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Clotrimazole Cream 50g

Clotrimazole Cream 50g

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  • ✔️ Treats athlete's foot, ringworm, and external thrush symptoms
  • ✔️ Contains 1% clotrimazole — clinically proven antifungal agent
  • ✔️ Relieves itching, redness, and soreness at the infection site
  • ✔️ Suitable for adults and children aged 12 and over
  • ✔️ Generous 50g tube provides a full treatment course

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What Is Clotrimazole Cream 50g and What Does It Treat?

 

Clotrimazole cream 50g is a topical antifungal treatment used to clear a range of common fungal skin infections. It contains 1% clotrimazole as its active ingredient — a well-established azole antifungal that has been used safely in the UK for decades. Whether you're dealing with the persistent itch of athlete's foot, the discomfort of ringworm, or the soreness of thrush, this cream offers targeted relief directly at the site of infection. You can explore the full range of treatments in our athletes foot and fungal infections collection.

Fungal infections are far more common than many people realise. The NHS estimates that athlete's foot alone affects around 15–25% of people at any one time. Clotrimazole is one of the most widely recommended first-line treatments for these conditions, and at just £6.89 for a 50g tube, it's an accessible option for most people.

 

How Does Clotrimazole Cream Work Against Fungal Infections?

 

Clotrimazole belongs to the azole class of antifungals. It works by targeting the fungal cell membrane — specifically by inhibiting an enzyme called lanosterol 14α-demethylase, which fungi need to produce ergosterol. Ergosterol is essential for maintaining the integrity of the fungal cell membrane. Without it, the membrane becomes leaky and the fungal cell eventually dies.

  • Clotrimazole inhibits ergosterol synthesis in the fungal cell membrane
  • The membrane becomes permeable, causing the cell contents to leak out
  • Fungal cells are unable to replicate and die off
  • The infection clears as the skin's natural flora is restored

This mechanism makes clotrimazole effective against a broad spectrum of fungi and yeasts, including Trichophyton species (responsible for athlete's foot and ringworm) and Candida albicans (the yeast behind thrush).

 

Who Should Use Clotrimazole Cream 50g?

 

This cream is suitable for adults and children over the age of 12 for most indications. It's particularly useful if you've been diagnosed with — or recognise the symptoms of — a common superficial fungal infection. Always confirm your diagnosis with a pharmacist or GP if you're unsure, especially if it's your first time experiencing symptoms.

  • Adults and children aged 12 and over with athlete's foot, ringworm, or jock itch
  • Women experiencing external itching and soreness associated with vaginal thrush
  • People with pityriasis versicolor (a yeast-related skin discolouration)
  • Those who have previously been diagnosed with a fungal skin infection and recognise a recurrence

 

How Does Clotrimazole Cream Compare to Other Antifungal Creams?

 

Feature Clotrimazole Cream 50g Miconazole Cream
Active ingredient Clotrimazole 1% Miconazole 2%
Application frequency 2–3 times daily Twice daily
Suitable for thrush (external) Yes Yes
Available OTC in UK Yes Yes

 

Is Clotrimazole Cream Suitable for Sensitive Skin?

 

Most people tolerate clotrimazole cream well, even those with sensitive skin. The formulation is free from unnecessary additives that commonly trigger reactions. That said, if you have a known allergy to clotrimazole or any other azole antifungal, you should not use this product. If you experience significant redness, swelling, or blistering after application, stop use immediately and seek pharmacist advice. You might also find our skin care collection helpful for complementary products to support skin recovery.

Store the cream below 25°C, away from direct sunlight and out of reach of children. Do not use after the expiry date printed on the tube.

This product is a medicine. Speak to your doctor or pharmacist before using if you have an underlying medical condition or are taking other medicines.

Clotrimazole Cream 50g specifications
Treatment category Antifungal / Dermatology
Mechanism of action Inhibits ergosterol synthesis in fungal cell membranes
Effective against Athlete's foot, ringworm, thrush (external), pityriasis versicolor
Suitable for Adults and children aged 12 and over
Active ingredient Clotrimazole 1%
Pack size 50g
Strength 1% w/w
UK classification Pharmacy (P)
Drug class Azole antifungal
Preparation Cream
Route of administration Topical (external use only)

Specifications of Clotrimazole Cream 50g

 

What Is Clotrimazole Cream 50g and What Is It Used For?

 

Clotrimazole cream 50g is an over-the-counter antifungal medicine used to treat superficial fungal infections of the skin. It contains 1% clotrimazole, an azole antifungal agent that kills the fungi and yeasts responsible for a range of common infections. The NHS recommends clotrimazole as a first-line treatment for conditions including athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), and external symptoms of vaginal thrush caused by Candida albicans. It may also be used for pityriasis versicolor, a yeast-related condition that causes patches of discoloured skin.

 

What Do You Need to Know Before Using Clotrimazole Cream 50g?

 

Before applying this cream, read the following carefully. Not everyone is suitable for this treatment, and certain conditions or medicines may affect how safely you can use it.

Do not use clotrimazole cream if you:

  • Are allergic to clotrimazole or any other azole antifungal
  • Are allergic to any of the other ingredients in the cream (check the patient information leaflet)
  • Are using it on a child under 12 years old without medical advice
  • Have broken, raw, or severely inflamed skin at the site of application

Warnings and precautions:

  • Avoid contact with eyes, ears, and mucous membranes
  • Do not use internally (vaginally) — this cream is for external use only
  • If you are pregnant or breastfeeding, speak to your GP or midwife before use
  • If symptoms do not improve within 4 weeks, consult a pharmacist or GP
  • Do not use latex condoms or diaphragms within 5 days of applying this cream to the genital area, as it may damage latex

Drug interactions:

  • Topical clotrimazole has no significant known drug interactions when used on the skin
  • It may damage latex contraceptives — use alternative contraception if applying near the genital area

 

How Should You Use Clotrimazole Cream 50g?

 

Always use this cream exactly as directed. If you're unsure about anything, ask your pharmacist. For women managing thrush-related symptoms, our thrush collection includes additional treatment options that may be used alongside this cream.

  1. Wash and thoroughly dry the affected area before applying the cream
  2. Squeeze a small amount of cream onto your fingertip
  3. Apply a thin layer to the affected skin and the area immediately surrounding it
  4. Rub in gently until fully absorbed
  5. Wash your hands after application (unless your hands are the area being treated)
  6. Apply 2–3 times daily, continuing for the full recommended course
Indication Age Group Dose Frequency
Athlete's foot 12 years and over Thin layer 2–3 times daily for 4 weeks
Ringworm / jock itch 12 years and over Thin layer 2–3 times daily for 4 weeks
External thrush symptoms Adults Thin layer 2–3 times daily for up to 2 weeks
Pityriasis versicolor Adults Thin layer 2–3 times daily for up to 4 weeks

 

What Are the Possible Side Effects of Clotrimazole Cream 50g?

 

Like all medicines, clotrimazole cream can cause side effects, although not everyone experiences them. Most side effects are mild and localised to the area of application.

Common side effects:

  • Mild burning or stinging sensation after application
  • Temporary itching at the application site
  • Slight redness or skin irritation

Less common side effects:

  • Skin rash or hives (urticaria)
  • Blistering or peeling of the skin
  • Swelling at the application site
  • Allergic contact dermatitis (rare)

If you experience a severe allergic reaction — including widespread rash, difficulty breathing, or swelling of the face — stop using the cream immediately and seek urgent medical attention. This type of reaction is rare but serious.

 

How Should You Store Clotrimazole Cream 50g?

 

Proper storage helps maintain the effectiveness of the cream throughout its shelf life. If you're looking for other topical treatments, browse our creams and ointments collection for a wide range of options.

  • Store below 25°C in a cool, dry place
  • Keep away from direct sunlight and heat sources
  • Keep the tube tightly closed when not in use
  • Keep out of the reach and sight of children
  • Do not use after the expiry date printed on the tube or carton
  • Do not dispose of medicines via wastewater or household waste — return unused medicine to your pharmacy

Written and reviewed by our qualified team

Your safety and success are our highest priorities. Our medical team rigorously evaluates every product and piece of advice we provide, ensuring you receive only the most effective, science-backed solutions available.

Frequently Asked Questions

Where can I buy clotrimazole cream 50g online in the UK?

You can buy clotrimazole cream 50g directly from Cured Pharmacy, a GPhC-registered UK online pharmacy, for just £6.89. It's available without a prescription and can be ordered for fast home delivery. Browse our full athletes foot and fungal infections collection for related treatments too.

How does clotrimazole cream work in the body?

Clotrimazole works by blocking an enzyme that fungi need to produce ergosterol — a key component of their cell membranes. Without ergosterol, the fungal cell membrane breaks down, causing the cell to die. This stops the infection from spreading and allows your skin to heal.

How do I apply clotrimazole cream step by step?

Start by washing and thoroughly drying the affected area. Apply a thin layer of cream to the infected skin and the surrounding area, rubbing it in gently. Wash your hands afterwards unless your hands are the area being treated, and repeat 2–3 times daily.

How long does clotrimazole cream take to work?

Many people notice an improvement in symptoms — such as reduced itching and redness — within a few days of starting treatment. However, it's important to continue using the cream for the full recommended course (usually 2–4 weeks) even if symptoms improve early, to prevent the infection returning.

What are the side effects of clotrimazole cream and how do I manage them?

The most common side effects are mild burning, stinging, or itching at the application site, which usually settle quickly. If you experience significant irritation, a rash, or blistering, stop using the cream and speak to your pharmacist. Serious allergic reactions are rare but require immediate medical attention.

Can women use clotrimazole cream for thrush symptoms?

Yes — clotrimazole cream can be applied externally to relieve the itching, soreness, and redness associated with vaginal thrush. It should only be used on the external genital area and is not intended for internal vaginal use in cream form. Visit our women's health collection for additional thrush treatment options.

Who is eligible to use clotrimazole cream 50g?

Clotrimazole cream is suitable for adults and children aged 12 and over for most fungal skin infections. It is not recommended for children under 12 without medical supervision. People with known allergies to azole antifungals should not use this product.

Is clotrimazole cream safe to use during pregnancy?

Topical clotrimazole is generally considered low-risk during pregnancy when used on the skin, as very little is absorbed into the bloodstream. However, you should always consult your GP or midwife before using any medicine during pregnancy or while breastfeeding, to ensure it is appropriate for your individual circumstances.

What happens if I miss an application of clotrimazole cream?

If you forget to apply the cream at your usual time, apply it as soon as you remember and then continue with your normal schedule. Do not apply a double amount to make up for a missed application. Consistency is important — missing doses can reduce the effectiveness of treatment and increase the risk of the infection returning.

What are the alternatives to clotrimazole cream for fungal infections?

Common alternatives include miconazole cream, terbinafine cream, and ketoconazole cream — all available OTC in the UK. The best choice depends on the type and location of your infection. Your pharmacist can help you decide which antifungal is most appropriate for your situation.

Can I use clotrimazole cream on my face?

Clotrimazole cream can be used on facial fungal infections such as ringworm, but you should take care to avoid the eyes, mouth, and mucous membranes. If the infection is near your eyes or covers a large area of your face, speak to your GP before using any topical antifungal.

How long can you use clotrimazole cream for?

Treatment duration depends on the condition being treated — typically 2 weeks for thrush-related symptoms and up to 4 weeks for athlete's foot or ringworm. If your symptoms have not improved after 4 weeks of consistent use, stop treatment and consult your GP or pharmacist, as you may need a different treatment or further investigation.

Will clotrimazole cream damage condoms or diaphragms?

Yes — clotrimazole cream can weaken latex, which means it may reduce the effectiveness of latex condoms and diaphragms. If you are applying the cream near the genital area, use an alternative form of contraception for at least 5 days after your last application. Non-latex condoms are not affected in the same way.

What does the latest research say about clotrimazole for fungal infections?

Clotrimazole has been used clinically for over 50 years and remains one of the most studied and recommended topical antifungals in the world. Current NHS and NICE guidance continues to support its use as a first-line treatment for superficial fungal skin infections, reflecting its well-established safety and efficacy profile.

Can I use clotrimazole cream at the same time as other skin treatments?

You should generally avoid applying other creams or ointments to the same area at the same time as clotrimazole, as this can dilute the active ingredient and reduce its effectiveness. If you are using a steroid cream or another topical medicine, ask your pharmacist whether it is safe to use them together and how to space out applications.

How Should You Use Clotrimazole Cream 50g?

Using clotrimazole cream correctly gives you the best chance of clearing your infection fully and preventing it from coming back. Always read the patient information leaflet before starting treatment, and follow these steps each time you apply the cream.

Avoid getting the cream in your eyes, ears, or mouth. Do not apply to broken or severely inflamed skin without first speaking to a pharmacist or GP.

What Is the Correct Dose of Clotrimazole Cream 50g?

The dose does not vary significantly between conditions, but the duration of treatment does. Always complete the full course, even if your symptoms improve before the end of treatment. Stopping early is one of the most common reasons fungal infections return.

When Is the Best Time to Use Clotrimazole Cream 50g?

There is no single "best" time of day to apply clotrimazole cream, but spacing your applications evenly throughout the day helps maintain a consistent level of the active ingredient on the skin. Many people find it easiest to apply the cream after their morning shower, at lunchtime, and again before bed. Applying it after bathing — when the skin is clean and dry — also helps the cream absorb more effectively.

If you are treating athlete's foot, applying the cream before putting on socks and shoes in the morning is a practical routine that many people find easy to stick to.

How Long Can You Use Clotrimazole Cream 50g For?

Treatment duration depends on the condition you are treating. For most fungal skin infections, a course of 2–4 weeks is recommended. For external thrush symptoms, 2 weeks is usually sufficient. Do not use the cream for longer than 4 weeks without speaking to a pharmacist or GP, as persistent symptoms may indicate a different condition or a need for a different treatment approach.

If your symptoms have not improved after 4 weeks of consistent use, stop treatment and seek professional advice. Recurring infections may require investigation to rule out underlying conditions such as diabetes, which can make people more susceptible to fungal infections.

Do not exceed the recommended dose. If in doubt, speak to your pharmacist.

Customer Reviews

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Anonymous

The cream helps with a fungal sweat rash I have had for a number of months. This is due I assume to the physical exercise I undertake 3 to. 4 times a week. The main exercise is cycling.

What Are the Most Common Side Effects of Clotrimazole Cream 50g?

Most people use clotrimazole cream without experiencing any significant side effects. When reactions do occur, they are usually mild and limited to the area where the cream has been applied. These typically settle on their own within a few days as your skin adjusts to the treatment.

  • Mild burning or stinging sensation immediately after application
  • Temporary itching at the treated site
  • Slight redness or skin irritation
  • Dry or flaking skin around the application area

What Are the Less Common Side Effects of Clotrimazole Cream 50g?

Less commonly, some people may experience a more noticeable skin reaction. These side effects are not dangerous in most cases, but they do warrant attention. If any of the following occur and do not settle within a day or two, stop using the cream and speak to your pharmacist.

  • Skin rash or hives (urticaria) at or near the application site
  • Blistering or peeling of the skin
  • Swelling or puffiness around the treated area
  • Allergic contact dermatitis — a delayed skin reaction that can cause redness, weeping, and crusting

What Are the Serious Side Effects of Clotrimazole Cream 50g?

Serious side effects from topical clotrimazole are rare, but they can occur. A severe allergic reaction (anaphylaxis) is extremely uncommon with a topical medicine, but you should be aware of the signs. If you experience any of the following after applying the cream, stop use immediately and seek urgent medical attention or call 999.

  • Widespread skin rash or swelling beyond the application site
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Dizziness or feeling faint

What Should You Do If You Experience Side Effects of Clotrimazole Cream?

For mild side effects such as temporary stinging or redness, you can usually continue using the cream and monitor whether the reaction settles. Applying the cream to clean, dry skin and using only a thin layer can help minimise irritation. If the reaction is more significant — such as a spreading rash or blistering — stop treatment and consult your pharmacist or GP before continuing.

You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk. This helps improve medicine safety monitoring across the UK.

Can Clotrimazole Cream Interact With Other Medicines?

Topical clotrimazole has very few known interactions with other medicines when used on the skin, as only a negligible amount is absorbed into the bloodstream. However, there is one important interaction to be aware of: clotrimazole cream can degrade latex, which means it may reduce the effectiveness of latex condoms and diaphragms. If you are applying the cream near the genital area, use a non-latex or alternative form of contraception for at least 5 days after your last application.

If you are using any other topical medicines on the same area of skin, speak to your pharmacist before combining treatments, as applying multiple creams to the same site can affect how well each one works.

If you are concerned about any side effects, contact your pharmacist or GP immediately.

Patient Information Leaflet

Important - Before taking any medication, it is always important to read the Patient Information Leaflet (PIL)

Written and reviewed by our qualified team

GPhC Number: 2233073
Tarun Kumar

Reviewed by:

Tarun Kumar

Superintendent/ Clinical Lead

📖 Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 31 Mar 2025

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