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Curanail Loceryl (Amorolfine) Nail Lacquer

Curanail Loceryl (Amorolfine) Nail Lacquer

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  • ✔️ Treats mild to moderate fungal nail infections effectively
  • ✔️ Active amorolfine 5% penetrates nail plate to source
  • ✔️ Suitable for both fingernail and toenail infections
  • ✔️ Once or twice weekly application — simple and convenient
  • ✔️ Available without a prescription for adults aged 18+

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What Is Amorolfine Nail Lacquer and How Can It Help You?

 

Fungal nail infections are more common than you might think. The NHS estimates they affect around 3 in 100 people in the UK at any given time, and they can be stubborn to shift without the right treatment. Amorolfine nail lacquer — sold under the brand name Curanail Loceryl — is a clinically proven, pharmacy-strength antifungal treatment available without a prescription for mild to moderate infections. At Cured Pharmacy, you can order it online for just £18.99, with no GP appointment needed. If you're also dealing with related skin concerns like athlete's foot, you'll find a wide range of options in our athletes foot and fungal infections collection.

Fungal nail infections — medically known as onychomycosis — typically cause nails to become thickened, discoloured, brittle, or distorted. They're caused by dermatophyte fungi, and occasionally by yeasts or non-dermatophyte moulds. Left untreated, the infection can spread to other nails or surrounding skin. Curanail Loceryl is designed to tackle the infection directly at the nail, making it a practical first-line option for many people.

 

How Does Curanail Loceryl Work Against Fungal Nail Infections?

 

Amorolfine belongs to the morpholine class of antifungals. It works by interfering with the biosynthesis of ergosterol — a vital component of the fungal cell membrane. Without sufficient ergosterol, the fungal cell membrane becomes structurally compromised, and the fungus cannot survive or replicate.

  • Amorolfine inhibits two key fungal enzymes: delta-14 reductase and delta-7-8 isomerase
  • This disrupts the ergosterol synthesis pathway, causing abnormal sterols to accumulate
  • The fungal cell membrane loses integrity, leading to fungistatic (growth-stopping) and fungicidal (cell-killing) effects
  • The lacquer formulation allows the active ingredient to penetrate the nail plate and reach the nail bed where the infection resides

Because the lacquer is applied directly to the nail, systemic absorption is minimal. This makes it a well-tolerated option for most adults who are not pregnant or breastfeeding.

 

Who Should Use Curanail Loceryl Nail Lacquer?

 

Curanail Loceryl is suitable for adults aged 18 and over with mild to moderate fungal nail infections affecting the fingernails or toenails, provided the infection has not spread to the nail matrix (the base of the nail where growth begins). It is not suitable for severe or total nail involvement — in those cases, oral antifungal therapy prescribed by a GP is usually required.

  • Adults with discoloured, thickened, or brittle nails caused by a fungal infection
  • People who prefer a topical, non-oral treatment option
  • Those with mild to moderate onychomycosis not involving the nail matrix
  • Individuals who have confirmed or strongly suspected fungal nail infection (ideally confirmed by a pharmacist or GP)

 

How Does Curanail Compare to Other Fungal Nail Treatments?

 

Feature Curanail Loceryl (Amorolfine 5%) Terbinafine Tablets (Oral)
Route of administration Topical (applied to nail) Oral (swallowed)
Prescription required? No — available OTC Yes — prescription only
Suitable for mild–moderate infection? Yes Yes (also used for severe)
Systemic side effects? Minimal — localised only Possible — liver effects, GI upset
Treatment duration 6–12 months 6 weeks (fingernails) to 3 months (toenails)

 

Is Curanail Loceryl Suitable for Long-Term Use and How Should It Be Stored?

 

Treating a fungal nail infection takes patience. Fingernail infections typically require around six months of treatment, while toenail infections can take up to twelve months — simply because nails grow slowly and the healthy nail needs time to replace the infected tissue. Consistency is key. Missing applications can allow the fungus to recover, prolonging your treatment course. If you're unsure whether your symptoms are improving, speak to your pharmacist.

Store Curanail Loceryl below 30°C, away from direct heat and naked flames — the lacquer is flammable. Keep the bottle tightly closed when not in use and store it out of reach of children. Do not use after the expiry date printed on the packaging. For those managing other skin or foot conditions alongside a fungal nail infection, our foot care collection may have additional products to support your routine.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Curanail Loceryl Amorolfine Nail Lacquer specifications
Treatment category Antifungal / Nail infection treatment
Active ingredient Amorolfine hydrochloride 5% w/v
Mechanism of action Inhibits ergosterol biosynthesis in fungal cell membranes
Effective against Dermatophytes, some yeasts and moulds causing onychomycosis
Suitable for Adults aged 18 and over with mild to moderate fungal nail infections
Pack sizes 2.5 ml
Strengths 5% w/v
UK classification Pharmacy (P) medicine
Drug class Morpholine antifungal
Preparation Nail lacquer (solution)
Route of administration Topical — applied directly to affected nail(s)

Specifications of Curanail Loceryl Amorolfine Nail Lacquer

 

What Is Curanail Loceryl and What Is It Used For?

 

Curanail Loceryl is a topical antifungal nail lacquer containing 5% amorolfine. It is used to treat mild to moderate fungal nail infections (onychomycosis) of the fingernails and toenails in adults aged 18 and over. The lacquer is applied directly to the affected nail(s) once or twice weekly and works by penetrating the nail plate to reach and destroy the fungal infection at its source. It is classified as a Pharmacy (P) medicine in the UK, meaning it can be purchased without a prescription but should be used under pharmacist guidance.

 

What Do You Need to Know Before Using Curanail Loceryl?

 

Before using this product, read the following carefully. Do not use Curanail Loceryl if any of the contraindications below apply to you, and always inform your pharmacist of any medicines you are currently taking.

Do not use Curanail Loceryl if you:

  • Are allergic to amorolfine or any other ingredient in the lacquer
  • Are pregnant or breastfeeding (unless specifically advised by your doctor)
  • Are under 18 years of age
  • Have a severe fungal nail infection involving the nail matrix (base of the nail)
  • Have a nail infection affecting more than two-thirds of the nail

Warnings and precautions:

  • Avoid contact with eyes, ears, and mucous membranes
  • Do not inhale the lacquer — apply in a well-ventilated area
  • The lacquer is flammable — keep away from naked flames and heat sources
  • Do not apply cosmetic nail varnish or artificial nails over treated nails during treatment
  • If you wear contact lenses, avoid touching them immediately after applying the lacquer
  • If your condition worsens or does not improve after three months, consult your GP

Known drug interactions:

  • No clinically significant interactions have been identified at topical doses
  • Always inform your pharmacist of all medicines you are taking, including herbal remedies

 

How Should You Use Curanail Loceryl Nail Lacquer?

 

Follow these steps carefully each time you apply the lacquer. Correct application is essential for the treatment to work effectively. If you are unsure about any step, ask your pharmacist for guidance.

  1. File down the affected nail as much as possible using the nail file provided — this helps the lacquer penetrate the nail plate
  2. Clean the nail surface thoroughly with one of the alcohol-soaked cleansing swabs included in the pack
  3. Allow the nail to dry completely before applying the lacquer
  4. Dip the spatula into the bottle and apply a thin, even coat of lacquer to the entire surface of the affected nail
  5. Allow the lacquer to dry for approximately three to five minutes before contact with water or other surfaces
  6. Clean the spatula with the swab after use and close the bottle tightly
  7. Repeat this process once or twice weekly throughout the full treatment course
Indication Age Group Dose Frequency
Fungal fingernail infection Adults 18+ One thin coat per affected nail Once or twice weekly for up to 6 months
Fungal toenail infection Adults 18+ One thin coat per affected nail Once or twice weekly for up to 12 months
Children under 18 Not applicable Not recommended Not recommended

 

What Are the Possible Side Effects of Curanail Loceryl?

 

Like all medicines, Curanail Loceryl can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application. If you experience any severe or unexpected reactions, stop using the product and seek medical advice promptly. You can also browse our skin care collection for products that may help soothe mild skin irritation around the nail area.

Common side effects (may affect up to 1 in 10 people):

  • Mild burning or stinging sensation at the application site
  • Itching around the treated nail
  • Redness of the surrounding skin
  • Nail discolouration

Less common side effects (may affect up to 1 in 100 people):

  • Nail brittleness or changes in nail texture
  • Skin rash near the treated area
  • Contact dermatitis (allergic skin reaction)

 

How Should You Store Curanail Loceryl?

 

  • Store below 30°C — do not refrigerate
  • Keep away from direct heat sources and naked flames — the lacquer is flammable
  • Keep the bottle tightly closed when not in use to prevent evaporation
  • Store out of sight and reach of children
  • Do not use after the expiry date printed on the carton or bottle label
  • Do not dispose of medicines via wastewater or household waste — return unused product to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy amorolfine nail lacquer online in the UK?

You can buy Curanail Loceryl amorolfine nail lacquer directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for £18.99. No prescription is required as it is classified as a Pharmacy (P) medicine. Simply add it to your basket and complete a short health questionnaire to confirm suitability before your order is dispatched.

How does amorolfine nail lacquer work in the body?

Amorolfine works by inhibiting two key enzymes — delta-14 reductase and delta-7-8 isomerase — that fungi need to produce ergosterol, a critical component of their cell membranes. Without ergosterol, the fungal cell membrane becomes unstable and the fungus cannot survive or replicate. Because it is applied topically, systemic absorption is minimal, making it well tolerated by most adults.

How do I use Curanail Loceryl step by step?

Start by filing down the affected nail as much as possible, then clean it with the alcohol swab provided in the pack. Apply a thin, even coat of lacquer to the entire nail surface using the spatula, allow it to dry for three to five minutes, then clean the spatula with the swab and close the bottle tightly. Repeat once or twice weekly throughout your full treatment course.

How long does it take for amorolfine nail lacquer to work?

Fingernail infections typically require around six months of treatment, while toenail infections can take up to twelve months because toenails grow more slowly. Visible improvement is gradual — you are essentially waiting for healthy nail to grow through and replace the infected nail. Consistency with weekly applications is essential to achieving a good outcome.

What is the correct dose of Curanail Loceryl?

Apply one thin coat of lacquer to each affected nail once or twice weekly — the exact frequency will depend on the severity of your infection and your pharmacist's advice. Do not apply more frequently than twice weekly, as this will not speed up recovery and may increase the risk of local irritation. Always follow the instructions in the patient information leaflet supplied with the product.

Can I use nail varnish while using Curanail Loceryl?

No — you should not apply cosmetic nail varnish, nail polish, or artificial nails over the treated nail during your course of treatment. Doing so can prevent the lacquer from penetrating the nail plate effectively, reducing its ability to reach and treat the fungal infection. Remove any existing nail varnish before starting treatment.

What are the side effects of Curanail Loceryl and how do I manage them?

The most common side effects are mild burning, itching, or redness around the treated nail, and these usually resolve on their own without any specific treatment. Less commonly, you may notice nail brittleness or changes in nail texture. If you experience a more significant skin reaction such as a rash or swelling, stop using the product and speak to your pharmacist or GP promptly.

Is Curanail Loceryl suitable for use during pregnancy or breastfeeding?

Curanail Loceryl is not recommended during pregnancy or breastfeeding unless your doctor has specifically advised that it is safe for you to use. There is insufficient clinical data to confirm its safety in these groups, so a GP consultation is essential before starting treatment. Your doctor may suggest alternative management options that are better suited to your situation.

Who is eligible to use Curanail Loceryl?

Curanail Loceryl is suitable for adults aged 18 and over with mild to moderate fungal nail infections of the fingernails or toenails, where the infection has not spread to the nail matrix. It is not suitable for children, pregnant or breastfeeding women (without medical advice), or people with severe nail involvement affecting more than two-thirds of the nail. If you are unsure whether it is right for you, speak to a pharmacist before purchasing.

What happens if I miss a dose of Curanail Loceryl?

If you miss a weekly application, simply apply the lacquer as soon as you remember and then continue with your usual schedule. Do not apply a double dose to make up for a missed one. Occasional missed applications are unlikely to significantly affect your overall outcome, but consistent weekly use gives you the best chance of clearing the infection fully.

What are the alternatives to amorolfine nail lacquer?

Alternatives to amorolfine nail lacquer include ciclopirox nail lacquer (another topical antifungal), and oral antifungal tablets such as terbinafine or itraconazole, which are available on prescription for more severe or widespread infections. You can explore other athletes foot and fungal infection treatments on our website. Your GP or pharmacist can advise on the most appropriate option based on the extent and severity of your infection.

How long can you use Curanail Loceryl for?

Treatment should continue until the infected nail has fully grown out and been replaced by healthy nail — this typically means six months for fingernails and up to twelve months for toenails. Do not stop treatment early even if the nail appears to be improving, as the fungus may still be present. If there is no improvement after three months of consistent use, consult your GP.

Can Curanail Loceryl be used on both fingernails and toenails?

Yes — Curanail Loceryl is licensed for use on both fingernails and toenails in adults with mild to moderate fungal nail infections. The treatment duration differs between the two: fingernail infections generally clear in around six months, while toenail infections typically require up to twelve months of treatment due to the slower growth rate of toenails.

What are the latest studies on amorolfine nail lacquer?

Clinical studies have consistently demonstrated that amorolfine 5% nail lacquer is effective against dermatophytes, the most common cause of fungal nail infections, with mycological cure rates reported in published literature. Some research has also explored combining amorolfine lacquer with oral terbinafine for more severe infections, showing improved outcomes compared to either treatment alone. For the most up-to-date clinical guidance, refer to the BNF or speak to your pharmacist or GP.

Does Curanail Loceryl interact with other medicines?

No clinically significant drug interactions have been identified with amorolfine nail lacquer at topical doses, as systemic absorption is minimal. However, you should always inform your pharmacist of all medicines you are taking — including prescription drugs, over-the-counter products, and herbal remedies — before starting any new treatment. If you are managing multiple health conditions, our creams and ointments collection may also be of interest for other topical needs.

How Should You Use Curanail Loceryl Nail Lacquer?

Correct application is essential for this treatment to work. Before each application, file down the affected nail as much as possible using the nail file provided — this removes infected nail material and helps the lacquer penetrate deeper into the nail plate. Always clean the nail with the alcohol swab included in the pack before applying the lacquer, and make sure the nail is completely dry before you begin.

What Is the Correct Dose of Curanail Loceryl?

One thin, even coat of lacquer applied to the entire surface of each affected nail constitutes a single dose. Do not apply more than twice weekly — applying more frequently will not speed up recovery and may cause unnecessary local irritation. The number of nails you treat at each application will depend on how many are affected.

When Is the Best Time to Use Curanail Loceryl?

Many people find it easiest to apply the lacquer in the evening, after bathing or showering, when the nail is clean and dry. Choosing a consistent day or days each week — for example, every Sunday, or every Wednesday and Sunday — helps you build the application into your routine and reduces the risk of missed doses. Avoid applying immediately before swimming or bathing, as prolonged water exposure can affect how well the lacquer adheres to the nail.

How Long Can You Use Curanail Loceryl For?

Treatment duration depends on which nails are affected. Fingernail infections typically clear within six months of consistent weekly treatment, while toenail infections can take up to twelve months because toenails grow considerably more slowly. Do not stop treatment early, even if the nail looks better — the fungus may still be present in the nail plate. If you see no improvement after three months of regular use, consult your GP or pharmacist, as you may need a different treatment approach.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

What Are the Most Common Side Effects of Curanail Loceryl?

Most people who use Curanail Loceryl tolerate it well, and side effects — when they do occur — are generally mild and confined to the area of application. Because the lacquer is applied topically rather than taken orally, systemic side effects are very uncommon.

  • Mild burning or stinging sensation at the application site
  • Itching around the treated nail
  • Redness of the skin surrounding the nail
  • Nail discolouration (the nail may appear slightly different in colour during treatment)

What Are the Less Common Side Effects of Curanail Loceryl?

Less frequently, some people may notice changes to the nail itself or a more noticeable skin reaction near the treated area. These effects are still generally mild but should be monitored throughout your treatment course.

  • Nail brittleness or changes in nail texture
  • Skin rash near the treated nail
  • Contact dermatitis — an allergic skin reaction causing redness, itching, or blistering
  • Nail pain or tenderness around the nail fold

What Are the Serious Side Effects of Curanail Loceryl?

Serious side effects with amorolfine nail lacquer are rare. However, if you develop signs of a severe allergic reaction — such as widespread rash, swelling of the face or throat, difficulty breathing, or dizziness — stop using the product immediately and seek emergency medical attention. These symptoms may indicate anaphylaxis, which requires urgent treatment.

If you notice significant worsening of the nail or surrounding skin, or if the infection appears to be spreading, do not continue self-treating — consult your GP promptly for further assessment.

What Should You Do If You Experience Side Effects?

For mild local reactions such as itching or redness, you may find that the symptoms settle on their own after a few applications as your skin adjusts. If irritation persists or worsens, stop using the lacquer and speak to your pharmacist. You can report suspected side effects of any medicine in the UK directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk — this helps improve medicine safety for everyone.

Never ignore a side effect that concerns you. Your pharmacist is always a good first point of contact for advice on managing mild reactions or deciding whether to continue treatment.

Can Curanail Loceryl Interact With Other Medicines?

No clinically significant drug interactions have been identified with amorolfine nail lacquer when used topically, as the amount absorbed into the bloodstream is negligible. That said, you should always tell your pharmacist about all medicines you are currently taking — including prescription drugs, over-the-counter products, vitamins, and herbal supplements — before starting any new treatment. This is particularly important if you are using other topical products on or near the affected nails.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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