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Cyanocobalamin 50mcg - 50 Tablets

Cyanocobalamin 50mcg - 50 Tablets

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  • ✔️ Supports red blood cell formation and helps prevent megaloblastic anaemia
  • ✔️ Maintains healthy nerve function and myelin sheath integrity
  • ✔️ Ideal for vegans, vegetarians, and older adults at risk of B12 deficiency
  • ✔️ Helps counteract B12 depletion caused by long-term metformin use
  • ✔️ Convenient once-daily 50mcg tablet — 50-day supply per pack

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What Are Cyanocobalamin 50mcg Tablets?

 

Vitamin B12 is one of those nutrients that quietly does an enormous amount of work behind the scenes. Cyanocobalamin 50mcg tablets are an over-the-counter vitamin B12 supplement designed to help maintain healthy B12 levels — particularly in people whose diet or health conditions put them at risk of falling short. Each pack contains 50 tablets, making it a straightforward, affordable option available from our vitamins and supplements range at Cured Pharmacy.

B12 deficiency is more common than many people realise. The NHS notes that certain groups — including older adults, vegans, and people taking specific medicines — are at higher risk. Left unaddressed, low B12 can lead to tiredness, nerve problems, and megaloblastic anaemia. A daily 50mcg tablet can help bridge the gap for those who struggle to get enough through food alone.

 

How Do Cyanocobalamin Tablets Work in the Body?

 

Cyanocobalamin is a synthetic, stable form of vitamin B12. Once swallowed, the body converts it into two active coenzyme forms — methylcobalamin and adenosylcobalamin — which are used in several critical biological processes:

  • Supporting the production of healthy red blood cells, preventing megaloblastic anaemia
  • Maintaining the myelin sheath that protects nerve fibres, supporting neurological function
  • Enabling DNA synthesis and cell division throughout the body
  • Contributing to normal homocysteine metabolism, which is linked to cardiovascular health

Absorption happens primarily in the small intestine, where B12 binds to a protein called intrinsic factor produced by the stomach. In people with pernicious anaemia or certain gastrointestinal conditions, this process is impaired — meaning oral supplementation at standard doses may not be sufficient, and medical review is needed.

 

Who Is Cyanocobalamin 50mcg Suitable For?

 

This supplement is suitable for adults who want to maintain adequate vitamin B12 levels or who have been identified as being at risk of deficiency. It is not a treatment for diagnosed pernicious anaemia or severe deficiency — those conditions typically require higher doses or intramuscular injections under medical supervision.

You may benefit from a daily cyanocobalamin supplement if you:

  • Follow a vegan or vegetarian diet, as B12 is found almost exclusively in animal products
  • Are aged 50 or over, since the ability to absorb B12 from food declines with age
  • Take metformin for type 2 diabetes, which is known to reduce B12 absorption over time
  • Have been advised by a healthcare professional to supplement your B12 intake

 

How Does Cyanocobalamin Compare to Methylcobalamin?

 

Feature Cyanocobalamin 50mcg Methylcobalamin
Form of B12 Synthetic precursor Active coenzyme form
Stability Very stable, longer shelf life Less stable, light-sensitive
Cost Generally lower cost Typically more expensive
Evidence base Extensive clinical evidence Growing but more limited evidence

 

How Should You Store Cyanocobalamin 50mcg Tablets?

 

Store your tablets below 25°C in a cool, dry place away from direct sunlight and moisture. Keep them in the original packaging and out of reach of children. Do not use after the expiry date printed on the pack. If you are looking for other everyday health essentials, you might also find our women's health range useful, particularly if you are managing nutritional needs during pregnancy or menopause.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Cyanocobalamin 50mcg - 50 Tablets specifications
Treatment category Vitamin B12 deficiency prevention; dietary supplementation
Active ingredient Cyanocobalamin (Vitamin B12) 50mcg
Mechanism of action Converted to active cobalamin coenzymes supporting red blood cell formation, DNA synthesis, and neurological function
Suitable for Adults; vegans; older adults; people on metformin
Pack size 50 tablets
Strength 50 micrograms (mcg)
UK classification General Sale List (GSL)
Drug class Water-soluble vitamin / cobalamin
Preparation Tablet
Route of administration Oral

Specifications of Cyanocobalamin 50mcg - 50 Tablets

 

What Is Cyanocobalamin and What Is It Used For?

 

Cyanocobalamin is a synthetic form of vitamin B12, an essential water-soluble vitamin that the body cannot produce on its own. It must be obtained through diet or supplementation. These 50mcg tablets are used to help prevent or address low B12 levels in people who do not get enough from food — particularly those following plant-based diets, older adults with reduced absorption, or individuals whose medication interferes with B12 uptake.

Vitamin B12 plays a central role in red blood cell production, DNA synthesis, and the maintenance of a healthy nervous system. Prolonged deficiency can lead to megaloblastic anaemia and irreversible neurological damage if left untreated. At the 50mcg dose, this product is intended for dietary supplementation rather than the treatment of clinically diagnosed deficiency, which may require higher doses or injectable therapy under medical supervision.

 

What Do You Need to Know Before Using Cyanocobalamin Tablets?

 

Before starting any supplement, it is worth checking whether it is appropriate for your situation. Do not take these tablets if any of the following apply to you:

  • You have Leber's hereditary optic neuropathy — cyanocobalamin can accelerate vision loss in this condition
  • You are allergic to cyanocobalamin, cobalt, or any other ingredient in the tablet
  • You have been diagnosed with pernicious anaemia without medical supervision — oral low-dose B12 is unlikely to be sufficient
  • You are a child under 18 — consult a GP before giving B12 supplements to children

The following medicines may interact with cyanocobalamin and reduce its absorption or effectiveness:

  • Metformin (used for type 2 diabetes) — long-term use is associated with reduced B12 absorption
  • Proton pump inhibitors (e.g. omeprazole) and H2 antagonists (e.g. ranitidine) — reduce stomach acid needed for B12 release from food
  • Chloramphenicol — may reduce the haematological response to B12
  • Colchicine and aminosalicylic acid — may impair B12 absorption

If you take any of these medicines, speak to your pharmacist or GP before starting supplementation. You can also browse our diabetes monitoring range if you are managing type 2 diabetes alongside your B12 supplementation.

 

How Should You Use Cyanocobalamin 50mcg Tablets?

 

Using this supplement correctly is straightforward. Follow these steps:

  1. Read the product label and this information carefully before starting
  2. Take one tablet daily, swallowed whole with a glass of water
  3. Tablets can be taken with or without food — whichever suits you best
  4. Try to take your tablet at the same time each day to build a consistent habit
  5. Do not crush or chew the tablet unless the product label specifically states this is acceptable
Indication Age Group Dose Frequency
Dietary supplementation Adults (18+) 50mcg (1 tablet) Once daily
Vegan/vegetarian diet support Adults (18+) 50mcg (1 tablet) Once daily
Children under 18 Under 18 Consult GP As directed

 

What Are the Possible Side Effects of Cyanocobalamin Tablets?

 

Cyanocobalamin is generally very well tolerated at the 50mcg dose. Serious side effects are uncommon, but it is important to know what to look out for.

Common side effects (may affect a small number of users):

  • Mild nausea, particularly if taken on an empty stomach
  • Headache
  • Diarrhoea

Less common side effects:

  • Skin reactions such as itching, rash, or flushing
  • Dizziness
  • Peripheral vascular thrombosis (very rare — seek immediate medical attention)
  • Hypersensitivity reactions including anaphylaxis (rare — stop taking and call 999 if you experience swelling of the face, lips, or throat, or difficulty breathing)

Because B12 is water-soluble, excess amounts are generally excreted in urine rather than accumulating to toxic levels. However, this does not mean you should exceed the recommended dose without medical advice. If you experience any unexpected symptoms, stop taking the tablets and speak to your pharmacist or GP.

 

How Should You Store Cyanocobalamin 50mcg Tablets?

 

Correct storage helps maintain the quality and effectiveness of your tablets throughout their shelf life. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and sources of heat or moisture
  • Store in the original packaging with the lid tightly closed
  • Keep out of the sight and reach of children
  • Do not use after the expiry date printed on the pack
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy

If you are managing multiple supplements or health products, our vitamins and supplements collection has a wide range of options to support your overall wellbeing.

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Frequently Asked Questions

Where can I buy cyanocobalamin 50mcg tablets online in the UK?

You can buy Cyanocobalamin 50mcg – 50 Tablets directly from Cured Pharmacy, a GPhC-registered online pharmacy. No prescription is needed as this is a General Sale List (GSL) supplement. Simply browse our vitamins and supplements collection and add it to your basket for fast UK delivery.

How does cyanocobalamin work in the body?

Once absorbed in the small intestine, cyanocobalamin is converted into two active coenzyme forms — methylcobalamin and adenosylcobalamin. These support red blood cell production, DNA synthesis, and the maintenance of the myelin sheath that protects nerve fibres. Without adequate B12, the body cannot carry out these processes efficiently, which can lead to anaemia and neurological symptoms over time.

How do I take cyanocobalamin 50mcg tablets step by step?

Take one tablet daily, swallowed whole with a full glass of water. You can take it with or without food, though taking it with a meal may reduce the chance of mild nausea. Try to take it at the same time each day to help you remember.

What is the best time of day to take cyanocobalamin tablets?

There is no clinically mandated time of day for taking cyanocobalamin — consistency matters more than timing. Many people find it easiest to take their tablet with breakfast, which also helps reduce any chance of stomach upset. Choose a time that fits naturally into your daily routine and stick to it.

What are the side effects of cyanocobalamin 50mcg tablets and how do I manage them?

Most people tolerate cyanocobalamin 50mcg very well. Mild side effects such as nausea, headache, or loose stools can occasionally occur, particularly when first starting. Taking the tablet with food usually helps — if symptoms persist or you develop a rash, swelling, or breathing difficulties, stop taking the tablets and seek medical advice promptly.

Who is eligible to take cyanocobalamin 50mcg tablets?

These tablets are suitable for adults aged 18 and over who want to maintain adequate vitamin B12 levels. They are particularly useful for vegans, vegetarians, older adults, and people taking metformin long-term. They are not suitable for people with Leber's hereditary optic neuropathy or those with a known allergy to cobalt or cobalamin compounds.

What happens if I miss a dose of cyanocobalamin?

If you forget to take your tablet, take it as soon as you remember — unless it is nearly time for your next dose, in which case simply skip the missed one. Never take two tablets at once to compensate for a missed dose. Missing the occasional tablet is unlikely to cause any harm, as B12 is stored in the liver for extended periods.

Can vegans take cyanocobalamin 50mcg tablets?

Yes — cyanocobalamin is a synthetic form of B12 and is not derived from animal sources, making it generally suitable for vegans. The NHS specifically recommends that people following a vegan diet take a B12 supplement, as the vitamin is found almost exclusively in animal-derived foods. Always check the full ingredient list on the product label to confirm suitability for your dietary requirements.

What are the alternatives to cyanocobalamin 50mcg tablets?

Alternatives include methylcobalamin (an active form of B12), hydroxocobalamin (available as an injection for severe deficiency), and high-dose cyanocobalamin tablets (e.g. 1,000mcg) for those with absorption issues. For clinically diagnosed deficiency or pernicious anaemia, intramuscular injections prescribed by a GP are typically more effective than oral supplementation at low doses.

How long can you take cyanocobalamin 50mcg tablets for?

For ongoing dietary supplementation — for example, if you follow a vegan diet or are at persistent risk of deficiency — cyanocobalamin can be taken long-term without concern, as excess B12 is excreted in urine. If you are supplementing to address a diagnosed deficiency, your GP will advise on how long to continue and whether a higher dose or different formulation is needed. Regular blood tests may be recommended to monitor your B12 levels.

Does metformin affect vitamin B12 levels?

Yes — long-term use of metformin is associated with reduced vitamin B12 absorption, and the NHS advises that people taking metformin should have their B12 levels monitored periodically. If you are managing type 2 diabetes and concerned about your B12 status, speak to your GP. You may also find our diabetes monitoring range helpful for keeping track of your health.

Can I take cyanocobalamin during pregnancy?

Vitamin B12 is important during pregnancy for foetal neurological development, and deficiency can be harmful. However, you should always consult your GP or midwife before starting any new supplement during pregnancy. They can advise on the appropriate dose and whether a combined prenatal supplement would be more suitable for your needs.

Is cyanocobalamin the same as vitamin B12?

Cyanocobalamin is one of several forms of vitamin B12 — it is the most commonly used synthetic form in supplements and medicines because of its stability and low cost. The body converts it into the active coenzyme forms it needs. Other forms include methylcobalamin, adenosylcobalamin, and hydroxocobalamin, each with slightly different properties and uses.

What are the latest studies on cyanocobalamin supplementation?

Research continues to support the role of vitamin B12 supplementation in preventing deficiency-related anaemia and neurological decline, particularly in older adults and those on plant-based diets. Studies have also explored the link between B12 status and cognitive function in ageing populations, though evidence for supplementation improving cognition in people without deficiency remains inconclusive. The NHS and BNF continue to recommend cyanocobalamin as a first-line oral supplement for B12 deficiency prevention.

Can I take cyanocobalamin alongside other vitamins and supplements?

Cyanocobalamin is generally safe to take alongside other vitamins and supplements, including folic acid, vitamin D, and iron. In fact, B12 and folate work closely together in red blood cell production, so they are often supplemented together. If you are taking multiple supplements, our vitamins and supplements range has a broad selection to help you build a routine that suits your needs — but always check with your pharmacist if you are unsure about combinations.

How Should You Use Cyanocobalamin 50mcg Tablets?

Using these tablets correctly is simple, but a consistent routine makes a real difference to how well they work for you. Always read the product label before starting, and follow the steps below:

If you have difficulty swallowing tablets, speak to your pharmacist about whether an alternative formulation — such as a sublingual spray or liquid — might be more suitable for you.

What Is the Correct Dose of Cyanocobalamin 50mcg Tablets?

The dose depends on why you are taking the supplement. For most adults using it as a dietary supplement, one 50mcg tablet daily is appropriate. Always follow the guidance on the product label or as directed by your GP or pharmacist — do not exceed the stated dose without medical advice.

When Is the Best Time to Use Cyanocobalamin Tablets?

There is no strict clinical requirement for a specific time of day. What matters most is consistency — taking your tablet at the same time every day helps maintain steady B12 levels and reduces the chance of forgetting a dose. Most people find that taking it with breakfast works well, as it fits naturally into an existing routine and food can help minimise any mild stomach discomfort.

If you take other medications in the morning, check with your pharmacist whether there are any timing considerations, particularly if you are on metformin or a proton pump inhibitor, both of which can affect B12 absorption.

How Long Can You Use Cyanocobalamin Tablets For?

For people supplementing due to an ongoing dietary restriction — such as a vegan or vegetarian diet — cyanocobalamin can be taken indefinitely, as B12 is water-soluble and excess is excreted rather than stored to harmful levels. If you are supplementing to correct a diagnosed deficiency, your GP will advise on the appropriate duration and whether a higher dose or injectable form is more suitable for your situation.

It is a good idea to have your B12 levels checked periodically through a blood test, especially if you have been supplementing for an extended period or have an underlying condition affecting absorption. This helps ensure the supplement is working effectively for you.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Cyanocobalamin Tablets?

Cyanocobalamin 50mcg is generally very well tolerated, and most people experience no side effects at all. When mild effects do occur, they are usually short-lived and often settle once your body adjusts to the supplement. Taking the tablet with food can help reduce the likelihood of stomach-related symptoms.

  • Nausea or stomach discomfort, particularly if taken on an empty stomach
  • Headache
  • Diarrhoea or loose stools
  • A feeling of general unwellness when first starting

What Are the Less Common Side Effects of Cyanocobalamin Tablets?

Less frequently, some people may notice skin or systemic reactions. These are uncommon at the 50mcg dose but worth being aware of. If any of the following occur and persist, stop taking the tablets and speak to your pharmacist or GP.

  • Skin itching, rash, or flushing
  • Dizziness or light-headedness
  • Swelling of the ankles or feet
  • Acne-like skin eruptions (more commonly associated with higher doses)

What Are the Serious Side Effects of Cyanocobalamin Tablets?

Serious side effects are rare with oral cyanocobalamin at 50mcg, but they can occur. Anaphylaxis — a severe allergic reaction — has been reported, though it is extremely uncommon with oral formulations. Peripheral vascular thrombosis (blood clots in the veins) has also been noted in very rare cases, primarily associated with injectable forms rather than oral tablets.

Seek emergency medical help immediately — call 999 — if you experience any of the following after taking this supplement:

  • Sudden swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe skin reaction or widespread rash
  • Collapse or loss of consciousness

What Should You Do If You Experience Side Effects?

For mild side effects such as nausea or headache, try taking your tablet with food and plenty of water. If symptoms persist beyond a few days or feel more than mild, stop taking the supplement and speak to your pharmacist. You do not need to visit A&E for minor reactions, but do not ignore symptoms that are worsening or unusual for you.

You can also report suspected side effects directly to the MHRA through the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety monitoring across the UK.

Can Cyanocobalamin Interact With Other Medicines?

Yes — certain medicines can reduce the absorption or effectiveness of cyanocobalamin. The most clinically significant interactions include metformin (used for type 2 diabetes), proton pump inhibitors such as omeprazole, H2 antagonists, and chloramphenicol. These medicines can impair either the release of B12 from food or its absorption in the gut.

If you are taking any of these medicines, it does not necessarily mean you cannot take cyanocobalamin — but you should discuss it with your pharmacist or GP first. They may recommend monitoring your B12 levels more regularly or adjusting your supplementation approach accordingly.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

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Content last updated: 31 Mar 2025

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