Skip to product information
1 of 1

  • Images are for illustration purposes only

Ibuprofen 400mg - 24 Tablets

Ibuprofen 400mg - 24 Tablets

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

  • ✔️ Relieves mild to moderate pain within 20–30 minutes
  • ✔️ Reduces inflammation as well as pain — paracetamol cannot
  • ✔️ Effective for headaches, period pain, dental pain and fever
  • ✔️ Suitable for adults and young people aged 12 and over
  • ✔️ 24-tablet pack provides several days of short-term relief

Price Checker

Regular price £4.59
Sale price £4.59
Sale Sold out
  • Lowest price guarantee
  • Includes FREE private prescription
View full details

 

What Are Ibuprofen 400mg Tablets Used For?

 

If you're dealing with a headache, toothache, period pain, or the aches that come with a cold, ibuprofen 400mg tablets are one of the most widely used over-the-counter options available in the UK. Each tablet contains 400mg of ibuprofen — a non-steroidal anti-inflammatory drug (NSAID) — and this 24-tablet pack gives you a reliable supply at an accessible price of just £4.59. Whether you need short-term relief from everyday pain or want to reduce a fever, this is a trusted choice for adults and young people aged 12 and over. You can find this and other options in our pain relief collection.

Ibuprofen has been used clinically for decades and is recommended by the NHS for a range of mild to moderate pain conditions. It works both as an analgesic (pain reliever) and an anti-inflammatory, which sets it apart from paracetamol. That dual action makes it particularly useful for conditions where inflammation is part of the problem — think muscle strains, joint pain, or dental discomfort.

 

How Does Ibuprofen Work to Relieve Pain?

 

Ibuprofen belongs to the NSAID class of medicines. Its mechanism of action centres on inhibiting cyclooxygenase (COX) enzymes — specifically COX-1 and COX-2. These enzymes drive the production of prostaglandins, which are lipid compounds that sensitise nerve endings to pain, trigger inflammation, and raise body temperature. By blocking this pathway, ibuprofen reduces all three responses simultaneously.

  • Inhibits COX-1 and COX-2 enzymes in peripheral and central tissues
  • Reduces prostaglandin synthesis, lowering pain sensitivity at nerve endings
  • Decreases local inflammation by limiting vasodilation and oedema
  • Acts on the hypothalamus to reduce fever (antipyretic effect)

The onset of action is typically within 20 to 30 minutes of taking a tablet orally, with peak plasma concentration reached within one to two hours. This relatively quick action makes it practical for acute pain episodes.

 

Who Is Ibuprofen 400mg Suitable For?

 

This product is suitable for a broad range of adults and adolescents. It's particularly helpful for people who need both pain relief and anti-inflammatory action — something paracetamol alone cannot provide. That said, it's not appropriate for everyone, so it's worth checking the contraindications carefully before you buy.

  • Adults aged 18 and over with mild to moderate pain
  • Adolescents aged 12–17 (under adult supervision where appropriate)
  • People with headaches, dental pain, period pain, or muscular aches
  • Those with fever who need an antipyretic alternative to paracetamol

It is not suitable for children under 12, pregnant women in their third trimester, or anyone with a history of peptic ulcers, severe renal impairment, or hypersensitivity to NSAIDs.

 

How Does Ibuprofen 400mg Compare to Paracetamol?

 

Feature Ibuprofen 400mg Paracetamol 500mg
Drug class NSAID Analgesic / antipyretic
Anti-inflammatory action Yes No
Suitable for stomach sensitivity Take with food — caution advised Generally well tolerated
Suitable in pregnancy Avoid in third trimester Generally considered safe (consult GP)

 

How Should You Store Ibuprofen 400mg Tablets?

 

Store your ibuprofen 400mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them in their original packaging so you can always check the expiry date and batch information. Always store medicines out of the reach and sight of children — this is especially important in households with young children. If you're also managing other health conditions, you might find our vitamins and supplements collection useful for supporting general wellbeing alongside your pain management routine.

Do not use tablets past their expiry date. If you have unused or expired tablets, return them to your local pharmacy for safe disposal — do not flush them down the toilet or put them in household waste.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Ibuprofen 400mg – 24 Tablets specifications
Treatment category Pain relief, anti-inflammatory, antipyretic
Mechanism of action COX-1 and COX-2 enzyme inhibitor (NSAID)
Effective for Headache, toothache, period pain, muscular pain, fever, cold and flu symptoms
Suitable for Adults and adolescents aged 12 and over
Active ingredient Ibuprofen 400mg
Pack size 24 tablets
Strength 400mg
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Non-steroidal anti-inflammatory drug (NSAID)
Preparation Film-coated tablet
Route of administration Oral

Specifications of Ibuprofen 400mg – 24 Tablets

 

What Is Ibuprofen 400mg and What Is It Used For?

 

Ibuprofen 400mg tablets are an over-the-counter NSAID used to relieve mild to moderate pain, reduce inflammation, and lower fever. The NHS recommends ibuprofen for a wide range of everyday conditions, including headaches, dental pain, period pain, back pain, and the symptoms of colds and flu. Each tablet contains 400mg of ibuprofen as the active ingredient, and this pack contains 24 tablets — enough for several days of short-term use at the standard adult dose.

Ibuprofen is also used to manage the discomfort associated with minor injuries such as sprains and strains, where both pain and swelling need to be addressed. If you're managing recurring discomfort alongside other conditions, it's worth exploring our first aid collection for complementary products.

 

What Do You Need to Know Before Taking Ibuprofen 400mg?

 

Before taking ibuprofen, it's important to check whether it's appropriate for you. There are several conditions and circumstances where ibuprofen should be avoided entirely.

Do not take ibuprofen 400mg if you:

  • Are allergic to ibuprofen, aspirin, or any other NSAID
  • Have or have had a peptic ulcer or gastrointestinal bleeding
  • Have severe heart failure, severe kidney disease, or severe liver disease
  • Are in the third trimester of pregnancy
  • Are under 12 years of age
  • Have been told by a doctor to avoid NSAIDs for any reason

Tell your pharmacist or doctor before use if you:

  • Have asthma, as NSAIDs can trigger bronchospasm in susceptible individuals
  • Have a history of high blood pressure or cardiovascular disease
  • Have mild to moderate kidney or liver impairment
  • Are in the first or second trimester of pregnancy or are breastfeeding

Known drug interactions — ibuprofen may interact with:

  • Anticoagulants such as warfarin (increased bleeding risk)
  • Aspirin and other NSAIDs (increased risk of gastrointestinal side effects)
  • Lithium (ibuprofen can raise lithium plasma levels)
  • Methotrexate (risk of toxicity increased)
  • Antihypertensive medicines including ACE inhibitors and diuretics
  • SSRIs (increased risk of gastrointestinal bleeding)

 

How Should You Take Ibuprofen 400mg Tablets?

 

Always take ibuprofen exactly as directed on the label or as advised by your pharmacist. Taking it with food or milk significantly reduces the risk of stomach irritation — this is one of the most important practical steps you can take.

  1. Take one 400mg tablet with or after food
  2. Swallow with a full glass of water
  3. Wait at least four to six hours before taking another dose
  4. Do not take more than three tablets (1,200mg) in any 24-hour period
  5. Use the lowest effective dose for the shortest time necessary
Indication Age Group Dose Frequency
Mild to moderate pain / fever Adults & over 12s 400mg (1 tablet) Every 4–6 hours, max 3 times daily
Period pain Adults 400mg (1 tablet) Every 4–6 hours as needed
Dental pain Adults & over 12s 400mg (1 tablet) Every 4–6 hours, max 3 times daily
Children under 12 Under 12 Not suitable Not applicable

 

What Are the Possible Side Effects of Ibuprofen 400mg?

 

Like all medicines, ibuprofen can cause side effects, although not everyone experiences them. The most common ones relate to the gastrointestinal tract, which is why taking it with food is so important.

Common side effects (may affect up to 1 in 10 people):

  • Nausea and vomiting
  • Indigestion and heartburn
  • Stomach pain or discomfort
  • Diarrhoea or constipation
  • Headache

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness or drowsiness
  • Fluid retention (oedema)
  • Raised blood pressure
  • Skin rash or itching
  • Worsening of asthma symptoms

Stop taking ibuprofen and seek urgent medical attention if you notice black or tarry stools, vomit blood, experience chest pain, or develop a severe skin reaction. These may indicate serious gastrointestinal or cardiovascular complications. If you're also experiencing digestive discomfort, our indigestion collection may offer supportive relief.

 

How Should You Store Ibuprofen 400mg Tablets?

 

  • Store below 25°C in a dry place away from direct heat and sunlight
  • Keep in the original blister packaging until use
  • Do not store in a bathroom or near a sink — moisture can degrade the tablets
  • Keep out of the reach and sight of children at all times
  • Do not use after the expiry date printed on the pack
  • Return unused or expired tablets to your pharmacy for safe disposal

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy ibuprofen 400mg tablets online in the UK?

You can buy ibuprofen 400mg tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. Simply add the 24-tablet pack to your basket and complete your order for convenient home delivery. We stock a wide range of pain relief products to suit different needs and budgets.

How does ibuprofen 400mg work in the body?

Ibuprofen works by inhibiting COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins — the chemicals that cause pain, inflammation, and fever. By reducing prostaglandin levels, ibuprofen relieves discomfort and brings down raised body temperature. It begins to take effect within 20 to 30 minutes of being swallowed, with peak action typically within one to two hours.

How do I take ibuprofen 400mg tablets step by step?

Take one 400mg tablet with or after food to protect your stomach lining, and swallow it with a full glass of water. Wait at least four to six hours before taking another dose, and do not exceed three tablets (1,200mg) in any 24-hour period. Always use the lowest effective dose for the shortest time needed to manage your symptoms.

What is the maximum daily dose of ibuprofen 400mg for adults?

The maximum over-the-counter dose for adults and young people aged 12 and over is 1,200mg per day — equivalent to three 400mg tablets. Each dose should be spaced at least four to six hours apart. Higher doses are sometimes used under medical supervision, but should never be self-administered without a doctor's guidance.

What are the most common side effects of ibuprofen 400mg?

The most common side effects include nausea, indigestion, stomach pain, and diarrhoea — all of which are more likely if you take ibuprofen on an empty stomach. Taking it with food or milk significantly reduces the risk of gastrointestinal upset. If side effects are severe or do not settle, stop taking the tablets and speak to your pharmacist or GP.

Who should not take ibuprofen 400mg tablets?

Ibuprofen is not suitable for people with a history of peptic ulcers, gastrointestinal bleeding, severe heart failure, severe kidney or liver disease, or those with a known allergy to ibuprofen, aspirin, or other NSAIDs. It should also be avoided by pregnant women in their third trimester and children under 12. Always check with your pharmacist if you are unsure whether ibuprofen is right for you.

Can I take ibuprofen 400mg if I have asthma?

Some people with asthma are sensitive to NSAIDs including ibuprofen, and taking it can trigger bronchospasm or worsen breathing in susceptible individuals. The NHS advises that people with asthma should speak to their doctor or pharmacist before taking ibuprofen. If you have been told previously that NSAIDs affect your asthma, do not take this product.

What happens if I miss a dose of ibuprofen 400mg?

If you miss a dose, take it as soon as you remember — provided it is not nearly time for your next scheduled dose. If it is close to the time of your next dose, simply skip the missed one and carry on as normal. Never take a double dose to compensate for a missed one, as this increases the risk of side effects.

Can I take ibuprofen 400mg with paracetamol?

Yes — ibuprofen and paracetamol work through different mechanisms and can generally be taken together safely, which is sometimes recommended by healthcare professionals for more effective pain control. However, always follow the dosing instructions for each medicine separately and do not exceed the maximum dose of either. If you are unsure, ask your pharmacist before combining them.

Is ibuprofen 400mg safe to take during pregnancy?

Ibuprofen should be avoided during the third trimester of pregnancy as it can harm the developing baby and affect labour. Use during the first and second trimesters should only occur under medical supervision. The NHS recommends paracetamol as the preferred pain reliever during pregnancy — always consult your midwife or GP before taking any medicine while pregnant.

What medicines interact with ibuprofen 400mg?

Ibuprofen can interact with several medicines, including warfarin and other anticoagulants, aspirin, lithium, methotrexate, antihypertensives such as ACE inhibitors, diuretics, and SSRIs. These interactions can increase the risk of bleeding, toxicity, or reduced effectiveness of other medicines. Always tell your pharmacist about all medicines you are taking before starting ibuprofen.

How long can I take ibuprofen 400mg for?

Ibuprofen 400mg tablets are intended for short-term use only — typically no longer than three days for fever and up to ten days for pain, unless directed otherwise by a doctor. Prolonged use increases the risk of gastrointestinal, cardiovascular, and renal side effects. If your symptoms persist beyond the recommended period, seek advice from your GP.

What are the alternatives to ibuprofen 400mg tablets?

Common alternatives include paracetamol for pain and fever, or aspirin for adults who are not at risk of gastrointestinal bleeding. For those who cannot tolerate NSAIDs, a pharmacist can advise on the most appropriate option. You can browse our full pain relief range to compare available products.

Can ibuprofen 400mg help with period pain?

Yes — ibuprofen is particularly effective for period pain (dysmenorrhoea) because prostaglandins play a direct role in causing uterine cramping, and ibuprofen reduces their production. The NHS recommends ibuprofen as a first-line option for managing period pain in adults. Take it with food and at the first sign of discomfort for best results. You can also explore our women's health collection for additional support.

What are the latest findings on long-term ibuprofen use?

Research continues to highlight that long-term or high-dose NSAID use — including ibuprofen — is associated with increased cardiovascular risk, gastrointestinal complications, and potential kidney damage. Regulatory bodies including the MHRA advise using the lowest effective dose for the shortest possible time. If you require ongoing pain management, speak to your GP about safer long-term strategies.

How Should You Use Ibuprofen 400mg Tablets?

Ibuprofen 400mg tablets are taken orally and should always be swallowed whole with a full glass of water. To protect your stomach, it is important to take each dose with or after food — never on an empty stomach. Follow these steps each time you take a dose:

If you experience stomach discomfort even when taking ibuprofen with food, speak to your pharmacist. They may suggest a gastroprotective medicine such as a proton pump inhibitor to take alongside it.

What Is the Correct Dose of Ibuprofen 400mg?

The correct dose depends on your age and the condition being treated. For most adults, one 400mg tablet taken up to three times daily is sufficient for effective symptom relief. Always use the lowest dose that controls your symptoms, and do not exceed the maximum daily limit.

When Is the Best Time to Take Ibuprofen 400mg?

There is no single "best" time of day to take ibuprofen — timing should be guided by when your pain or fever occurs. For predictable pain such as period cramps, taking a dose at the first sign of discomfort (rather than waiting until pain is severe) tends to give better results. For ongoing pain management throughout the day, spacing doses evenly — for example, morning, afternoon, and evening with meals — helps maintain consistent relief. Always ensure at least four to six hours between doses regardless of timing.

How Long Can You Use Ibuprofen 400mg For?

Ibuprofen 400mg tablets are intended for short-term use only. For fever, the NHS advises using ibuprofen for no longer than three days without medical review. For pain, use should generally not exceed ten days without consulting a doctor. Prolonged use increases the risk of gastrointestinal, cardiovascular, and renal complications. If your symptoms have not improved within the recommended timeframe, or if they worsen at any point, stop taking the tablets and seek advice from your GP or pharmacist.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Ibuprofen 400mg?

Gastrointestinal side effects are the most frequently reported with ibuprofen, particularly when it is taken on an empty stomach. These effects occur because ibuprofen inhibits COX-1 enzymes, which also play a role in protecting the stomach lining. Taking each dose with food or milk significantly reduces this risk.

  • Nausea and vomiting
  • Indigestion and heartburn
  • Stomach pain or cramping
  • Diarrhoea or constipation
  • Bloating or flatulence

What Are the Less Common Side Effects of Ibuprofen 400mg?

Less common side effects may affect up to 1 in 100 people. These are generally mild and resolve once you stop taking the medicine, but you should still be aware of them — particularly if you are taking ibuprofen regularly over several days.

  • Dizziness or light-headedness
  • Headache
  • Fluid retention (swollen ankles or feet)
  • Raised blood pressure
  • Skin rash or itching
  • Worsening of asthma symptoms or breathlessness
  • Tinnitus (ringing in the ears)

What Are the Serious Side Effects of Ibuprofen 400mg?

Although rare, ibuprofen can cause serious side effects that require immediate medical attention. These are more likely in people who take high doses, use ibuprofen long-term, or have pre-existing cardiovascular or gastrointestinal conditions. Stop taking ibuprofen immediately and call 999 or go to A&E if you experience any of the following:

  • Black, tarry, or blood-streaked stools — a sign of gastrointestinal bleeding
  • Vomiting blood or material that looks like coffee grounds
  • Severe chest pain, shortness of breath, or sudden weakness — possible signs of a heart attack or stroke
  • Severe allergic reaction (anaphylaxis): swelling of the face, lips, or throat, difficulty breathing, or collapse
  • Severe skin reactions such as blistering, peeling, or widespread rash
  • Significant reduction in urine output — a sign of acute kidney injury

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or indigestion, try taking ibuprofen with a larger meal or a glass of milk. If the side effect persists or becomes bothersome, stop taking the tablets and speak to your pharmacist before continuing. You should never ignore side effects that feel unusual or disproportionate to what you'd expect from a pain reliever. Report any suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Ibuprofen 400mg Interact With Other Medicines?

Yes — ibuprofen has several clinically significant drug interactions that can increase the risk of serious harm. Always tell your pharmacist or doctor about every medicine you are taking, including over-the-counter products and herbal remedies, before starting ibuprofen. Key interactions include warfarin (increased bleeding risk), lithium (raised plasma levels), methotrexate (increased toxicity), antihypertensives including ACE inhibitors and diuretics (reduced effectiveness and increased kidney risk), and SSRIs (increased gastrointestinal bleeding risk). Taking ibuprofen alongside other NSAIDs or aspirin also significantly increases the risk of gastrointestinal side effects and should be avoided unless specifically directed by a doctor.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

We’re a safe and
regulated UK service

Registered Pharmacy Badge

Lowest Price Guarantee

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

100% discreet packaging

We're convinced you won't find your treatment cheaper, but if you do we'll refund the difference.

Find out more

Agent

Need help?
Talk to our friendly experts now

How our service works

Service Setup

Service setup

Discreet Packaging

Discreet packaging

Express Delivery

Express delivery