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EMLA Cream 5% - 5g

EMLA Cream 5% - 5g

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  • ✔️ Numbs skin effectively before blood tests and injections
  • ✔️ Contains lidocaine and prilocaine for dual anaesthetic action
  • ✔️ Suitable for adults and children aged 1 year and over
  • ✔️ Numbing effect lasts up to 2 hours after cream removal
  • ✔️ Works within 60 minutes for most needle procedures

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What Is EMLA Cream Numbing and How Does It Help?

 

If needles make you anxious — and you're far from alone in that — EMLA cream numbing could make a real difference. EMLA Cream 5% is a topical local anaesthetic that temporarily desensitises the skin before minor procedures such as blood tests, cannula insertion, or vaccinations. It contains two active ingredients: lidocaine 2.5% and prilocaine 2.5%, both well-established local anaesthetics used widely across NHS settings. At just £3.79 for a 5g tube, it's an accessible option for adults and children alike who want to reduce discomfort before a needle procedure. You can browse our full range of pain relief products if you're looking for additional comfort solutions.

EMLA is a licensed, over-the-counter medicine in the UK, meaning you don't need a prescription to purchase it. It's been used clinically for decades and is recommended by healthcare professionals for reducing procedural pain in both adults and children aged 1 year and over.

 

How Does EMLA Cream Work on the Skin?

 

EMLA works by penetrating the outer layers of the skin and temporarily blocking the sodium channels in nerve endings. This interrupts the transmission of pain signals to the brain — so when the needle goes in, you feel significantly less (or nothing at all).

  • Lidocaine and prilocaine diffuse through intact skin into the dermis
  • They stabilise neuronal membranes by inhibiting sodium ion influx
  • Pain signal transmission is blocked at the local nerve level
  • The effect is temporary and fully reversible once the cream is removed

The cream must be applied under an occlusive dressing (such as the Tegaderm patch sometimes included in packs) to allow proper absorption. Without occlusion, the active ingredients won't penetrate deeply enough to be effective.

 

Who Should Use EMLA Cream 5%?

 

EMLA Cream is suitable for a wide range of people who need to reduce skin sensitivity before a procedure. It's particularly useful if you have needle phobia, are preparing a child for a vaccination, or simply want to make a blood test more comfortable.

  • Adults and children aged 1 year and over undergoing needle procedures
  • Patients with needle anxiety or phobia
  • People having minor skin procedures such as laser treatment or superficial surgery
  • Individuals with diabetes who require frequent blood tests or insulin injections

It is not suitable for use on broken or inflamed skin, near the eyes, or on mucous membranes. People with known hypersensitivity to amide-type local anaesthetics should avoid it. Always check the full list of contraindications before use.

 

How Does EMLA Cream Compare to Other Numbing Creams?

 

Feature EMLA Cream 5% Ametop Gel 4%
Active ingredient(s) Lidocaine 2.5% + Prilocaine 2.5% Tetracaine 4%
Application time needed 60–120 minutes 30–45 minutes
Suitable for neonates No (not under 37 weeks gestation) Yes (from 1 month)
OTC availability in UK Yes Yes

 

Is EMLA Cream Safe to Store at Home?

 

Yes — EMLA Cream is straightforward to store. Keep it below 25°C and do not freeze it. The tube should be kept tightly closed when not in use, and stored out of the sight and reach of children. Once opened, use within the period indicated on the packaging. If you're managing a condition that requires regular procedures, it's worth keeping a tube in your medicine cabinet alongside other first aid essentials.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

EMLA Cream 5% - 5g specifications
Treatment category Topical local anaesthesia
Mechanism of action Sodium channel blockade in peripheral nerve endings
Effective 60–120 minutes after application
Suitable for Adults and children aged 1 year and over
Active ingredient Lidocaine 2.5%, Prilocaine 2.5%
Pack sizes 5g
Strengths 5% (lidocaine 25mg/g + prilocaine 25mg/g)
UK classification Pharmacy (P) medicine
Drug class Amide-type local anaesthetic
Preparation Cream
Route of administration Topical (intact skin only)

Specifications of EMLA Cream 5% - 5g

 

What Is EMLA Cream 5% and What Is It Used For?

 

EMLA Cream 5% is a topical local anaesthetic containing lidocaine 2.5% and prilocaine 2.5%. It is applied to intact skin to produce surface numbness before minor painful procedures. Common uses include preparation for venepuncture (blood tests), intravenous cannulation, vaccination, and superficial skin surgery. It is also used before certain dermatological procedures such as laser hair removal or curettage of minor skin lesions. EMLA cream numbing is well established in both adult and paediatric clinical practice across the NHS.

 

What Do You Need to Know Before Using EMLA Cream 5%?

 

Before applying EMLA Cream, it's important to check whether it is appropriate for you. Do not use it if any of the following apply:

  • You are allergic to lidocaine, prilocaine, or any other amide-type local anaesthetic
  • You have congenital or idiopathic methaemoglobinaemia
  • You are applying it to broken, damaged, or infected skin
  • You are applying it near the eyes or on mucous membranes
  • The patient is a premature infant or neonate under 37 weeks gestational age
  • Infants under 12 months who are receiving treatment with methaemoglobin-inducing agents

The following medicines may interact with EMLA Cream and should be discussed with your pharmacist or GP before use:

  • Class I antiarrhythmic drugs (e.g. mexiletine, tocainide) — risk of additive cardiac effects
  • Other local anaesthetics — additive systemic toxicity possible
  • Sulphonamides, dapsone, nitrofurantoin — may increase risk of methaemoglobinaemia, particularly in children
  • Cimetidine and beta-blockers — may reduce clearance of lidocaine

 

How Should You Use EMLA Cream 5%?

 

Using EMLA Cream correctly is key to getting the numbing effect you need. Follow these steps carefully:

  1. Identify the area of intact skin where the procedure will take place
  2. Apply a thick layer of EMLA Cream — approximately 1.5–2g per 10cm² of skin
  3. Cover the cream with an occlusive dressing (such as a Tegaderm film) to prevent evaporation
  4. Leave in place for at least 60 minutes for needle procedures; up to 2 hours for deeper anaesthesia
  5. Remove the dressing and wipe away the cream immediately before the procedure
  6. The skin should appear pale — this is normal and expected
Indication Age Group Dose Application Time
Venepuncture / cannulation Adults 1.5–2g per site 60 minutes minimum
Venepuncture / cannulation Children 1–12 years 1–2g per site 60 minutes minimum
Minor skin procedures Adults 1.5–2g per 10cm² 120 minutes
Vaccination Children 1 year+ 1g per site 60 minutes

If you're using EMLA Cream to help a child through a vaccination or blood test, it can be reassuring to know that the NHS recommends topical anaesthetics as a safe and effective way to reduce procedural pain in children. You might also find our baby and toddler health range helpful for other child health essentials.

 

What Are the Possible Side Effects of EMLA Cream 5%?

 

Like all medicines, EMLA Cream can cause side effects, although not everyone experiences them. Most side effects are mild, local, and temporary.

Common side effects (may affect up to 1 in 10 people):

  • Temporary paleness (blanching) of the skin at the application site
  • Redness (erythema) after the cream is removed
  • Mild swelling or oedema at the site
  • Mild burning or itching sensation during application

Less common side effects (may affect up to 1 in 100 people):

  • Small areas of bruising (petechiae) at the application site, particularly in children
  • Methaemoglobinaemia — a rare but serious condition where blood carries less oxygen; more likely in infants or with prolonged use
  • Allergic skin reactions such as contact dermatitis
  • Systemic effects (e.g. dizziness, headache) if large amounts are absorbed — very rare with correct use

If you notice any signs of a serious allergic reaction — such as swelling of the face, difficulty breathing, or a widespread rash — seek emergency medical attention immediately.

 

How Should You Store EMLA Cream 5%?

 

Correct storage keeps the cream effective and safe to use. Follow these guidelines:

  • Store below 25°C — do not refrigerate or freeze
  • Keep the tube tightly closed after each use
  • Store out of the sight and reach of children
  • Do not use after the expiry date printed on the tube or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacist

For other topical treatments and skin preparations, explore our creams and ointments collection at Cured Pharmacy.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy EMLA Cream 5% online in the UK?

You can buy EMLA Cream 5% 5g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £3.79. It is available without a prescription as a Pharmacy (P) medicine. Simply add it to your basket and it will be dispatched promptly to your door.

How does EMLA Cream work in the body?

EMLA Cream contains lidocaine and prilocaine, two amide-type local anaesthetics that penetrate intact skin and block sodium channels in nearby nerve endings. This stops pain signals from travelling to the brain, producing temporary numbness at the application site. The effect is entirely local and reversible once the cream is removed.

How do I use EMLA Cream step by step?

Using EMLA Cream correctly ensures the best numbing effect. Follow these steps:

  1. Apply a thick layer to clean, intact skin at the procedure site
  2. Cover with an occlusive dressing and leave for at least 60 minutes
  3. Remove the dressing and wipe away the cream just before the procedure
How long before a blood test or injection should I apply EMLA Cream?

For most needle procedures such as blood tests or vaccinations, EMLA Cream should be applied at least 60 minutes beforehand. For deeper procedures or minor skin surgery, up to 2 hours of application time is recommended. Applying it too late will reduce its effectiveness significantly.

How long does the numbing effect of EMLA Cream last?

After removing the cream and dressing, the numbing effect typically lasts for 1 to 2 hours. The exact duration depends on how long the cream was applied and the individual's skin type. Plan your procedure to take place within this window for maximum benefit.

Can children use EMLA Cream 5%?

Yes, EMLA Cream can be used in children aged 1 year and over. It is not suitable for premature infants or neonates under 37 weeks gestational age due to the risk of methaemoglobinaemia. Always follow age-appropriate dosing guidance and consult a pharmacist or GP if you are unsure. You can find other child health products in our baby and toddler range.

What are the common side effects of EMLA Cream?

The most common side effects are local skin reactions at the application site, including temporary paleness, redness, mild swelling, or a slight burning sensation. These are generally harmless and resolve on their own shortly after the cream is removed. Serious side effects are rare when the cream is used as directed.

How do I manage side effects of EMLA Cream?

Most side effects such as redness or paleness at the application site require no treatment and resolve within an hour or two. If you notice signs of an allergic reaction — such as widespread rash, swelling, or difficulty breathing — remove the cream immediately and seek urgent medical attention. Always use the minimum effective amount to reduce the risk of systemic absorption.

Can I use EMLA Cream on my face or broken skin?

EMLA Cream must only be applied to intact, unbroken skin. It should not be used near the eyes, on mucous membranes, or on damaged, inflamed, or infected skin. If you are unsure whether a particular area is suitable, speak to your pharmacist before applying.

Who is not eligible to use EMLA Cream?

EMLA Cream is not suitable for people with a known allergy to lidocaine, prilocaine, or other amide-type local anaesthetics. It should also be avoided in those with congenital or idiopathic methaemoglobinaemia, and in premature infants. Infants under 12 months taking methaemoglobin-inducing medicines should not use EMLA without medical supervision.

What happens if I leave EMLA Cream on for too long?

Leaving EMLA Cream on for longer than recommended increases the risk of systemic absorption of lidocaine and prilocaine, which can cause side effects such as dizziness or, in rare cases, methaemoglobinaemia. Always follow the recommended application times and do not exceed the stated dose. If you accidentally leave it on for significantly longer, remove it and contact your pharmacist for advice.

What are the alternatives to EMLA Cream for numbing skin?

The main alternative available in the UK is Ametop Gel (tetracaine 4%), which works faster — typically within 30 to 45 minutes — but is not suitable for neonates under 1 month. Ice packs or cooling sprays are sometimes used but provide less reliable anaesthesia. For a broader range of topical treatments, browse our creams and ointments collection.

Can I use EMLA Cream before laser hair removal or tattooing?

EMLA Cream is sometimes used before cosmetic procedures such as laser hair removal or superficial skin treatments to reduce discomfort. However, it is not licensed for use before tattooing, and some practitioners advise against it as it may affect skin texture. Always check with your practitioner before applying EMLA Cream ahead of any cosmetic procedure.

Does EMLA Cream interact with any other medicines?

Yes, EMLA Cream can interact with certain medicines. Class I antiarrhythmic drugs (such as mexiletine), other local anaesthetics, and medicines that can cause methaemoglobinaemia (such as dapsone or sulphonamides) may interact with EMLA. Always inform your pharmacist of all medicines you are taking before using EMLA Cream.

What are the latest clinical findings on EMLA Cream numbing effectiveness?

EMLA Cream has been studied extensively over several decades and remains one of the most widely validated topical anaesthetics in clinical use. Research consistently supports its effectiveness in reducing pain from venepuncture and minor procedures in both adults and children. It continues to be recommended in NHS clinical guidelines for procedural pain management.

How Should You Use EMLA Cream 5%?

Applying EMLA Cream correctly is essential to achieve adequate skin numbing before your procedure. Always apply it to clean, dry, intact skin — never on broken, inflamed, or infected areas. The cream must be covered with an occlusive dressing to allow the active ingredients to penetrate the skin properly.

What Is the Correct Dose of EMLA Cream 5%?

The correct dose depends on the type of procedure and the age of the patient. Do not apply more cream than recommended, as excessive amounts increase the risk of systemic absorption. Use the table below as a guide.

When Is the Best Time to Use EMLA Cream 5%?

Timing is everything with EMLA Cream. For standard needle procedures such as blood tests or injections, apply the cream at least 60 minutes before your appointment. If you are having a deeper procedure or minor skin surgery, apply it up to 2 hours beforehand to ensure adequate depth of anaesthesia. Plan ahead — applying it too close to the procedure time will reduce its effectiveness.

Remove the cream and dressing immediately before the procedure begins. The numbing effect will last for approximately 1 to 2 hours after removal, so try to time your application so the procedure falls within this window.

How Long Can You Use EMLA Cream 5% For?

EMLA Cream is intended for single-use application before individual procedures. It is not designed for continuous or daily long-term use. If you require repeated procedures over time — for example, regular blood tests or insulin injections — you may use EMLA Cream each time, but always follow the recommended dose and application time for each individual use.

If you find you are needing to use EMLA Cream very frequently, it is worth speaking to your GP or pharmacist to discuss your situation. Prolonged or excessive use increases the risk of systemic absorption of lidocaine and prilocaine, which can cause unwanted effects.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

How Should You Use EMLA Cream 5%?

Applying EMLA Cream correctly is essential to achieve adequate skin numbing before your procedure. Always apply it to clean, dry, intact skin — never on broken, inflamed, or infected areas. The cream must be covered with an occlusive dressing to allow the active ingredients to penetrate the skin properly.

What Is the Correct Dose of EMLA Cream 5%?

The correct dose depends on the type of procedure and the age of the patient. Do not apply more cream than recommended, as excessive amounts increase the risk of systemic absorption. Use the table below as a guide.

When Is the Best Time to Use EMLA Cream 5%?

Timing is everything with EMLA Cream. For standard needle procedures such as blood tests or injections, apply the cream at least 60 minutes before your appointment. If you are having a deeper procedure or minor skin surgery, apply it up to 2 hours beforehand to ensure adequate depth of anaesthesia. Plan ahead — applying it too close to the procedure time will reduce its effectiveness.

Remove the cream and dressing immediately before the procedure begins. The numbing effect will last for approximately 1 to 2 hours after removal, so try to time your application so the procedure falls within this window.

How Long Can You Use EMLA Cream 5% For?

EMLA Cream is intended for single-use application before individual procedures. It is not designed for continuous or daily long-term use. If you require repeated procedures over time — for example, regular blood tests or insulin injections — you may use EMLA Cream each time, but always follow the recommended dose and application time for each individual use.

If you find you are needing to use EMLA Cream very frequently, it is worth speaking to your GP or pharmacist to discuss your situation. Prolonged or excessive use increases the risk of systemic absorption of lidocaine and prilocaine, which can cause unwanted effects.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of EMLA Cream 5%?

Most people who use EMLA Cream experience only mild, local side effects at the application site. These are generally short-lived and resolve on their own once the cream is removed. They are not a sign that anything has gone seriously wrong.

  • Temporary paleness (blanching) of the skin
  • Redness (erythema) after the cream is wiped away
  • Mild swelling or puffiness at the site
  • Slight burning or itching sensation during application

What Are the Less Common Side Effects of EMLA Cream 5%?

Less common side effects occur in a small number of people and are more likely if the cream is used incorrectly, applied to large areas, or left on for longer than recommended. If you notice any of the following, remove the cream and seek advice from your pharmacist or GP.

  • Small bruise-like spots (petechiae) at the application site, particularly in children
  • Contact dermatitis or allergic skin reaction
  • Methaemoglobinaemia — a rare condition where the blood carries less oxygen; more likely in infants or with excessive use
  • Mild dizziness or headache if significant systemic absorption occurs

What Are the Serious Side Effects of EMLA Cream 5%?

Serious side effects from EMLA Cream are rare when it is used as directed on intact skin in appropriate amounts. However, you should be aware of the signs of a serious allergic reaction (anaphylaxis), which can include swelling of the face, lips, or throat, difficulty breathing, a widespread rash, or a sudden drop in blood pressure. Methaemoglobinaemia, though uncommon, is a serious condition that can cause the skin to appear bluish (cyanosis), shortness of breath, and fatigue — particularly in young infants or when the cream is misused.

If you suspect a serious reaction, remove the cream immediately and call 999 or go to your nearest A&E department without delay.

What Should You Do If You Experience Side Effects of EMLA Cream?

For mild local reactions such as redness or paleness, no specific treatment is needed — simply remove the cream and allow the skin to recover naturally. Avoid rubbing the area vigorously. If you experience any unusual symptoms beyond the expected local effects, or if a child appears unwell after application, contact your pharmacist or GP promptly. Always use the smallest effective amount of cream and adhere strictly to the recommended application times to minimise risk.

Can EMLA Cream Interact With Other Medicines?

Yes, EMLA Cream can interact with certain medicines, particularly those that affect the heart's electrical system or that increase the risk of methaemoglobinaemia. Tell your pharmacist about all medicines you are taking before using EMLA Cream, including prescription and over-the-counter treatments.

  • Class I antiarrhythmic drugs (e.g. mexiletine, tocainide) — additive cardiac effects possible
  • Other local anaesthetics — risk of additive systemic toxicity
  • Sulphonamides, dapsone, nitrofurantoin — increased risk of methaemoglobinaemia, especially in children
  • Cimetidine and beta-blockers — may slow the breakdown of lidocaine in the body

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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