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Fixodent Plus Best Hold Premium Denture Adhesive Cream - 40g

Fixodent Plus Best Hold Premium Denture Adhesive Cream - 40g

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  • ✔️ Provides all-day secure hold for full and partial dentures
  • ✔️ Reduces denture movement during eating and speaking
  • ✔️ Cushions gum tissue to improve daily wearing comfort
  • ✔️ Suitable for both full and partial denture wearers
  • ✔️ Convenient 40g tube for easy, precise daily application

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What Is Fixodent Plus Best Hold Denture Adhesive Cream?

 

If you wear dentures, you'll know how much confidence comes from knowing they'll stay firmly in place throughout the day. Fixodent Plus Best Hold denture adhesive cream is a trusted, over-the-counter product designed to give you exactly that — a secure, comfortable hold from morning to night. Available in a convenient 40g tube, it's one of the most widely recognised denture fixatives available in the UK. You can find it alongside a full range of oral health products at Cured Pharmacy.

Denture wearers often find that even well-fitted dentures can shift slightly over time as the shape of the gums changes. This is completely normal. A reliable adhesive cream can help bridge that gap, reducing movement and the discomfort that comes with it.

 

How Does Fixodent Plus Best Hold Denture Adhesive Cream Work?

 

The mechanism behind this product is straightforward but effective. The cream contains a calcium-zinc salt polymer — specifically a vinyl methyl ether/maleic acid copolymer — that reacts with saliva once the denture is placed in the mouth.

  • The polymer absorbs moisture and swells, filling the space between the denture base and the gum tissue.
  • This creates a firm, cushioning seal that reduces lateral and vertical movement of the denture.
  • The zinc component contributes to the adhesive strength of the bond.
  • The seal remains stable throughout normal eating, drinking, and speaking activities.

It's worth noting that this product is not a substitute for a properly fitted denture. If your dentures feel very loose or uncomfortable, speak to your dentist — adhesive cream works best as a supplement to a good fit, not a replacement for one.

 

Who Should Use Fixodent Plus Best Hold Denture Adhesive Cream?

 

This product is intended for adults who wear full or partial dentures and want additional security and comfort during daily activities. It's particularly useful if you:

  • Notice your dentures shifting when eating or speaking
  • Experience mild gum soreness caused by denture movement
  • Have recently had new dentures fitted and are adjusting to the feel
  • Want added confidence in social situations

It is not suitable for children, and you should not use it if you have known allergies to any of the listed ingredients. If you are unsure whether this product is right for you, a quick conversation with your pharmacist or dentist will help clarify things.

 

How Does Fixodent Plus Best Hold Compare to Other Denture Adhesives?

 

Feature Fixodent Plus Best Hold Denture Adhesive Powder
Form Cream Powder
Ease of application Precise, targeted dots or strips Sprinkled over denture surface
Hold duration All-day hold Variable, often shorter
Suitable for partial dentures Yes Yes

 

Is Fixodent Plus Best Hold Denture Adhesive Cream Suitable for Sensitive Gums?

 

Many people with sensitive gum tissue find that a denture adhesive cream actually helps reduce irritation by minimising the friction and movement that causes soreness in the first place. The cushioning effect of the cream can make wearing dentures more comfortable day to day. That said, if you have a known sensitivity to zinc-containing products or have been advised by a healthcare professional to avoid zinc, you should check the ingredient list carefully before use.

Store the tube below 25°C, away from direct sunlight, and keep it out of reach of children. You'll find this product listed under our dental products collection at Cured Pharmacy.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Fixodent Plus Best Hold Premium Denture Adhesive Cream 40g specifications
Treatment category Dental / Oral Care
Mechanism of action Polymer adhesive forms a cushioning seal between denture and gum tissue
Effective for Securing full and partial dentures
Suitable for Adults wearing full or partial dentures
Active ingredient Calcium-zinc salt of vinyl methyl ether/maleic acid copolymer
Pack size 40g
UK classification General Sale (GSL)
Drug class Denture fixative / adhesive
Preparation Cream
Route of administration Topical (oral)

Specifications of Fixodent Plus Best Hold Premium Denture Adhesive Cream 40g

 

What Is Fixodent Plus Best Hold Denture Adhesive Cream and What Is It Used For?

 

Fixodent Plus Best Hold Denture Adhesive Cream is an over-the-counter topical oral product used to improve the fit, comfort, and stability of full and partial dentures. It is applied directly to the fitting surface of the denture before insertion into the mouth. The cream helps to reduce denture movement during everyday activities such as eating, speaking, and laughing — things that matter enormously to quality of life.

Denture adhesive cream is not a treatment for any medical condition. It is a supportive aid for denture wearers. The NHS advises that dentures should be cleaned daily and removed at night, and that any persistent problems with fit should be assessed by a dentist.

 

What Do You Need to Know Before Using Fixodent Plus Best Hold Denture Adhesive Cream?

 

Before using this product, read the following carefully:

Do not use this product if you:

  • Are allergic to any of the listed ingredients, including zinc-containing compounds
  • Have open sores, ulcers, or wounds in the mouth — seek dental advice first
  • Are under 18 years of age
  • Have been advised by a healthcare professional to avoid zinc

Warnings and precautions:

  • Use only the recommended amount — excessive use may lead to zinc accumulation over time
  • This product does not correct a poorly fitting denture; consult your dentist if your dentures feel very loose
  • If irritation, swelling, or discomfort develops, discontinue use and seek advice
  • Keep out of reach of children

Known drug interactions:

  • No clinically significant drug interactions are currently documented for topical denture adhesive cream used as directed
  • If you have concerns about zinc intake alongside other treatments, speak to your pharmacist

 

How Should You Use Fixodent Plus Best Hold Denture Adhesive Cream?

 

Using the correct technique makes a real difference to how well the product performs. Follow these steps each morning:

  1. Remove your dentures and clean them thoroughly, then dry the fitting surface.
  2. Apply small dots or short strips of cream to the fitting surface — do not spread it all over.
  3. Avoid applying cream too close to the denture edges.
  4. Insert the denture into your mouth and press firmly into position for a few seconds.
  5. Bite down gently and hold for around 5 seconds to allow the adhesive to set.
  6. Avoid eating or drinking for at least 15 minutes after application.
Indication Age Group Amount Frequency
Full denture adhesion Adults Small dots or strips (pea-sized amounts) Once daily, in the morning
Partial denture adhesion Adults Smaller amount than for full dentures Once daily, in the morning

If you find you need to reapply during the day, this may indicate your dentures need refitting. Speak to your dentist. You might also find it helpful to browse our pain relief range if you experience any associated mouth discomfort.

 

What Are the Possible Side Effects of Fixodent Plus Best Hold Denture Adhesive Cream?

 

Side effects from denture adhesive cream are uncommon when the product is used as directed. However, it's important to be aware of what to look out for.

Common side effects:

  • Mild gum irritation at the denture margins
  • Slight taste change in the mouth

Less common side effects:

  • Mouth soreness or sensitivity
  • Allergic reaction (rash, swelling, or itching) — stop use immediately if this occurs
  • Nausea if large amounts are accidentally swallowed

There have been historical reports linking excessive long-term use of zinc-containing denture adhesives with neurological symptoms, but these cases involved far greater quantities than recommended for normal daily use. Using only the advised amount significantly reduces any such risk.

 

How Should You Store Fixodent Plus Best Hold Denture Adhesive Cream?

 

Correct storage keeps the product effective for longer. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Replace the cap firmly after each use
  • Keep out of reach and sight of children
  • Do not use after the expiry date printed on the tube
  • Do not store in the bathroom — humidity can affect the product's consistency

For a broader range of products supporting your everyday health, take a look at our vitamins and supplements collection at Cured Pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Fixodent Plus Best Hold Denture Adhesive Cream online in the UK?

You can buy Fixodent Plus Best Hold Denture Adhesive Cream 40g directly from Cured Pharmacy online for just £3.09, with fast UK delivery. It is available without a prescription as a general sale product. Browse our full range of dental products for more oral care options.

How does Fixodent denture adhesive cream work in the mouth?

The cream contains a calcium-zinc polymer that reacts with saliva once the denture is placed in the mouth. It swells to fill the gap between the denture base and gum tissue, creating a firm cushioning seal. This reduces movement and improves comfort throughout the day.

How do I apply Fixodent Plus Best Hold Denture Adhesive Cream step by step?

Clean and dry your dentures first, then apply small dots or short strips of cream to the fitting surface — avoid the edges. Insert the denture, press firmly, and bite down gently for around five seconds. Wait at least 15 minutes before eating or drinking.

How much Fixodent denture adhesive cream should I use each time?

Use only small, pea-sized dots or short strips — less is more with denture adhesive cream. Using too much can cause the cream to ooze out from under the denture, which is uncomfortable and wasteful. If you feel you need a lot of adhesive to keep your dentures in place, it may be time to see your dentist about the fit.

How long does Fixodent Plus Best Hold last throughout the day?

Fixodent Plus Best Hold is formulated to provide all-day hold with a single morning application. The actual duration can vary depending on your diet, saliva production, and how well your dentures fit. Most users find one application is sufficient for a full day of normal activity.

What are the side effects of using Fixodent denture adhesive cream?

Side effects are uncommon when the product is used as directed. Some people may experience mild gum irritation, a slight change in taste, or mouth soreness. Rarely, an allergic reaction may occur — if you notice swelling, rash, or itching, stop use immediately and seek advice from a pharmacist or GP.

Is it safe to use Fixodent denture adhesive cream every day?

Yes, daily use is safe when you follow the recommended application instructions and use only the advised amount. Remove and clean your dentures thoroughly each night and do not apply fresh adhesive over old residue. If you have concerns about long-term zinc exposure, speak to your pharmacist.

Can I use Fixodent Plus Best Hold with partial dentures?

Yes, this denture adhesive cream is suitable for both full and partial dentures. Use a slightly smaller amount for partial dentures compared to full ones. Always apply to the fitting surface only and avoid getting cream on the natural teeth or gum areas not covered by the denture.

Who is eligible to use Fixodent Plus Best Hold Denture Adhesive Cream?

This product is intended for adults aged 18 and over who wear full or partial dentures. It is not suitable for children, and should not be used by anyone with a known allergy to zinc or other listed ingredients. If you have open mouth sores or ulcers, consult your dentist before use.

What happens if I accidentally swallow Fixodent denture adhesive cream?

Swallowing a small amount of denture adhesive cream during normal use is unlikely to cause harm. However, if a large amount is swallowed — particularly by a child — seek medical advice promptly. Keep the product out of reach of children at all times.

What are the alternatives to Fixodent Plus Best Hold Denture Adhesive Cream?

Alternatives include other denture adhesive creams such as Poligrip and Corega, as well as denture adhesive strips, pads, or powders. The right choice depends on your denture type and personal preference. Your dentist or pharmacist can help you decide which format suits you best.

How do I remove Fixodent denture adhesive cream from my dentures at night?

Remove your dentures and rinse them under warm water to loosen the adhesive. Use a soft-bristled denture brush to gently scrub away any remaining cream. The NHS recommends cleaning dentures daily and soaking them overnight in a denture-cleaning solution.

How do I remove Fixodent adhesive residue from my gums?

After removing your dentures, rinse your mouth with warm water and gently wipe your gums with a damp cloth or soft toothbrush to remove any adhesive residue. Avoid using sharp objects or abrasive materials on your gum tissue. Good daily oral hygiene helps keep your gums healthy under the denture.

How long can you keep using Fixodent Plus Best Hold Denture Adhesive Cream?

There is no set time limit for using denture adhesive cream, provided you use it as directed and maintain good denture hygiene. However, if you find you are relying on increasing amounts to keep your dentures in place, this is a sign that your dentures may need refitting — see your dentist. You can also explore our oral health range for complementary products.

What does the latest research say about zinc in denture adhesive creams?

Historical case reports linked excessive use of zinc-containing denture adhesives with neurological symptoms, but these involved quantities far above normal recommended use. Regulatory bodies including the MHRA have reviewed the evidence and concluded that products used as directed pose no significant risk. Always use only the recommended amount and follow the instructions provided.

How Should You Use Fixodent Plus Best Hold Denture Adhesive Cream?

Before applying the cream, make sure your dentures are clean and completely dry on the fitting surface. Moisture on the denture before application can reduce how well the adhesive bonds, so take a moment to pat the surface dry with a clean cloth or tissue.

What Is the Correct Dose of Fixodent Plus Best Hold Denture Adhesive Cream?

There is no fixed "dose" in the traditional medical sense, but using the right amount is important for both effectiveness and safety. Always use the minimum amount needed to achieve a comfortable hold — more is not better with denture adhesive cream.

When Is the Best Time to Use Fixodent Plus Best Hold Denture Adhesive Cream?

Apply the cream in the morning, after cleaning and drying your dentures, before you start your day. This gives you the benefit of a secure hold throughout your waking hours, covering meals, conversations, and social activities. Do not apply fresh cream over old adhesive residue — always clean your dentures and gums thoroughly before reapplying.

If you find the hold weakening significantly before the end of the day, this is worth mentioning to your dentist, as it may indicate a change in the fit of your dentures rather than a product limitation.

How Long Can You Use Fixodent Plus Best Hold Denture Adhesive Cream For?

This product can be used on an ongoing daily basis as part of your regular denture care routine, provided you use only the recommended amount and maintain good oral hygiene. There is no defined maximum duration of use for correctly applied denture adhesive cream. However, if you notice you are needing more and more product to achieve the same hold, or if your dentures feel increasingly uncomfortable, book an appointment with your dentist to have the fit assessed. Denture adhesive cream is a comfort aid — it works best alongside well-fitting dentures, not as a long-term substitute for proper dental care.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Fixodent Plus Best Hold Denture Adhesive Cream?

Most people use denture adhesive cream without experiencing any side effects, particularly when they follow the application instructions carefully. The most commonly reported issues tend to be mild and localised to the mouth.

  • Mild gum irritation at the denture margins
  • Slight change in taste or a temporary aftertaste
  • Sensation of excess cream in the mouth if too much product is applied

These effects are usually short-lived and often resolve once you adjust the amount of cream you are using. If irritation persists, stop using the product and speak to your pharmacist or dentist.

What Are the Less Common Side Effects of Fixodent Plus Best Hold Denture Adhesive Cream?

Less common side effects are rare but worth being aware of, especially if you are using the product for the first time or have sensitive gum tissue.

  • Mouth soreness or increased sensitivity of the gum tissue
  • Nausea, if a significant amount is accidentally swallowed
  • Dry mouth sensation in some users
  • Difficulty removing the denture cleanly at the end of the day

If any of these effects are persistent or troublesome, reduce the amount of cream you are applying and consult your dentist if the problem continues.

What Are the Serious Side Effects of Fixodent Plus Best Hold Denture Adhesive Cream?

Serious side effects are very uncommon with normal use. However, you should be aware of the following:

  • Allergic reaction — symptoms may include swelling of the lips, tongue, or throat, skin rash, or difficulty breathing. Stop use immediately and seek emergency medical help if this occurs.
  • Neurological symptoms — historical case reports have linked excessive long-term use of zinc-containing denture adhesives with nerve-related symptoms such as numbness or weakness. These cases involved quantities far exceeding normal recommended use. Using only the advised amount significantly reduces any such risk.

If you experience any unusual symptoms that you think may be related to this product, stop use and seek medical advice promptly.

What Should You Do If You Experience Side Effects of Fixodent Plus Best Hold Denture Adhesive Cream?

For mild side effects such as gum irritation or taste changes, try reducing the amount of cream you apply. Ensure you are cleaning your dentures and gums thoroughly each night to remove all adhesive residue before reapplying in the morning. If symptoms do not improve within a few days of reducing the amount used, stop the product and speak to your pharmacist or dentist.

For any signs of an allergic reaction or more serious symptoms, stop use immediately and seek urgent medical attention. You can report suspected side effects to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Fixodent Plus Best Hold Denture Adhesive Cream Interact With Other Medicines?

No clinically significant drug interactions have been documented for this product when used as directed. The active ingredient is applied topically in the mouth and is not intended to be swallowed in meaningful quantities. If you are taking medicines that are affected by zinc levels, or if you use other zinc-containing products, mention this to your pharmacist to ensure your total zinc intake remains within safe limits.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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