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Flexiseq Gel for Joint Pain – 50g Tube

Flexiseq Gel for Joint Pain – 50g Tube

  • 1. Ozempic®️-equivalent therapy now available for weight management
  • 2. Average weight loss of 17%, with 1 in 3 patients achieving over 20%
  • 3. May help reduce osteoarthritis-related pain
  • 4. Wegovy®️ is not expected to impact the effectiveness of oral contraceptives
  • 5. Supports cardiovascular risk reduction
  • 6. Over 22 million patients treated with semaglutide-based therapies since 2018

  • ✔️ Relieves osteoarthritis joint pain without any drug ingredients
  • ✔️ Lubricates joint cartilage using patented Sequessome vesicle technology
  • ✔️ Suitable for people who cannot tolerate NSAID-based pain relief
  • ✔️ Clinically studied for knee, hip, and hand joint pain relief
  • ✔️ CE-marked medical device for safe, regulated daily use

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Is FlexiSEQ Gel for Joint Pain Right for You?

 

Living with joint pain can make even the simplest daily tasks feel like a challenge. Whether it's stiffness first thing in the morning or an aching knee that slows you down on the stairs, osteoarthritis affects millions of people across the UK. FlexiSEQ gel for joint pain offers a drug-free approach to managing that discomfort — one that works differently from conventional pain relief gels. You can explore our full range of pain relief products at Cured Pharmacy if you're weighing up your options.

FlexiSEQ is a CE-marked medical device, not a medicine, which means it contains no active pharmaceutical ingredients. It's been clinically studied and is available over the counter without a prescription. The 50g tube is a practical size for regular daily use on joints such as the knees, hips, fingers, and ankles.

 

How Does FlexiSEQ Gel Work on Your Joints?

 

FlexiSEQ uses a patented technology called Sequessome vesicles. These are tiny, flexible lipid-based particles — far smaller than a human cell — that are able to penetrate the skin and travel to the joint surface. Once there, they deposit a lubricating layer onto the cartilage, helping to reduce the friction that causes pain and stiffness in osteoarthritic joints.

  • Sequessome vesicles are applied topically and absorbed through the skin
  • They migrate to the joint space and integrate with the synovial fluid
  • A lubricating film is deposited on the cartilage surface
  • Reduced friction leads to less pain and improved joint movement over time

Because there are no drug molecules involved, the mechanism is entirely physical rather than pharmacological. That's a meaningful distinction for people who are sensitive to NSAIDs or who prefer to avoid medication where possible.

 

Who Should Consider Using FlexiSEQ Gel?

 

FlexiSEQ is designed primarily for adults experiencing joint pain associated with osteoarthritis. It's particularly well suited to those who want to manage symptoms without relying on oral or topical anti-inflammatory drugs. That said, it's always worth speaking to your GP or pharmacist before starting any new treatment for joint pain, especially if your symptoms are new or worsening.

  • Adults with mild to moderate osteoarthritis of the knee, hip, or hand joints
  • People who cannot tolerate NSAIDs due to stomach problems, kidney issues, or cardiovascular concerns
  • Those looking for a drug-free complement to their existing pain management plan
  • Individuals who prefer a topical approach over oral medication

 

How Does FlexiSEQ Compare to Other Joint Pain Gels?

 

Feature FlexiSEQ Gel Ibuprofen Gel (e.g. Voltarol)
Active ingredient None (drug-free) Ibuprofen or diclofenac (NSAID)
Mechanism Joint lubrication via Sequessome vesicles Anti-inflammatory action
Suitable for NSAID-intolerant patients Yes No
Long-term daily use Yes, no known restrictions Limited — check PIL for duration

 

Is FlexiSEQ Gel Suitable for Sensitive Skin and How Should It Be Stored?

 

FlexiSEQ gel is generally well tolerated, including by people with sensitive skin. It is fragrance-free and does not contain NSAIDs, steroids, or other pharmaceutical agents that commonly cause skin reactions. If you notice any persistent redness or irritation after application, discontinue use and consult a pharmacist. You might also find it helpful to browse our creams and ointments collection for alternative topical options.

Store the tube below 25°C, away from direct sunlight, and do not freeze. Keep the cap tightly closed when not in use and store out of reach of children. The product should not be used after the expiry date printed on the packaging.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

FlexiSEQ Gel for Joint Pain 50g specifications
Treatment category Joint pain / Osteoarthritis
Mechanism of action Sequessome vesicle technology — topical joint lubrication
Effective for Osteoarthritis joint pain and stiffness
Suitable for Adults 18 years and over
Active ingredient None (drug-free medical device)
Pack size 50g tube
UK classification CE-marked medical device (Class IIa)
Drug class N/A — drug-free
Preparation Topical gel
Route of administration Topical (external use only)

Specifications of FlexiSEQ Gel for Joint Pain 50g

 

What Is FlexiSEQ Gel and What Is It Used For?

 

FlexiSEQ Gel for Joint Pain is a CE-marked, drug-free medical device used to relieve the pain and stiffness associated with osteoarthritis. Osteoarthritis is the most common form of arthritis in the UK, affecting around 8.75 million people according to NHS data. It occurs when the protective cartilage on the ends of your bones gradually wears down, causing pain, swelling, and reduced movement in the affected joint.

Unlike conventional pain relief gels that contain anti-inflammatory drugs, FlexiSEQ works by physically lubricating the joint surface. It is intended for use on peripheral joints such as the knees, hips, fingers, thumbs, and ankles. It is not a cure for osteoarthritis, but regular use can help manage day-to-day symptoms and improve quality of life.

 

What Do You Need to Know Before Using FlexiSEQ Gel?

 

FlexiSEQ is generally safe for most adults, but there are some important points to be aware of before you start using it.

Do not use FlexiSEQ if:

  • You are under 18 years of age
  • You have broken, infected, or inflamed skin at the application site
  • You have a known allergy to any of the ingredients listed in the product leaflet
  • The affected joint is swollen, hot, or red — this may indicate a different condition requiring medical assessment

Warnings and precautions:

  • For external use only — do not swallow or apply near the eyes or mouth
  • If symptoms worsen or do not improve after four weeks of regular use, consult your GP
  • Keep out of reach and sight of children
  • Do not use on the same area as other topical products without pharmacist advice

Drug interactions:

  • No known drug interactions — FlexiSEQ contains no pharmaceutical active ingredients
  • If you are using other topical treatments on the same joint, speak to your pharmacist before combining them

 

How Should You Use FlexiSEQ Gel Correctly?

 

Using FlexiSEQ correctly is important to get the most benefit. Apply it consistently twice a day — missing applications may reduce its effectiveness, as the lubricating layer needs to be maintained over time.

  1. Wash and dry the skin over the affected joint before applying
  2. Squeeze a small amount of gel (approximately 1–2g, roughly the size of a 10p coin) onto your fingertips
  3. Apply the gel directly to the skin over the joint
  4. Massage gently in a circular motion until fully absorbed — this usually takes 1–2 minutes
  5. Wash your hands after application unless the hands themselves are being treated
  6. Allow the gel to absorb fully before covering the area with clothing or bandages
Indication Age Group Dose Frequency
Osteoarthritis joint pain Adults (18+) 1–2g per application Twice daily (morning and evening)
Not recommended Under 18

If you are managing multiple areas of joint discomfort, you may find it useful to explore our vitamins and supplements range, which includes products such as glucosamine and omega-3 that are commonly used alongside topical joint treatments.

 

What Are the Possible Side Effects of FlexiSEQ Gel?

 

FlexiSEQ is very well tolerated by most people. Because it contains no drug ingredients, the risk of systemic side effects is negligible. However, as with any topical product, localised skin reactions can occasionally occur.

Common side effects (may affect up to 1 in 10 users):

  • Mild skin irritation at the application site
  • Temporary redness or warmth of the skin

Less common side effects (may affect up to 1 in 100 users):

  • Itching or a mild rash at the site of application
  • Dry skin following repeated use

If you experience a severe skin reaction, significant swelling, or signs of an allergic response such as difficulty breathing or widespread rash, stop using the product immediately and seek medical attention. These reactions are rare but should be taken seriously.

 

How Should You Store FlexiSEQ Gel?

 

Correct storage helps maintain the integrity of the Sequessome vesicles and ensures the product remains effective throughout its shelf life.

  • Store below 25°C in a cool, dry place
  • Do not freeze or expose to extreme heat
  • Keep away from direct sunlight
  • Replace the cap firmly after each use
  • Do not use after the expiry date printed on the tube and carton
  • Keep out of reach and sight of children
  • Do not store in the bathroom — humidity can affect the product

If you are unsure whether your product has been stored correctly or has passed its expiry date, do not use it. Dispose of unused medicines responsibly — your local pharmacy can accept them for safe disposal. You can also browse our first aid collection for other everyday health essentials.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy FlexiSEQ gel for joint pain online in the UK?

You can buy FlexiSEQ Gel for Joint Pain 50g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy. No prescription is needed — it is available over the counter. Simply add it to your basket and choose your preferred delivery option at checkout.

How does FlexiSEQ gel work on joints?

FlexiSEQ uses Sequessome vesicle technology — microscopic lipid-based particles that penetrate the skin and travel to the joint surface. Once there, they deposit a lubricating layer onto the cartilage, reducing friction and easing pain. The process is entirely physical, with no drug molecules involved.

How do I apply FlexiSEQ gel step by step?

Clean and dry the skin over the affected joint first. Apply approximately 1–2g of gel (about the size of a 10p coin) and massage gently in circular motions until fully absorbed. Repeat this process twice daily — once in the morning and once in the evening — for consistent results.

How long does it take for FlexiSEQ gel to start working?

Many users begin to notice a reduction in joint stiffness and discomfort within two weeks of regular twice-daily use. Clinical studies suggest that continued improvement occurs with consistent use over four weeks. If you see no benefit after four weeks, speak to your GP.

What is the correct dose of FlexiSEQ gel?

The recommended dose is 1–2g per application, applied twice daily to the affected joint. This equates to roughly a 10p coin-sized amount each time. Do not apply more than directed, as this will not increase effectiveness.

Can I use FlexiSEQ gel alongside other medicines?

Because FlexiSEQ contains no active pharmaceutical ingredients, it has no known interactions with oral medicines. If you are already using another topical gel or cream on the same joint, check with your pharmacist before combining them. You can browse our full pain relief range to compare your options.

Who is eligible to use FlexiSEQ gel?

FlexiSEQ is suitable for adults aged 18 and over who experience joint pain associated with osteoarthritis. It is not recommended for children or adolescents under 18. People with broken, infected, or inflamed skin at the application site should not use it until the skin has healed.

Is FlexiSEQ gel safe for long-term use?

Yes — FlexiSEQ is designed for ongoing daily use to maintain joint lubrication over time. There are no known risks associated with long-term topical application, as it contains no pharmaceutical drugs. Many users incorporate it into their daily routine alongside other lifestyle measures recommended by the NHS for osteoarthritis management.

What are the side effects of FlexiSEQ gel?

FlexiSEQ is very well tolerated and serious side effects are rare. Mild skin irritation, temporary redness, or itching at the application site may occasionally occur. If you experience a severe skin reaction or signs of an allergic response, stop using the product and seek medical advice promptly.

How does FlexiSEQ gel compare to ibuprofen gel?

Ibuprofen gel works by reducing inflammation through an NSAID mechanism, whereas FlexiSEQ works by physically lubricating the joint — it contains no drug ingredients at all. This makes FlexiSEQ a suitable option for people who cannot use NSAIDs due to stomach problems, kidney issues, or cardiovascular conditions. The two products work differently and are not directly interchangeable.

Can I use FlexiSEQ gel if I am pregnant or breastfeeding?

There is no specific clinical data on the use of FlexiSEQ during pregnancy or breastfeeding. As a precaution, speak to your GP or midwife before using any new topical product during pregnancy or whilst breastfeeding. Your healthcare professional can advise on the most appropriate pain management approach for your situation.

What happens if I miss an application of FlexiSEQ gel?

If you miss an application, simply apply the gel at your next scheduled time and continue as normal. Do not apply a double dose to make up for a missed one. Consistent twice-daily use is important for maintaining the lubricating layer on the joint surface, so try to build it into your daily routine.

What are the alternatives to FlexiSEQ gel for joint pain?

Alternatives include topical NSAIDs such as ibuprofen or diclofenac gel, oral pain relief such as paracetamol, and lifestyle measures including exercise and weight management as recommended by the NHS. Some people also use vitamins and supplements such as glucosamine or omega-3 fatty acids alongside topical treatments. Speak to your GP or pharmacist to find the most suitable combination for your needs.

How long can I keep using FlexiSEQ gel?

FlexiSEQ can be used continuously as part of your daily joint care routine, as there is no recommended maximum duration of use. However, if your symptoms change significantly, worsen, or do not respond after four weeks of regular use, you should consult your GP. Osteoarthritis management often involves a combination of approaches reviewed over time.

What does the latest research say about FlexiSEQ gel?

Published clinical studies have demonstrated that FlexiSEQ Sequessome vesicle technology can reduce pain and improve function in people with knee osteoarthritis, with results comparable to topical NSAIDs in some trials. The product holds CE marking as a Class IIa medical device, reflecting its evidence base and safety profile. Research into Sequessome technology continues, with ongoing interest in its application across different joint types.

How Should You Use FlexiSEQ Gel?

Using FlexiSEQ correctly makes a real difference to how well it works. The gel needs to be applied consistently and massaged in thoroughly so the Sequessome vesicles can penetrate the skin and reach the joint surface. Skipping applications or applying too little may reduce the benefit you experience over time.

What Is the Correct Dose of FlexiSEQ Gel?

The recommended dose is 1–2g per application, applied twice daily. This is sufficient to deliver an effective concentration of Sequessome vesicles to the joint surface. Applying more than the recommended amount will not increase effectiveness and may simply be wasteful.

When Is the Best Time to Use FlexiSEQ Gel?

Apply FlexiSEQ once in the morning and once in the evening, ideally at roughly the same times each day. Morning application can help ease the stiffness that many people with osteoarthritis experience on waking, while the evening application helps maintain the lubricating layer overnight. Building it into an existing routine — such as after washing your face or brushing your teeth — makes it easier to stay consistent.

Avoid applying immediately before exercise or bathing, as this may reduce absorption. If you do exercise, apply the gel afterwards once the skin has cooled and dried.

How Long Can You Use FlexiSEQ Gel For?

FlexiSEQ can be used continuously as part of your daily joint care routine. There is no maximum recommended duration of use, and many people incorporate it into their long-term osteoarthritis management plan. However, if your symptoms have not improved after four weeks of consistent twice-daily use, or if they worsen at any point, you should speak to your GP for further assessment.

Osteoarthritis is a long-term condition, and managing it well often involves a combination of approaches — including exercise, weight management, and appropriate pain relief — reviewed regularly with your healthcare team.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of FlexiSEQ Gel?

FlexiSEQ is very well tolerated by the vast majority of users. Because it contains no active pharmaceutical ingredients, the risk of systemic side effects — the kind that affect your whole body — is negligible. The most commonly reported reactions are localised to the skin at the application site and are generally mild and short-lived.

  • Mild skin irritation at the site of application
  • Temporary redness or warmth of the skin
  • A slight tingling sensation immediately after application

What Are the Less Common Side Effects of FlexiSEQ Gel?

Less common reactions have been reported in a small number of users. These are not dangerous in most cases, but you should stop using the product if they persist or cause significant discomfort.

  • Itching at the application site
  • A mild localised rash
  • Dry or flaky skin following repeated use in the same area

If any of these reactions continue beyond a few days or worsen with continued use, discontinue the gel and consult your pharmacist or GP. They can help determine whether the reaction is related to FlexiSEQ or another cause.

What Are the Serious Side Effects of FlexiSEQ Gel?

Serious side effects are rare with FlexiSEQ. However, as with any topical product, allergic reactions can occasionally occur. Signs of a serious allergic reaction include widespread rash, significant swelling of the skin, difficulty breathing, or a feeling of faintness. These symptoms require immediate medical attention.

If you suspect you are having a severe allergic reaction, stop using the product immediately, call 999 or go to your nearest A&E department. Do not wait to see if symptoms resolve on their own.

What Should You Do If You Experience Side Effects of FlexiSEQ Gel?

For mild skin reactions, simply stop applying the gel to the affected area and allow the skin to recover. You can report any suspected side effects or adverse reactions to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps regulators monitor the safety of medical devices and medicines in the UK.

If you are unsure whether a symptom is related to FlexiSEQ, your pharmacist is a good first point of contact. They can review your full medication and product history and advise on next steps without the need for a GP appointment.

Can FlexiSEQ Gel Interact With Other Medicines?

FlexiSEQ contains no active pharmaceutical ingredients, so it has no known pharmacological interactions with oral or topical medicines. That said, applying multiple topical products to the same area of skin at the same time is generally not recommended without professional advice, as it may affect absorption or cause localised irritation. If you are using a topical NSAID, steroid cream, or any other gel on the same joint, speak to your pharmacist before combining them.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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