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Co-codamol 8/500mg - 32 Tablets

Co-codamol 8/500mg - 32 Tablets

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  • ✔️ Relieves mild-to-moderate pain including headaches and migraines
  • ✔️ Dual-action formula: paracetamol plus codeine for stronger relief
  • ✔️ Works within 30–60 minutes of taking the correct dose
  • ✔️ Suitable for adults and young people aged 16 and over
  • ✔️ Convenient 32-tablet pack for short-term pain management at home

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What Are Co-Codamol 8/500mg Tablets Used For?

 

When paracetamol alone isn't quite cutting it, co-codamol 8/500mg tablets offer a step up in pain relief without needing a prescription. Each tablet contains two active ingredients — 500mg of paracetamol and 8mg of codeine phosphate — working together to tackle mild-to-moderate pain more effectively than either ingredient could manage on its own. Whether you're dealing with a persistent headache, a tension migraine, dental discomfort, or muscular aches, this combination has been a trusted option in UK pharmacies for decades. You can browse our full pain relief collection if you're looking for other options alongside or instead of co-codamol.

This pack contains 32 tablets, making it a practical choice for short-term use at home. It's available over the counter in the UK for adults and young people aged 16 and over, though it's important to use it correctly and only for as long as necessary. The NHS advises that codeine-containing medicines should not be used for more than three days without medical guidance, due to the risk of dependence.

 

How Does Co-Codamol Work to Relieve Pain?

 

The two ingredients in co-codamol work through different but complementary mechanisms. Together, they provide more effective analgesia than paracetamol alone for many types of pain.

  • Paracetamol (500mg): Inhibits the production of prostaglandins in the brain and spinal cord, reducing the perception of pain and lowering fever.
  • Codeine phosphate (8mg): A weak opioid that is partially converted to morphine in the liver. It binds to opioid receptors in the central nervous system, dampening pain signals and producing mild sedation.
  • Combined effect: The dual action means pain is addressed both peripherally (via paracetamol) and centrally (via codeine), which is why the combination is more effective for moderate pain than paracetamol alone.

It's worth noting that around 7–10% of people are "poor metabolisers" of codeine due to genetic variation in the CYP2D6 enzyme, meaning codeine may be less effective for them. Conversely, "ultra-rapid metabolisers" may experience stronger effects and are at higher risk of side effects.

 

Who Is Co-Codamol 8/500mg Suitable For?

 

Co-codamol 8/500mg is suitable for adults and young people aged 16 and over who need short-term relief from pain that hasn't responded adequately to paracetamol or ibuprofen alone. It's particularly useful for:

  • Tension headaches and migraines
  • Dental pain (while awaiting treatment)
  • Muscular aches and back pain
  • Period pain (dysmenorrhoea)
  • Post-operative or post-injury discomfort (mild-to-moderate)

It is not suitable for children under 12 years of age, or for anyone aged 12–18 who has breathing problems. People with liver disease, kidney impairment, or a history of substance dependence should speak to a pharmacist or GP before using this medicine.

 

How Does Co-Codamol Compare to Paracetamol Alone?

 

Feature Co-Codamol 8/500mg Paracetamol 500mg
Active ingredients Paracetamol + Codeine Paracetamol only
Pain level addressed Mild-to-moderate Mild
Risk of dependence Yes (codeine) No
Suitable for under 12s No Yes (age-appropriate dose)
OTC availability (UK) Yes (pharmacy only) Yes (general sale)

 

How Should Co-Codamol 8/500mg Be Stored?

 

Store your co-codamol 8/500mg tablets below 25°C in a dry place, away from direct sunlight and moisture. Keep them out of the reach and sight of children at all times. Do not use the tablets after the expiry date printed on the packaging — if in doubt, return unused medicines to your local pharmacy for safe disposal.

If you're managing multiple health conditions and need to keep track of various medicines, it may also be worth exploring our vitamins and supplements range to support your overall wellbeing alongside any pain management plan.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Co-codamol 8/500mg – 32 Tablets specifications
Treatment category Pain relief / Analgesic
Mechanism of action Opioid receptor agonism (codeine) + prostaglandin inhibition (paracetamol)
Effective for Mild-to-moderate pain, headache, migraine, dental pain, muscular pain
Suitable for Adults and young people aged 16 and over
Active ingredient Codeine phosphate 8mg, Paracetamol 500mg
Pack size 32 tablets
Strengths 8mg codeine phosphate / 500mg paracetamol per tablet
UK classification Pharmacy (P) medicine
Drug class Opioid analgesic combination
Preparation Tablet
Route of administration Oral

Specifications of Co-codamol 8/500mg – 32 Tablets

 

What Is Co-Codamol 8/500mg and What Is It Used For?

 

Co-codamol 8/500mg is a combination analgesic medicine containing two active ingredients: paracetamol (500mg) and codeine phosphate (8mg) per tablet. It is used for the short-term relief of mild-to-moderate pain that has not responded to paracetamol or ibuprofen alone. Conditions it is commonly used for include headaches, migraines, toothache, period pain, and muscular aches. It is classified as a Pharmacy (P) medicine in the UK, meaning it can be sold without a prescription but only under the supervision of a pharmacist.

 

What Do You Need to Know Before Using Co-Codamol 8/500mg?

 

Before taking co-codamol, it is essential to check whether it is appropriate for you. Do not take this medicine if any of the following apply:

  • You are allergic to paracetamol, codeine, or any other ingredient in the tablet
  • You are under 12 years of age
  • You are aged 12–18 and have breathing problems (e.g. asthma)
  • You have severe liver or kidney disease
  • You have a condition affecting your breathing, such as chronic obstructive pulmonary disease (COPD)
  • You are breastfeeding (codeine passes into breast milk and can harm a baby)
  • You know you are an ultra-rapid metaboliser of codeine (CYP2D6)
  • You are taking or have recently taken monoamine oxidase inhibitors (MAOIs)

Co-codamol can interact with several other medicines. Tell your pharmacist if you are taking any of the following:

  • Other opioid painkillers (e.g. tramadol, morphine)
  • Sedatives, sleeping tablets, or anxiolytics (e.g. diazepam)
  • Antidepressants, including SSRIs and tricyclics
  • Anticoagulants such as warfarin (paracetamol can affect INR at higher doses)
  • Alcohol — increases the risk of drowsiness and liver damage
  • Medicines for epilepsy (e.g. carbamazepine)

 

How Should You Use Co-Codamol 8/500mg?

 

Always take co-codamol exactly as directed on the label or as advised by your pharmacist. Do not exceed the recommended dose, and do not take it for longer than three days without seeking medical advice. If your pain persists beyond three days, speak to your GP.

  1. Swallow 1–2 tablets whole with a full glass of water.
  2. Allow at least 4–6 hours between each dose.
  3. Do not take more than 8 tablets in any 24-hour period.
  4. Do not take any other paracetamol-containing products at the same time.
  5. Do not crush or chew the tablets.
  6. If you miss a dose, take the next one when needed — do not double up.
Age Group Dose Frequency Maximum Daily Dose
Adults and young people aged 16+ 1–2 tablets Every 4–6 hours 8 tablets (4g paracetamol)
Children under 12 Not suitable — do not use
Ages 12–15 (no breathing problems) Only under medical supervision — not for OTC use

 

What Are the Possible Side Effects of Co-Codamol 8/500mg?

 

Like all medicines, co-codamol can cause side effects, although not everyone experiences them. If you're also managing other conditions, our cold and flu range may be relevant if your pain is associated with viral illness — but always check for ingredient overlaps before combining products.

Common side effects (may affect up to 1 in 10 people):

  • Constipation
  • Nausea or feeling sick
  • Drowsiness or sedation
  • Dizziness or light-headedness

Less common side effects (may affect up to 1 in 100 people):

  • Headache (paradoxically, with overuse)
  • Dry mouth
  • Sweating
  • Skin rash or itching
  • Difficulty urinating
  • Mood changes or confusion (particularly in older adults)

Serious but rare reactions include severe allergic reactions (anaphylaxis), liver damage (from paracetamol overdose), and respiratory depression (slowed breathing from codeine). Seek emergency medical help immediately if you experience difficulty breathing, swelling of the face or throat, or signs of liver problems such as yellowing of the skin or eyes.

 

How Should You Store Co-Codamol 8/500mg?

 

Correct storage helps maintain the medicine's safety and effectiveness. Follow these guidelines:

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and moisture
  • Keep out of the reach and sight of children
  • Do not store in a bathroom or near a sink
  • Do not use after the expiry date printed on the pack
  • Return unused or expired tablets to your local pharmacy — do not flush or bin them

If you're looking for additional support for pain-related conditions or complementary health products, you might also find our first aid collection useful for managing minor injuries at home.

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy co-codamol 8/500mg tablets online in the UK?

You can buy co-codamol 8/500mg tablets from Cured Pharmacy, a GPhC-registered online pharmacy. A short consultation is required to confirm the medicine is appropriate for you before purchase. This ensures your safety and complies with UK pharmacy regulations for codeine-containing medicines.

How does co-codamol work in the body?

Co-codamol contains paracetamol, which reduces pain signals by inhibiting prostaglandin synthesis in the brain, and codeine phosphate, which is converted to morphine in the liver and acts on opioid receptors to reduce pain perception. The two ingredients complement each other, providing more effective relief for moderate pain than either alone. This dual mechanism is why co-codamol is often recommended when standard paracetamol hasn't been sufficient.

What is the correct dose of co-codamol 8/500mg for adults?

Adults and young people aged 16 and over should take 1–2 tablets every 4–6 hours when needed. The maximum dose is 8 tablets in any 24-hour period. Never exceed this limit, as doing so risks serious liver damage from the paracetamol content.

Can I take co-codamol 8/500mg for a migraine?

Co-codamol can help relieve the pain associated with a migraine attack. However, the NHS warns that taking painkillers — including co-codamol — on more than 10–15 days per month can lead to medication overuse headache, which makes migraines worse over time. If your migraines are frequent, speak to your GP about a longer-term management plan.

What are the side effects of co-codamol 8/500mg tablets?

Common side effects include constipation, nausea, drowsiness, and dizziness. Less commonly, you may experience dry mouth, sweating, or skin itching. Serious reactions such as difficulty breathing or signs of liver damage are rare but require immediate medical attention — stop taking the medicine and call 999 or go to A&E if these occur.

Is co-codamol 8/500mg addictive or habit-forming?

Yes, co-codamol can cause physical and psychological dependence because it contains codeine, a weak opioid. The NHS advises using it for no more than three days at a time to minimise this risk. If you find yourself needing it regularly, speak to your GP rather than continuing to purchase it over the counter.

Who should not take co-codamol 8/500mg?

Co-codamol is not suitable for children under 12, people with severe liver or kidney disease, those with breathing conditions such as COPD or asthma (in younger patients), or anyone who is breastfeeding. People taking MAOIs or other opioid medicines should also avoid it. Always read the patient information leaflet and consult a pharmacist if you are unsure.

What happens if I accidentally take too much co-codamol?

Taking too much co-codamol is a medical emergency, primarily because of the paracetamol content, which can cause severe and potentially fatal liver damage even if you feel well initially. Go to your nearest A&E immediately or call 999 — do not wait for symptoms to appear. Take the medicine packaging with you so doctors know exactly what and how much you have taken.

Can I drink alcohol while taking co-codamol 8/500mg?

No — you should avoid alcohol while taking co-codamol. Alcohol increases the sedative effects of codeine, raising the risk of dangerous drowsiness and respiratory depression. It also increases the risk of liver damage when combined with paracetamol. The NHS advises not drinking alcohol during a course of co-codamol.

How long can I take co-codamol 8/500mg for?

Co-codamol should only be used for short-term pain relief — a maximum of three days without medical advice. Using it for longer increases the risk of codeine dependence and medication overuse headache. If your pain persists beyond three days, see your GP to identify the underlying cause and discuss appropriate treatment. You can also explore our broader pain relief collection for alternative options.

Can I take co-codamol 8/500mg if I am pregnant?

Co-codamol is not recommended during pregnancy, particularly in the third trimester, as codeine can cause breathing problems in the newborn. Paracetamol alone is generally considered safer for pain relief during pregnancy, but you should always seek advice from your midwife or GP before taking any medicine while pregnant.

What are the alternatives to co-codamol 8/500mg?

Alternatives include paracetamol 500mg (for mild pain), ibuprofen 200–400mg (for inflammatory pain), or aspirin (for adults only). For headaches and migraines specifically, triptans are available on prescription. If you're looking for non-opioid options, our pain relief collection includes a range of alternatives to suit different needs.

Can I take co-codamol 8/500mg with ibuprofen?

Yes, co-codamol and ibuprofen can generally be taken together as they work through different mechanisms and do not interact directly. This combination is sometimes recommended by healthcare professionals for moderate pain. However, always check with your pharmacist first, especially if you have a stomach condition, kidney problems, or are taking other medicines.

What is the best time to take co-codamol 8/500mg?

Take co-codamol as soon as pain begins rather than waiting for it to become severe — this tends to give better results. Taking it with or after food can help reduce the risk of nausea. Space doses evenly throughout the day, ensuring at least 4–6 hours between each dose, and never take more than 8 tablets in 24 hours.

What are the latest guidelines on codeine use in the UK?

The MHRA and NHS have tightened guidance on codeine-containing medicines in recent years, particularly restricting their use in children under 18 with breathing problems and in breastfeeding mothers. The NHS recommends codeine only for short-term use and advises patients to seek medical review if pain is not controlled within three days. If you're managing ongoing pain, consider speaking to your GP about a structured pain management plan alongside any vitamins and supplements that may support recovery.

How Should You Use Co-Codamol 8/500mg?

Co-codamol 8/500mg tablets are taken orally with a full glass of water. Always follow the instructions on the label or as directed by your pharmacist, and never take more than the recommended dose. Do not crush or chew the tablets — swallow them whole.

What Is the Correct Dose of Co-Codamol 8/500mg?

The correct dose depends on your age. Children under 12 must never take co-codamol. For those aged 12–15, it should only be used under medical supervision and is not available OTC for this age group. Always check the packaging before use.

When Is the Best Time to Use Co-Codamol 8/500mg?

Take co-codamol as soon as pain begins — acting early tends to give better results than waiting until pain becomes severe. If you experience nausea, taking the tablets with a light meal or snack can help settle your stomach without significantly affecting how the medicine works.

Avoid taking co-codamol late at night unless necessary, as drowsiness is a common side effect and may affect your ability to function safely the following morning. Space your doses evenly throughout the day to maintain consistent pain relief.

How Long Can You Use Co-Codamol 8/500mg For?

Co-codamol is intended for short-term use only. The NHS recommends using it for no more than three days at a time. Using it beyond this period increases the risk of codeine dependence and can lead to medication overuse headache if taken regularly for head pain.

If your pain has not improved after three days, or if you find yourself reaching for co-codamol frequently, speak to your GP. They can investigate the underlying cause and recommend a more appropriate long-term management strategy. Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

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What Are the Most Common Side Effects of Co-Codamol 8/500mg?

Most people tolerate co-codamol well when taken at the correct dose for a short period. However, because it contains codeine — a weak opioid — some side effects are relatively common, particularly with the first few doses. These usually improve as your body adjusts.

  • Constipation (the most frequently reported side effect)
  • Nausea or feeling sick
  • Drowsiness or sedation
  • Dizziness or light-headedness
  • Headache (with prolonged or overuse)

What Are the Less Common Side Effects of Co-Codamol 8/500mg?

Less common side effects affect a smaller proportion of users but are still worth being aware of. If any of the following become troublesome or persistent, stop taking the medicine and speak to your pharmacist or GP.

  • Dry mouth
  • Sweating
  • Skin rash or itching
  • Difficulty urinating or urinary retention
  • Mood changes, confusion, or agitation (more common in older adults)
  • Stomach discomfort or abdominal pain

What Are the Serious Side Effects of Co-Codamol 8/500mg?

Serious side effects are rare but can be life-threatening. Seek emergency medical help immediately — call 999 or go to A&E — if you experience any of the following:

  • Difficulty breathing or very slow, shallow breathing (respiratory depression)
  • Severe allergic reaction: swelling of the face, lips, tongue, or throat; hives; difficulty swallowing
  • Signs of liver damage: yellowing of the skin or whites of the eyes (jaundice), dark urine, severe upper abdominal pain
  • Loss of consciousness or extreme confusion

Paracetamol overdose is particularly dangerous because liver damage may not become apparent for 24–72 hours. If you suspect you or someone else has taken too much, go to A&E immediately — do not wait for symptoms.

What Should You Do If You Experience Side Effects of Co-Codamol?

For mild side effects such as constipation or nausea, practical measures can help. Drinking plenty of water, eating a high-fibre diet, and staying mobile can ease constipation. Taking tablets with food may reduce nausea. Avoid driving or operating machinery if you feel drowsy.

If side effects are moderate or worsening, stop taking co-codamol and speak to your pharmacist. You can also report side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety for everyone.

Can Co-Codamol 8/500mg Interact With Other Medicines?

Yes. Co-codamol has several clinically significant interactions. The codeine component interacts with other central nervous system depressants, increasing the risk of sedation and respiratory depression. The paracetamol component can affect the anticoagulant effect of warfarin at higher doses. Always tell your pharmacist about all medicines, supplements, and herbal remedies you are taking before starting co-codamol. Key interactions include MAOIs, other opioids, benzodiazepines, antidepressants, and alcohol.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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