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Levocetirizine 5mg

Levocetirizine 5mg

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  • ✔️ Relieves hay fever, hives, and allergic rhinitis symptoms effectively
  • ✔️ Starts working within one hour of taking a single tablet
  • ✔️ Once-daily 5mg dose provides up to 24 hours of allergy relief
  • ✔️ Suitable for adults and children aged six years and over
  • ✔️ Less sedating than older antihistamines, supporting daily functioning

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What Are Levocetirizine 5mg Tablets and How Do They Help?

 

If you suffer from hay fever, persistent hives, or year-round nasal allergies, you'll know how disruptive those symptoms can be. Sneezing fits at work, itchy eyes that won't settle, a runny nose that follows you everywhere — it adds up. Levocetirizine 5mg tablets are a third-generation antihistamine designed to tackle exactly these kinds of allergic reactions, offering targeted relief without the heavy sedation associated with older antihistamines. Available from Cured Pharmacy as part of our allergy and hay fever range, these tablets are a well-established option for adults and children aged 6 and over.

Levocetirizine is the active R-enantiomer of cetirizine, meaning it is a more refined form of a widely used antihistamine compound. It works at a lower dose while maintaining effective symptom control. The NHS recognises antihistamines as a first-line treatment for allergic rhinitis and urticaria, and levocetirizine sits firmly within that category.

 

How Does Levocetirizine Work to Relieve Allergy Symptoms?

 

When your body encounters an allergen — pollen, dust mites, pet dander — it releases a chemical called histamine. Histamine binds to H1 receptors throughout the body, triggering the familiar cascade of allergy symptoms. Levocetirizine works by selectively and competitively blocking those H1 receptors, stopping histamine from doing its damage.

  • Histamine is released in response to an allergen
  • Levocetirizine binds to peripheral H1 receptors before histamine can
  • Symptoms such as sneezing, itching, and nasal congestion are reduced
  • Effects typically begin within one hour of taking the tablet
  • A single daily dose provides up to 24 hours of symptom control

Because levocetirizine has a high receptor selectivity and low CNS penetration compared to first-generation antihistamines, it is far less likely to cause significant sedation — though some people may still feel mildly drowsy.

 

Who Is Levocetirizine 5mg Suitable For?

 

Levocetirizine is suitable for a broad range of people dealing with allergic conditions. It is particularly useful if you need daily, consistent relief rather than occasional symptom management. That said, it is not appropriate for everyone, so it is worth checking the criteria below before purchasing.

  • Adults and adolescents aged 12 and over — standard 5mg once-daily dose
  • Children aged 6 to 11 — a lower dose may be appropriate; seek pharmacist advice
  • People with seasonal allergic rhinitis (hay fever)
  • Those with perennial (year-round) allergic rhinitis due to dust mites or pet allergens
  • Individuals experiencing chronic spontaneous urticaria (persistent hives)

It is not suitable for people with severe renal impairment, those with a known hypersensitivity to cetirizine or hydroxyzine, or children under 6 years of age.

 

How Does Levocetirizine Compare to Other Antihistamines?

 

Feature Levocetirizine 5mg Cetirizine 10mg Loratadine 10mg
Generation Third Second Second
Dosing frequency Once daily Once daily Once daily
Sedation risk Low Low–moderate Very low
Onset of action ~1 hour ~1 hour ~1–3 hours

 

Is Levocetirizine Safe to Store and Use Long-Term?

 

Levocetirizine 5mg tablets should be stored below 25°C in a dry place, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the packaging. If you are managing a long-term condition such as chronic urticaria, it is worth discussing ongoing use with your GP or pharmacist — particularly if you are also using other medicines. For those who experience eye-related allergy symptoms alongside nasal symptoms, you may also find it helpful to explore our eye care range for complementary relief options.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Levocetirizine 5mg Tablets specifications
Treatment category Allergy / Antihistamine
Mechanism of action Selective H1 receptor antagonist
Effective for Hay fever, allergic rhinitis, chronic urticaria
Suitable for Adults and children aged 6 and over
Active ingredient Levocetirizine dihydrochloride 5mg
Strengths 5mg
UK classification P (Pharmacy medicine)
Drug class Third-generation antihistamine
Preparation Film-coated tablet
Route of administration Oral

Specifications of Levocetirizine 5mg Tablets

 

What Is Levocetirizine and What Is It Used For?

 

Levocetirizine 5mg tablets belong to a class of medicines called antihistamines. They are used to relieve the symptoms of allergic conditions by blocking the action of histamine — the chemical your immune system releases when it encounters something it considers a threat, such as pollen or dust mites. The NHS lists antihistamines as a first-line treatment for hay fever and urticaria, and levocetirizine is one of the more targeted options available without a prescription.

Specifically, levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (both seasonal and perennial) and chronic spontaneous urticaria. Symptoms it can help with include sneezing, a runny or blocked nose, itchy and watery eyes, skin itching, and hives (raised, itchy welts on the skin).

 

What Do You Need to Know Before Using Levocetirizine?

 

Before taking levocetirizine, it is important to check whether it is appropriate for you. Do not take this medicine if any of the following apply:

  • You are allergic to levocetirizine, cetirizine, hydroxyzine, or any other ingredient in the tablet
  • You have severe kidney disease (severe renal impairment)
  • You are under 6 years of age
  • You have hereditary problems of galactose intolerance (if the formulation contains lactose)

Speak to your pharmacist or GP before taking levocetirizine if you have moderate kidney impairment, epilepsy, or a predisposition to urinary retention. Elderly patients should use with caution due to a potentially increased risk of sedation.

The following medicines may interact with levocetirizine:

  • Alcohol and other CNS depressants — may increase sedative effects
  • Ritonavir (used in HIV treatment) — may increase levocetirizine blood levels
  • Theophylline — may slightly reduce the clearance of levocetirizine

 

How Should You Use Levocetirizine Correctly?

 

Always take levocetirizine exactly as directed on the packaging or as advised by your pharmacist. The tablet should be swallowed whole with a glass of water and can be taken with or without food.

  1. Check the packaging to confirm the correct dose for your age group
  2. Swallow one tablet whole — do not crush or chew
  3. Take with a full glass of water
  4. Take at the same time each day, preferably in the evening
  5. Do not take more than the recommended daily dose
Indication Age Group Dose Frequency
Allergic rhinitis / Urticaria Adults and adolescents (12+) 5mg (1 tablet) Once daily
Allergic rhinitis / Urticaria Children 6–11 years 2.5mg (half tablet) Once daily in the evening
Renal impairment (mild) Adults 5mg Once daily (seek medical advice)

 

What Are the Possible Side Effects of Levocetirizine?

 

Like all medicines, levocetirizine can cause side effects, although not everyone experiences them. Most side effects are mild and tend to resolve on their own. If you are also managing skin-related allergy symptoms, our skin care range may offer additional support alongside your antihistamine treatment.

Common side effects (may affect up to 1 in 10 people):

  • Drowsiness or somnolence
  • Headache
  • Dry mouth
  • Fatigue or tiredness
  • Nasopharyngitis (inflammation of the nose and throat)

Less common side effects (may affect up to 1 in 100 people):

  • Abdominal pain
  • Nausea
  • Dizziness
  • Pruritus (itching)
  • Rash or urticaria (paradoxically, in rare cases)
  • Agitation or restlessness

Seek immediate medical attention if you experience signs of a serious allergic reaction, including swelling of the face, lips, tongue or throat, difficulty breathing, or a severe skin rash. These reactions are rare but require urgent care.

 

How Should You Store Levocetirizine Tablets?

 

Correct storage helps maintain the effectiveness and safety of your tablets. For those managing multiple allergy-related products at home, it is worth checking our ear, nose and throat range for complementary treatments stored under similar conditions.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the carton or blister pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy levocetirizine 5mg tablets online in the UK?

You can buy levocetirizine 5mg tablets directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. Simply browse our allergy and hay fever collection and add the product to your basket. Orders are dispatched quickly with tracked UK delivery options available.

How does levocetirizine work in the body?

Levocetirizine is a selective H1 receptor antagonist, meaning it blocks the histamine receptors that trigger allergy symptoms. When an allergen enters your body, histamine is released — levocetirizine prevents it from binding to those receptors, stopping sneezing, itching, and a runny nose before they take hold. Effects typically begin within one hour of taking a tablet.

How do I take levocetirizine 5mg step by step?

Swallow one 5mg tablet whole with a full glass of water — do not crush or chew it. It can be taken with or without food, and most people find it easiest to take in the evening to minimise any daytime drowsiness. Take it at the same time each day for consistent symptom control.

What is the best time of day to take levocetirizine?

The evening is generally recommended, as any mild drowsiness the tablet may cause will occur during sleep rather than during your working day. That said, levocetirizine can be taken at any time of day as long as you take it at the same time consistently. If you find morning dosing works better for your routine, that is also acceptable.

Can levocetirizine cause drowsiness?

Yes, drowsiness is listed as a common side effect, though levocetirizine is significantly less sedating than older first-generation antihistamines such as chlorphenamine. If you feel drowsy after taking it, avoid driving or operating heavy machinery until you know how the medicine affects you. Taking it in the evening can help reduce any impact on your daytime alertness.

Who should not take levocetirizine 5mg tablets?

Levocetirizine is not suitable for people with severe kidney impairment, those with a known allergy to cetirizine or hydroxyzine, or children under 6 years of age. Pregnant or breastfeeding women should speak to their GP before use, as safety data in these groups is limited. Always read the full patient information leaflet before starting any new medicine.

What happens if I miss a dose of levocetirizine?

If you forget to take a dose, take it as soon as you remember — unless it is nearly time for your next scheduled dose, in which case simply skip the missed one. Never take two tablets at once to compensate for a missed dose. Continuing your regular schedule is the most important thing.

How does levocetirizine compare to cetirizine?

Levocetirizine is the active enantiomer of cetirizine, which means it is a more refined version of the same compound and works at half the dose (5mg versus 10mg). Clinical studies suggest it has a comparable or slightly improved tolerability profile, with similar efficacy for hay fever and urticaria. Both are considered second- or third-generation antihistamines and are available without a prescription in the UK.

Is levocetirizine safe for long-term use?

Levocetirizine can be used long-term for conditions such as chronic spontaneous urticaria, but ongoing use should ideally be reviewed by your GP or pharmacist. There is no evidence of tolerance developing with regular use, meaning it should remain effective over time. If your symptoms persist beyond a few weeks without improvement, seek medical advice.

Can I take levocetirizine during hay fever season every year?

Yes, many people use levocetirizine seasonally each year during the pollen season without any issues. It is safe to restart treatment at the beginning of each hay fever season, and some people begin taking it a few days before the season starts to build up protection. Speak to your pharmacist if you are unsure about the timing or duration of seasonal use.

Can I drink alcohol while taking levocetirizine?

It is advisable to avoid alcohol while taking levocetirizine, as both substances can cause drowsiness and combining them may increase this effect. Even if you do not feel particularly drowsy from the tablet alone, alcohol could amplify sedation unexpectedly. If you do choose to drink, do so in moderation and avoid driving afterwards.

What are the alternatives to levocetirizine for hay fever?

Common alternatives include cetirizine, loratadine, and fexofenadine — all available OTC in the UK. Nasal corticosteroid sprays such as beclometasone are also recommended by the NHS for moderate-to-severe hay fever symptoms. You can explore a range of options in our allergy and hay fever collection to find what suits you best.

Can levocetirizine be used for dust mite allergy?

Yes, levocetirizine is indicated for perennial allergic rhinitis, which includes year-round allergies triggered by dust mites, pet dander, and mould spores. It can be taken daily throughout the year if your symptoms are persistent. Reducing dust mite exposure in your home — through allergen-proof bedding and regular hoovering — can also help alongside medication.

How long does it take for levocetirizine to start working?

Most people notice symptom relief within one hour of taking levocetirizine, with peak plasma concentration reached within approximately 0.9 hours. The effects last for up to 24 hours, which is why a single daily dose is sufficient. If you do not notice any improvement after a few days of consistent use, speak to your pharmacist.

What are the latest findings on levocetirizine for chronic urticaria?

Clinical evidence continues to support levocetirizine as an effective and well-tolerated treatment for chronic spontaneous urticaria. Current NICE and BSACI guidelines recommend second- and third-generation antihistamines, including levocetirizine, as first-line therapy for this condition. Research also suggests that up-dosing (under medical supervision) may benefit patients who do not respond adequately to standard doses.

How Should You Use Levocetirizine 5mg Tablets?

Levocetirizine 5mg tablets are taken orally, once a day. Always follow the instructions on the packaging or as directed by your pharmacist — taking the tablet correctly ensures you get the most from each dose.

What Is the Correct Dose of Levocetirizine 5mg?

The dose varies depending on age and the condition being treated. Always refer to the patient information leaflet included in the pack, and speak to your pharmacist if you are unsure about the appropriate dose for yourself or your child.

When Is the Best Time to Use Levocetirizine?

Most healthcare professionals recommend taking levocetirizine in the evening, as this is when any mild drowsiness is least likely to interfere with your daily activities. Taking it at a consistent time each day also helps maintain steady levels of the medicine in your bloodstream, which is particularly important for managing chronic conditions like urticaria or perennial allergic rhinitis.

If you are using it for hay fever, you may wish to start taking it a couple of days before your typical pollen season begins, rather than waiting for symptoms to appear. This proactive approach can help reduce the severity of your initial reaction.

How Long Can You Use Levocetirizine For?

For seasonal hay fever, levocetirizine is typically used for the duration of the pollen season — usually a few weeks to a few months. For perennial allergic rhinitis or chronic urticaria, longer-term use may be appropriate, but this should be discussed with your GP or pharmacist to ensure it remains the right treatment for you.

There is no evidence that levocetirizine loses effectiveness over time, and tolerance has not been reported with regular use. However, if your symptoms are not adequately controlled after a reasonable period, seek medical advice rather than increasing the dose yourself.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Levocetirizine 5mg Tablets?

Levocetirizine 5mg tablets are taken orally, once a day. Always follow the instructions on the packaging or as directed by your pharmacist — taking the tablet correctly ensures you get the most from each dose.

What Is the Correct Dose of Levocetirizine 5mg?

The dose varies depending on age and the condition being treated. Always refer to the patient information leaflet included in the pack, and speak to your pharmacist if you are unsure about the appropriate dose for yourself or your child.

When Is the Best Time to Use Levocetirizine?

Most healthcare professionals recommend taking levocetirizine in the evening, as this is when any mild drowsiness is least likely to interfere with your daily activities. Taking it at a consistent time each day also helps maintain steady levels of the medicine in your bloodstream, which is particularly important for managing chronic conditions like urticaria or perennial allergic rhinitis.

If you are using it for hay fever, you may wish to start taking it a couple of days before your typical pollen season begins, rather than waiting for symptoms to appear. This proactive approach can help reduce the severity of your initial reaction.

How Long Can You Use Levocetirizine For?

For seasonal hay fever, levocetirizine is typically used for the duration of the pollen season — usually a few weeks to a few months. For perennial allergic rhinitis or chronic urticaria, longer-term use may be appropriate, but this should be discussed with your GP or pharmacist to ensure it remains the right treatment for you.

There is no evidence that levocetirizine loses effectiveness over time, and tolerance has not been reported with regular use. However, if your symptoms are not adequately controlled after a reasonable period, seek medical advice rather than increasing the dose yourself.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Levocetirizine?

Most people tolerate levocetirizine well, but like all medicines, it can cause side effects in some individuals. Common side effects — those affecting up to 1 in 10 people — are generally mild and often resolve without any intervention.

  • Drowsiness or somnolence
  • Headache
  • Dry mouth
  • Fatigue or tiredness
  • Nasopharyngitis (runny nose or sore throat)

What Are the Less Common Side Effects of Levocetirizine?

Less common side effects affect up to 1 in 100 people. These are not experienced by most users, but it is worth being aware of them so you can recognise them if they occur.

  • Nausea or stomach discomfort
  • Dizziness
  • Skin rash or itching (pruritus)
  • Agitation or restlessness
  • Weight gain (with prolonged use in some cases)
  • Palpitations
  • Difficulty passing urine (urinary retention)

What Are the Serious Side Effects of Levocetirizine?

Serious side effects are rare but require immediate medical attention. Stop taking levocetirizine and seek emergency help if you experience any of the following signs of a severe allergic reaction (anaphylaxis):

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe skin rash, blistering, or peeling
  • Rapid or irregular heartbeat
  • Sudden drop in blood pressure causing dizziness or collapse

Seizures have been reported very rarely in patients taking levocetirizine, particularly in those with a pre-existing seizure disorder. If you have epilepsy, discuss this with your GP before starting treatment.

What Should You Do If You Experience Side Effects?

If you experience mild side effects such as drowsiness or a dry mouth, these often improve after the first few days as your body adjusts to the medicine. Taking the tablet in the evening can help reduce the impact of drowsiness on your daily life. If side effects persist or become bothersome, speak to your pharmacist — they may be able to suggest an alternative antihistamine that suits you better.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety monitoring across the UK.

Can Levocetirizine Interact With Other Medicines?

Levocetirizine can interact with certain other medicines, which may increase the risk of side effects or reduce effectiveness. Always inform your pharmacist or GP of all medicines you are currently taking, including over-the-counter products and herbal remedies.

  • Alcohol and CNS depressants — increased sedation risk
  • Ritonavir (HIV medication) — may increase levocetirizine plasma levels
  • Theophylline — may slightly reduce clearance of levocetirizine
  • Other antihistamines — avoid combining without medical advice

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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