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Lyclear Creme Rinse Twin Pack 2 x 59ml

Lyclear Creme Rinse Twin Pack 2 x 59ml

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  • ✔️ Kills head lice and eggs with permethrin 1% w/w
  • ✔️ Twin pack provides both doses for a complete course
  • ✔️ Works in just 10 minutes on damp hair
  • ✔️ Suitable for adults and children aged 6 months and over
  • ✔️ Two-step treatment reduces risk of reinfestation

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Is Lyclear Creme Rinse an Effective Head Lice Treatment?

 

Head lice are a common problem in the UK, particularly among school-age children. They spread easily through direct head-to-head contact and can affect anyone, regardless of hair type or hygiene. If you've spotted the telltale signs — itching, tiny eggs (nits) stuck to hair shafts, or live lice moving through the hair — you'll want something that actually works. Head lice treatment with Lyclear Creme Rinse Twin Pack 2 x 59ml offers a clinically established approach using permethrin, a well-studied active ingredient. You can browse our full range of head lice products to find the right option for your family.

The twin pack format is particularly practical. Because a second application is recommended seven days after the first — to catch any lice that hatch from eggs surviving the initial treatment — having both doses ready removes the hassle of reordering. At £11.99, it represents straightforward value for a two-step treatment course.

 

How Does Lyclear Creme Rinse Work Against Lice?

 

Lyclear Creme Rinse contains permethrin 1% w/w as its active ingredient. Permethrin is a synthetic pyrethroid — a class of insecticide modelled on naturally occurring compounds found in chrysanthemum flowers. It works by targeting the nervous system of head lice specifically.

  • Permethrin binds to voltage-gated sodium channels in the nerve cell membranes of lice.
  • This disrupts normal nerve impulse transmission, causing prolonged nerve firing.
  • The result is paralysis and death of both adult lice and nymphs (immature lice).
  • Permethrin also has some ovicidal (egg-killing) activity, though a second treatment is still advised to address any surviving eggs.

Because permethrin acts on insect-specific sodium channels, it has a very low toxicity profile in humans when used topically as directed. The NHS recognises permethrin-based treatments as one of the recommended options for managing head lice infestations.

 

Who Is Lyclear Creme Rinse Suitable For?

 

This product is suitable for most people who have a confirmed head lice infestation. It's worth noting that treatment is only recommended when live lice are detected — not simply as a precaution. Wet combing with a detection comb is the most reliable way to confirm an active infestation before starting any treatment.

  • Adults and children aged 6 months and over
  • Individuals who prefer a rinse-through application over a leave-in lotion or spray
  • Families needing a two-dose course in a single purchase
  • Those who have confirmed live lice through wet detection combing

It is not recommended for children under 6 months without specific medical advice. If you are pregnant, breastfeeding, or have a known allergy to permethrin or chrysanthemums, speak to your pharmacist or GP before use.

 

How Does Lyclear Creme Rinse Compare to Other Head Lice Treatments?

 

Feature Lyclear Creme Rinse Dimeticone-Based Lotion (e.g. Hedrin)
Active ingredient Permethrin 1% Dimeticone 4% or 92%
Mechanism Neurotoxic to lice Physical suffocation of lice
Application time 10 minutes on damp hair 8 hours or overnight
Suitable from 6 months of age Varies by product

 

How Should You Store Lyclear Creme Rinse?

 

Store Lyclear Creme Rinse below 25°C, away from direct heat and sunlight. Keep the bottles tightly closed when not in use, and always store them out of reach and sight of children. Do not use the product after the expiry date printed on the packaging.

If you're managing other skin or scalp conditions alongside a lice infestation, you may find it helpful to explore our skin care range for complementary products. Always check with your pharmacist if you're unsure whether two products can be used together safely.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Lyclear Creme Rinse Twin Pack 2 x 59ml specifications
Treatment category Head lice (pediculosis capitis)
Active ingredient Permethrin 1% w/w
Mechanism of action Disrupts sodium channel function in lice nerve cells, causing paralysis and death
Suitable for Adults and children aged 6 months and over
Pack size 2 x 59ml
UK classification P (Pharmacy medicine)
Drug class Synthetic pyrethroid insecticide
Preparation Creme rinse (topical liquid)
Route of administration Topical (applied to hair and scalp)

Specifications of Lyclear Creme Rinse Twin Pack 2 x 59ml

 

What Is Lyclear Creme Rinse and What Is It Used For?

 

Lyclear Creme Rinse is a topical insecticidal treatment used to eliminate head lice (Pediculus humanus capitis) infestations of the scalp and hair. It contains permethrin 1% w/w as the active ingredient. Head lice are tiny wingless insects that live close to the scalp, feeding on blood. They do not jump or fly — they spread only through prolonged direct head-to-head contact. The NHS advises that head lice are very common, especially in primary school children, and that anyone can get them.

The twin pack format is designed to support the full two-treatment course. The first application kills live lice; the second, applied seven days later, targets any lice that have hatched from eggs that survived the initial treatment. This approach is consistent with NHS guidance on treating head lice effectively.

 

What Do You Need to Know Before Using Lyclear Creme Rinse?

 

Before using this product, read the following carefully. Do not use Lyclear Creme Rinse if any of the following apply to you:

  • You are allergic to permethrin, any pyrethroid or pyrethrin insecticide, or chrysanthemums
  • The person to be treated is under 6 months of age (seek medical advice first)
  • You have broken, infected, or severely inflamed skin on the scalp
  • You have asthma — permethrin can occasionally trigger bronchospasm; seek advice before use

Speak to your pharmacist or GP before use if you are pregnant or breastfeeding. Wet combing is generally considered the preferred first-line option during pregnancy. Also tell your pharmacist about any other medicines you are using, including topical products applied to the scalp.

Drug interactions:

  • No clinically significant interactions are known at the topical doses used in this product
  • Avoid using other scalp treatments at the same time without pharmacist advice

 

How Should You Use Lyclear Creme Rinse?

 

Follow these steps carefully to get the most from your treatment. Using a non-conditioning shampoo beforehand is important — conditioner can coat the hair shaft and reduce how well the product penetrates.

  1. Wash hair with a non-conditioning shampoo and rinse thoroughly.
  2. Towel dry hair so it is damp but not dripping wet.
  3. Apply Lyclear Creme Rinse generously to the hair, working from the roots to the tips. Ensure the scalp is well covered.
  4. Leave the product on the hair for 10 minutes. Do not rinse off before this time.
  5. Rinse hair thoroughly with warm water.
  6. Use a fine-toothed detection comb to remove dead lice and eggs from the hair while it is still wet.
  7. Repeat the entire process seven days later using the second bottle.

Avoid getting the product in the eyes. If contact occurs, rinse immediately with plenty of water. For children, it may help to have them lean over a sink or bath with eyes closed during application and rinsing.

Indication Age Group Dose Frequency
Head lice infestation Adults and children ≥ 6 months Apply sufficient amount to cover all hair and scalp Two applications, 7 days apart
Head lice infestation Children under 6 months Only under medical supervision As directed by a doctor

 

What Are the Possible Side Effects of Lyclear Creme Rinse?

 

Like all medicines, Lyclear Creme Rinse can cause side effects, although not everyone experiences them. Most side effects are mild and resolve quickly after rinsing the product off. If you're also managing other conditions and browsing treatments, our hair care collection includes a range of supportive products.

Common side effects (may affect up to 1 in 10 people):

  • Mild scalp irritation or itching
  • Temporary stinging or burning sensation on the scalp
  • Mild redness of the scalp
  • Tingling sensation during or after application

Less common side effects:

  • Skin rash or hives (urticaria)
  • Swelling of the face, lips, or throat (seek urgent medical attention if this occurs)
  • Difficulty breathing — stop use immediately and call 999 if this happens

It is worth noting that some itching after treatment may simply be a reaction to the dead lice rather than a side effect of the product itself. If symptoms persist or worsen, stop use and consult your pharmacist or GP.

 

How Should You Store Lyclear Creme Rinse?

 

Proper storage helps maintain the product's effectiveness and safety. If you have other medicines at home, it's good practice to keep everything stored correctly — you might also want to check our baby and toddler range if you're treating younger children and need additional products.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the bottles tightly closed when not in use
  • Store out of the sight and reach of children
  • Do not use after the expiry date printed on the bottle and carton
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Lyclear Creme Rinse online in the UK?

You can buy Lyclear Creme Rinse Twin Pack 2 x 59ml directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £11.99. It is available without a prescription as an over-the-counter medicine. Browse our full head lice range for additional treatment options and detection combs.

How does Lyclear Creme Rinse work in the body?

Lyclear Creme Rinse contains permethrin 1%, a synthetic pyrethroid that binds to voltage-gated sodium channels in the nerve cell membranes of head lice. This disrupts normal nerve impulse transmission, causing paralysis and death of the lice. It works locally on the scalp and hair and is not significantly absorbed into the bloodstream at the doses used.

How do I use Lyclear Creme Rinse step by step?

Wash hair with a non-conditioning shampoo, towel dry until damp, then apply the creme rinse generously from roots to tips. Leave it on for 10 minutes before rinsing thoroughly with warm water. Follow up with a fine-toothed detection comb to remove dead lice and eggs, and repeat the full process seven days later with the second bottle.

Why does the Lyclear Creme Rinse come as a twin pack?

The twin pack provides both doses needed for a complete treatment course. The first application kills live lice, but some eggs may survive; the second application, seven days later, kills any lice that have hatched in the interim. Having both bottles in one purchase means you won't need to reorder mid-course.

Is Lyclear Creme Rinse safe for children?

Yes, Lyclear Creme Rinse is suitable for adults and children aged 6 months and over when used as directed. Children under 6 months should only be treated under direct medical supervision. Always keep the product away from a child's eyes during application and rinsing.

Can I use Lyclear Creme Rinse if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, you should speak to your doctor or pharmacist before using Lyclear Creme Rinse. The NHS recommends wet combing as the preferred first-line option during pregnancy, as it avoids any chemical exposure. Your pharmacist can help you weigh up the options.

What are the side effects of Lyclear Creme Rinse?

The most common side effects are mild scalp irritation, temporary stinging or burning, and tingling during or after application. These usually resolve quickly once the product is rinsed off. Rarely, an allergic reaction can occur — stop use immediately and seek medical attention if you develop swelling, hives, or difficulty breathing.

What happens if I only do one treatment and skip the second?

Skipping the second treatment significantly increases the risk of the infestation returning. Permethrin has limited ovicidal activity, meaning some eggs may survive the first application and hatch within 7–10 days. The second treatment, applied on day seven, is essential to kill those newly hatched lice before they can reproduce.

How long does it take for Lyclear Creme Rinse to work?

Lyclear Creme Rinse begins killing lice during the 10-minute application period. Most live lice will be dead by the time you rinse the product off. You may still see lice in the hair immediately after treatment — use a fine-toothed comb to remove them. Full clearance of the infestation is expected after the second treatment on day seven.

What is the difference between Lyclear Creme Rinse and dimeticone-based treatments?

Lyclear Creme Rinse uses permethrin 1%, which works by disrupting the nervous system of lice — a chemical mode of action. Dimeticone-based products (such as Hedrin) work physically by coating and suffocating lice, and are often left on for 8 hours or overnight. Both are recognised treatment options; the choice may depend on personal preference, age of the person being treated, or previous treatment history.

Can head lice become resistant to Lyclear Creme Rinse?

There is published evidence that some head lice populations in the UK have developed reduced sensitivity to permethrin over time. If you complete two full treatments correctly and live lice are still present 48 hours after the second application, speak to your pharmacist. They may recommend switching to a product with a different mechanism, such as a dimeticone-based lotion.

Do I need to treat everyone in the household?

The NHS advises that only people with a confirmed live lice infestation should be treated — not everyone in the household as a precaution. Check all close contacts using a wet detection comb, and treat only those in whom live lice are found. This helps avoid unnecessary chemical exposure and reduces the risk of contributing to resistance.

Should I use conditioner after Lyclear Creme Rinse?

Avoid using conditioner before applying Lyclear Creme Rinse, as it can coat the hair shaft and reduce the product's effectiveness. After rinsing the treatment off, you may use conditioner if desired to help with combing out dead lice and eggs. A fine-toothed nit comb used on wet, conditioned hair can make removal easier.

What are the latest studies on permethrin for head lice?

Research continues to monitor permethrin resistance patterns in UK lice populations. Current NHS and BNF guidance still lists permethrin as a recommended treatment option, alongside dimeticone and malathion. If a permethrin-based head lice treatment fails after two correctly completed courses, clinicians recommend switching to a product with a different active ingredient rather than repeating the same treatment.

How should I wash bedding and clothing after a head lice infestation?

The NHS states that head lice cannot survive for long away from the scalp, so extensive environmental cleaning is not necessary. Washing pillowcases and any items that have been in close contact with the head on a hot wash (60°C or above) is a sensible precaution. You do not need to treat furniture, carpets, or the wider home environment. For other family health needs, explore our baby and toddler collection.

How Should You Use Lyclear Creme Rinse?

Before you begin, confirm the infestation by combing through damp hair with a fine-toothed detection comb. Treatment is only recommended when live lice are found — not as a precaution. Follow these steps carefully for both applications.

Avoid getting the product in the eyes, nose, or mouth. If accidental eye contact occurs, rinse immediately with plenty of cool water.

What Is the Correct Dose of Lyclear Creme Rinse?

There is no fixed volume dose — you should apply enough product to thoroughly saturate all the hair and scalp. The amount needed will vary depending on hair length and thickness. One 59ml bottle is generally sufficient for short to medium-length hair; longer or thicker hair may require more.

When Is the Best Time to Use Lyclear Creme Rinse?

There is no specific time of day required, but many people find it easiest to apply during bath or shower time. Applying in the evening can be practical for children, as it fits naturally into a bedtime routine and avoids disruption to the school day. The key is ensuring you have 10 uninterrupted minutes for the product to work before rinsing.

Mark the date of your first application so you remember to apply the second treatment exactly seven days later. Consistency with the timing of the second dose is important for treatment success.

How Long Can You Use Lyclear Creme Rinse For?

Lyclear Creme Rinse is intended for a single two-dose treatment course — one application on day one and a second on day seven. It is not designed for ongoing or preventative use. If live lice are still detected 48 hours after the second treatment, do not simply repeat the same product.

In that situation, speak to your pharmacist, who may recommend switching to a treatment with a different active ingredient, such as a dimeticone-based lotion. Repeated use of the same insecticidal product without clinical need may contribute to resistance. If infestations recur frequently, your pharmacist can advise on detection combing techniques and prevention strategies.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Lyclear Creme Rinse?

Most people tolerate Lyclear Creme Rinse well. The side effects that do occur are usually mild, localised to the scalp, and resolve quickly once the product is rinsed off. It is also worth knowing that some itching after treatment may simply be a reaction to the dead lice on the scalp rather than a direct effect of the product itself.

  • Mild scalp irritation or itching
  • Temporary stinging or burning sensation during or after application
  • Tingling of the scalp
  • Mild redness of the scalp

What Are the Less Common Side Effects of Lyclear Creme Rinse?

Less commonly, some people may experience skin reactions that go beyond mild irritation. These are more likely in individuals with sensitive skin or a history of skin conditions. If any of the following occur, stop using the product and seek advice from your pharmacist or GP.

  • Skin rash or hives (urticaria)
  • Increased scalp dryness or flaking
  • Contact dermatitis (redness, itching, and inflammation at the site of application)
  • Eye irritation if the product accidentally contacts the eyes

What Are the Serious Side Effects of Lyclear Creme Rinse?

Serious side effects are rare but can occur, particularly in people with a known allergy to permethrin, pyrethroids, or chrysanthemums. A severe allergic reaction (anaphylaxis) is a medical emergency. Stop using the product immediately and call 999 if you or the person being treated experiences any of the following:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or wheezing
  • Rapid heartbeat or dizziness
  • Sudden widespread skin rash or flushing

People with asthma should use this product with caution, as permethrin can occasionally trigger bronchospasm. Speak to your pharmacist before use if you have asthma or any respiratory condition.

What Should You Do If You Experience Side Effects?

For mild side effects such as scalp irritation or stinging, rinse the product off thoroughly with cool water and allow the scalp to settle. Avoid scratching, as this can break the skin and increase the risk of secondary infection. If irritation persists for more than 24 hours after rinsing, contact your pharmacist.

For any signs of an allergic reaction — however mild — stop use immediately. Do not re-use the product if you have had a reaction to it previously. Your pharmacist can recommend an alternative head lice treatment with a different active ingredient if needed.

Can Lyclear Creme Rinse Interact With Other Medicines?

No clinically significant drug interactions are known at the topical doses used in Lyclear Creme Rinse. Because permethrin is applied to the scalp and hair and is not significantly absorbed into the bloodstream, systemic interactions are unlikely. However, you should avoid applying other scalp treatments, medicated shampoos, or topical products to the scalp at the same time without first checking with your pharmacist. This is particularly relevant if you are using any prescription scalp treatments.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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