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Drapolene Cream Tube 100g

Drapolene Cream Tube 100g

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  • ✔️ Treats and prevents nappy rash with dual antiseptic action
  • ✔️ Contains benzalkonium chloride and cetrimide to fight bacteria
  • ✔️ Forms a protective skin barrier against urine and faeces
  • ✔️ Suitable for babies from birth, including sensitive newborn skin
  • ✔️ Gentle emollient base soothes and conditions irritated skin

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What Is Drapolene Cream for Nappy Rash?

 

If you've ever watched your baby squirm during a nappy change, you'll know how distressing nappy rash can be — for both of you. Drapolene cream nappy rash treatment is a well-established, over-the-counter barrier cream that has been trusted by parents in the UK for decades. Available in a convenient 100g tube, it works to both prevent and treat the soreness, redness, and irritation that nappy rash causes on delicate baby skin. You can find it alongside other trusted baby and toddler products at Cured Pharmacy, priced at just £4.78.

Nappy rash is extremely common. The NHS estimates that most babies will experience it at some point, typically caused by prolonged contact with urine or faeces, friction, or sensitivity to certain products. Drapolene Cream addresses this directly with a dual-action formula — antiseptic and barrier protection in one.

 

How Does Drapolene Cream Work?

 

Drapolene Cream contains two active ingredients that work together to protect and heal the skin:

  • Benzalkonium chloride 0.01% — a quaternary ammonium antiseptic that helps prevent bacterial infection in broken or irritated skin.
  • Cetrimide 0.2% — another antiseptic agent that also has mild cleansing properties, helping to keep the nappy area hygienic.
  • The cream base itself forms a physical barrier on the skin surface, reducing direct contact between the skin and moisture from urine or faeces.
  • Together, these ingredients help soothe existing irritation while reducing the risk of secondary infection.

It's worth noting that the cream's emollient base also helps to soften and condition the skin, which supports the natural healing process. It doesn't just mask the problem — it actively creates the conditions the skin needs to recover.

 

Who Should Use Drapolene Cream?

 

Drapolene Cream is designed primarily for babies and infants, but it can also be used by adults experiencing skin irritation in areas prone to moisture and friction. It's suitable for:

  • Babies and infants with nappy rash, from newborn age onwards
  • Babies prone to recurrent nappy rash who need a preventative barrier at each change
  • Adults with incontinence-related skin irritation
  • Anyone with minor skin soreness caused by friction or prolonged moisture exposure

It is not suitable for use on infected skin where a prescription treatment may be required, or for individuals with a known allergy to benzalkonium chloride, cetrimide, or any other ingredient in the formulation. Always check the full ingredient list before use.

 

How Does Drapolene Cream Compare to Other Nappy Rash Creams?

 

Feature Drapolene Cream 100g Sudocrem Antiseptic Healing Cream
Active ingredient Benzalkonium chloride 0.01%, Cetrimide 0.2% Zinc oxide 15.25%
Antiseptic action Yes Yes (mild)
Barrier protection Yes Yes
Suitable from birth Yes Yes

 

Is Drapolene Cream Safe to Store and Use Long-Term?

 

Drapolene cream nappy rash treatment should be stored below 25°C, away from direct sunlight and out of reach of children. Once opened, check the expiry date on the tube and do not use beyond it. The 100g tube is a practical size — large enough for regular use but easy to keep in a changing bag. If you're also managing other skin concerns, you might find our skin care range useful for the wider family.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Drapolene Cream Tube 100g specifications
Treatment category Nappy rash / Skin barrier protection
Mechanism of action Antiseptic barrier cream — forms protective layer, prevents bacterial infection
Effective for Nappy rash prevention and treatment, minor skin irritation
Suitable for Babies from birth, infants, adults with incontinence-related skin irritation
Active ingredient Benzalkonium chloride 0.01%, Cetrimide 0.2%
Pack size 100g tube
UK classification General Sale List (GSL)
Drug class Antiseptic / Barrier cream
Preparation Cream
Route of administration Topical (cutaneous)

Specifications of Drapolene Cream Tube 100g

 

What Is Drapolene Cream and What Is It Used For?

 

Drapolene Cream is a topical antiseptic barrier cream used to prevent and treat nappy rash in babies and infants. It contains two active antiseptic ingredients — benzalkonium chloride and cetrimide — suspended in an emollient cream base. The cream is applied directly to the nappy area to create a protective layer between the skin and irritants such as urine and faeces. It can also be used by adults experiencing skin soreness due to incontinence or prolonged moisture exposure.

Nappy rash typically appears as red, sore, or inflamed skin in the nappy area. It is one of the most common skin conditions in babies, and the NHS advises that keeping the area clean, dry, and protected with a barrier cream is the cornerstone of both prevention and treatment.

 

What Do You Need to Know Before Using Drapolene Cream?

 

Before applying Drapolene Cream, read the following carefully. Do not use this product if any of the contraindications below apply:

  • Do not use if your baby or you are allergic to benzalkonium chloride, cetrimide, or any other ingredient listed on the packaging
  • Do not apply to infected skin — if the rash looks weepy, crusted, or is spreading rapidly, seek medical advice before using any OTC cream
  • Avoid contact with the eyes
  • Do not use on broken or severely damaged skin without first consulting a pharmacist or GP
  • If the rash does not improve within a few days of treatment, stop use and seek professional advice

Regarding drug interactions, Drapolene Cream is applied topically and is not known to interact with other medicines when used as directed. However:

  • Avoid using alongside other topical antiseptics or medicated creams on the same area without pharmacist guidance
  • If your baby is using a prescribed topical steroid or antifungal cream, consult your GP or pharmacist before combining with Drapolene

 

How Should You Use Drapolene Cream?

 

Using Drapolene Cream correctly makes a real difference to how quickly the skin recovers. Follow these steps at every nappy change:

  1. Remove the soiled nappy and dispose of it safely
  2. Gently clean the entire nappy area with warm water and cotton wool, or fragrance-free baby wipes
  3. Pat the skin completely dry — do not rub, as this can worsen irritation
  4. Apply a thin, even layer of Drapolene Cream to the affected or at-risk area
  5. Put on a clean, fresh nappy
  6. Repeat at every nappy change until the rash has resolved, then continue as a preventative measure
Indication Age Group Dose Frequency
Nappy rash treatment Babies and infants (from birth) Thin layer to affected area At every nappy change
Nappy rash prevention Babies and infants (from birth) Thin layer to nappy area At every nappy change
Incontinence-related skin irritation Adults Thin layer to affected area As required, after cleaning and drying

 

What Are the Possible Side Effects of Drapolene Cream?

 

Drapolene Cream is generally well tolerated. Side effects are uncommon, but as with any topical product, some individuals may experience a reaction. You'll find a range of creams and ointments at Cured Pharmacy if you need an alternative formulation.

Common side effects (may affect a small number of users):

  • Mild skin redness at the application site
  • Temporary stinging or tingling sensation on application

Less common side effects (rare, but stop use if these occur):

  • Allergic contact dermatitis — increased redness, swelling, or blistering
  • Worsening of skin irritation rather than improvement
  • Rash spreading beyond the original area

If you notice any signs of a serious allergic reaction — such as swelling of the face, difficulty breathing, or widespread hives — seek emergency medical attention immediately.

 

How Should You Store Drapolene Cream?

 

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacist

Proper storage helps maintain the integrity of the active ingredients and ensures the cream remains effective throughout its shelf life. If you're looking for other products to support your baby's health, explore our first aid range for everyday essentials.

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Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy Drapolene Cream online in the UK?

You can buy Drapolene Cream Tube 100g directly from Cured Pharmacy online for £4.78, with fast UK delivery to your door. It is available without a prescription as a General Sale List medicine. No consultation is required — simply add it to your basket and check out.

How does Drapolene Cream work on nappy rash?

Drapolene Cream works in two ways: its emollient base forms a physical barrier on the skin to protect it from moisture and irritants, while the active antiseptic ingredients benzalkonium chloride and cetrimide help prevent bacterial infection. This dual action makes it effective for both treating existing nappy rash and preventing new episodes. It's one of the reasons it has remained a go-to choice for parents for many years.

How do I apply Drapolene Cream correctly?

Clean the nappy area gently with warm water or fragrance-free wipes, then pat the skin completely dry before applying a thin, even layer of Drapolene Cream. Apply at every nappy change for continuous protection. Avoid rubbing the cream in vigorously — a gentle spreading motion is all that's needed.

How often should I apply Drapolene Cream to my baby?

Apply Drapolene Cream at every nappy change — both when treating an existing rash and when using it preventatively. Consistent application is key, as gaps in coverage can allow moisture and irritants to reach the skin. There is no maximum number of daily applications when used as directed.

Is Drapolene Cream safe for newborn babies?

Yes, Drapolene Cream is suitable for use on babies from birth when applied as directed. The concentration of active ingredients is low and designed for use on sensitive infant skin. If you have any concerns about using it on a very young or premature baby, speak to your health visitor or pharmacist first.

What are the side effects of Drapolene Cream?

Side effects are uncommon but can include mild redness or a temporary stinging sensation at the application site. In rare cases, an allergic reaction may occur — signs include increased redness, swelling, or blistering. If any of these occur, stop using the cream and consult a pharmacist or GP promptly.

Can I use Drapolene Cream on infected nappy rash?

Drapolene Cream is not suitable for use on skin that is already infected — for example, if the rash looks weepy, crusted, or is spreading rapidly. In those cases, you should seek advice from a GP, as a prescription antifungal or antibiotic cream may be needed. Using a barrier cream on infected skin without treating the underlying infection can delay recovery.

What is the difference between Drapolene Cream and Sudocrem?

The key difference lies in the active ingredients: Drapolene Cream uses benzalkonium chloride and cetrimide as antiseptics, while Sudocrem relies primarily on zinc oxide for its barrier and mild antiseptic effect. Both are effective for nappy rash, but Drapolene's antiseptic combination may offer more targeted protection against bacterial colonisation. The choice often comes down to personal preference and how your baby's skin responds.

Who else can use Drapolene Cream besides babies?

Adults experiencing skin irritation due to incontinence or prolonged moisture exposure can also use Drapolene Cream. It can be applied to any area of skin prone to friction or moisture-related soreness. If you're managing skin conditions across the family, our skin care collection has a wide range of options to suit different needs.

How long does it take for Drapolene Cream to work on nappy rash?

Mild nappy rash often begins to improve within 2 to 3 days of consistent use at every nappy change. More persistent or severe rashes may take longer, and if there is no improvement after a few days, you should consult a pharmacist or GP. Keeping the nappy area clean and dry between changes will support faster recovery.

How long can I use Drapolene Cream for?

Drapolene cream nappy rash treatment can be used for as long as needed — both as a short-term treatment and as an ongoing preventative measure at each nappy change. There is no defined maximum duration of use when applied as directed. However, if the rash persists beyond a week despite treatment, seek medical advice to rule out a fungal or bacterial infection.

Does Drapolene Cream contain any fragrances or parabens?

Drapolene Cream does not contain added fragrances, making it generally suitable for sensitive skin. Always check the full ingredient list on the packaging for the most up-to-date formulation details, as manufacturers can occasionally update excipients. If your baby has known skin sensitivities, discuss the ingredient list with your pharmacist before use.

What are the alternatives to Drapolene Cream for nappy rash?

Common alternatives include Sudocrem (zinc oxide), Metanium Ointment (titanium compounds), and Bepanthen Nappy Care Ointment (dexpanthenol). Each works slightly differently — some focus on barrier protection, others on healing or antiseptic action. You can browse a range of options in our baby and toddler collection to find the right fit for your child.

Can Drapolene Cream be used with cloth nappies?

Barrier creams including Drapolene can reduce the absorbency of cloth nappies over time, as the cream can build up in the fabric fibres. If you use cloth nappies, consider using a liner between the nappy and your baby's skin to protect the fabric. Check with your cloth nappy supplier for specific guidance on compatible barrier creams.

What are the latest recommendations for treating nappy rash in the UK?

The NHS recommends keeping the nappy area clean and dry, changing nappies frequently, and applying a barrier cream at each change as the primary approach to both preventing and treating nappy rash. Antiseptic barrier creams like Drapolene are considered appropriate first-line OTC options for mild to moderate cases. If the rash is severe, spreading, or associated with fever, medical assessment is advised.

How Should You Use Drapolene Cream?

Drapolene Cream is applied topically to the nappy area at every nappy change. Correct application technique matters — the skin must be clean and completely dry before you apply the cream, as applying it to damp skin reduces its effectiveness as a barrier. Follow these steps each time:

There is no need to remove all traces of the previous application before reapplying — simply clean away any soiling and reapply as above.

What Is the Correct Dose of Drapolene Cream?

There is no fixed measured dose for Drapolene Cream — the amount used depends on the size of the area being treated. A thin, even layer is all that is needed; applying a thicker layer does not improve effectiveness and may make the nappy area feel uncomfortable. Use the table below as a guide:

When Is the Best Time to Use Drapolene Cream?

The best time to apply Drapolene Cream is immediately after cleaning and drying the nappy area at every nappy change — whether that is during the day or overnight. Consistent application is more important than timing. Applying it before bedtime is particularly useful, as babies often go longer between night changes, meaning the skin is exposed to moisture for extended periods. Keeping the cream within easy reach of your changing station makes it easier to use it every single time.

How Long Can You Use Drapolene Cream For?

Drapolene Cream can be used continuously for as long as your baby is in nappies, both as a treatment and as a preventative measure. There is no recommended maximum duration of use. However, if a nappy rash does not show signs of improvement within 3 to 5 days of consistent treatment, or if the rash appears to be spreading, becoming weepy, or is associated with other symptoms such as fever, you should consult a pharmacist or GP. A persistent rash may indicate a fungal or bacterial infection requiring a different treatment.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Drapolene Cream?

Drapolene Cream is generally very well tolerated, particularly in babies and infants. Most people — and most babies — use it without experiencing any adverse effects at all. That said, as with any topical product containing antiseptic ingredients, a small number of users may notice mild reactions at the application site.

  • Mild redness or flushing of the skin at the application site
  • Temporary stinging or tingling sensation immediately after application
  • Slight dryness of the surrounding skin with prolonged use

These reactions are usually short-lived and resolve on their own. If they persist beyond a day or two, stop using the cream and speak to a pharmacist.

What Are the Less Common Side Effects of Drapolene Cream?

Less common side effects are rare but can occur, particularly in individuals with sensitive skin or a pre-existing skin condition. If you notice any of the following, discontinue use immediately:

  • Allergic contact dermatitis — characterised by increased redness, swelling, itching, or blistering beyond the original rash area
  • Worsening of the nappy rash rather than gradual improvement
  • Spreading of the rash to areas not previously affected
  • Unusual skin discolouration at the application site

These reactions may indicate a sensitivity to benzalkonium chloride, cetrimide, or one of the excipients in the cream base. A pharmacist can help you identify a suitable alternative.

What Are the Serious Side Effects of Drapolene Cream?

Serious side effects from topical Drapolene Cream are extremely rare. However, a severe allergic reaction (anaphylaxis) is theoretically possible with any medicine, including topical products. Seek emergency medical attention immediately if you or your baby experiences:

  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or wheezing
  • Widespread hives or a rapidly spreading rash across the body
  • Sudden dizziness or collapse

These symptoms require urgent medical assessment and should not be managed at home.

What Should You Do If You Experience Side Effects?

If you notice any side effects that concern you, the first step is to stop applying the cream and clean the area gently with warm water. For mild reactions, this is usually sufficient. For more significant reactions — particularly signs of allergy — contact your pharmacist or GP for advice. You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Drapolene Cream Interact With Other Medicines?

Drapolene Cream is applied topically and is not absorbed into the bloodstream in significant amounts, so systemic drug interactions are not expected. However, using multiple topical products on the same area of skin simultaneously is not recommended without pharmacist guidance. In particular, if your baby has been prescribed a topical corticosteroid or antifungal cream for the same area, check with your GP or pharmacist before combining it with Drapolene Cream, as this could affect how each product performs.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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