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Fluconazole Capsule 150mg

Fluconazole Capsule 150mg

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  • ✔️ Single 150mg capsule clears vaginal thrush in one dose
  • ✔️ Targets Candida fungus at the source with proven antifungal action
  • ✔️ Symptom relief often felt within 24 hours of taking
  • ✔️ Suitable for women aged 16 to 60 with diagnosed thrush
  • ✔️ Oral capsule — no messy creams or internal applicators needed

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What Is Fluconazole 150mg Capsule and How Does It Treat Thrush?

 

Thrush is one of the most common fungal infections in the UK, affecting millions of women every year. It is caused by an overgrowth of a yeast called Candida albicans, which naturally lives on the skin and in the body but can multiply out of control under certain conditions. The fluconazole 150mg capsule is a single-dose oral antifungal medicine that targets this infection directly, offering a convenient and clinically proven way to relieve the itching, soreness, and discharge that thrush causes. You can browse our full range of thrush treatments if you would like to compare your options before deciding.

Available over the counter for women aged 16 to 60, this capsule is taken just once — no repeat doses, no complicated schedules. It is classified as a pharmacy (P) medicine in the UK, meaning a pharmacist must be involved in the sale to ensure it is appropriate for you. At just £3.49, it is an accessible and straightforward option for uncomplicated vaginal thrush.

 

How Does Fluconazole 150mg Work Against Fungal Infections?

 

Fluconazole belongs to a class of medicines called triazole antifungals. It works by interfering with the fungal cell membrane — specifically, it inhibits an enzyme called lanosterol 14-alpha-demethylase, which the Candida fungus needs to synthesise ergosterol. Ergosterol is essential for maintaining the integrity of the fungal cell membrane. Without it, the membrane becomes leaky and unstable, ultimately killing the fungus.

  • Fluconazole is absorbed rapidly after oral ingestion
  • It reaches peak plasma concentration within 1 to 2 hours
  • It distributes widely throughout body tissues, including vaginal secretions
  • A single 150mg dose achieves therapeutic concentrations sufficient to clear uncomplicated vaginal thrush

 

Who Is Fluconazole 150mg Capsule Suitable For?

 

This capsule is suitable for women aged 16 to 60 who have previously been diagnosed with vaginal thrush and recognise the same symptoms returning. It is not intended for first-time sufferers who have never had a confirmed diagnosis, as other conditions can mimic thrush symptoms. If you are unsure, always speak to a pharmacist or GP first.

  • Women aged 16 to 60 with recurrent, previously diagnosed vaginal thrush
  • Adults with oral thrush (under medical supervision)
  • Those who prefer a single oral dose over topical creams or pessaries
  • People who find topical treatments uncomfortable or inconvenient

It is not suitable for use during pregnancy, breastfeeding, or in children under 16 without a doctor's advice. Women who have had more than two episodes of thrush in the past six months should also consult their GP rather than self-treating.

 

How Does Fluconazole 150mg Compare to Topical Thrush Treatments?

 

Feature Fluconazole 150mg Capsule Clotrimazole Cream / Pessary
Route of administration Oral (swallowed) Topical (applied locally)
Number of doses Single dose 1–7 days depending on strength
Suitable during pregnancy No Yes (with caution — seek advice)
Treats internal infection Yes — systemic action Primarily local/surface action

 

How Should You Store Fluconazole 150mg Capsule?

 

Store your fluconazole 150mg capsule below 30°C in a dry place, away from direct sunlight and moisture. Keep it out of reach and sight of children at all times. Do not use the capsule after the expiry date printed on the packaging — even if it looks unchanged, the medicine may no longer be effective or safe.

If you are managing other aspects of intimate health alongside thrush, you may find it helpful to explore our women's health range for complementary products. Always check with your pharmacist if you are unsure whether any additional products are appropriate for you.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Fluconazole Capsule 150mg specifications
Treatment category Antifungal / Thrush treatment
Mechanism of action Inhibits fungal lanosterol 14-alpha-demethylase, disrupting ergosterol synthesis
Effective against Candida albicans (vaginal thrush, oral thrush)
Suitable for Women aged 16–60 with previously diagnosed vaginal thrush
Active ingredient Fluconazole 150mg
Pack sizes 1 capsule
Strengths 150mg
UK classification Pharmacy (P) medicine
Drug class Triazole antifungal
Preparation Hard capsule
Route of administration Oral

Specifications of Fluconazole Capsule 150mg

 

What Is Fluconazole 150mg Capsule and What Is It Used For?

 

Fluconazole 150mg capsule is an oral antifungal medicine used to treat vaginal thrush (vulvovaginal candidiasis) in women aged 16 to 60. It may also be used under medical supervision to treat oral thrush (oropharyngeal candidiasis). Thrush is caused by an overgrowth of the yeast Candida albicans, which can cause itching, soreness, redness, and a thick white discharge. A single fluconazole 150mg capsule is usually sufficient to clear an uncomplicated episode of vaginal thrush.

 

What Do You Need to Know Before Using Fluconazole 150mg Capsule?

 

Do not take this capsule if any of the following apply to you:

  • You are pregnant or think you might be pregnant
  • You are breastfeeding
  • You are under 16 or over 60 years of age
  • You are allergic to fluconazole or any other azole antifungal medicine
  • You have liver or kidney disease
  • You have a heart rhythm problem (QT prolongation)
  • This is your first ever episode of thrush (seek a confirmed diagnosis first)
  • You have had more than two episodes of thrush in the past six months
  • Your symptoms are different from previous episodes

Fluconazole can interact with a number of other medicines. Tell your pharmacist if you are taking any of the following:

  • Warfarin or other anticoagulants (fluconazole can increase bleeding risk)
  • Terfenadine or astemizole (antihistamines — combination is contraindicated)
  • Rifampicin (reduces fluconazole effectiveness)
  • Phenytoin or carbamazepine (levels may be altered)
  • Ciclosporin or tacrolimus (immunosuppressants — levels may increase)
  • Certain statins such as simvastatin (increased risk of muscle problems)
  • Oral contraceptives (minor interaction — continue as normal but be aware)

 

How Should You Use Fluconazole 150mg Capsule?

 

Always use this medicine exactly as directed by your pharmacist or as described in the patient information leaflet. Do not take more than the recommended dose.

  1. Remove the capsule from its blister pack carefully
  2. Swallow the capsule whole with a full glass of water
  3. You may take it with or without food — it makes no difference to absorption
  4. Take it at any time of day that suits you
  5. One capsule is the complete course for uncomplicated vaginal thrush — do not take a second dose unless advised by a doctor
Indication Age Group Dose Frequency
Vaginal thrush (OTC) Women aged 16–60 150mg (1 capsule) Single dose
Oral thrush Adults (under medical supervision) 50mg daily 7–14 days (prescription only)
Recurrent thrush prevention Adults (under medical supervision) 150mg Once weekly for 6 months (prescription only)

If you are also experiencing symptoms of a urinary tract infection alongside thrush, you may wish to explore our cystitis and bladder infection range, as the two conditions can sometimes occur together.

 

What Are the Possible Side Effects of Fluconazole 150mg Capsule?

 

Like all medicines, fluconazole can cause side effects, although not everyone gets them. Most side effects are mild and resolve on their own.

Common side effects (may affect up to 1 in 10 people):

  • Nausea or feeling sick
  • Headache
  • Stomach pain or discomfort
  • Diarrhoea
  • Indigestion or wind

Less common side effects (may affect up to 1 in 100 people):

  • Dizziness
  • Skin rash or itching
  • Taste disturbance
  • Elevated liver enzymes (detected on blood tests)
  • Muscle pain

Stop taking fluconazole and seek urgent medical attention if you develop a severe skin reaction (blistering, peeling), signs of liver problems (yellowing of the skin or eyes, dark urine, persistent nausea), or an irregular heartbeat. These are rare but serious reactions.

 

How Should You Store Fluconazole 150mg Capsule?

 

  • Store below 30°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused medicines to your pharmacy

For other fungal skin conditions such as athlete's foot, you may find our athlete's foot and fungal infections collection useful, which includes topical antifungal treatments suited to different areas of the body.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy fluconazole 150mg capsule online in the UK?

You can buy Fluconazole 150mg Capsule directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.49. It is available over the counter for women aged 16 to 60 with previously diagnosed vaginal thrush. You can also browse our full thrush treatment range for additional options including creams and pessaries.

How does fluconazole 150mg work in the body?

Fluconazole works by blocking an enzyme called lanosterol 14-alpha-demethylase, which the Candida fungus needs to produce ergosterol — a vital component of its cell membrane. Without ergosterol, the fungal cell membrane breaks down and the infection clears. It is absorbed quickly after swallowing and reaches the site of infection within a few hours.

How do I take fluconazole 150mg capsule step by step?

Taking fluconazole 150mg is straightforward. Simply swallow the single capsule whole with a full glass of water — you can take it with or without food, at any time of day. One capsule is the complete treatment for uncomplicated vaginal thrush; do not take a second dose unless a doctor advises you to.

How long does fluconazole 150mg take to work?

Many women notice an improvement in symptoms such as itching and soreness within 24 hours of taking fluconazole 150mg. Full resolution of symptoms, including discharge, typically occurs within 3 to 7 days. If your symptoms have not improved after 7 days, you should see your GP rather than taking another dose.

What is the best time of day to take fluconazole 150mg?

There is no specific best time of day to take fluconazole 150mg — it can be taken morning, afternoon, or evening, with or without food. The most important thing is that you take the full single dose as soon as you decide to treat your thrush. Consistency with timing is not relevant for a single-dose medicine.

What are the side effects of fluconazole 150mg and how do I manage them?

The most common side effects include nausea, headache, stomach pain, and diarrhoea, which are usually mild and short-lived. Taking the capsule with food may help reduce nausea if you find it bothersome. If you develop a severe skin rash, yellowing of the skin or eyes, or an irregular heartbeat, stop taking it immediately and seek urgent medical attention.

Who is eligible to buy fluconazole 150mg capsule over the counter?

Fluconazole 150mg is available over the counter for women aged 16 to 60 who have previously been diagnosed with vaginal thrush and recognise the same symptoms returning. It is not suitable for first-time sufferers, pregnant or breastfeeding women, or those who have had more than two episodes of thrush in the past six months. A pharmacist will ask you a few short questions before supplying it to ensure it is safe for you.

Can I take fluconazole 150mg if I am pregnant or breastfeeding?

No — fluconazole 150mg should not be taken during pregnancy, as studies have suggested a potential risk of harm to the unborn baby, particularly with repeated doses. It is also not recommended during breastfeeding as fluconazole passes into breast milk. If you are pregnant or breastfeeding and have thrush, speak to your GP or midwife for a safe alternative such as a topical clotrimazole cream.

What happens if I miss a dose of fluconazole 150mg?

Because fluconazole 150mg for vaginal thrush is a single-dose treatment, there is no "missed dose" in the traditional sense — you simply take the one capsule when you are ready. If you are on a longer course prescribed by a doctor and miss a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case skip the missed one. Never double up doses.

Can men use fluconazole 150mg for thrush?

Fluconazole 150mg is licensed over the counter specifically for vaginal thrush in women aged 16 to 60. Men with penile thrush (balanitis caused by Candida) should speak to a pharmacist or GP before using this product, as it is not licensed OTC for men. A doctor may still prescribe it off-label in appropriate cases.

What are the alternatives to fluconazole 150mg for thrush?

The main alternative to fluconazole is clotrimazole, which is available as a cream, pessary, or combination pack applied directly to the affected area. Clotrimazole is suitable during pregnancy (with caution) and works locally rather than systemically. You can explore both options in our women's health collection to find the most suitable treatment for you.

How long can you keep taking fluconazole for recurrent thrush?

For recurrent vaginal thrush (defined as four or more episodes per year), a doctor may prescribe a maintenance course of fluconazole 150mg once weekly for up to six months — but this requires a prescription and medical supervision. Over-the-counter use is limited to a single dose for an uncomplicated episode. If you are experiencing frequent recurrences, please see your GP for a full assessment.

Does fluconazole 150mg interact with the contraceptive pill?

A single dose of fluconazole 150mg is not expected to significantly affect the efficacy of combined oral contraceptives. However, fluconazole can interact with certain medicines including warfarin, terfenadine, and some statins, so always tell your pharmacist about everything you are taking before purchasing. If you are on any long-term medication, it is worth double-checking with a pharmacist or GP.

What is the difference between fluconazole 150mg and clotrimazole for thrush?

Fluconazole 150mg is a single oral capsule that works systemically throughout the body, while clotrimazole is a topical treatment applied directly to the vaginal area as a cream or pessary. Both are clinically effective for uncomplicated vaginal thrush. The choice often comes down to personal preference — some women prefer the convenience of a single swallowed capsule, while others prefer a localised topical approach.

What does the latest research say about fluconazole for thrush treatment?

Fluconazole has been used clinically for decades and remains one of the most well-studied antifungal medicines available. Current NHS guidance confirms it as a first-line treatment for uncomplicated vaginal thrush in non-pregnant women. Ongoing research continues to examine its role in managing recurrent candidiasis and antifungal resistance, though resistance to fluconazole in community-acquired vaginal thrush remains uncommon in the UK.

How Should You Use Fluconazole 150mg Capsule?

Using fluconazole 150mg capsule correctly is simple, but it is important to follow the steps below to ensure the medicine works as intended. Always read the patient information leaflet supplied with your pack before taking the capsule.

If your symptoms do not improve within 7 days of taking the capsule, or if they worsen at any point, stop self-treating and consult your GP. Thrush symptoms can sometimes be caused by other conditions that require different treatment.

What Is the Correct Dose of Fluconazole 150mg Capsule?

For uncomplicated vaginal thrush, the standard over-the-counter dose is a single 150mg capsule taken once. This single dose is clinically sufficient to clear the infection in most women. Do not take additional doses without medical advice, as this medicine is licensed OTC as a one-off treatment only.

When Is the Best Time to Use Fluconazole 150mg Capsule?

There is no specific time of day that is clinically superior for taking fluconazole 150mg — you can take it morning, afternoon, or evening, whichever suits your routine. Because it is a single-dose treatment, timing consistency is not a concern. The most practical advice is to take it as soon as you decide to treat your thrush, so the medicine can begin working promptly.

You do not need to avoid food, alcohol in small amounts, or any particular activities after taking the capsule, though it is sensible to stay well hydrated and avoid anything that might further irritate the affected area while you recover.

How Long Can You Use Fluconazole 150mg Capsule For?

Over-the-counter fluconazole 150mg is intended for a single episode of uncomplicated vaginal thrush — one capsule, one time. It should not be used repeatedly without medical supervision. If you find yourself needing it more than twice in six months, this is a sign that you should see your GP, as recurrent thrush may require investigation and a longer prescribed treatment course.

Long-term or repeated self-treatment without medical review is not recommended, as it may mask an underlying condition or contribute to antifungal resistance over time. Your GP can assess whether a supervised maintenance course is appropriate for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Fluconazole 150mg Capsule?

Most people tolerate fluconazole 150mg well, and side effects from a single dose are generally mild and short-lived. The following common side effects may affect up to 1 in 10 people:

  • Nausea or feeling sick
  • Headache
  • Abdominal pain or stomach discomfort
  • Diarrhoea
  • Flatulence (wind) or indigestion

Taking the capsule with a light meal may help reduce nausea if you find it troublesome. These effects typically resolve within a day or two without any specific treatment.

What Are the Less Common Side Effects of Fluconazole 150mg Capsule?

Less common side effects may affect up to 1 in 100 people. These are not usually serious but are worth being aware of:

  • Dizziness or feeling lightheaded
  • Skin rash or itching unrelated to the thrush itself
  • Altered or unpleasant taste in the mouth
  • Muscle pain or weakness
  • Raised liver enzymes (usually only detected on blood tests)
  • Decreased appetite

If any of these persist or feel particularly uncomfortable, contact your pharmacist for advice. They can help you decide whether you need further assessment.

What Are the Serious Side Effects of Fluconazole 150mg Capsule?

Serious side effects are rare but require immediate medical attention. Stop taking fluconazole and seek urgent help if you experience any of the following:

  • Severe skin reactions such as blistering, peeling, or a widespread rash (possible Stevens-Johnson syndrome)
  • Yellowing of the skin or whites of the eyes (jaundice — a sign of liver problems)
  • Dark urine or pale stools alongside persistent nausea
  • Irregular or fast heartbeat (palpitations)
  • Severe allergic reaction: swelling of the face, lips, tongue, or throat, difficulty breathing

These reactions are uncommon with a single 150mg dose but are more likely in people with pre-existing liver conditions or those taking interacting medicines. Always disclose your full medication list to your pharmacist before purchasing.

What Should You Do If You Experience Side Effects of Fluconazole 150mg?

For mild side effects such as nausea or headache, rest and staying hydrated is usually sufficient. If a side effect is bothering you significantly, contact your pharmacist — they can advise whether you need to seek further medical attention or whether the symptom is expected to resolve on its own. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Never ignore a side effect that feels severe or unusual. When in doubt, it is always safer to seek professional advice promptly rather than waiting to see if it improves.

Can Fluconazole 150mg Interact With Other Medicines?

Yes — fluconazole has a number of clinically significant drug interactions. It inhibits certain liver enzymes (particularly CYP2C9 and CYP3A4), which means it can increase the blood levels of other medicines you may be taking. Key interactions include warfarin (increased bleeding risk), terfenadine and astemizole (risk of serious heart rhythm problems — combination is contraindicated), rifampicin (reduces fluconazole levels), phenytoin, ciclosporin, tacrolimus, and certain statins such as simvastatin. Always tell your pharmacist about every medicine, supplement, or herbal remedy you are taking before using fluconazole.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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