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Colofac For IBS Relief 135mg – 15 Tablets

Colofac For IBS Relief 135mg – 15 Tablets

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  • ✔️ Relieves IBS abdominal cramps and painful spasms
  • ✔️ Targets gut muscle directly without anticholinergic side effects
  • ✔️ Each tablet contains 135mg mebeverine hydrochloride
  • ✔️ Suitable for adults 18+ with a confirmed IBS diagnosis
  • ✔️ Convenient 15-tablet pack for short-term IBS symptom control

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What Are Mebeverine 135mg Tablets for IBS?

 

If you live with irritable bowel syndrome, you'll know how unpredictable and uncomfortable it can be. Cramping, bloating, and sudden changes in bowel habit can disrupt your day in ways that are hard to explain to others. Mebeverine 135mg tablets — sold here as Colofac For IBS Relief — offer targeted relief from these symptoms by working directly on the muscles of your gut. Each pack contains 15 film-coated tablets, making it a convenient option to keep at home or carry with you. You can browse our full range of treatments in our IBS and Cramps collection if you'd like to explore further options alongside this product.

IBS affects roughly one in five people in the UK at some point in their lives, according to the NHS. It's a long-term condition, and while there's no single cure, medicines like mebeverine can make a real difference to day-to-day comfort. This product is available over the counter for adults aged 18 and over who have already had their IBS diagnosed by a doctor.

 

How Does Colofac Mebeverine Work in the Gut?

 

Mebeverine is classified as an antispasmodic. Rather than working through the nervous system, it acts directly on the smooth muscle lining the walls of your intestines. This distinction matters — it means mebeverine relaxes gut spasms without causing the dry mouth, blurred vision, or urinary retention that some older antispasmodics (like hyoscine) can produce.

  • Mebeverine blocks sodium channels in smooth muscle cells, reducing their ability to contract excessively.
  • This relaxes the intestinal wall and eases painful cramping.
  • Normal gut motility is largely preserved — so it doesn't simply "switch off" your bowel.
  • It is not absorbed significantly into the bloodstream, which limits systemic side effects.

 

Who Is Colofac Mebeverine Suitable For?

 

This product is intended for adults aged 18 and over who have been formally diagnosed with irritable bowel syndrome by a GP or specialist. It is not a first-time diagnostic tool — if you haven't yet spoken to a doctor about your gut symptoms, please do so before starting any IBS treatment. Mebeverine 135mg tablets are particularly suited to people who experience:

  • Recurrent abdominal cramps or spasms linked to IBS
  • Bloating and discomfort after eating
  • Alternating diarrhoea and constipation associated with IBS
  • Symptoms that flare around mealtimes

It is not suitable for children under 18, and caution is advised if you are pregnant or breastfeeding. Always speak to your pharmacist or GP if you are unsure whether this medicine is right for you.

 

How Does Colofac Compare to Other IBS Antispasmodics?

 

Feature Colofac Mebeverine 135mg Buscopan (Hyoscine Butylbromide)
Active ingredient Mebeverine hydrochloride Hyoscine butylbromide
Mechanism Direct smooth muscle relaxant Anticholinergic (nervous system)
Anticholinergic side effects Not associated Possible (dry mouth, blurred vision)
Suitable for IBS (diagnosed) Yes Yes

 

How Should You Store Colofac Mebeverine Tablets?

 

Store your tablets below 25°C in a dry place, away from direct sunlight. Keep them out of reach and sight of children at all times. Do not use the tablets after the expiry date printed on the packaging. If you're managing multiple health products at home — for example, alongside items from our Vitamins and Supplements collection — it's good practice to store all medicines separately and check expiry dates regularly.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Colofac For IBS Relief 135mg – 15 Tablets specifications
Treatment category Irritable bowel syndrome (IBS)
Mechanism of action Direct smooth muscle relaxant (antispasmodic)
Effective for Abdominal cramps, spasms, bloating associated with IBS
Suitable for Adults aged 18 and over with diagnosed IBS
Active ingredient Mebeverine hydrochloride 135mg
Pack size 15 tablets
Strength 135mg
UK classification General Sale List (GSL) / Pharmacy (P) medicine
Drug class Antispasmodic
Preparation Film-coated tablet
Route of administration Oral

Specifications of Colofac For IBS Relief 135mg – 15 Tablets

 

What Is Colofac Mebeverine and What Is It Used For?

 

Colofac For IBS Relief 135mg tablets contain the active ingredient mebeverine hydrochloride. Mebeverine is an antispasmodic medicine used to relieve the symptoms of irritable bowel syndrome, including abdominal pain, cramping, bloating, and bowel irregularity. It works by relaxing the smooth muscle of the gut wall, reducing painful spasms without significantly disrupting normal bowel function. This product is for use in adults aged 18 and over who have already received a confirmed diagnosis of IBS from a healthcare professional.

 

What Do You Need to Know Before Using Colofac Mebeverine?

 

Before taking these tablets, read the following carefully. There are certain situations where mebeverine should not be used, and others where extra caution is needed.

Do not take Colofac mebeverine if you:

  • Are allergic to mebeverine hydrochloride or any other ingredient in the tablet
  • Have paralytic ileus (a condition where the bowel stops moving)
  • Are under 18 years of age

Speak to your doctor or pharmacist before taking this medicine if you:

  • Are pregnant or think you may be pregnant
  • Are breastfeeding
  • Have recently noticed a change in your bowel habits lasting more than two weeks
  • Have rectal bleeding, unexplained weight loss, or are over 40 with new IBS-type symptoms
  • Have been told you have porphyria

Drug interactions:

  • No clinically significant drug interactions have been identified for mebeverine at standard OTC doses
  • Always tell your pharmacist about all medicines you are taking, including herbal remedies and supplements

 

How Should You Take Colofac Mebeverine Tablets?

 

Always take this medicine exactly as described on the label or as directed by your pharmacist. Do not exceed the stated dose.

  1. Take one tablet (135mg) three times a day.
  2. Swallow each tablet whole with a glass of water.
  3. Take each dose approximately 20 minutes before a main meal.
  4. Do not crush or chew the tablets.
  5. Do not take more than three tablets in any 24-hour period.
Indication Age Group Dose Frequency
IBS symptom relief Adults 18+ 135mg (1 tablet) Three times daily, 20 min before meals
Children under 18 Under 18 Not recommended

If your symptoms do not improve after two weeks, stop taking the tablets and consult your GP. You may also find it helpful to look at our Diarrhoea collection if loose stools are a prominent part of your IBS symptoms, as complementary products may support your overall management plan.

 

What Are the Possible Side Effects of Colofac Mebeverine?

 

Like all medicines, mebeverine can cause side effects, although not everyone gets them. Mebeverine is generally considered well tolerated, and many people complete a course without experiencing any adverse effects at all.

Common side effects (may affect up to 1 in 10 people):

  • Nausea (feeling sick)
  • Dizziness

Less common or rare side effects:

  • Skin rash or itching (urticaria)
  • Facial swelling or angioedema
  • Allergic reactions — stop taking immediately and seek medical advice if this occurs

If you notice any side effect not listed here, or if a listed side effect becomes severe, contact your pharmacist or GP. Do not ignore symptoms that concern you. For those managing IBS alongside other digestive complaints, our Indigestion collection includes additional products that may help with related upper gut discomfort.

 

How Should You Store Colofac Mebeverine Tablets?

 

  • Store below 25°C in a dry place, away from direct heat and sunlight
  • Keep the tablets in their original packaging until use
  • Keep all medicines out of the sight and reach of children
  • Do not use after the expiry date printed on the carton
  • Do not dispose of medicines via wastewater or household waste — return unused tablets to your pharmacy for safe disposal

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy mebeverine 135mg tablets online in the UK?

You can buy Colofac mebeverine 135mg tablets directly from Cured Pharmacy, a UK GPhC-registered online pharmacy. No prescription is needed as this is an over-the-counter medicine for adults with a confirmed IBS diagnosis. Simply add the product to your basket and complete your order for fast UK delivery.

How does mebeverine 135mg work in the body?

Mebeverine acts directly on the smooth muscle cells lining the intestinal wall, blocking sodium channels and reducing excessive muscle contractions. Unlike anticholinergic antispasmodics, it does not work through the nervous system, so it avoids side effects like dry mouth or blurred vision. This targeted action makes it well suited to long-term IBS symptom management.

How do I take Colofac mebeverine 135mg tablets step by step?

Take one tablet three times a day, approximately 20 minutes before each main meal. Swallow the tablet whole with a full glass of water — do not crush or chew it. Never take more than three tablets in a 24-hour period, and always read the label before use.

What is the best time to take mebeverine 135mg tablets?

The ideal time is 20 minutes before breakfast, lunch, and dinner. Taking the tablet before eating allows the medicine to act on the gut muscle before food triggers spasms or cramping. Try to keep to a consistent schedule each day for the most reliable symptom control.

What are the side effects of Colofac mebeverine and how do I manage them?

Mebeverine is generally well tolerated, but rare side effects can include skin rash, itching, or facial swelling, which may indicate an allergic reaction. If you experience any of these, stop taking the tablets immediately and seek medical advice. Nausea and dizziness have also been reported occasionally — if these persist, speak to your pharmacist.

Who is eligible to take Colofac mebeverine 135mg tablets?

This medicine is suitable for adults aged 18 and over who have already been diagnosed with IBS by a doctor. It is not recommended for children under 18, and those who are pregnant, breastfeeding, or have paralytic ileus should not take it without medical advice. If you have any other underlying health conditions, check with your pharmacist before starting treatment.

What happens if I miss a dose of Colofac mebeverine?

If you miss a dose, simply skip it and take your next tablet at the usual time before your next meal. Do not take two tablets at once to compensate for a missed dose. Maintaining a regular routine — taking each tablet before meals — helps you stay on track.

What are the alternatives to mebeverine for IBS?

Other antispasmodics available in the UK include hyoscine butylbromide (Buscopan) and peppermint oil capsules (Colpermin). Buscopan works via the nervous system and may cause anticholinergic side effects, while peppermint oil is a natural option with a different mechanism. You can explore related products in our IBS and Cramps collection to compare your options.

How long can you take mebeverine 135mg tablets for?

Mebeverine can be used for short-term relief of IBS symptoms, typically for up to two weeks without medical review. If your symptoms have not improved after two weeks, or if they worsen at any point, stop taking the tablets and consult your GP. Long-term use should be discussed with a healthcare professional who can assess your overall IBS management plan.

Can I take mebeverine 135mg if I am pregnant or breastfeeding?

The safety of mebeverine during pregnancy and breastfeeding has not been fully established, so it is not routinely recommended in these situations. You should speak to your GP or midwife before taking any new medicine during pregnancy or while nursing. They can advise on the safest approach to managing IBS symptoms at this time.

Does mebeverine cause constipation or make IBS worse?

Mebeverine relaxes gut muscle spasms but does not significantly slow normal bowel transit, so it is unlikely to cause or worsen constipation in most people. However, IBS itself can fluctuate, and if you notice a change in your symptoms, it is worth reviewing your diet and fluid intake. If constipation becomes a concern, our Constipation collection has products that may help alongside your IBS treatment.

Can I drink alcohol while taking mebeverine 135mg tablets?

There is no known direct interaction between mebeverine and alcohol, but alcohol is a well-recognised trigger for IBS symptoms in many people. Drinking alcohol can irritate the gut lining and worsen cramping, bloating, and diarrhoea, potentially counteracting the benefit of your medication. It is sensible to limit alcohol intake while managing IBS.

Is mebeverine 135mg the same as Colofac?

Yes — Colofac is a well-known brand name for mebeverine hydrochloride 135mg tablets, and both contain the same active ingredient at the same strength. The Colofac For IBS Relief product sold here at Cured Pharmacy delivers the same clinically recognised antispasmodic action. Brand and generic versions are considered therapeutically equivalent.

What are the latest studies on mebeverine for IBS?

Mebeverine has been used clinically for several decades and is included in NHS treatment guidance for IBS as an antispasmodic option. Published reviews support its use for reducing abdominal pain and cramping in IBS patients, with a favourable tolerability profile compared to anticholinergic alternatives. The NHS recommends antispasmodics as a first-line pharmacological option for IBS-related pain.

Do I need a prescription to buy mebeverine 135mg tablets in the UK?

No — mebeverine 135mg tablets are available over the counter in the UK for adults aged 18 and over who have a confirmed IBS diagnosis. You do not need a prescription to purchase them from Cured Pharmacy. However, if you have not yet been diagnosed with IBS, please see your GP before starting treatment, as other conditions can cause similar symptoms.

How Should You Use Colofac Mebeverine 135mg Tablets?

Using Colofac correctly gives you the best chance of managing your IBS symptoms effectively. Always read the label before you start, and follow the steps below carefully. If you have any doubts about whether this medicine is right for you, speak to your pharmacist before taking your first dose.

If you accidentally take too many tablets, contact NHS 111 or go to your nearest A&E immediately. Always keep the packaging with you so medical staff can see what you have taken.

What Is the Correct Dose of Colofac Mebeverine 135mg?

The standard adult dose is one 135mg tablet taken three times daily. This dose has been established through clinical use and is the dose recommended for OTC use in adults with diagnosed IBS. Do not adjust your dose without speaking to a healthcare professional first.

When Is the Best Time to Use Colofac Mebeverine 135mg?

Timing really does matter with mebeverine. Taking each tablet around 20 minutes before a meal means the medicine is already working on your gut muscle by the time food arrives — which is when IBS spasms are most likely to be triggered. Try to build this into your daily routine so it becomes second nature. Consistency is key to getting the most from your treatment.

If you find that your IBS symptoms are worse at particular times of day — for example, after breakfast — make sure you don't skip that pre-meal dose. Missing a dose before a known trigger meal is when symptoms are most likely to break through.

How Long Can You Use Colofac Mebeverine 135mg For?

For OTC use, mebeverine 135mg tablets should be taken for no longer than two weeks without a review by your GP. If your symptoms improve within that time, you may be able to reduce or stop treatment — but do not stop abruptly without considering whether your IBS is well controlled. If symptoms persist beyond two weeks, or if they worsen at any point, stop taking the tablets and seek medical advice promptly.

Long-term use of mebeverine may be appropriate for some people with chronic IBS, but this should be managed under the guidance of a GP or gastroenterologist rather than continued on a self-care basis indefinitely.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Colofac Mebeverine?

Mebeverine is generally considered one of the better-tolerated antispasmodics available for IBS. Most people complete a course without experiencing any notable side effects. That said, as with any medicine, some people do report unwanted effects, and it's important to know what to look out for.

  • Nausea (feeling sick)
  • Dizziness

These effects are uncommon and usually mild. If nausea is a problem, try taking the tablet with a small amount of water and avoid lying down immediately after your dose.

What Are the Less Common Side Effects of Colofac Mebeverine?

Less commonly, some people may experience skin-related reactions. These are rare but worth being aware of, particularly if you have a history of allergies or sensitive skin.

  • Skin rash
  • Urticaria (hives — raised, itchy welts on the skin)
  • Facial swelling (angioedema)
  • General allergic reaction symptoms

If you notice any of these, stop taking the tablets immediately. Do not take another dose until you have spoken to a pharmacist or doctor.

What Are the Serious Side Effects of Colofac Mebeverine?

Serious side effects with mebeverine are very rare. However, a severe allergic reaction (anaphylaxis) is a medical emergency. Signs include sudden swelling of the face, lips, tongue, or throat, difficulty breathing, or a rapid drop in blood pressure causing dizziness or collapse. If you or someone nearby shows these signs after taking mebeverine, call 999 immediately.

You should also seek urgent medical attention if you develop severe abdominal pain that is different from your usual IBS symptoms, rectal bleeding, or unexplained weight loss while taking this medicine — these may indicate a condition other than IBS that requires investigation.

What Should You Do If You Experience Side Effects of Colofac Mebeverine?

For mild side effects like nausea or dizziness, monitor your symptoms and see if they settle after a few doses. If they persist or become bothersome, speak to your pharmacist — they can advise whether to continue or switch to an alternative. For any skin reaction or signs of allergy, stop the tablets straight away and seek advice promptly. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk.

Can Colofac Mebeverine Interact With Other Medicines?

No clinically significant drug interactions have been identified for mebeverine at standard over-the-counter doses. However, you should always tell your pharmacist about every medicine you are taking — including prescription drugs, over-the-counter products, herbal remedies, and dietary supplements — before starting a new treatment. This is especially important if you are managing multiple conditions simultaneously. Your pharmacist can carry out a full medicines review to ensure there are no concerns specific to your situation.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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