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Lyclear Express Lotion 100ml

Lyclear Express Lotion 100ml

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  • ✔️ Kills head lice with clinically established permethrin 1%
  • ✔️ Fast 10-minute application — no overnight waiting required
  • ✔️ Suitable for adults and children aged 6 months and over
  • ✔️ Two-treatment course eliminates lice and newly hatched eggs
  • ✔️ Topical lotion format for precise, easy scalp application

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What Is Lyclear Express Lotion — a Head Lice Treatment?

 

Head lice are a common problem, particularly in school-age children, and they spread quickly through close head-to-head contact. If you've spotted the telltale signs — persistent itching, tiny eggs stuck to hair shafts, or live lice moving through the hair — you'll want something that works without a lengthy, complicated process. Head lice treatment with Lyclear Express Lotion 100ml offers a straightforward, clinically established option you can use at home. Available from our head lice collection, it's priced at just £8.99 and requires no prescription.

Lyclear Express Lotion contains permethrin 1% as its active ingredient. Permethrin is a synthetic pyrethroid insecticide that has been used in head lice management for decades. It is classified as a Pharmacy (P) medicine in the UK, meaning it can be purchased over the counter without a prescription, though a pharmacist should be consulted if you have any concerns about suitability.

 

How Does Lyclear Express Lotion Work Against Lice?

 

Permethrin works by targeting the nervous system of head lice. It binds to sodium channels in the nerve cell membranes of the louse, preventing them from closing properly. This causes prolonged nerve firing, leading to paralysis and death of the louse. It's a well-understood mechanism that has been studied extensively.

  • Permethrin 1% penetrates the exoskeleton of the louse on contact
  • It disrupts sodium channel function in the louse's nervous system
  • This leads to paralysis and death within minutes to hours
  • The lotion also has some ovicidal (egg-killing) activity, though a second treatment is still recommended

 

Who Should Use Lyclear Express Lotion?

 

This lotion is suitable for most people dealing with an active head lice infestation. It can be used on adults and children aged 6 months and over. That said, it's not appropriate for everyone — always read the label carefully before use.

  • Adults and children aged 6 months and over with confirmed head lice
  • Households where multiple family members need treating simultaneously
  • Those who prefer a quick 10-minute application over longer leave-on treatments
  • People who have not responded to wet combing alone

It is not recommended for infants under 6 months without specific medical advice. If you are pregnant, breastfeeding, or have a known allergy to permethrin or chrysanthemums, speak to your pharmacist before use.

 

How Does Lyclear Express Lotion Compare to Other Head Lice Treatments?

 

Feature Lyclear Express Lotion Dimeticone Lotion (e.g. Hedrin)
Active ingredient Permethrin 1% Dimeticone 4% or 92%
Mechanism Neurotoxic (kills lice via nervous system) Physical (suffocates lice by coating them)
Application time 10 minutes 8 hours (overnight)
Suitable from 6 months 6 months (varies by product)

 

Is Lyclear Express Lotion Suitable for Sensitive Scalps?

 

If you or your child has a sensitive scalp, it's worth knowing that Lyclear Express Lotion is applied for only 10 minutes before rinsing, which limits prolonged skin contact. However, if there is any broken, inflamed, or infected skin on the scalp, you should avoid using this product until the skin has healed. Those with a known sensitivity to permethrin or related compounds should consider an alternative head lice treatment — your pharmacist can advise on suitable options. You might also find it helpful to browse our hair care collection for complementary products to use alongside treatment.

Store the lotion below 25°C, away from direct sunlight, and keep it out of reach of children. Do not use after the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Express Lotion 100ml specifications
Treatment category Head lice (pediculosis capitis)
Active ingredient Permethrin 1%
Mechanism of action Neurotoxic pyrethroid — disrupts sodium channels in louse nervous system
Suitable for Adults and children aged 6 months and over
Pack size 100ml
UK classification Pharmacy (P) medicine
Drug class Synthetic pyrethroid insecticide
Preparation Topical lotion
Route of administration Topical (scalp and hair)

Specifications of Lyclear Express Lotion 100ml

 

What Is Lyclear Express Lotion and What Is It Used For?

 

Lyclear Express Lotion 100ml is a topical insecticidal lotion used to treat head lice infestations (pediculosis capitis) in adults and children aged 6 months and over. It contains permethrin 1% as its active ingredient — a synthetic pyrethroid that kills live lice by disrupting their nervous system. Head lice are tiny parasitic insects that live on the scalp and feed on blood. They do not jump or fly; they spread through direct head-to-head contact, which is why they are so common in school-age children. The NHS advises that head lice should only be treated when a live louse is found — not simply because the scalp is itchy.

 

What Do You Need to Know Before Using Lyclear Express Lotion?

 

Before applying this lotion, read the following carefully. There are certain situations where this product should not be used, or where extra caution is needed.

Do not use Lyclear Express Lotion if you:

  • Are allergic to permethrin, any pyrethroid, pyrethrin, or any other ingredient in the lotion
  • Have an allergy to chrysanthemums or plants in the Asteraceae family
  • Have broken, infected, or severely inflamed skin on the scalp
  • Are treating an infant under 6 months of age without medical supervision

Take extra care and speak to your pharmacist if you:

  • Are pregnant or breastfeeding — wet combing may be a preferred first option
  • Have asthma, as some people with asthma may be sensitive to topical insecticides
  • Are treating a child under 2 years of age
  • Have previously had a reaction to a similar head lice product

Known drug interactions:

  • No significant drug interactions with permethrin 1% topical lotion are currently documented
  • Avoid using other scalp treatments at the same time without pharmacist advice

 

How Should You Use Lyclear Express Lotion?

 

Always use this product exactly as described in the patient information leaflet. Do not apply to wet hair — the lotion works best on dry hair. Keep it away from the eyes, nose, and mouth. If contact with eyes occurs, rinse immediately with plenty of water.

  1. Confirm the presence of live head lice before starting treatment
  2. Apply the lotion to dry hair, starting at the roots and working through to the tips
  3. Ensure all hair is thoroughly coated, paying particular attention to the nape of the neck and behind the ears
  4. Leave the lotion on for 10 minutes — do not exceed this time
  5. Rinse the hair thoroughly with warm water
  6. Shampoo the hair as normal and towel dry
  7. Use a fine-toothed nit comb to remove dead lice and eggs from the hair
  8. Repeat the treatment after 7 days to kill any lice that may have hatched since the first application
Indication Age Group Dose Frequency
Head lice infestation Adults and children ≥ 6 months Sufficient to cover all hair and scalp Two applications, 7 days apart
Head lice infestation Children under 2 years As above, under medical supervision Two applications, 7 days apart

If you are treating multiple family members, check our baby and toddler range for additional products suitable for younger children.

 

What Are the Possible Side Effects of Lyclear Express Lotion?

 

Like all medicines, Lyclear Express Lotion can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the scalp.

Common side effects:

  • Mild scalp itching or irritation (this may also be a symptom of the lice infestation itself)
  • Temporary burning or stinging sensation on the scalp
  • Mild redness of the scalp

Less common side effects:

  • Skin rash or hives at the site of application
  • Numbness or tingling of the scalp
  • Swelling of the face, lips, or throat — seek immediate medical attention if this occurs, as it may indicate a serious allergic reaction

Stop using the product and contact your GP or pharmacist immediately if you experience signs of a severe allergic reaction, including difficulty breathing, swelling of the face, or a widespread rash.

 

How Should You Store Lyclear Express Lotion?

 

Correct storage helps maintain the effectiveness and safety of the product. Follow these guidelines carefully.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the bottle tightly closed when not in use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the bottle and carton
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

If you have any questions about storage or suitability, our pharmacists are available to help. You may also find useful information in our skin care collection if you are looking for products to soothe any post-treatment scalp irritation.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Express Lotion online in the UK?

You can buy Lyclear Express Lotion 100ml directly from Cured Pharmacy online for £8.99, with no prescription required. It is a Pharmacy (P) medicine available over the counter. Browse our full head lice collection for additional treatment options if needed.

How does Lyclear Express Lotion work in the body?

Lyclear Express Lotion contains permethrin 1%, a synthetic pyrethroid that binds to sodium channels in the nervous system of head lice, causing prolonged nerve firing, paralysis, and death. It acts directly on the louse rather than being absorbed into your bloodstream. This makes it a localised, topical head lice treatment with minimal systemic exposure.

How do I use Lyclear Express Lotion step by step?

Apply the lotion to dry hair, covering all hair from root to tip, and leave it on for exactly 10 minutes before rinsing thoroughly. After rinsing, shampoo as normal and use a fine-toothed nit comb to remove dead lice and eggs. Repeat the process after 7 days to ensure any newly hatched lice are also eliminated.

How long do I leave Lyclear Express Lotion on my hair?

The recommended contact time for Lyclear Express Lotion is 10 minutes — no longer. Leaving it on for longer than instructed does not improve effectiveness and may increase the risk of scalp irritation. Always follow the instructions in the patient information leaflet supplied with the product.

What are the side effects of Lyclear Express Lotion?

The most commonly reported side effects are mild scalp itching, a temporary burning or stinging sensation, and slight redness — all of which usually resolve quickly after rinsing. Less commonly, some people may experience a skin rash or tingling at the application site. If you notice swelling of the face, lips, or throat, stop use immediately and seek urgent medical attention.

Is Lyclear Express Lotion safe for children?

Yes, Lyclear Express Lotion is suitable for children aged 6 months and over when used as directed. Children under 2 years should only be treated under the supervision of a healthcare professional. Always keep the lotion away from a child's eyes, nose, and mouth during application.

Can I use Lyclear Express Lotion if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your pharmacist or GP before using Lyclear Express Lotion. The NHS recommends wet combing as the preferred first-line option during pregnancy, as it avoids any chemical exposure. Your pharmacist can help you weigh up the options based on your individual circumstances.

How many treatments of Lyclear Express Lotion do I need?

Two treatments are recommended — the first application kills live lice, and a second application 7 days later targets any lice that may have hatched from eggs not fully eliminated by the first treatment. This two-dose approach is consistent with NHS guidance on head lice management. Skipping the second treatment increases the risk of re-infestation.

What happens if Lyclear Express Lotion does not work?

If live lice are still present after completing both treatments, it may indicate a degree of permethrin resistance in the local lice population. In this case, speak to your pharmacist, who may recommend switching to a product with a different mechanism of action, such as a dimeticone-based lotion. Resistance to pyrethroids has been documented in some UK lice populations.

What are the alternatives to Lyclear Express Lotion?

Alternatives include dimeticone-based lotions (such as Hedrin), which work by physically coating and suffocating lice rather than using a chemical insecticide. Wet combing with a fine-toothed nit comb and conditioner is also a non-chemical option recommended by the NHS. Your pharmacist can advise on the most appropriate choice based on your situation and any previous treatments used.

Who is eligible to use Lyclear Express Lotion?

Lyclear Express Lotion is suitable for adults and children aged 6 months and over who have a confirmed head lice infestation. It should not be used by people with a known allergy to permethrin, pyrethroids, or chrysanthemums. Those who are pregnant, breastfeeding, or have asthma should seek pharmacist advice before use.

Can I use Lyclear Express Lotion to prevent head lice?

No — Lyclear Express Lotion is a treatment for active head lice infestations and is not intended for use as a preventative measure. The NHS advises against using insecticidal treatments unless live lice have been confirmed. Regular wet combing and checking hair after known exposure are the recommended preventative approaches.

Does Lyclear Express Lotion kill nits (eggs) as well as lice?

Permethrin has some ovicidal activity, meaning it can kill some lice eggs, but it is not reliably effective against all eggs. This is why a second treatment after 7 days is essential — to catch any lice that hatch after the first application. Using a fine-toothed nit comb after each treatment helps physically remove eggs from the hair shaft.

How long can you use Lyclear Express Lotion for?

Lyclear Express Lotion is intended for short-term use — specifically two applications, 7 days apart, per treatment course. It should not be used continuously or as a long-term preventative. If head lice return after a completed course, speak to your pharmacist before starting another round of treatment, as repeated use of the same product may be less effective if resistance is a factor.

What are the latest findings on permethrin resistance in head lice?

Permethrin resistance in head lice has been reported in various parts of the UK and internationally, linked to genetic mutations in louse sodium channels — sometimes called "knockdown resistance" or kdr mutations. If you find that a permethrin-based head lice treatment is not working after two correctly applied treatments, a pharmacist can recommend a product with a different mode of action. Staying informed and rotating treatment types when needed is the most practical approach.

How Should You Use Lyclear Express Lotion?

Before you begin, confirm that live head lice are present by checking the hair carefully with a fine-toothed detection comb. There is no benefit in treating hair that does not have an active infestation. Make sure the hair is completely dry before applying the lotion — applying to wet hair reduces the effectiveness of the treatment.

Follow these steps carefully for each application:

What Is the Correct Dose of Lyclear Express Lotion?

There is no fixed volume dose for Lyclear Express Lotion — you should use enough lotion to thoroughly coat all of the hair and scalp. For short hair, a smaller amount may be sufficient; for longer or thicker hair, more lotion will be needed. The 100ml bottle is generally sufficient for one to two full applications depending on hair length.

When Is the Best Time to Use Lyclear Express Lotion?

There is no specific time of day required for applying Lyclear Express Lotion. However, many people find it easiest to apply during a bath or shower routine, as rinsing is straightforward and the hair can be combed through while still damp. Avoid applying the lotion just before bedtime if you are concerned about the lotion coming into contact with pillows or bedding during the 10-minute contact period.

It is also worth treating all affected household members on the same day where possible, to prevent re-infestation between family members. Check all close contacts' hair before deciding whether treatment is needed.

How Long Can You Use Lyclear Express Lotion For?

Lyclear Express Lotion is intended for short-term use only — a single treatment course consists of two applications, 7 days apart. Do not use the product more frequently than this without pharmacist advice. If lice persist after completing both applications, speak to your pharmacist before repeating the course, as this may indicate resistance to permethrin and an alternative product may be more appropriate.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Lyclear Express Lotion?

Most people tolerate Lyclear Express Lotion well, and side effects are generally mild and short-lived. Because the lotion is applied topically and rinsed off after just 10 minutes, systemic absorption is minimal. The most frequently reported effects are localised to the scalp and hair.

  • Mild itching or irritation of the scalp (note: this may also be a symptom of the lice infestation itself)
  • Temporary burning or stinging sensation during or shortly after application
  • Mild redness of the scalp
  • Slight tingling at the application site

What Are the Less Common Side Effects of Lyclear Express Lotion?

Less commonly, some people may experience a more noticeable skin reaction. These effects are not typical but are worth being aware of before you use the product for the first time.

  • Skin rash or hives (urticaria) at the site of application
  • Numbness or a persistent tingling sensation on the scalp
  • Dryness or flaking of the scalp following treatment
  • Temporary changes in hair texture

What Are the Serious Side Effects of Lyclear Express Lotion?

Serious side effects from topical permethrin 1% are rare but can occur, particularly in people with a known allergy to pyrethroids or chrysanthemums. If you experience any of the following, stop using the product immediately and seek urgent medical attention.

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Widespread skin rash or blistering
  • Severe dizziness or feeling faint

These symptoms may indicate a serious allergic reaction (anaphylaxis), which requires immediate emergency treatment. Call 999 or go to your nearest A&E department without delay.

What Should You Do If You Experience Side Effects of Lyclear Express Lotion?

For mild side effects such as scalp irritation or temporary stinging, rinsing the hair thoroughly with cool water is usually sufficient to relieve discomfort. Avoid scratching the scalp, as this can worsen irritation and increase the risk of secondary infection. If mild symptoms persist for more than 24 hours after rinsing, contact your pharmacist for advice.

Do not apply the lotion again before the recommended 7-day interval, even if you feel the first application was not fully effective. Repeated application within a short period does not improve outcomes and may increase the likelihood of skin reactions.

Can Lyclear Express Lotion Interact With Other Medicines?

No significant interactions between permethrin 1% topical lotion and other medicines are currently documented. However, you should avoid using other scalp treatments, medicated shampoos, or topical products on the scalp at the same time as Lyclear Express Lotion without first checking with your pharmacist. Using multiple products simultaneously may alter the effectiveness of the treatment or increase the risk of skin irritation.

If you are currently using any prescription scalp treatments or have a skin condition affecting the scalp, speak to your GP or pharmacist before using this product.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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