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Enstilar Cutaneous Foam 60g For Psoriasis

Enstilar Cutaneous Foam 60g For Psoriasis

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  • ✔️ Treats mild to moderate plaque psoriasis on trunk and limbs
  • ✔️ Dual-action formula targets inflammation and abnormal skin cell growth
  • ✔️ Once-daily foam application for straightforward treatment adherence
  • ✔️ Clinically studied with significant improvement seen within four weeks
  • ✔️ Suitable for adults with psoriasis unresponsive to other topical treatments

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What Is Enstilar Foam Psoriasis Treatment?

 

Psoriasis affects around 1.8 million people in the UK, causing patches of red, flaky, and sometimes itchy skin that can significantly impact daily life. Enstilar foam psoriasis treatment is a prescription-only cutaneous foam that combines two active ingredients — calcipotriol and betamethasone dipropionate — in a single, easy-to-apply formulation. It is licensed for the topical treatment of mild to moderate plaque psoriasis in adults. If you're managing a skin condition and looking for targeted topical options, you may also find our skin care collection useful for complementary products.

Each gram of Enstilar foam contains calcipotriol 50 micrograms and betamethasone dipropionate 0.5 mg. The foam vehicle is designed to spread easily across affected skin, making it particularly practical for larger body surface areas. It is applied once daily and has been studied in clinical trials involving adults with plaque psoriasis on the trunk and limbs.

 

How Does Enstilar Cutaneous Foam Work?

 

The two active ingredients in Enstilar work through distinct but complementary mechanisms to address the key features of plaque psoriasis:

  • Calcipotriol is a synthetic vitamin D analogue. It binds to vitamin D receptors in keratinocytes, slowing the abnormally rapid skin cell turnover that causes the characteristic plaques of psoriasis.
  • Betamethasone dipropionate is a potent corticosteroid. It suppresses the local inflammatory response by inhibiting the release of pro-inflammatory cytokines, reducing redness, swelling, and itching.
  • Together, these two ingredients target both the proliferative and inflammatory components of plaque psoriasis simultaneously.
  • The foam vehicle enhances skin penetration compared to some other formulations, which may contribute to its clinical effectiveness.

 

Who Is Enstilar Foam Suitable For?

 

Enstilar is indicated for adults aged 18 and over with mild to moderate plaque psoriasis affecting the body (trunk and limbs). It is not suitable for use on the face, scalp, or in skin folds. Your prescriber will assess whether it is appropriate for you based on the extent and location of your psoriasis.

Enstilar may be particularly suitable for:

  • Adults with plaque psoriasis on the trunk or limbs who have not responded adequately to other topical treatments
  • Patients who prefer a foam formulation over ointments or gels due to ease of application
  • Those with larger affected areas where spreading a foam is more practical
  • Adults seeking a once-daily treatment to simplify their skincare routine

 

How Does Enstilar Foam Compare to Dovobet Gel?

 

Feature Enstilar Cutaneous Foam 60g Dovobet Gel
Active ingredients Calcipotriol 50 mcg/g + betamethasone 0.5 mg/g Calcipotriol 50 mcg/g + betamethasone 0.5 mg/g
Formulation Cutaneous foam Gel or ointment
Application frequency Once daily Once daily
Licensed area Trunk and limbs Trunk, limbs, and scalp (gel)

 

How Should You Store Enstilar Foam?

 

Enstilar foam is supplied in a pressurised aerosol canister. Store it below 30°C and keep it away from direct sunlight, heat sources, and naked flames — the canister is flammable. Do not puncture or incinerate the container, even when empty. Keep it out of the reach and sight of children.

Once you have started using your canister, it should be used within the treatment course as directed by your prescriber. If you are browsing other topical options, our creams and ointments collection includes a range of dermatological products. This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Enstilar Cutaneous Foam 60g specifications
Treatment category Topical psoriasis treatment
Mechanism of action Vitamin D analogue (calcipotriol) + corticosteroid (betamethasone dipropionate)
Effective for Mild to moderate plaque psoriasis (trunk and limbs)
Suitable for Adults aged 18 and over
Active ingredient Calcipotriol 50 micrograms/g; betamethasone dipropionate 0.5 mg/g
Pack size 60g
UK classification Prescription Only Medicine (POM)
Drug class Vitamin D analogue + topical corticosteroid combination
Preparation Cutaneous foam (pressurised aerosol)
Route of administration Topical (cutaneous)

Specifications of Enstilar Cutaneous Foam 60g

 

What Is Enstilar Cutaneous Foam and What Is It Used For?

 

Enstilar Cutaneous Foam 60g is a prescription topical treatment used in adults to manage mild to moderate plaque psoriasis on the body. Plaque psoriasis is a chronic inflammatory skin condition characterised by raised, red patches covered with silvery scales. The NHS describes psoriasis as a long-lasting condition that tends to go through cycles of flaring and remission. Enstilar addresses both the inflammation and the abnormal skin cell turnover that drive these plaques, making it a dual-action option within the range of topical therapies available.

 

What Do You Need to Know Before Using Enstilar Foam?

 

Before starting Enstilar, your prescriber will review your medical history. There are important contraindications and warnings you should be aware of:

  • Do not use Enstilar if you are allergic to calcipotriol, betamethasone dipropionate, or any other ingredient in the foam
  • Do not apply to the face, scalp, groin, or axillae (armpits)
  • Do not use if you have disorders of calcium metabolism (e.g. hypercalcaemia)
  • Avoid use in patients with viral skin infections (e.g. herpes simplex), bacterial or fungal skin infections, or rosacea
  • Not recommended during pregnancy or breastfeeding unless clearly necessary — discuss with your doctor
  • Do not use in children under 18 years of age
  • Avoid contact with eyes and mucous membranes
  • The foam is flammable — do not use near naked flames or while smoking

Regarding drug interactions, no significant systemic drug interactions have been established for topical use at recommended doses. However:

  • Extensive use over large body surface areas may increase systemic absorption of betamethasone, potentially interacting with other corticosteroids
  • Calcipotriol may increase serum calcium if used excessively — caution with calcium or vitamin D supplements
  • Always inform your prescriber of all medicines, including over-the-counter products and supplements

 

How Should You Use Enstilar Cutaneous Foam?

 

Always use Enstilar exactly as your prescriber has told you. The foam is applied once daily to affected areas on the trunk and limbs only. Follow these steps carefully:

  1. Shake the canister gently before use
  2. Hold the canister upside down and press the nozzle to dispense a small amount of foam onto your fingertips or directly onto the affected skin
  3. Spread the foam gently and evenly over the psoriasis plaques
  4. Wash your hands thoroughly after application (unless your hands are the area being treated)
  5. Allow the foam to absorb before dressing — avoid covering treated areas with occlusive dressings unless directed by your doctor
  6. Do not apply more than the recommended amount — using too much increases the risk of side effects
Indication Age Group Dose Frequency
Mild to moderate plaque psoriasis (trunk and limbs) Adults (18+) Apply a thin layer to affected areas; max 15g per day / 100g per week Once daily for up to 4 weeks
Children under 18 Not applicable Not licensed Do not use

 

What Are the Possible Side Effects of Enstilar Foam?

 

Like all medicines, Enstilar can cause side effects, although not everyone experiences them. If you are also managing other skin concerns, our skin care range includes products that may support your overall skin health alongside prescribed treatments.

Common side effects (may affect up to 1 in 10 people):

  • Skin irritation or burning sensation at the application site
  • Itching (pruritus) at the treated area
  • Folliculitis (inflammation of hair follicles)

Less common side effects (may affect up to 1 in 100 people):

  • Skin thinning (atrophy) with prolonged use
  • Hypercalcaemia (raised blood calcium) if used over large areas or for extended periods
  • Stretch marks (striae) at application sites
  • Worsening of psoriasis or rebound flare on stopping treatment
  • Contact dermatitis

Stop using Enstilar and seek medical advice if you notice signs of hypercalcaemia such as nausea, weakness, or confusion, or if your skin condition worsens significantly.

 

How Should You Store Enstilar Foam?

 

  • Store below 30°C
  • Keep away from direct sunlight and heat sources
  • Do not freeze
  • The canister is pressurised and flammable — never puncture, incinerate, or expose to temperatures above 50°C
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the canister

If you have unused or expired Enstilar foam, return it to your local pharmacy for safe disposal. Do not dispose of it via household waste or down the drain. For other prescription skin treatments and related products, you can explore our creams and ointments collection.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Enstilar foam for psoriasis online in the UK?

You can order Enstilar Cutaneous Foam 60g from Cured Pharmacy, a GPhC-registered online pharmacy in the UK. A valid prescription is required, and our pharmacy team will verify it before dispensing. Simply upload your prescription during checkout and our team will process your order promptly.

How does Enstilar foam work for psoriasis?

Enstilar foam contains two active ingredients that work together to tackle plaque psoriasis. Calcipotriol, a vitamin D analogue, slows the abnormally rapid skin cell turnover that causes plaques, while betamethasone dipropionate, a corticosteroid, reduces the inflammation, redness, and itching. Together they address both the proliferative and inflammatory aspects of the condition simultaneously.

How do I apply Enstilar foam step by step?

Shake the canister, hold it upside down, and dispense a small amount of foam onto your fingertips or directly onto the affected skin on your trunk or limbs. Spread it gently and evenly over the plaques, then wash your hands thoroughly afterwards. Allow the foam to absorb before getting dressed, and avoid covering the area with tight or occlusive dressings unless your doctor has advised otherwise.

How long does it take for Enstilar foam to show results?

Many patients begin to notice an improvement in their psoriasis symptoms within 2 to 4 weeks of once-daily use. Clinical studies have demonstrated significant reductions in plaque severity after a 4-week treatment course. If you see no improvement after 4 weeks, speak to your prescriber before continuing.

What is the correct dose of Enstilar foam for adults?

The recommended dose is a thin layer applied once daily to the affected areas on the trunk and limbs. The maximum daily amount is 15g, and the maximum weekly amount is 100g — exceeding these limits increases the risk of systemic side effects from both calcipotriol and betamethasone. Always follow your prescriber's specific instructions.

Can I use Enstilar foam on my face or scalp?

No — Enstilar foam is not licensed for use on the face, scalp, groin, or armpits. Applying it to these areas significantly increases the risk of skin thinning and other corticosteroid-related side effects due to thinner skin and higher absorption. If you have psoriasis on your scalp, speak to your GP about alternative licensed treatments.

What are the most common side effects of Enstilar foam?

The most commonly reported side effects include skin irritation, a burning or stinging sensation at the application site, itching, and folliculitis (inflammation of hair follicles). These effects are usually mild and tend to settle as your skin adjusts to the treatment. If irritation is severe or persistent, stop using the foam and contact your GP or pharmacist.

Who is not suitable for Enstilar foam treatment?

Enstilar is not suitable for children under 18, people with calcium metabolism disorders such as hypercalcaemia, or those with viral, bacterial, or fungal skin infections at the treatment site. It should also be avoided by anyone with a known allergy to calcipotriol, betamethasone dipropionate, or any other ingredient in the foam. Pregnant or breastfeeding women should discuss the risks with their doctor before use.

What happens if I miss a dose of Enstilar foam?

If you forget to apply Enstilar on a particular day, simply apply it as soon as you remember — unless it is nearly time for your next scheduled application, in which case skip the missed dose entirely. Do not apply a double amount to make up for a missed application. Consistency is important for best results, so try to apply it at the same time each day.

How long can you use Enstilar foam for continuously?

Enstilar foam is typically prescribed for treatment courses of up to 4 weeks. Prolonged continuous use is not recommended without medical supervision, as long-term corticosteroid application can cause skin thinning, stretch marks, and suppression of the adrenal glands. Your prescriber will advise on whether a further course is appropriate after reviewing your response to treatment.

What is the difference between Enstilar foam and Dovobet gel?

Both Enstilar foam and Dovobet gel contain the same active ingredients — calcipotriol and betamethasone dipropionate — at the same concentrations. The key difference is the formulation: Enstilar is a foam that spreads easily over larger or hairier areas of skin, while Dovobet is available as a gel or ointment and the gel formulation is also licensed for scalp psoriasis. Your prescriber will choose the most appropriate formulation based on where your psoriasis is located.

Is Enstilar foam safe to use during pregnancy?

Enstilar foam is not recommended during pregnancy unless your doctor considers it clearly necessary, as the safety of calcipotriol and betamethasone in pregnancy has not been fully established. If you are pregnant, planning a pregnancy, or breastfeeding, always discuss your treatment options with your GP or dermatologist before using any topical corticosteroid. They can help you weigh the potential benefits against any risks.

Can Enstilar foam be used alongside other psoriasis treatments?

Enstilar foam may be used as part of a broader psoriasis management plan, but you should always inform your prescriber of any other topical or systemic treatments you are using. Combining multiple corticosteroid-containing products increases the risk of systemic absorption and side effects. If you are exploring other skin health options, our skin care collection includes a range of supportive products.

What are the alternatives to Enstilar foam for plaque psoriasis?

Alternatives to Enstilar foam include other topical calcipotriol and betamethasone combinations such as Dovobet ointment or gel, as well as standalone topical corticosteroids, coal tar preparations, and dithranol. For more extensive or severe psoriasis, systemic treatments such as methotrexate, ciclosporin, or biologic therapies may be considered by a dermatologist. The right choice depends on the severity and location of your psoriasis.

What are the latest clinical findings on Enstilar foam for psoriasis?

Clinical studies, including the PSO-ABLE trial, have demonstrated that Enstilar foam is effective and well-tolerated for mild to moderate plaque psoriasis, with significant improvements in Physician's Global Assessment scores after 4 weeks of once-daily use. Research has also suggested that the foam vehicle may offer improved skin penetration compared to some other formulations. Always discuss the latest evidence with your dermatologist or GP when considering your treatment options.

How Should You Use Enstilar Cutaneous Foam?

Enstilar foam is applied directly to the affected skin on your trunk and limbs once daily. Always follow your prescriber's instructions carefully, and never apply it to your face, scalp, groin, or armpits. The foam formulation is designed to spread easily, so you only need a small amount to cover each plaque.

What Is the Correct Dose of Enstilar Foam?

The dose of Enstilar foam is determined by the area of skin being treated. There are strict maximum limits to prevent excessive systemic absorption of both calcipotriol and betamethasone. Do not exceed these limits, and always apply the smallest effective amount needed to cover your plaques.

When Is the Best Time to Use Enstilar Foam?

There is no strict requirement to apply Enstilar at a specific time of day, but choosing a consistent time — such as after your evening shower or bath — can help you remember your daily application. Applying to clean, dry skin may also support better absorption. Avoid applying immediately before swimming or bathing, as this will wash the product away before it has had time to work.

If you are using any other topical products on the same area, ask your pharmacist or prescriber about the best order and timing of application to avoid reducing the effectiveness of either product.

How Long Can You Use Enstilar Foam For?

Enstilar foam is intended for short-term treatment courses of up to 4 weeks. After completing a course, your prescriber will review your skin and decide whether a further course is appropriate. Long-term continuous use without breaks is not recommended, as prolonged application of topical corticosteroids can lead to skin thinning, stretch marks, and in rare cases, suppression of the body's natural cortisol production.

If your psoriasis returns after stopping treatment, do not restart Enstilar without speaking to your GP or dermatologist first. They may recommend a different treatment approach or a supervised maintenance regimen.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use Enstilar Cutaneous Foam?

Enstilar foam is applied directly to the affected skin on your trunk and limbs once daily. Always follow your prescriber's instructions carefully, and never apply it to your face, scalp, groin, or armpits. The foam formulation is designed to spread easily, so you only need a small amount to cover each plaque.

What Is the Correct Dose of Enstilar Foam?

The dose of Enstilar foam is determined by the area of skin being treated. There are strict maximum limits to prevent excessive systemic absorption of both calcipotriol and betamethasone. Do not exceed these limits, and always apply the smallest effective amount needed to cover your plaques.

When Is the Best Time to Use Enstilar Foam?

There is no strict requirement to apply Enstilar at a specific time of day, but choosing a consistent time — such as after your evening shower or bath — can help you remember your daily application. Applying to clean, dry skin may also support better absorption. Avoid applying immediately before swimming or bathing, as this will wash the product away before it has had time to work.

If you are using any other topical products on the same area, ask your pharmacist or prescriber about the best order and timing of application to avoid reducing the effectiveness of either product.

How Long Can You Use Enstilar Foam For?

Enstilar foam is intended for short-term treatment courses of up to 4 weeks. After completing a course, your prescriber will review your skin and decide whether a further course is appropriate. Long-term continuous use without breaks is not recommended, as prolonged application of topical corticosteroids can lead to skin thinning, stretch marks, and in rare cases, suppression of the body's natural cortisol production.

If your psoriasis returns after stopping treatment, do not restart Enstilar without speaking to your GP or dermatologist first. They may recommend a different treatment approach or a supervised maintenance regimen.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Enstilar Foam?

As with any topical medicine, Enstilar foam can cause side effects at the application site. Most are mild and tend to improve as your skin adjusts to the treatment. If any of the following persist or become bothersome, speak to your pharmacist or GP.

  • Skin irritation or a burning sensation at the treated area
  • Itching (pruritus) at or around the application site
  • Folliculitis — inflammation or infection of the hair follicles, appearing as small red bumps
  • Dry or flaking skin at the treated site

What Are the Less Common Side Effects of Enstilar Foam?

Less common side effects are more likely to occur if Enstilar is used over large areas of skin, applied under occlusive dressings, or used for longer than the recommended 4-week course. These effects are related to the systemic absorption of betamethasone dipropionate and calcipotriol.

  • Skin thinning (cutaneous atrophy) at the application site
  • Stretch marks (striae) developing at treated areas
  • Hypercalcaemia — raised blood calcium levels, which may cause nausea, fatigue, confusion, or muscle weakness
  • Contact dermatitis — an allergic or irritant skin reaction
  • Worsening or rebound flare of psoriasis on stopping treatment
  • Telangiectasia — small, visible blood vessels appearing near the skin surface

What Are the Serious Side Effects of Enstilar Foam?

Serious side effects from Enstilar are uncommon when the product is used correctly and within the recommended dose limits. However, you should seek urgent medical attention if you experience any of the following, as they may indicate significant systemic absorption of betamethasone or calcipotriol.

Signs of adrenal suppression — such as unexplained weight loss, persistent fatigue, dizziness, or low blood pressure — require immediate medical review. Symptoms of hypercalcaemia, including nausea, vomiting, constipation, excessive thirst, or confusion, should also be reported to your GP without delay. Stop using Enstilar and seek advice if your psoriasis worsens significantly or spreads to new areas.

What Should You Do If You Experience Side Effects?

If you notice mild irritation or itching, this often settles within the first few days of use. Reducing the amount of foam applied or spacing applications slightly further apart (with your prescriber's agreement) may help. Do not apply the foam more frequently than once daily in an attempt to speed up results — this will not improve outcomes and increases the risk of side effects.

For any side effect that is severe, unexpected, or does not resolve, stop using Enstilar and contact your GP or pharmacist. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Enstilar Foam Interact With Other Medicines?

At recommended doses, Enstilar foam is unlikely to cause significant drug interactions because systemic absorption is low. However, using Enstilar alongside other topical or oral corticosteroids may increase the total corticosteroid load on your body, raising the risk of adrenal suppression. Similarly, using calcipotriol alongside calcium or vitamin D supplements may increase the risk of hypercalcaemia. Always tell your prescriber and pharmacist about every medicine, supplement, or topical product you are currently using.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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