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Gina 10mcg Vaginal Tablets - 24 Tablets

Gina 10mcg Vaginal Tablets - 24 Tablets

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  • ✔️ Relieves postmenopausal vaginal dryness, itching, and soreness
  • ✔️ Low-dose 10mcg estradiol acts locally with minimal systemic absorption
  • ✔️ Initial results often noticeable within two to four weeks of use
  • ✔️ Suitable for postmenopausal women aged 50 and over
  • ✔️ Available over the counter — no GP appointment required

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What Are Vaginal Dryness Tablets and How Can Gina 10mcg Help?

 

If you've been experiencing dryness, itching, or discomfort around the vaginal area since your menopause, you're far from alone. These symptoms — collectively known as vaginal atrophy or genitourinary syndrome of menopause — affect a significant number of women after their periods stop. Vaginal dryness tablets like Gina 10mcg offer a targeted, locally acting solution that works directly where you need it most. Available without a prescription for eligible women, Gina is one of the few licensed over-the-counter hormonal treatments of its kind in the UK.

Each pack contains 24 tablets of estradiol hemihydrate 10mcg — a low-dose form of oestrogen delivered vaginally rather than systemically. Because the hormone acts locally, systemic absorption is minimal, which is reassuring for many women who have concerns about whole-body hormone exposure. You can explore other products relevant to your intimate health in our women's health collection.

 

How Does Gina 10mcg Work to Relieve Vaginal Symptoms?

 

After the menopause, oestrogen levels fall significantly. The vaginal lining — which depends on oestrogen to stay thick, moist, and elastic — gradually thins and dries out. Gina works by replenishing oestrogen locally in the vaginal tissue, helping to restore its natural condition over time.

  • Estradiol is absorbed directly through the vaginal mucosa into the surrounding tissue.
  • It stimulates the vaginal epithelium to thicken and produce more natural lubrication.
  • Symptoms such as dryness, soreness, and painful intercourse typically begin to improve within a few weeks of starting treatment.
  • Because the dose is very low and localised, it does not significantly raise oestrogen levels in the bloodstream for most women.

 

Who Should Consider Using Gina 10mcg Vaginal Tablets?

 

Gina is specifically licensed for postmenopausal women aged 50 and over who have not had a period for at least 12 months. It is intended for those experiencing symptoms of vaginal atrophy that are affecting their quality of life — whether that's day-to-day discomfort, difficulty with intimacy, or recurrent urinary symptoms linked to vaginal changes.

  • Women aged 50 or over who are postmenopausal (no period for at least one year).
  • Those experiencing vaginal dryness, itching, burning, or soreness.
  • Women who find sexual intercourse uncomfortable due to vaginal changes.
  • Those who prefer a localised hormonal option rather than systemic HRT.

It is not suitable for women who are pregnant, breastfeeding, or who have not yet reached the menopause. Always read the full list of contraindications before starting treatment.

 

How Does Gina 10mcg Compare to Other Vaginal Oestrogen Products?

 

Feature Gina 10mcg Vaginal Tablets Vaginal Oestrogen Cream
Active ingredient Estradiol hemihydrate 10mcg Varies (e.g. estriol)
Route of administration Vaginal tablet (applicator) Topical cream (applicator)
Prescription required? No — available OTC for eligible women Usually prescription-only
Dosing frequency (maintenance) Twice weekly Varies by product

 

Is Gina 10mcg Suitable for Long-Term Use and How Should It Be Stored?

 

Gina can be used for up to 24 weeks without a formal medical review, but if you feel you need to continue beyond this point, it's worth speaking to your GP. Some women use localised vaginal oestrogen long-term under medical supervision, as the NHS acknowledges that symptoms of vaginal atrophy are often ongoing and may not resolve without continued treatment. If you're also managing other intimate health concerns, our personal lubricants collection may offer complementary support alongside treatment.

Store Gina tablets below 25°C, away from direct heat and moisture. Keep the pack out of reach of children. Do not use after the expiry date printed on the packaging. Each tablet comes individually sealed and should only be removed from its blister immediately before use.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Gina 10mcg Vaginal Tablets - 24 Tablets specifications
Treatment category Vaginal atrophy / Genitourinary syndrome of menopause
Mechanism of action Local oestrogen replacement via vaginal mucosa absorption
Effective for Vaginal dryness, itching, soreness, and discomfort associated with menopause
Suitable for Postmenopausal women aged 50 and over
Active ingredient Estradiol hemihydrate 10mcg
Pack size 24 tablets
Strength 10mcg estradiol per tablet
UK classification Pharmacy (P) medicine
Drug class Local oestrogen / Hormone replacement therapy (topical)
Preparation Vaginal tablet
Route of administration Vaginal

Specifications of Gina 10mcg Vaginal Tablets - 24 Tablets

 

What Is Gina 10mcg and What Is It Used For?

 

Gina 10mcg vaginal tablets contain estradiol hemihydrate, a naturally occurring form of oestrogen. They are used to treat the symptoms of vaginal atrophy — a condition that occurs when falling oestrogen levels after the menopause cause the vaginal lining to become thin, dry, and inflamed. Symptoms can include vaginal dryness, itching, burning, soreness, and pain during sexual intercourse. Some women also notice urinary symptoms such as increased urgency or discomfort when passing urine. Gina is a licensed over-the-counter treatment for postmenopausal women aged 50 and over in the UK.

 

What Do You Need to Know Before Using Gina 10mcg?

 

Before using Gina, it's important to check whether it is appropriate for you. Do not use Gina if any of the following apply:

  • You have or have previously had breast cancer, or suspect you might have it.
  • You have or have previously had endometrial (womb) cancer or other oestrogen-sensitive cancers.
  • You have unexplained vaginal bleeding — this must be investigated by a doctor before starting treatment.
  • You have untreated endometrial hyperplasia (thickening of the womb lining).
  • You have a history of blood clots (deep vein thrombosis or pulmonary embolism).
  • You have active or recent arterial thromboembolic disease (e.g. angina or heart attack).
  • You have acute liver disease or a history of liver disease where liver function has not returned to normal.
  • You are allergic to estradiol or any other ingredient in the tablet.
  • You are under 50 years of age or have not yet reached the menopause.

Regarding drug interactions, systemic absorption from Gina is very low at the recommended dose, so significant drug interactions are unlikely. However, you should still inform your pharmacist or GP if you are taking:

  • Other hormone-containing medicines or HRT products.
  • Medicines that affect liver enzymes (e.g. certain anticonvulsants or antibiotics), as these may theoretically affect oestrogen metabolism.

 

How Should You Use Gina 10mcg Vaginal Tablets?

 

Always use Gina exactly as described in the patient information leaflet. The applicator provided makes insertion straightforward, even if you've never used a vaginal tablet before. Wash your hands thoroughly before and after each use.

  1. Remove one tablet from the blister pack immediately before use.
  2. Place the tablet into the tip of the applicator provided.
  3. Lie on your back with your knees bent, or stand with one foot raised on a step.
  4. Gently insert the applicator into the vagina as far as is comfortable.
  5. Press the plunger to release the tablet, then carefully withdraw the applicator.
  6. Wash the applicator with warm water and mild soap after each use; allow to dry before storing.
Phase Age Group Dose Frequency
Initial (first 2 weeks) Women aged 50+ (postmenopausal) One 10mcg tablet Once daily for 14 days
Maintenance (ongoing) Women aged 50+ (postmenopausal) One 10mcg tablet Twice weekly (at least 3 days apart)

Gina is not recommended for use in women under 50 or those who have not yet reached the menopause. If you are unsure whether this product is right for you, speak to a pharmacist before purchasing. You may also find our cystitis and bladder infection collection helpful if you're experiencing urinary symptoms alongside vaginal dryness.

 

What Are the Possible Side Effects of Gina 10mcg?

 

Like all medicines, Gina can cause side effects, although not everyone experiences them. Because the dose is localised and low, side effects are generally mild and limited to the vaginal area.

Common side effects (may affect up to 1 in 10 women):

  • Vaginal irritation or discomfort
  • Vaginal discharge
  • Vaginal bleeding or spotting (particularly in the first few weeks)
  • Discomfort or itching at the site of insertion

Less common side effects (may affect up to 1 in 100 women):

  • Headache
  • Nausea
  • Abdominal discomfort or bloating
  • Breast tenderness
  • Urinary tract symptoms such as increased frequency

Stop using Gina and seek medical advice promptly if you experience any unexpected vaginal bleeding, breast changes, or signs of a blood clot such as sudden leg pain, breathlessness, or chest pain. These are rare but require immediate attention.

 

How Should You Store Gina 10mcg Vaginal Tablets?

 

Correct storage helps maintain the quality and effectiveness of your tablets throughout the course of treatment. If you're managing multiple health products at home, it's worth keeping all medicines in a dedicated, safe location away from children. Our thrush treatments collection also contains products that benefit from similar careful storage.

  • Store below 25°C in a cool, dry place.
  • Do not store in the bathroom or near sources of heat or moisture.
  • Keep the tablets in their original blister packaging until immediately before use.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date printed on the carton.
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Gina 10mcg vaginal tablets online in the UK?

You can buy Gina 10mcg vaginal tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy, without needing a prescription. They are classified as a Pharmacy (P) medicine, meaning a pharmacist must confirm your suitability before purchase. Simply complete the short eligibility questionnaire at checkout and your order will be reviewed and dispatched promptly.

How do Gina 10mcg vaginal tablets work in the body?

Gina tablets contain estradiol, a form of oestrogen that is absorbed locally through the vaginal mucosa into the surrounding tissue. After the menopause, falling oestrogen levels cause the vaginal lining to thin and dry out — estradiol helps restore its natural thickness and moisture. Because the dose is very low and acts locally, it does not significantly raise oestrogen levels in the bloodstream for most women.

How do I insert Gina 10mcg vaginal tablets step by step?

Place one tablet into the tip of the applicator provided, then lie on your back with knees bent or stand with one foot raised. Gently insert the applicator into the vagina as far as is comfortable, press the plunger to release the tablet, and carefully withdraw the applicator. Wash your hands before and after, and clean the applicator with warm soapy water after each use.

What is the correct dose of Gina 10mcg vaginal tablets?

The initial dose is one 10mcg tablet inserted vaginally once daily for 14 consecutive days. After this initial phase, the maintenance dose is one tablet twice weekly, with at least three days between each dose. Do not exceed the recommended dose, and do not use more than one tablet at a time.

When is the best time to use Gina 10mcg vaginal tablets?

There is no specific time of day required, but many women find it easiest to insert the tablet at bedtime when lying down, as this reduces the chance of the tablet slipping out before it dissolves. Consistency matters more than timing — try to use your tablet at roughly the same time on your scheduled days. Establishing a routine helps you remember your twice-weekly maintenance doses.

What are the side effects of Gina 10mcg vaginal tablets?

Common side effects include vaginal irritation, discharge, or mild discomfort at the site of insertion, particularly during the first few weeks of treatment. Less commonly, some women experience headache, nausea, or breast tenderness. If you notice unexpected vaginal bleeding, signs of a blood clot, or any side effect that concerns you, stop using Gina and contact your GP or pharmacist promptly.

Who is eligible to use Gina 10mcg vaginal tablets?

Gina is suitable for postmenopausal women aged 50 or over who have not had a period for at least 12 months and are experiencing symptoms of vaginal atrophy such as dryness, itching, or discomfort. It is not suitable for women who are pregnant, breastfeeding, under 50, or who have certain hormone-sensitive conditions including a history of breast or womb cancer. A pharmacist eligibility check is required before purchase.

What happens if I miss a dose of Gina 10mcg?

If you miss a dose, insert the tablet as soon as you remember — unless it is almost time for your next scheduled dose, in which case simply skip the missed one and continue as normal. Never insert two tablets at once to compensate for a missed dose. Keeping a simple calendar or phone reminder can help you stay on track with your twice-weekly schedule.

How long can you use Gina 10mcg vaginal tablets for?

Gina can be used for up to 24 weeks (around six months) as an over-the-counter treatment without a formal medical review. If you feel you need to continue beyond this period, you should speak to your GP, who can assess whether ongoing treatment is appropriate for you. Many women use localised vaginal oestrogen long-term under medical supervision, as vaginal atrophy symptoms often persist without continued treatment.

Can I use Gina 10mcg if I am also taking systemic HRT?

This is an important question to raise with your GP or pharmacist before combining treatments. Some women on systemic HRT still experience vaginal symptoms and may be prescribed localised vaginal oestrogen alongside it, but this should always be done under medical guidance. Do not start Gina alongside other hormone treatments without professional advice, as combined oestrogen exposure needs to be carefully managed.

What are the alternatives to Gina 10mcg vaginal tablets?

Alternatives to Gina include other forms of localised vaginal oestrogen such as vaginal creams, rings, or pessaries — most of which are prescription-only in the UK. Non-hormonal options include vaginal moisturisers and lubricants, which can help manage dryness without hormones. You can browse our personal lubricants collection for complementary products that may help alongside or instead of hormonal treatment.

Is Gina 10mcg safe if I have a history of blood clots?

Gina is contraindicated in women with a history of blood clots (deep vein thrombosis or pulmonary embolism), as oestrogen — even at low local doses — may carry some risk in this group. You must speak to your GP before using any oestrogen-containing product if you have a personal or family history of clotting disorders. Your doctor can advise on whether localised vaginal oestrogen is appropriate for your individual circumstances.

Can Gina 10mcg help with urinary symptoms after the menopause?

Yes — localised vaginal oestrogen can help with urinary symptoms that are linked to vaginal atrophy, such as urinary urgency, frequency, and discomfort when passing urine. This is because the urethra and bladder are also oestrogen-sensitive tissues that can be affected by the menopause. If you're also experiencing recurrent urinary tract infections or bladder discomfort, our cystitis and bladder infection collection may offer additional support.

Does Gina 10mcg affect the risk of breast cancer?

Because Gina delivers a very low dose of oestrogen locally with minimal systemic absorption, current evidence suggests the risk of breast cancer associated with localised vaginal oestrogen at this dose is very low compared to systemic HRT. However, Gina is contraindicated in women who have or have had breast cancer, and you should always discuss your personal risk with your GP if you have concerns. The NHS recommends that all women using any form of oestrogen attend their regular breast screening appointments.

What are the latest studies on vaginal oestrogen for menopause symptoms?

Recent clinical evidence continues to support the safety and effectiveness of low-dose localised vaginal oestrogen for treating genitourinary syndrome of menopause, with studies showing improvements in vaginal dryness, pH, and sexual comfort. The NHS and NICE both recognise localised vaginal oestrogen as an effective treatment option for postmenopausal vaginal symptoms. Research also suggests that, unlike systemic HRT, low-dose vaginal oestrogen does not appear to significantly increase the risk of endometrial hyperplasia when used at recommended doses.

How Should You Use Gina 10mcg Vaginal Tablets?

Using Gina correctly makes a real difference to how well it works. The applicator provided is designed to make insertion as straightforward as possible, and with a little practice most women find the process quick and comfortable. Always wash your hands thoroughly before and after handling the tablet and applicator.

What Is the Correct Dose of Gina 10mcg Vaginal Tablets?

The dosing schedule for Gina has two distinct phases: an initial daily phase to build up oestrogen in the vaginal tissue, followed by a lower-frequency maintenance phase. It is important not to skip the initial phase, as this helps establish the treatment effect more quickly.

When Is the Best Time to Use Gina 10mcg Vaginal Tablets?

There is no medically required time of day for using Gina, but many women prefer to insert the tablet at bedtime. Using it while lying down means gravity is less likely to cause the tablet to move before it has fully dissolved, and it also fits naturally into an existing evening routine. Whatever time you choose, try to keep it consistent — particularly on your twice-weekly maintenance days — to avoid accidentally missing a dose.

Setting a recurring reminder on your phone for your two chosen days each week is a simple but effective way to stay on track. Some women find it helpful to pick two fixed days — for example, Monday and Thursday — so the schedule becomes second nature.

How Long Can You Use Gina 10mcg Vaginal Tablets For?

As an over-the-counter medicine, Gina is licensed for use for up to 24 weeks without a formal medical review. This gives you approximately six months of treatment, which is often enough time to see a meaningful and sustained improvement in vaginal symptoms. Many women notice a difference within the first few weeks, though full benefit may take a little longer.

If your symptoms have not improved after a few weeks of correct use, or if you feel you need to continue treatment beyond 24 weeks, speak to your GP. Long-term use of localised vaginal oestrogen is common and considered appropriate for many women, but it should be reviewed by a healthcare professional to ensure it remains the right option for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Gina 10mcg Vaginal Tablets?

Because Gina delivers oestrogen locally at a very low dose, most side effects — when they do occur — are mild and confined to the vaginal area. They are most likely to appear during the initial daily dosing phase and often settle down once you move to the twice-weekly maintenance schedule.

  • Vaginal irritation or itching
  • Vaginal discharge (usually clear or white)
  • Mild discomfort or burning sensation at the site of insertion
  • Light vaginal bleeding or spotting, particularly in the first few weeks

What Are the Less Common Side Effects of Gina 10mcg Vaginal Tablets?

Some women experience side effects that are not directly related to the vaginal area. These are less frequent but worth being aware of, particularly if you notice them shortly after starting treatment.

  • Headache
  • Nausea or stomach discomfort
  • Abdominal bloating
  • Breast tenderness or swelling
  • Increased urinary frequency or urgency
  • Pelvic pain or discomfort

What Are the Serious Side Effects of Gina 10mcg Vaginal Tablets?

Serious side effects are rare with localised low-dose vaginal oestrogen, but they can occur. You should stop using Gina immediately and seek urgent medical attention if you experience any of the following:

  • Sudden, unexplained vaginal bleeding — particularly if you are well past the menopause
  • Signs of a blood clot: sudden leg pain or swelling, breathlessness, chest pain, or coughing up blood
  • Sudden severe headache, vision changes, or weakness on one side of the body (possible signs of stroke)
  • Jaundice (yellowing of the skin or eyes)
  • New or worsening breast changes such as lumps, skin dimpling, or nipple discharge

What Should You Do If You Experience Side Effects of Gina 10mcg?

If you experience mild local side effects such as irritation or discharge, these often resolve on their own within the first few weeks as your body adjusts to treatment. Avoid using perfumed soaps or intimate washes in the vaginal area, as these can worsen irritation. If side effects persist or feel severe, stop using Gina and speak to your pharmacist or GP before continuing.

You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medicines in real-world use and is encouraged for all patients and healthcare professionals.

Can Gina 10mcg Interact With Other Medicines?

Because systemic absorption of estradiol from Gina is very low at the recommended dose, clinically significant drug interactions are unlikely. However, medicines that induce liver enzymes — such as certain anticonvulsants (e.g. phenytoin, carbamazepine), rifampicin, or St John's Wort — may theoretically affect oestrogen metabolism if any systemic absorption does occur. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting Gina, including any other hormone-containing products.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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