toothed nit comb to remove dead lice and eggs.
  7. Repeat the entire process after 7 days to kill any lice that may have hatched from surviving eggs.
Indication Age Group Dose Frequency
Head lice infestation Adults and children aged 6 months+ Apply sufficient lotion to cover all hair and scalp Two applications, 7 days apart
Head lice infestation Children under 2 years As above, under medical supervision only Two applications, 7 days apart

If you are also dealing with skin irritation from scratching, you may find our skin care collection helpful for soothing the affected area once treatment is complete.

 

What Are the Possible Side Effects of Lyclear Extra Strong?

 

Like all medicines, Lyclear Extra Strong can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the scalp.

Common side effects:

  • Mild scalp itching or irritation after application
  • Temporary burning or stinging sensation on the scalp
  • Redness of the scalp
  • Tingling sensation in the hair or scalp

Less common side effects:

  • Skin rash or hives at the application site
  • Swelling of the scalp or surrounding skin
  • Numbness or altered sensation on the scalp

It is worth noting that some itching after treatment is normal and does not necessarily mean the treatment has failed — it can be a reaction to the dead lice and eggs remaining in the hair. If symptoms persist or worsen significantly, stop use and consult your pharmacist or GP. Signs of a serious allergic reaction — including facial swelling, difficulty breathing, or a widespread rash — require immediate medical attention.

 

How Should You Store Lyclear Extra Strong?

 

  • Store below 25°C in a cool, dry place.
  • Keep away from direct heat sources and open flames — the lotion contains alcohol and is flammable.
  • Do not store in a bathroom or anywhere subject to high humidity.
  • Keep the bottle tightly closed when not in use.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the bottle.
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacist for safe disposal.

If you're looking for other treatments for your family, our baby and toddler collection includes a range of products suitable for younger children, always with safety at the forefront.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Extra Strong 100ml online in the UK?

You can buy Lyclear Extra Strong 100ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £8.79. It is available without a prescription as an over-the-counter medicine. Browse our full head lice treatment range for more options.

How does Lyclear Extra Strong work to kill head lice?

Lyclear Extra Strong contains permethrin 1% w/v, a synthetic pyrethroid that binds to sodium channels in the nerve cell membranes of lice. This disrupts normal nerve impulse transmission, causing paralysis and death of both live lice and their eggs. It begins working on contact during the 10-minute application period.

How do I use Lyclear Extra Strong step by step?

Follow these steps for effective treatment:

  1. Shampoo hair without conditioner and towel-dry until damp.
  2. Apply the lotion generously from roots to tips, covering all hair and scalp.
  3. Leave on for 10 minutes, then rinse thoroughly.
  4. Comb through with a fine-toothed nit comb to remove dead lice and eggs.
  5. Repeat the full process after 7 days.
How long does Lyclear Extra Strong take to work?

The lotion starts killing lice on contact during the 10-minute application period. However, a second treatment is required 7 days after the first to kill any lice that have hatched from eggs that survived the initial application. You may still notice some itching after treatment — this is normal and does not mean the product has failed.

Is Lyclear Extra Strong safe for children?

Lyclear Extra Strong is suitable for adults and children aged 6 months and over. Children under 2 years should only be treated under medical supervision. Always keep the lotion away from the eyes and mouth, and rinse immediately with water if accidental contact occurs.

Can I use Lyclear Extra Strong if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should consult your doctor or pharmacist before using Lyclear Extra Strong. While topical permethrin is considered low-risk due to minimal systemic absorption, professional guidance is always recommended during pregnancy and breastfeeding to ensure the safest option is chosen for you.

What are the side effects of Lyclear Extra Strong?

Most side effects are mild and temporary. Common ones include:

  • Scalp itching or irritation
  • Mild burning or stinging sensation
  • Temporary redness of the scalp

If you experience signs of a serious allergic reaction such as facial swelling or difficulty breathing, stop use immediately and seek urgent medical attention.

Do I need to treat everyone in the household at the same time?

The NHS recommends that all household members with a confirmed head lice infestation are treated on the same day to prevent re-infestation. Simply treating one person while others remain untreated is a common reason why lice keep coming back. Check all household contacts by wet combing before deciding who needs treatment.

What happens if Lyclear Extra Strong does not work?

If live lice are still present after completing both applications (day 1 and day 7), this may indicate permethrin resistance in the local louse population. In this case, speak to your pharmacist about switching to a product with a different mechanism of action, such as a dimeticone-based lotion. Resistance to insecticide-based treatments has been documented in parts of the UK.

Can I use conditioner before applying Lyclear Extra Strong?

No — you should not use a conditioning shampoo or leave-in conditioner before applying Lyclear Extra Strong. Conditioner coats the hair shaft and can significantly reduce the lotion's ability to penetrate and make contact with lice and eggs. Use a plain shampoo only, rinse thoroughly, and towel-dry before applying the lotion.

What are the alternatives to Lyclear Extra Strong for head lice?

Alternatives include dimeticone-based products (such as Hedrin 4% Lotion), which work by physically coating and suffocating lice rather than using an insecticide — making resistance impossible. Wet combing with a fine-toothed comb is also a non-chemical option recommended by the NHS. Your pharmacist can help you choose the most appropriate treatment based on your situation.

How many applications of Lyclear Extra Strong are needed?

Two applications are required for a complete course of treatment. The first is applied on day 1, and the second exactly 7 days later. This two-dose approach ensures that any lice hatching from eggs that survived the first treatment are eliminated before they can mature and lay new eggs.

Is Lyclear Extra Strong the same as regular Lyclear?

Lyclear Extra Strong contains permethrin 1% w/v and is formulated as a lotion applied to damp hair for 10 minutes. Standard Lyclear Creme Rinse also contains permethrin but is applied differently. Always check the product label and patient information leaflet to confirm the correct formulation and instructions for the specific product you have purchased.

Can Lyclear Extra Strong be used to treat scabies?

Lyclear Extra Strong (permethrin 1% lotion) is specifically licensed for the treatment of head lice. Scabies treatment typically requires a higher-strength permethrin preparation (5% cream), which is a prescription-only medicine in the UK. Do not use this product for scabies — speak to your GP for appropriate treatment. You can also explore our skin care collection for related products.

What are the latest findings on permethrin resistance in head lice in the UK?

Permethrin resistance in head lice has been documented in the UK and other countries, linked to genetic mutations (known as kdr mutations) that alter the sodium channel target site. This is why the NHS and BNF recommend rotating between insecticide-based and non-insecticide-based treatments, and why a second application is always advised. If treatment fails after two correctly applied doses, consult your pharmacist about switching to a dimeticone-based alternative.

How Should You Use Lyclear Extra Strong?

Using Lyclear Extra Strong correctly is essential to getting rid of head lice effectively. The lotion must be applied to damp hair — not dry hair — and left on for the full 10 minutes to allow the permethrin to work. Skipping steps or cutting the contact time short can reduce how well the treatment works.

What Is the Correct Dose of Lyclear Extra Strong?

The amount of lotion you need will depend on the length and thickness of the hair. Use enough to ensure every part of the scalp and all hair strands are thoroughly covered. One 100ml bottle is typically sufficient for short to medium-length hair; longer or thicker hair may require more.

When Is the Best Time to Use Lyclear Extra Strong?

There is no specific time of day that is clinically superior for applying this lotion. However, many people find it easiest to apply during a bath or shower routine, when the hair is already freshly washed. Applying in the evening can also be practical, as it allows time for thorough combing afterwards without rushing.

Make sure you treat all affected household members on the same day to avoid passing lice back and forth. Mark the second treatment date (7 days later) in your calendar so you don't forget it — completing both applications is critical to the success of the treatment.

How Long Can You Use Lyclear Extra Strong For?

Lyclear Extra Strong is intended for short-term use only — a single course consists of two applications, 7 days apart. It is not designed for ongoing or preventative use. If you complete the full two-dose course and live lice are still present, do not simply repeat the same treatment. Instead, speak to your pharmacist, as this may indicate permethrin resistance and a different type of treatment may be needed.

Once the infestation has cleared, regular wet combing (every few days) is the most reliable way to detect any new infestation early. The NHS does not recommend using insecticide treatments as a preventative measure.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Lyclear Extra Strong?

Most people who use Lyclear Extra Strong tolerate it well, and side effects are generally mild and short-lived. Because the lotion is applied topically to the scalp, any reactions tend to be localised to the area of application rather than affecting the whole body.

  • Scalp itching or irritation after application
  • Mild burning or stinging sensation on the scalp
  • Temporary redness of the scalp
  • Tingling sensation in the hair or on the scalp

It is worth knowing that some itching after treatment is entirely normal. It can be caused by the body's reaction to dead lice and eggs still present in the hair, rather than the lotion itself. This should settle within a day or two.

What Are the Less Common Side Effects of Lyclear Extra Strong?

Less commonly, some people may experience more noticeable skin reactions, particularly if they have sensitive skin or a history of skin conditions. These are not typical but should be monitored.

  • Skin rash or hives at the application site
  • Swelling of the scalp or surrounding skin
  • Numbness or altered sensation on the scalp
  • Increased scalp dryness or flaking

If any of these less common effects persist beyond 48 hours or cause significant discomfort, stop using the product and consult your pharmacist or GP for advice.

What Are the Serious Side Effects of Lyclear Extra Strong?

Serious side effects are rare with topical permethrin at the concentration used in this product, as systemic absorption through intact skin is minimal. However, a small number of people may experience a serious allergic reaction (hypersensitivity), which requires immediate medical attention.

Signs of a serious allergic reaction include:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or urticaria
  • Dizziness or feeling faint

If you experience any of these symptoms, stop using the lotion immediately and call 999 or go to your nearest A&E department.

What Should You Do If You Experience Side Effects?

For mild side effects such as scalp irritation or tingling, no specific treatment is usually needed — they typically resolve on their own within a short time. Rinsing the scalp thoroughly with cool water can help ease discomfort. Avoid scratching the scalp, as this can break the skin and increase the risk of secondary infection.

If you are concerned about a side effect or it does not improve, contact your pharmacist or GP. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Lyclear Extra Strong Interact With Other Medicines?

No clinically significant drug interactions have been identified for permethrin 1% lotion used topically at the doses in this product. Systemic absorption is very low when applied to intact skin, which limits the potential for interactions with oral medicines. However, you should avoid applying other scalp treatments, hair products, or medicated shampoos at the same time as Lyclear Extra Strong, as these may affect how well the lotion works or increase the risk of skin irritation.

Always tell your pharmacist about any other medicines or topical products you are currently using before starting treatment.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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